Details of the Target

General Information of Target

Target ID LDTP11852
Target Name Presenilin-associated rhomboid-like protein, mitochondrial (PARL)
Gene Name PARL
Gene ID 55486
Synonyms
PSARL; Presenilin-associated rhomboid-like protein, mitochondrial; EC 3.4.21.105; Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta; Pbeta)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGE
EEEEDYFDKELIQLIKQRKEQSRQDEPSNSNQEINSDDRRPQWRREDRIPYQDRESYSQP
AWHHRGPPQRDWKWEKDGFNNTRKNSFPHSLRNGGGPRGRSGWHKGVAGGSSTWFHNHSN
SGGGWLSNSGAVDWNHNGTGRNSSWLSEGTGGFSSWHMNNSNGNWKSSVRSTNNWNYSGP
GDKFQPGRNRNSNCQMEDMTMLWNKKSNKSNKYSHDRYNWQRQENDKLGTVATYRGPSEG
FTSDKFPSEGLLDFNFEQLESQTTKQADTATSKVSGKNGSAAREKPRRWTPYPSQKTLDL
QSGLKDITGNKSEMIEKPLFDFSLITTGIQEPQTDETRNSPTQKTQKEIHTGSLNHKASS
DSAASFEVVRQCPTAEKPEQEHTPNKMPSLKSPLLPCPATKSLSQKQDPKNISKNTKTNF
FSPGEHSNPSNKPTVEDNHGPYISKLRSSCPHVLKGNKSTFGSQKQSGDNLNDTLRKAKE
VLQCHESLQNPLLSTSKSTRNYAKASRNVEESEKGSLKIEFQVHALEDESDGETSDTEKH
GTKIGTLGSATTELLSGSTRTADEKEEDDRILKTSRELSTSPCNPIVRQKESELQMTSAA
SPHPGLLLDLKTSLEDAQVDDSIKSHVSYETEGFESASLDAELQKSDISQPSGPLLPELS
KLGFPASLQRDLTRHISLKSKTGVHLPEPNLNSARRIRNISGHRKSETEKESGLKPTLRQ
ILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEALDLDGEPDLSSLEG
FQWEGVSISSSPGLARKRSLSESSVIMDRAPSVYSFFSEEGTGKENEPQQMVSPSNSLRA
GQSQKATMHLKQEVTPRAASLRTGERAENVATQRRHSAQLSSDHIIPLMHLAKDLNSQER
SIPPSENQNSQESNGEGNCLSSSASSALAISSLADAATDSSCTSGAEQNDGQSIRKKRRA
TGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLNISLREEELSKSLQCMDNNLLQARAA
LQTAYVEVQRLLMLKQQITMEMSALRTHRIQILQGLQETYEPSEHPDQVPCSLTRERRNS
RSQTSIDAALLPTPFFPLFLEPPSSHVSPSPTGASLQITTSPTFQTHGSVPAPDSSVQIK
QEPMSPEQDENVNAVPPSSACNVSKELLEANREISDSCPVYPVITARLSLPESTESFHEP
SQELKFSVEQRNTRNRENSPSSQSAGLSSINKEGEEPTKGNSGSEACTSSFLRLSFASET
PLEKEPHSPADQPEQQAESTLTSAETRGSKKKKKLRKKKSLRAAHVPENSDTEQDVLTVK
PVRKVKAGKLIKGGKVTTSTWEDSRTGREQESVRDEPDSDSSLEVLEIPNPQLEVVAIDS
SESGEEKPDSPSKKDIWNSTEQNPLETSRSGCDEVSSTSEIGTRYKDGIPVSVAETQTVI
SSIKGSKNSSEISSEPGDDDEPTEGSFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVS
RKCIGVFEGHTSKVNCLLVTQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLEDRVLC
LHSRWRILYAGLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDC
TISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHN
HAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDG
SIQAVRLNLMQNYRCWWHGCSLIFGVVDHLKQHLLTDHTNPNFQTLKCRWKNCDAFFTAR
KGSKQDAAGHIERHAEDDSKIDS
Target Bioclass
Enzyme
Family
Peptidase S54 family
Subcellular location
Mitochondrion inner membrane; Nucleus
Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential. Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss. Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide. Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity. Also required for cleavage of STARD7 and TTC19. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Uniprot ID
Q9H300
Ensemble ID
ENST00000311101.9
HGNC ID
HGNC:18253
ChEMBL ID
CHEMBL4879516

