Details of the Target

General Information of Target

Target ID LDTP07964
Target Name Golgi to ER traffic protein 4 homolog (GET4)
Gene Name GET4
Gene ID 51608
Synonyms
C7orf20; CEE; TRC35; Golgi to ER traffic protein 4 homolog; Conserved edge-expressed protein; Transmembrane domain recognition complex 35 kDa subunit; TRC35
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAMAEQESARNGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHT
EARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVADELLENLAKVFSLMDPNSP
ERVTFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSADGEGCANMLV
EYSTSRGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTTYTQKHPSIEDGPPFVEPLLNFI
WFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGN
LLTSLMGSSEQEDGEESPSDGSPIELD
Target Bioclass
Other
Family
GET4 family
Subcellular location
Cytoplasm, cytosol
Function
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Uniprot ID
Q7L5D6
Ensemble ID
ENST00000265857.8
HGNC ID
HGNC:21690

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.T256I .
HCT116 SNV: p.S211G DBIA    Probe Info 
HS578T SNV: p.R267L DBIA    Probe Info 
HT115 SNV: p.S162L .
HUPT3 Insertion: p.S55VfsTer48 DBIA    Probe Info 
LS180 SNV: p.S183F DBIA    Probe Info 
NALM6 SNV: p.G187S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K110(20.00)  LDD2217  [2]
Probe 1
 Probe Info  		Y40(9.74); Y53(71.73)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C160(3.13)  LDD0168  [4]
DBIA
 Probe Info  		C160(1.56)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C160(0.00); C175(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C160(0.00); C175(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		13.64  LDD1740  [13]
C403
 Probe Info  		15.24  LDD2061  [13]
C407
 Probe Info  		17.63  LDD2064  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C160(3.13)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C160(5.53)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C160(1.49); C259(1.25)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C160(1.11); C259(1.06)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C160(1.09)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C160(1.13)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C160(1.05)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C160(1.31)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C160(1.27)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C160(1.27)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C160(1.25)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C160(1.14)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C160(0.86)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C160(0.90)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C160(1.29); C259(1.04)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C160(0.93)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C160(0.87)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C160(0.99)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C160(1.10)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C160(1.36)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C160(1.49)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C160(1.53)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C160(1.28)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C160(1.19)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C160(1.31)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C160(0.96); C259(1.05)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C160(1.24)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C160(1.20)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C160(1.13)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C160(1.06)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C160(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C160(1.18)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C160(1.38)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C160(1.45)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C160(1.30)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C160(0.91)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C160(1.28)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C160(0.81)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C160(1.05)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C160(1.05)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C160(1.49)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C160(1.15)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C160(1.18)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C160(1.07)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C160(1.34)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C160(1.16)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C160(0.91); C259(1.07)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C160(1.41)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C160(1.23)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C160(0.86)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C160(1.26)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C160(2.08)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C160(1.71)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C160(1.87)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C160(1.73)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C160(2.53)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C160(2.10)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C160(1.04); C259(1.17)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C160(1.44)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C160(1.50)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C160(1.79)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C160(2.81)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C160(1.68)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C160(1.87)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C160(1.20)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C160(1.23)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C160(0.93)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C160(1.00)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C160(1.14)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C259(1.00); C160(1.64)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C160(1.01)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C160(0.85)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C160(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C160(0.94)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C160(0.82)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C160(1.31)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C160(1.79)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C160(1.28)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C160(1.33)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C160(1.96)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C259(1.13); C160(1.31)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C160(1.84)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C160(1.54)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C160(2.03)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C160(1.13)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C160(1.05)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C160(0.89)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C160(0.84)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C160(0.89)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C160(0.97)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C160(0.97)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C259(1.00); C160(1.63)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C160(1.05)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C160(1.18)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C160(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C160(1.04)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C160(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C160(1.18)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C160(1.09)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C160(1.02)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C160(1.10)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C160(1.41)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C259(1.02); C160(2.01)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C160(1.48)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C160(0.93)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C160(1.16)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C160(1.04)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C160(1.34)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C160(1.32)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C160(1.61)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C160(1.62)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C160(1.62)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C160(1.76)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C259(1.08); C160(1.10)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C160(1.65)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C160(1.63)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C160(1.95)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C160(1.78)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C160(1.80)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C160(1.75)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C160(1.86)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C160(2.21)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C160(1.12)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C160(1.20)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C160(1.29); C259(1.41)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C160(1.44)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C160(1.09)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C160(1.27)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C160(1.65)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C160(1.78)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C160(1.86)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C160(1.51)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C160(1.39)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C160(1.21)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C160(1.19)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C259(0.89); C160(1.12)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C160(1.40)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C160(0.99)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C160(1.88)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C160(1.70)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C160(1.89)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C160(1.66)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C160(1.44)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C160(1.09)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C160(1.29)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C160(1.53)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C160(1.18)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C160(2.34)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C160(2.09)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C160(1.51)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C160(1.24)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C160(1.27)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C160(1.49)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