Details of the Target

General Information of Target

Target ID LDTP09965
Target Name Cullin-5 (CUL5)
Gene Name CUL5
Gene ID 8065
Synonyms
VACM1; Cullin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSV
YLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYE
CHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHL
SVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQ
SSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPL
ELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAF
SLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNK
QQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSY
HGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESS
LQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGT
IEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASA
ISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVST
NASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAV
EEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVG
SSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVE
MEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLF
ICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEG
N
Target Bioclass
Enzyme
Family
Cullin family
Subcellular location
Nucleus
Function
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A. May form a cell surface vasopressin receptor.; (Microbial infection) Seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein.
Uniprot ID
Q93034
Ensemble ID
ENST00000393094.7
HGNC ID
HGNC:2556

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		8.37  LDD0066  [2]
STPyne
 Probe Info  		K455(4.73); K492(4.35); K518(10.00); K750(10.00)  LDD0277  [3]
HHS-475
 Probe Info  		Y221(0.70)  LDD0264  [4]
IPM
 Probe Info  		C112(2.99)  LDD1701  [5]
HHS-465
 Probe Info  		Y221(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C112(1.75)  LDD0080  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C188(0.00); C281(0.00); C104(0.00); C51(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C188(0.00); C51(0.00)  LDD0037  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		13.36  LDD1713  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C104(0.51); C404(0.43); C412(0.43)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C104(1.17); C404(0.66); C412(0.66)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C104(1.35); C404(0.37); C412(0.37)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C104(0.95); C404(0.42); C412(0.42)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C104(1.01); C404(0.38); C412(0.38)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C104(0.88); C404(0.37); C412(0.37)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C104(1.09); C404(0.29); C412(0.29)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C104(0.96); C404(0.37); C412(0.37)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C104(0.99); C404(0.46); C412(0.46)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C104(1.08); C404(0.36); C412(0.31)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C104(1.04); C404(0.59); C412(0.57)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C104(1.13); C404(0.51); C412(0.55)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C104(0.89); C404(0.65); C412(0.65)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C104(0.90); C404(0.50); C412(0.48)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C104(0.86); C404(0.55); C412(0.58)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C104(0.80); C404(0.31); C412(0.33)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C104(0.96); C404(1.15); C412(1.15)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C104(0.99); C404(0.80); C412(0.80)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C104(0.89); C404(0.72); C412(0.72)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C104(0.92); C404(0.92); C412(0.92)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C104(0.85); C404(1.10); C412(1.10)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C104(1.07); C404(0.94); C412(0.94)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C104(0.92); C404(0.76); C412(0.76)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C104(1.16); C404(0.81); C412(0.81)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C104(0.93); C404(0.50); C412(0.50)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C104(1.10); C404(1.14); C412(1.14)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C104(1.04); C404(0.94); C412(0.94)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C104(1.09); C404(0.93); C412(0.93)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C104(1.14); C404(1.47); C412(1.47)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C104(1.07); C404(1.16); C412(1.16)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C104(1.22); C404(0.80); C412(0.80)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C104(1.15); C404(0.88); C412(0.88)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C104(1.49); C404(0.99); C412(0.99)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C104(1.59); C404(1.19); C412(1.19)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C104(1.30); C404(0.97); C412(0.97)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C104(1.22); C404(1.18); C412(1.18)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C104(1.17); C404(1.09); C412(1.09)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C104(1.26); C404(1.13); C412(1.13)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C104(1.00); C404(1.19); C412(1.19)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C104(1.16); C404(1.21); C412(1.21)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C104(1.07); C404(0.85); C412(0.85)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C104(1.16); C404(0.96); C412(0.96)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C104(1.06); C404(1.03); C412(1.03)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C104(0.99); C404(1.28); C412(1.28)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C104(0.99); C404(0.68); C412(0.68)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C104(1.04); C404(1.06); C412(1.06)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C104(1.01); C404(0.87); C412(0.87)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C104(1.05); C404(1.09); C412(1.09)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C404(0.81); C412(0.81)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C404(0.69); C412(0.69)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C404(0.77); C412(0.77)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C404(0.50); C412(0.50)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C404(0.54); C412(0.54)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C404(0.45); C412(0.45)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C404(0.63); C412(0.63)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C404(0.78); C412(0.78); C104(1.39)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C404(0.76); C412(0.76)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C404(0.72); C412(0.72)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C404(0.49); C412(0.49)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C404(0.39); C412(0.39)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C404(0.66); C412(0.66)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C404(0.58); C412(0.58)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C404(0.96); C412(0.96)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C404(1.14); C412(1.14)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C104(1.05); C412(1.08); C404(1.25)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