Details of the Target

General Information of Target

Target ID LDTP10583
Target Name E3 SUMO-protein ligase NSE2 (NSMCE2)
Gene Name NSMCE2
Gene ID 286053
Synonyms
C8orf36; MMS21; E3 SUMO-protein ligase NSE2; EC 2.3.2.-; E3 SUMO-protein transferase NSE2; MMS21 homolog; hMMS21; Non-structural maintenance of chromosomes element 2 homolog; Non-SMC element 2 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPI
YYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRC
KNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFET
LRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDK
HKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNF
IIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDF
LEEI
Target Bioclass
Enzyme
Family
NSE2 family
Subcellular location
Nucleus
Function
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
Uniprot ID
Q96MF7
Ensemble ID
ENST00000287437.8
HGNC ID
HGNC:26513

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K107(3.99)  LDD0277  [2]
IPM
 Probe Info  		C185(0.00); C140(0.00)  LDD0241  [3]
BTD
 Probe Info  		C140(1.04)  LDD2092  [4]
DBIA
 Probe Info  		C210(0.96); C215(0.96)  LDD0078  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C185(0.00); C140(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C140(0.00); C185(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Phosphinate-6
 Probe Info  		C185(0.00); C210(0.00)  LDD0018  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		15.24  LDD1713  [12]
C296
 Probe Info  		16.80  LDD1966  [12]
C390
 Probe Info  		25.81  LDD2049  [12]
C391
 Probe Info  		34.78  LDD2050  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C140(0.67)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C140(1.27)  LDD2112  [4]
 LDCM0214  AC1 HCT 116 C140(0.80); C210(1.21); C215(1.21)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C140(1.31); C210(1.23); C215(1.23)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C140(1.11); C210(1.17); C215(1.17)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C140(0.80); C210(1.31); C215(1.31)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C140(0.83); C210(1.04); C215(1.04)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C140(0.94); C210(1.34); C215(1.34)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C140(0.78); C210(0.99); C215(0.99)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C140(0.79); C210(1.13); C215(1.13)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C140(0.80); C210(1.62); C215(1.62)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C140(0.81); C210(1.21); C215(1.21)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C140(0.76); C210(1.59); C215(1.59)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C140(0.71); C210(1.08); C215(1.08)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C140(1.21); C210(1.36); C215(1.36)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C140(0.81); C210(1.41); C215(1.41)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C140(1.04); C210(1.62); C215(1.62)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C140(0.93); C210(1.47); C215(1.47)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C140(0.99); C210(1.04); C215(1.04)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C140(1.11); C210(1.17); C215(1.10)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C140(1.08); C210(1.13); C215(1.19)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C140(0.95); C210(0.97); C215(1.03)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C140(1.08); C210(1.18); C215(1.17)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C140(0.97); C210(1.20); C215(1.19)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C140(1.29); C210(1.16); C215(1.34)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C140(0.81); C210(1.37); C215(1.37)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C140(1.11); C210(1.28); C215(1.20)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C140(0.85); C210(1.11); C215(1.21)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C140(1.27); C210(1.14); C215(1.15)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C140(0.88); C210(1.10); C215(1.12)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C140(1.17); C210(1.13); C215(1.20)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C140(1.14); C210(1.07); C215(1.14)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C140(1.07); C210(1.10); C215(1.15)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C140(1.05); C210(1.09); C215(1.09)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C140(1.14); C210(0.44); C215(0.44)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C140(1.61); C210(0.31); C215(0.31)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C140(1.45); C210(0.37); C215(0.37)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C140(0.87); C210(0.45); C215(0.45)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C140(1.11); C210(0.44); C215(0.44)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C140(1.02); C210(0.37); C215(0.37)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C140(1.51); C210(0.42); C215(0.42)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C140(0.98); C210(0.65); C215(0.65)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C140(1.29); C210(0.46); C215(0.46)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C140(1.24); C210(0.60); C215(0.60)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C140(1.70); C210(0.69); C215(0.69)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C140(1.20); C210(0.64); C215(0.64)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C140(1.14); C210(1.25); C215(1.25)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C140(1.54); C210(0.76); C215(0.76)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C140(1.39); C210(0.63); C215(0.63)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C140(1.21); C210(0.54); C215(0.54)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C140(1.10); C210(1.16); C215(1.16)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C210(0.86); C215(1.07); C140(1.21)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C210(0.84); C140(1.06); C215(1.17)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C210(0.69); C140(0.92); C215(1.24)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C140(0.99); C210(1.10); C215(1.19)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C210(0.74); C140(1.14); C215(1.91)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C210(0.68); C140(1.08); C215(1.48)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C210(0.89); C215(0.89); C140(1.04)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C210(0.78); C215(1.28); C140(1.32)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C210(0.82); C215(0.94); C140(1.15)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C210(0.71); C140(0.91); C215(1.42)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