Details of the Target

General Information of Target

Target ID LDTP04091
Target Name Adapter molecule crk (CRK)
Gene Name CRK
Gene ID 1398
Synonyms
Adapter molecule crk; Proto-oncogene c-Crk; p38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS
Target Type
Literature-reported
Target Bioclass
Other
Family
CRK family
Subcellular location
Cytoplasm
Function
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
TTD ID
T27297
Uniprot ID
P46108
DrugMap ID
TTFEUYR
Ensemble ID
ENST00000300574.3
HGNC ID
HGNC:2362
ChEMBL ID
CHEMBL5005

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN229 SNV: p.K178N .
SKNSH SNV: p.S11R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y186(5.39)  LDD0257  [1]
STPyne
 Probe Info  		K105(10.60)  LDD2217  [2]
Probe 1
 Probe Info  		Y47(11.86); Y136(70.92); Y186(12.64); Y251(56.59)  LDD3495  [3]
DBIA
 Probe Info  		C279(1.22)  LDD3424  [4]
HHS-482
 Probe Info  		Y108(0.79); Y186(0.81); Y47(0.81)  LDD0285  [5]
HHS-475
 Probe Info  		Y136(0.74); Y47(0.85); Y108(0.93); Y186(1.43)  LDD0264  [6]
HHS-465
 Probe Info  		Y108(10.00); Y186(9.46); Y251(10.00)  LDD2237  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
SF
 Probe Info  		Y108(0.00); Y186(0.00)  LDD0028  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C178
 Probe Info  		32.45  LDD1857  [12]
C211
 Probe Info  		9.19  LDD1885  [12]
C347
 Probe Info  		5.46  LDD2008  [12]
C356
 Probe Info  		8.82  LDD2017  [12]
C391
 Probe Info  		20.11  LDD2050  [12]
C431
 Probe Info  		45.25  LDD2086  [12]
FFF probe13
 Probe Info  		17.11  LDD0475  [13]
FFF probe2
 Probe Info  		15.16  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
FFF probe4
 Probe Info  		20.00  LDD0466  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C279(1.00)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C279(1.00)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C279(1.01)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C279(0.96)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C279(1.05)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C279(1.03)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C279(0.99)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C279(0.96)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C279(0.83)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C279(1.03)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C279(0.96)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C279(0.98)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C279(0.98)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C279(1.13)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C279(1.00)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C279(1.00)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C279(1.08)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C279(1.04)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C279(0.97)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C279(1.04)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C279(0.98)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C279(1.00)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C279(0.96)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C279(0.97)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C279(0.91)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C279(1.06)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C279(0.93)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C279(0.95)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C279(0.96)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C279(1.07)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C279(0.97)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C279(0.90)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C279(0.91)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C279(0.95)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C279(0.99)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C279(0.98)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C279(1.01)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C279(0.95)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C279(0.99)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C279(1.07)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C279(0.99)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C279(0.98)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C279(0.97)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C279(1.05)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C279(1.02)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C279(1.00)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C279(1.01)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C279(1.01)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C279(1.02)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C279(1.00)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C279(0.94)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C279(1.06)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C279(0.93)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C279(1.05)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C279(0.93)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C279(0.90)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C279(1.02)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C279(0.98)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C279(0.95)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C279(1.05)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C279(0.91)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C279(0.99)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C279(1.00)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C279(0.97)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C279(1.05)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C279(0.93)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C279(0.97)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C279(0.96)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C279(0.85)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C279(0.99)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C279(0.94)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C279(0.98)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C279(0.97)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C279(0.97)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C279(0.97)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C279(1.01)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C279(1.14)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C279(0.82)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C279(1.10)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C279(1.00)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C279(1.06)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C279(0.88)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C279(1.00)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C279(1.08)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C279(1.05)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C279(0.94)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C279(1.02)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C279(0.93)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C279(0.99)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C279(1.09)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C279(0.98)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C279(1.03)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C279(1.01)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C279(1.09)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C279(0.95)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C279(1.05)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C279(1.02)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C279(1.02)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C279(1.06)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C279(0.97)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C279(1.02)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C279(0.92)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C279(1.08)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C279(1.04)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C279(0.93)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C279(1.10)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C279(0.96)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C279(1.10)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C279(1.19)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C279(0.99)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C279(1.06)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C279(0.95)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C279(0.94)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C279(0.97)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C279(1.03)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C279(1.03)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