C412(1.07); C404(1.23); C104(1.52)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C412(1.24); C104(1.24); C404(1.41)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C104(0.82); C404(0.86); C412(0.86)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C104(0.95); C412(1.00); C404(1.07)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C412(0.87); C404(1.17); C104(1.43)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C104(0.97); C412(1.12); C404(1.14)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C104(1.20); C412(1.26); C404(1.26)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C104(1.01); C412(1.18); C404(1.29)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C104(0.76); C404(1.03); C412(1.03)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C104(0.63); C404(1.02); C412(1.02)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C104(0.56); C404(0.78); C412(0.78)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C104(0.55); C404(0.99); C412(0.99)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C104(0.56); C404(0.71); C412(0.71)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C104(0.78); C404(0.95); C412(0.95)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C104(0.52); C404(0.80); C412(0.80)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C104(0.49); C404(0.85); C412(0.85)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C104(0.44); C404(0.70); C412(0.70)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C104(0.44); C404(0.91); C412(0.91)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C104(0.46); C404(0.74); C412(0.74)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C104(1.32)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C104(1.17)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C104(1.10)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C104(1.01)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C104(1.19)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C104(0.58); C404(0.63); C412(0.63)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C104(1.02)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C104(1.00)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C104(0.92)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C104(0.80)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C104(0.82)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C104(0.85)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C104(0.62); C404(0.98); C412(0.98)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C104(0.79); C404(1.04); C412(1.04)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C104(0.62); C404(0.77); C412(0.77)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C104(0.54); C404(0.56); C412(0.56)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C104(0.63); C404(0.65); C412(0.65)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C104(0.62); C404(0.71); C412(0.71)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C104(0.58); C404(1.27); C412(1.27)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C104(0.60); C404(0.96); C412(0.96)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C404(0.73); C412(0.73); C104(0.92)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C104(0.63); C404(0.79); C412(0.79)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C404(0.66); C412(0.66); C104(1.22)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C404(0.53); C412(0.53); C104(0.65)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C404(0.68); C412(0.68)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C404(0.60); C412(0.60)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C404(0.71); C412(0.71)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C404(0.69); C412(0.69); C104(1.01)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C404(0.70); C412(0.70)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C404(0.55); C412(0.55)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C404(0.70); C412(0.70)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C404(0.68); C412(0.68)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C404(0.70); C412(0.70)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C404(0.63); C412(0.63)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C404(0.62); C412(0.62)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C404(0.52); C412(0.52)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C104(0.74); C404(1.01); C412(1.01)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C104(0.60); C404(1.08); C412(1.08)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C404(0.97); C412(0.97); C104(1.06)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C104(0.69); C404(0.80); C412(0.80)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C104(0.94); C404(1.05); C412(1.05)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C104(0.78); C404(0.90); C412(0.90)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C104(0.66); C404(0.90); C412(0.90)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C104(0.65); C404(1.23); C412(1.23)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C104(0.65); C404(1.17); C412(1.17)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C104(0.70); C404(1.31); C412(1.31)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C104(0.73); C404(0.87); C412(0.87)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C104(0.64); C404(0.94); C412(0.94)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C104(0.93); C404(0.97); C412(0.97)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C404(0.61); C412(0.61); C104(1.00)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C104(0.70); C404(1.35); C412(1.35)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C104(0.84); C404(1.22); C412(1.22)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C104(0.83); C404(1.18); C412(1.18)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C404(0.50); C412(0.50); C104(0.82)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C404(0.43); C412(0.43); C104(0.81)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C404(0.54); C412(0.54); C104(0.78)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C104(0.77); C404(1.14); C412(1.14)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C404(0.78); C412(0.78); C104(0.94)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C404(0.86); C412(0.86); C104(0.91)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C104(0.75); C404(0.90); C412(0.90)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C104(0.92); C404(1.74); C412(1.74)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C404(0.61); C412(0.61); C104(0.85)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C104(0.82); C404(0.83); C412(0.83)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C404(0.72); C412(0.72); C104(0.84)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C404(0.60); C412(0.60); C104(1.01)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C404(0.58); C412(0.58); C104(0.89)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C404(0.79); C412(0.79); C104(0.96)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C404(0.67); C412(0.67); C104(0.71)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C404(0.15); C412(0.15); C104(0.80)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C404(0.49); C412(0.49); C104(1.00)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C104(1.10); C404(1.07); C412(1.07)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C404(0.76); C412(0.76); C104(0.91)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C404(0.54); C412(0.54); C104(1.17)  LDD0592  [7]
