Details of the Target

General Information of Target

Target ID LDTP01661
Target Name Synaptosomal-associated protein 29 (SNAP29)
Gene Name SNAP29
Gene ID 9342
Synonyms
Synaptosomal-associated protein 29; SNAP-29; Soluble 29 kDa NSF attachment protein; Vesicle-membrane fusion protein SNAP-29
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSAYPKSYNPFDDDGEDEGARPAPWRDARDLPDGPDAPADRQQYLRQEVLRRAEATAAST
SRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLV
NYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGA
GSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTK
VDKLDVNIKSTERKVRQL
Target Bioclass
Other
Family
SNAP-25 family
Subcellular location
Cytoplasm
Function
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Uniprot ID
O95721
Ensemble ID
ENST00000215730.12
HGNC ID
HGNC:11133

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y122(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K107(3.44); K191(9.13)  LDD0277  [2]
Probe 1
 Probe Info  		Y68(8.63); Y160(14.27)  LDD3495  [3]
HHS-475
 Probe Info  		Y160(0.90)  LDD0264  [4]
ATP probe
 Probe Info  		K191(0.00); K201(0.00)  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		17.27  LDD1793  [7]
C362
 Probe Info  		26.17  LDD2023  [7]
C388
 Probe Info  		37.53  LDD2047  [7]
C390
 Probe Info  		31.78  LDD2049  [7]
C391
 Probe Info  		20.82  LDD2050  [7]
FFF probe11
 Probe Info  		12.37  LDD0472  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y160(0.90)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y160(0.71)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y160(1.48)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y160(2.48)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y160(0.88)  LDD0268  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) Glycosyltransferase 41 family O15294
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Vesicle-associated membrane protein 1 (VAMP1) Synaptobrevin family P23763
Vesicle-associated membrane protein 2 (VAMP2) Synaptobrevin family P63027
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Vesicle-associated membrane protein 8 (VAMP8) Synaptobrevin family Q9BV40
Syntaxin-17 (STX17) Syntaxin family P56962
Syntaxin-3 (STX3) Syntaxin family Q13277
Syntaxin-6 (STX6) Syntaxin family O43752
EH domain-containing protein 1 (EHD1) Dynamin/Fzo/YdjA family Q9H4M9
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Protein FAM9C (FAM9C) FAM9 family Q8IZT9
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Syntaxin-1B (STX1B) Syntaxin family P61266
Putative uncharacterized protein TXNRD3NB (TXNRD3NB) . Q6F5E7

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.