C210(0.61); C140(1.28); C215(1.58)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C140(1.09); C210(0.77); C215(1.11)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C140(1.12); C210(0.68); C215(1.29)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C140(1.04); C210(0.77); C215(1.21)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C140(1.02); C210(0.87); C215(1.17)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C140(0.85); C210(0.91); C215(0.91)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C210(0.80); C215(0.80); C140(1.56)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C210(0.78); C215(0.78); C140(0.86)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C210(1.07); C215(1.07); C140(1.10)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C210(0.85); C215(0.85); C140(0.91)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C210(0.77); C215(0.77); C140(0.88)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C210(0.66); C215(0.66); C140(0.86)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C210(0.53); C215(0.53); C140(0.91)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C210(0.58); C215(0.58); C140(0.78)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C140(1.29)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C140(1.36)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C140(1.24)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C140(1.17)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C140(1.15)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C140(0.90); C210(1.25); C215(1.25)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C140(1.13)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C140(1.32)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C140(1.53)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C140(1.40)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C140(1.33)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C140(0.97); C210(1.31); C215(1.31)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C140(0.98); C210(1.50); C215(1.50)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C140(0.94); C210(1.29); C215(1.29)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C140(0.98); C210(1.37); C215(1.37)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C140(1.07); C210(1.40); C215(1.40)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C140(0.84); C210(1.27); C215(1.27)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C140(1.04); C210(1.45); C215(1.45)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C140(1.15); C210(1.34); C215(1.34)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C210(1.26); C215(1.26); C140(1.26)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C140(1.33); C210(1.44); C215(1.44)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C140(1.22); C210(1.27); C215(1.27)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C140(1.09); C210(1.36); C215(1.36)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C210(0.93); C215(0.93); C140(1.16)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C140(0.90); C210(1.05); C215(1.05)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C140(1.00); C210(1.19); C215(1.19)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C210(0.65); C215(0.65); C140(1.19)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C140(0.96); C210(1.38); C215(1.38)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C210(0.84); C215(0.84); C140(1.38)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C210(0.76); C215(0.76); C140(0.78)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C210(0.89); C215(0.89); C140(1.01)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C210(0.80); C215(0.80); C140(1.22)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C140(0.96); C210(1.03); C215(1.03)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C210(0.85); C215(0.85); C140(1.45)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C210(0.86); C215(0.86); C140(2.04)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C210(0.85); C215(0.85); C140(0.97)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C210(0.90); C215(0.90); C140(1.04)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C140(1.03); C210(1.19); C215(1.19)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C210(0.94); C215(0.94); C140(1.29)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C140(0.89); C210(1.09); C215(1.09)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C140(0.85); C210(1.05); C215(1.05)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C140(0.95); C210(1.11); C215(1.11)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C140(0.87); C210(1.39); C215(1.39)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C140(1.10); C210(1.25); C215(1.25)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C140(0.95); C210(1.26); C215(1.26)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C140(0.87); C210(1.04); C215(1.04)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C140(0.96); C210(1.46); C215(1.46)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C140(0.90); C210(1.09); C215(1.09)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C210(0.72); C215(0.72); C140(0.89)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C140(0.87); C210(1.08); C215(1.08)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C210(0.74); C215(0.74); C140(1.06)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C210(0.63); C215(0.63); C140(1.07)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C210(0.73); C215(0.73); C140(1.07)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C210(0.99); C215(0.99); C140(1.43)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C210(0.66); C215(0.66); C140(1.20)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C210(0.76); C215(0.76); C140(1.41)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C210(0.74); C215(0.74); C140(1.11)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C210(0.78); C215(0.78); C140(1.16)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C210(0.77); C215(0.77); C140(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C210(0.80); C215(0.80); C140(1.09)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C210(0.87); C215(0.87); C140(1.24)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C210(0.65); C215(0.65); C140(1.11)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C210(0.74); C215(0.74); C140(0.92)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C210(0.65); C215(0.65); C140(1.50)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C210(0.82); C215(0.82); C140(1.60)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C210(0.64); C215(0.64); C140(1.63)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C210(0.61); C215(0.61); C140(1.30)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C210(0.92); C215(0.92); C140(1.43)