General Information of Target

Target ID LDTP09814
Target Name Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1)
Gene Name LPGAT1
Gene ID 9926
Synonyms
FAM34A; KIAA0205; Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; 2-acylglycerophosphocholine O-acyltransferase; EC 2.3.1.62; Acyl-CoA:monoacylglycerol acyltransferase LPGAT1; EC 2.3.1.22; Lysophospholipid acyltransferase 7; LPLAT7; EC 2.3.1.-; Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSF
GTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLY
PFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKT
VATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLS
DNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
Target Bioclass
Enzyme
Family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane. Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor. Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span. Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors. Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols. Has no activity toward lysophosphatidic acids (LPA).
Uniprot ID
Q92604
Ensemble ID
ENST00000366996.1
HGNC ID
HGNC:28985

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info 
K164(10.00); K165(8.33); K219(10.00)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info 
7.57  LDD1728  [2]
C040
 Probe Info 
9.78  LDD1740  [2]
C056
 Probe Info 
18.13  LDD1753  [2]
C091
 Probe Info 
9.99  LDD1782  [2]
C092
 Probe Info 
17.88  LDD1783  [2]
C094
 Probe Info 
28.25  LDD1785  [2]
C112
 Probe Info 
20.11  LDD1799  [2]
C134
 Probe Info 
20.11  LDD1816  [2]
C201
 Probe Info 
23.92  LDD1877  [2]
C228
 Probe Info 
16.45  LDD1901  [2]
C231
 Probe Info 
19.29  LDD1904  [2]
C235
 Probe Info 
19.97  LDD1908  [2]
C289
 Probe Info 
36.25  LDD1959  [2]
C343
 Probe Info 
11.63  LDD2005  [2]
C349
 Probe Info 
14.42  LDD2010  [2]
C350
 Probe Info 
30.70  LDD2011  [2]
C362
 Probe Info 
29.04  LDD2023  [2]
C388
 Probe Info 
39.12  LDD2047  [2]
C407
 Probe Info 
10.85  LDD2064  [2]
FFF probe11
 Probe Info 
20.00  LDD0471  [3]
FFF probe14
 Probe Info 
20.00  LDD0477  [3]
OEA-DA
 Probe Info 
8.45  LDD0046  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
4 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570