C160(1.99)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C160(1.60)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C160(0.98)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C160(0.82); C259(1.04)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C259(0.97); C160(1.02)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C259(1.39); C160(1.60)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C160(1.56)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C160(0.67)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C160(1.03)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C160(1.41)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C259(0.92); C160(1.76)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C259(1.00); C160(1.30)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C160(0.98); C259(1.21)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C160(0.97); C259(1.05)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C160(0.89); C259(1.14)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C160(0.93)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C160(1.05)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C160(1.01)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C160(0.95)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C160(1.08)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C160(1.31)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C160(1.12)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C160(1.08)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C160(1.77)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C160(1.62)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C160(2.00)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C160(1.44)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C160(1.13)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C160(1.43)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C160(1.11)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C160(1.12)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C160(1.34)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C160(0.98)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C160(1.46)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C160(1.31)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C160(1.36)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C160(1.62)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C160(1.26)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C160(1.38)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C160(1.36)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C160(1.63)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C160(1.15)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C160(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C160(1.23)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C259(0.99); C160(1.05)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C160(1.07); C259(1.13)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C160(0.86); C259(1.12)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C160(0.85); C259(1.01)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C160(0.98)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C259(1.11); C160(1.16)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C259(1.15); C160(1.16)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C259(1.44); C160(1.59)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C160(1.09); C259(1.22)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C259(1.10); C160(1.42)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C160(1.06); C259(1.06)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C160(0.98); C259(1.05)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C160(0.87); C259(1.07)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C160(1.16); C259(1.21)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C160(1.10); C259(1.15)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C160(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C160(0.97); C259(1.00)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C160(1.39)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C160(1.32)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C160(3.57)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C160(1.43)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C160(1.50)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C160(1.42)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C160(1.71)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C160(2.18)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C160(1.59)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C160(1.51)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C160(1.36)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C160(2.44)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C160(1.72)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C160(1.55)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C160(1.85)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C160(1.02)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C160(0.97)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C160(0.97)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C160(1.00)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C160(0.90)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C160(0.92)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C160(1.02)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C160(1.10)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C160(0.92)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C160(0.88)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C160(0.85)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C160(1.04)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C160(0.85)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C160(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C160(0.95)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C160(1.17)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C160(1.08)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C160(1.24); C259(0.79)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C160(1.40); C259(0.81)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C160(1.41); C259(0.68)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C160(1.52); C259(0.75)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C160(1.34); C259(0.78)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C160(1.65); C259(1.04)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C160(1.59); C259(1.02)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C160(1.37); C259(0.89)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C160(1.26); C259(0.89)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C160(1.29)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C160(1.27); C259(0.87)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C160(1.70); C259(0.83)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C160(1.17); C259(0.66)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C160(1.60); C259(0.94)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C160(1.40); C259(0.83)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C160(0.99); C259(0.78)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C160(0.97); C259(0.92)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C160(1.16); C259(0.98)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C160(1.28); C259(0.83)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C160(2.26)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C160(1.08); C259(1.06)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C160(1.30); C259(0.78)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C160(1.41); C259(0.99)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C160(1.67); C259(0.90)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C160(2.00); C259(1.17)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C160(1.22); C259(0.86)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C160(1.14); C259(0.89)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C160(1.10); C259(1.14)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C160(1.39); C259(1.13)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C160(1.97); C259(1.22)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C160(1.16)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C160(1.17); C259(0.85)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C160(1.45); C259(1.05)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C160(1.66); C259(0.88)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C160(1.39); C259(0.92)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C160(1.75); C259(1.12)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C160(2.44); C259(0.87)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C160(1.72); C259(0.82)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C160(1.60); C259(0.95)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C160(1.51); C259(1.05)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C160(1.51); C259(1.15)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C160(0.93)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C160(1.00); C175(0.89)  LDD1698  [16]
 LDCM0625  F8 Ramos C160(1.46)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C160(4.21)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C160(1.99)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C160(2.86)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C160(1.01)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C160(1.42)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C160(2.49)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C160(1.02)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C160(0.84)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C160(0.93)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C160(0.73)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C160(1.25)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C160(0.78)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C160(6.88)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C160(1.38); C259(1.10)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C160(1.10)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C160(1.13)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C160(1.76)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C160(1.30)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C160(1.24)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C160(2.79)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C160(6.98)  LDD2188  [17]
 LDCM0022  KB02 HEK-293T C160(0.96); C175(0.97); C205(0.97)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C160(102.82)  LDD0209  [18]
 LDCM0024  KB05 COLO792 C160(1.65)  LDD3310  [19]
 LDCM0627  NUDT7-COV-1 HEK-293T C160(0.88)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C160(1.05)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C160(1.17)  LDD0304  [21]
 LDCM0021  THZ1 HCT 116 C160(0.98)  LDD2173  [5]
 LDCM0113  W17 Hep-G2 C160(8.05)  LDD0240  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
ATPase GET3 (GET3) ArsA ATPase family O43681
Dual specificity protein phosphatase 21 (DUSP21) Protein-tyrosine phosphatase family Q9H596
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore complex protein Nup85 (NUP85) Nucleoporin Nup85 family Q9BW27
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibrillin-1 (FBN1) Fibrillin family P35555
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.