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.C206Y .
HEC1 Deletion: p.G375EfsTer12 .
HEC1B Deletion: p.G375EfsTer12 .
MELJUSO SNV: p.G5V; p.Q37H .
RD SNV: p.V21G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y74(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K136(5.26)  LDD0277  [2]
Jackson_1
 Probe Info  		3.67  LDD0121  [3]
DBIA
 Probe Info  		C288(0.97)  LDD1492  [4]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.99  LDD1740  [5]
C055
 Probe Info  		13.64  LDD1752  [5]
C056
 Probe Info  		32.22  LDD1753  [5]
C091
 Probe Info  		14.22  LDD1782  [5]
C092
 Probe Info  		26.91  LDD1783  [5]
C094
 Probe Info  		39.67  LDD1785  [5]
C100
 Probe Info  		5.13  LDD1789  [5]
C106
 Probe Info  		19.16  LDD1793  [5]
C225
 Probe Info  		5.35  LDD1898  [5]
C228
 Probe Info  		36.25  LDD1901  [5]
C289
 Probe Info  		38.05  LDD1959  [5]
C348
 Probe Info  		12.13  LDD2009  [5]
C349
 Probe Info  		17.88  LDD2010  [5]
C350
 Probe Info  		45.57  LDD2011  [5]
C388
 Probe Info  		38.32  LDD2047  [5]
C390
 Probe Info  		27.10  LDD2049  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C288(0.97)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C288(1.07)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C288(0.92)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C288(1.13)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C288(1.09)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C288(0.89)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C288(0.87)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C288(0.94)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C288(0.80)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C288(0.89)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C288(0.89)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C288(1.00)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C288(1.20)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C288(0.99)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C288(1.15)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C288(0.99)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C288(0.90)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C288(0.83)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C288(1.02)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C288(0.98)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C288(0.84)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C288(1.05)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C288(1.00)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C288(1.01)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C288(0.93)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C288(0.95)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C288(0.89)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C288(0.91)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C288(0.96)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C288(1.15)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C288(0.89)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C288(0.98)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C288(1.15)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C288(0.98)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C288(0.84)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C288(0.99)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C288(0.94)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C288(0.96)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C288(1.13)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C288(0.92)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C288(0.96)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C288(1.03)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C288(0.89)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C288(0.82)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C288(0.93)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C288(0.98)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C288(1.02)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C288(1.01)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C288(0.88)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C288(1.00)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C288(1.10)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C288(1.10)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C288(0.91)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C288(1.06)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C288(0.96)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C288(1.03)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C288(1.17)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C288(1.05)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C288(1.19)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C288(1.01)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C288(1.16)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C288(0.96)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C288(0.96)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C288(1.02)  LDD1514  [4]
 LDCM0071  Cisar_cp14 MDA-MB-231 3.67  LDD0121  [3]
 LDCM0367  CL1 HEK-293T C288(0.94)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C288(1.59)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C288(0.92)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C288(0.93)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C288(0.92)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C288(1.13)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C288(1.01)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C288(0.98)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C288(0.93)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C288(1.13)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C288(0.99)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C288(0.88)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C288(1.31)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C288(0.74)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C288(1.17)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C288(0.97)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C288(0.89)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C288(0.95)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C288(1.16)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C288(0.83)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C288(0.93)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C288(1.00)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C288(1.16)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C288(1.27)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C288(0.90)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C288(0.99)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C288(1.00)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C288(1.19)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C288(0.95)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C288(1.13)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C288(0.93)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C288(1.15)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C288(1.03)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C288(0.88)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C288(0.84)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C288(1.13)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C288(1.00)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C288(1.07)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C288(1.10)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C288(1.00)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C288(0.95)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C288(1.25)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C288(1.17)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C288(1.26)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C288(1.17)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C288(1.18)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C288(1.08)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C288(0.92)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C288(1.17)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C288(0.91)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C288(1.01)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C288(1.24)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C288(0.92)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C288(1.00)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C288(1.05)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C288(1.14)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C288(1.39)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C288(1.03)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C288(1.09)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C288(0.90)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C288(1.08)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C288(0.95)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C288(0.86)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C288(0.92)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C288(1.12)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C288(1.00)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C288(0.97)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C288(1.02)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C288(1.19)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C288(1.17)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C288(1.20)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C288(1.09)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C288(1.11)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C288(0.90)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C288(1.01)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C288(1.08)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C288(1.09)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C288(1.12)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C288(0.92)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C288(1.02)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C288(1.15)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C288(1.03)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C288(1.09)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C288(1.14)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C288(1.01)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C288(0.94)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C288(1.11)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C288(1.14)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C288(1.09)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C288(0.91)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C288(0.95)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C288(0.96)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C288(1.11)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C288(1.13)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C288(1.06)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C288(1.07)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C288(1.20)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C288(0.83)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C288(0.88)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C288(1.00)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C288(1.02)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C288(0.99)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C288(0.88)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C288(1.52)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C288(0.98)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C288(1.02)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C288(1.12)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C288(0.96)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C288(1.15)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C288(1.30)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C288(0.98)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C288(1.18)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C288(0.99)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C288(1.10)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C288(1.19)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C288(1.08)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C288(1.11)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C288(0.97)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C288(1.22)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C288(1.27)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C288(1.16)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C288(1.58)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C288(1.07)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C288(0.92)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C288(1.26)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C288(1.23)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C288(1.25)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C288(0.92)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C288(0.97)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C288(1.03)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C288(0.85)  LDD1502  [4]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587