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C210(0.96); C215(0.96); C140(1.12)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C210(0.82); C215(0.82); C140(1.13)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C210(0.82); C215(0.82); C140(1.40)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C210(1.03); C215(1.03); C140(1.14)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C210(0.80); C215(0.80); C140(1.44)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C210(0.66); C215(0.66); C140(1.62)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C210(0.80); C215(0.80); C140(1.25)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C210(0.53); C215(0.53); C140(1.35)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C210(0.90); C215(0.90); C140(1.23)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C210(0.60); C215(0.60); C140(1.35)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C210(0.84); C215(0.84); C140(1.53)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C140(1.23); C210(1.31); C215(1.31)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C140(0.85); C210(1.19); C215(1.19)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C140(0.94); C210(1.26); C215(1.26)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C140(0.89); C210(1.36); C215(1.36)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C210(0.78); C215(0.78); C140(1.49)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C210(0.96); C215(0.96)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C185(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C210(0.65); C215(0.65); C140(0.99)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C210(0.60); C215(0.60); C140(1.21)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C140(0.77); C210(1.16); C215(1.16)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C210(1.07); C215(1.07); C140(1.18)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C140(0.88); C210(1.27); C215(1.27)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C140(0.83); C210(1.27); C215(1.27)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C140(1.03); C210(1.24); C215(1.24)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C210(0.65); C215(0.65); C140(1.00)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C210(0.65); C215(0.65); C140(0.89)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C210(0.80); C215(0.80); C140(1.31)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C210(0.61); C215(0.61); C140(0.97)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C210(0.68); C215(0.68); C140(1.01)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C210(0.47); C215(0.47); C140(1.14)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C210(0.42); C215(0.42); C140(1.06)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C210(0.53); C215(0.53); C140(1.41)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C140(0.90)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C140(1.21)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C140(1.55)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C140(1.20)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C140(1.27)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C140(1.16); C210(1.21); C215(1.21)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C140(0.98); C210(1.28); C215(1.28)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C140(1.13); C210(1.44); C215(1.44)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C210(0.63); C215(0.63); C140(1.43)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C140(1.30); C210(1.36); C215(1.36)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C210(1.03); C215(1.03); C140(1.04)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C210(0.98); C215(0.98); C140(1.12)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C210(0.97); C215(0.97); C140(1.16)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C210(1.01); C215(1.01); C140(1.38)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C210(0.88); C215(0.88); C140(1.03)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C210(0.79); C215(0.79); C140(0.81)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C140(0.89); C210(0.98); C215(0.98)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C210(0.76); C215(0.76); C140(0.84)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C210(0.51); C215(0.51); C140(1.31)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C210(0.51); C215(0.51); C140(1.20)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C210(0.51); C215(0.51); C140(1.22)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C210(1.29); C215(1.29); C140(1.34)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C210(0.95); C215(0.95); C140(1.09)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C210(1.28); C215(1.28); C140(1.49)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C210(1.11); C215(1.11); C140(1.29)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C210(0.80); C215(0.80); C140(1.06)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C210(1.40); C215(1.40); C140(1.75)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C210(1.19); C215(1.19); C140(2.19)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C210(1.35); C215(1.35); C140(2.95)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C210(1.26); C215(1.26); C140(1.49)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C210(1.27); C215(1.27); C140(2.02)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C140(1.68); C210(1.18); C215(1.18)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C140(1.45); C210(1.29); C215(1.29)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C140(1.34); C210(1.25); C215(1.25)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C140(1.78); C210(1.29); C215(1.29)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C140(1.80); C210(1.26); C215(1.26)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C140(0.85); C210(0.72); C215(0.72)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C140(1.28); C210(1.30); C215(1.30)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C140(0.94); C210(0.92); C215(0.92)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C140(1.06); C210(1.40); C215(1.40)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C140(1.09); C210(0.79); C215(0.79)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C140(1.04); C210(1.00); C215(1.00)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C140(1.06); C210(1.05); C215(1.05)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C140(0.88); C210(0.87); C215(0.87)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C140(0.99); C210(0.99); C215(0.99)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C140(1.09); C210(0.88); C215(0.88)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C140(1.14); C210(0.78); C215(0.78)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C140(1.21); C210(0.81); C215(0