C279(1.13)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C279(1.07)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C279(1.08)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C279(0.96)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C279(1.08)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C279(1.23)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C279(1.00)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C279(0.99)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C279(0.99)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C279(1.04)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C279(1.04)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C279(0.88)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C279(1.07)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C279(1.04)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C279(0.97)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C279(0.90)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C279(1.15)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C279(1.13)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C279(1.00)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C279(1.18)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C279(0.99)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C279(0.86)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C279(0.96)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C279(0.90)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C279(1.00)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C279(0.99)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C279(0.92)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C279(0.88)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C279(1.03)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C279(1.07)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C279(1.01)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C279(1.00)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C279(1.10)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C279(1.02)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C279(1.01)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C279(0.98)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C279(0.97)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C279(0.99)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C279(1.00)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C279(1.07)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C279(0.97)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C279(1.05)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C279(1.03)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C279(1.02)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C279(0.95)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C279(1.02)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C279(0.93)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C279(1.08)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C279(1.01)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C279(1.09)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C279(1.07)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C279(0.94)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C279(1.09)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C279(1.00)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C279(1.11)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C279(1.17)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C279(0.94)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C279(1.09)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C279(1.05)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C279(1.09)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C279(1.09)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C279(1.02)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C279(1.05)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C279(1.05)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C279(1.17)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C279(0.96)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C279(1.02)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C279(0.93)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C279(1.00)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C279(0.91)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C279(1.08)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C279(0.86)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C279(1.11)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C279(1.12)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C279(1.08)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C279(1.00)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y136(0.74); Y47(0.85); Y108(0.93); Y186(1.43)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y47(0.86); Y108(0.90); Y186(0.96); Y136(1.02)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y136(0.75); Y47(0.86); Y186(0.91); Y108(0.94)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y136(0.84); Y108(0.87); Y186(0.87); Y47(0.92)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y108(0.86); Y47(0.92); Y136(0.96); Y186(1.15)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0123  JWB131 DM93 Y108(0.79); Y186(0.81); Y47(0.81)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y108(0.91); Y186(0.60); Y47(1.25)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y108(1.05); Y186(1.11); Y47(1.40)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y108(4.53); Y186(2.42); Y47(1.65)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y108(2.97); Y186(1.33); Y47(1.86)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y108(1.83); Y186(0.60); Y47(0.10)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y108(0.61); Y186(0.51); Y47(1.03)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y108(1.28); Y186(0.99); Y47(1.12)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C279(0.98)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C279(0.99)  LDD1497  [14]
 LDCM0024  KB05 SK-HEP1 C279(1.22)  LDD3424  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
Peptidyl-prolyl cis-trans isomerase A (PPIA) Cyclophilin-type PPIase family P62937
E3 ubiquitin-protein ligase DTX1 (DTX1) Deltex family Q86Y01
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) Inositol 1,4,5-trisphosphate 5-phosphatase family O15357
Inactive ubiquitin carboxyl-terminal hydrolase 53 (USP53) Peptidase C19 family Q70EK8
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) Ser/Thr protein kinase family O43683
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) STE Ser/Thr protein kinase family Q9Y4K4
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Platelet-derived growth factor receptor alpha (PDGFRA) Tyr protein kinase family P16234
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) Protein-tyrosine phosphatase family P29074
E3 ubiquitin-protein ligase CBL (CBL) . P22681
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filamin-A (FLNA) Filamin family P21333
Filamin-C (FLNC) Filamin family Q14315
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-3 (SNX3) Sorting nexin family O60493
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AF4/FMR2 family member 1 (AFF1) AF4 family P51825
ETS domain-containing protein Elk-3 (ELK3) ETS family P41970
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Msx2-interacting protein (SPEN) RRM Spen family Q96T58
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 9 (ASB9) Ankyrin SOCS box (ASB) family Q96DX5
Ataxin-1 (ATXN1) ATXN1 family P54253
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Dedicator of cytokinesis protein 1 (DOCK1) DOCK family Q14185
Dedicator of cytokinesis protein 3 (DOCK3) DOCK family Q8IZD9
Dedicator of cytokinesis protein 5 (DOCK5) DOCK family Q9H7D0
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
GRB2-associated and regulator of MAPK protein 1 (GAREM1) GAREM family Q9H706
Liprin-beta-2 (PPFIBP2) Liprin family Q8ND30
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
Ras and Rab interactor 3 (RIN3) RIN (Ras interaction/interference) family Q8TB24
Disks large-associated protein 2 (DLGAP2) SAPAP family Q9P1A6
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) SHANK family Q9UPX8
Mimecan (OGN) Small leucine-rich proteoglycan (SLRP) family P20774
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) . Q96P48
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2) . O43150
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3) . Q8TDY4
BRD4-interacting chromatin-remodeling complex-associated protein (BICRA) . Q9NZM4
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Insulin receptor substrate 4 (IRS4) . O14654
Rap guanine nucleotide exchange factor 1 (RAPGEF1) . Q13905
Rho guanine nucleotide exchange factor 11 (ARHGEF11) . O15085
Son of sevenless homolog 1 (SOS1) . Q07889
Son of sevenless homolog 2 (SOS2) . Q07890
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402