.81)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C140(1.05); C210(0.94); C215(0.94)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C140(0.95); C210(0.83); C215(0.83)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C140(0.98); C210(1.06); C215(1.06)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C140(0.93); C210(1.17); C215(1.17)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C140(0.99); C210(0.90); C215(0.90)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C140(1.06); C210(0.76); C215(0.76)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C140(0.97); C210(0.99); C215(0.99)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C140(0.93); C210(0.78); C215(0.78)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C140(1.04); C210(0.77); C215(0.77)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C140(0.98); C210(0.68); C215(0.68)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C140(0.97); C210(0.95); C215(0.95)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C140(1.06); C210(0.88); C215(0.88)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C140(1.09); C210(1.14); C215(1.14)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C140(1.18); C210(0.98); C215(0.98)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C140(1.09); C210(0.97); C215(0.97)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C140(1.08); C210(1.07); C215(1.07)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C140(0.93); C210(0.92); C215(0.92)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C140(0.94); C210(0.86); C215(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C140(1.09); C210(0.88); C215(0.88)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C140(0.95); C210(1.05); C215(1.05)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C140(0.97); C210(0.76); C215(0.76)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C140(1.14); C210(0.98); C215(0.98)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C140(0.90); C210(1.51); C215(1.51)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C140(0.90); C210(1.69); C215(1.69)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C140(1.10); C210(1.20); C215(1.20)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C140(1.01); C210(1.14); C215(1.14)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C140(0.99); C210(0.94); C215(0.94)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C140(1.38); C210(0.94); C215(0.94)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C140(1.06); C210(0.88); C215(0.88)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C140(0.93); C210(1.18); C215(1.18)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C140(0.99); C210(1.18); C215(1.18)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C140(1.09); C210(0.48); C215(0.48)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C140(1.09); C210(0.84); C215(0.84)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C140(1.14); C210(1.12); C215(1.12)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C140(1.04); C210(1.00); C215(1.00)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C140(1.04); C210(1.01); C215(1.01)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C140(1.01); C210(1.15); C215(1.15)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C140(1.03); C210(0.70); C215(0.70)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C140(0.89); C210(0.62); C215(0.62)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C140(1.41); C210(0.86); C215(0.86)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C140(2.20); C210(0.77); C215(0.77)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C140(1.92); C210(0.33); C215(0.33)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C140(1.10); C210(0.78); C215(0.78)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C140(1.18); C210(0.70); C215(0.70)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C140(1.35); C210(0.75); C215(0.75)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C140(1.38); C210(0.87); C215(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C140(1.96); C210(0.84); C215(0.84)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C140(1.26); C210(0.81); C215(0.81)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C140(1.15); C210(0.69); C215(0.69)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C140(1.08); C210(0.71); C215(0.71)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C140(1.19); C210(0.70); C215(0.70)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C140(2.11); C210(0.80); C215(0.80)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C140(1.18); C210(0.73); C215(0.73)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C140(0.94); C210(0.54); C215(0.54)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C140(0.77); C210(0.99); C215(0.99)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C140(0.75); C210(0.91); C215(0.91)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C140(0.78); C210(1.06); C215(1.06)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C140(0.90); C210(1.01); C215(1.01)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C140(0.87); C210(1.08); C215(1.08)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C140(0.87); C210(1.20); C215(1.20)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C140(0.74); C210(1.05); C215(1.05)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C140(0.90); C210(1.16); C215(1.16)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C140(1.10); C210(1.22); C215(1.22)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C140(1.10); C185(1.01); C215(0.75)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C140(1.05); C210(1.17); C215(1.17)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C140(0.96); C210(1.01); C215(1.01)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C140(0.99); C185(1.02); C215(0.87)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C140(0.94); C185(1.01); C215(0.87)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C140(4.25)  LDD3310  [14]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C140(1.04)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C140(1.07)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C140(0.85)  LDD2098  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C140(0.64)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C140(0.58)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C140(1.04)  LDD2105  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C140(1.10)  LDD2124  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C140(2.61)  LDD2145  [4]
 LDCM0021  THZ1 HCT 116 C140(1.09); C210(1.30); C215(1.30)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Structural maintenance of chromosomes protein 6 (SMC6) SMC family Q96SB8
Alpha-taxilin (TXLNA) Taxilin family P40222
Gelsolin (GSN) Villin/gelsolin family P06396
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840