 LDCM0367  CL1 HCT 116 C104(0.78); C404(1.27); C412(1.27)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C404(0.62); C412(0.62); C104(0.78)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C104(0.63); C404(0.65); C412(0.65)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C404(0.74); C412(0.74); C104(1.15)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C404(0.77); C412(0.77); C104(0.95)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C404(0.93); C412(0.93); C104(1.02)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C404(0.94); C412(0.94); C104(1.11)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C104(1.28); C412(1.30); C404(1.32)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C412(1.08); C404(1.20); C104(2.08)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C412(1.07); C404(1.37); C104(1.48)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C104(1.28); C412(1.30); C404(1.42)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C104(1.16); C412(1.22); C404(1.26)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C404(0.49); C412(0.49); C104(0.91)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C104(1.21); C404(1.34); C412(1.40)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C412(1.08); C104(1.10); C404(1.12)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C404(0.79); C412(0.79); C104(0.84)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C104(0.50); C404(0.70); C412(0.70)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C104(0.63); C404(0.67); C412(0.67)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C104(0.53); C404(0.89); C412(0.89)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C104(0.56); C404(1.00); C412(1.00)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C104(1.14)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C104(0.99)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C104(0.97)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C404(0.67); C412(0.67); C104(1.00)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C104(1.05)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C104(0.72); C404(1.26); C412(1.26)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C104(0.66); C404(0.67); C412(0.67)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C404(0.71); C412(0.71); C104(0.83)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C104(0.63); C404(0.69); C412(0.69)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C404(0.95); C412(0.95)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C404(0.70); C412(0.70)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C404(0.80); C412(0.80)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C404(0.72); C412(0.72)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C404(0.54); C412(0.54); C104(0.97)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C104(0.79); C404(1.04); C412(1.04)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C404(0.54); C412(0.54); C104(0.92)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C404(0.85); C412(0.85)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C404(0.92); C412(0.92)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C404(0.71); C412(0.71)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C404(0.86); C412(0.86)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C104(0.82); C404(1.11); C412(1.11)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C404(0.97); C412(0.97)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C404(0.90); C412(0.90)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C404(0.78); C412(0.78)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C404(1.02); C412(1.02)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C404(0.84); C412(0.84)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C404(0.77); C412(0.77)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C404(0.85); C412(0.85)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C404(1.02); C412(1.02)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C404(0.74); C412(0.74)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C404(0.95); C412(0.95)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C104(0.78); C404(0.99); C412(0.99)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C404(0.98); C412(0.98)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C104(0.96); C404(0.64); C412(0.64)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C104(1.14); C404(0.56); C412(0.56)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C104(0.84); C404(0.60); C412(0.60)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C104(0.88); C404(0.66); C412(0.66)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C104(0.77); C404(0.76); C412(0.76)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C104(0.79); C404(0.88); C412(0.88)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C104(0.91); C404(0.85); C412(0.85)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C104(1.17); C404(0.57); C412(0.57)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C104(0.97); C404(0.85); C412(0.85)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C104(0.78); C404(0.70); C412(0.70)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C104(0.99); C404(0.83); C412(0.83)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C104(0.93); C404(0.66); C412(0.66)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C104(1.27); C404(0.65); C412(0.65)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C104(0.91); C404(0.70); C412(0.70)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C104(0.88); C404(0.63); C412(0.63)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C104(0.67); C404(2.23); C412(2.23)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C104(0.60); C404(2.42); C412(2.42)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C104(0.77); C404(2.37); C412(2.37)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C104(0.98); C404(1.86); C412(1.86)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C104(1.07); C404(0.86); C412(0.86)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C104(0.96); C404(1.46); C412(1.46)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C104(0.86); C404(3.19); C412(3.19)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C104(0.73); C404(3.06); C412(3.06)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C104(0.58); C404(2.01); C412(2.01)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C104(0.72); C404(2.20); C412(2.20)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C104(0.84); C404(2.58); C412(2.58)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C104(0.68); C404(1.40); C412(1.40)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C104(0.61); C404(2.58); C412(2.58)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C104(0.84); C404(1.80); C412(1.80)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C104(0.80); C404(1.73); C412(1.73)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C104(0.70); C404(0.49); C412(0.49)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C104(0.76); C404(1.25); C412(1.25)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C104(0.78); C404(1.17); C412(1.25)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C104(0.85); C404(0.79); C412(0.83)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C104(0.79); C404(0.75); C412(0.83)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C104(0.88); C404(0.57); C412(0.55)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C104(1.11); C404(0.75); C412(0.70)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C104(0.93); C404(0.53); C412(0.51)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C104(0.99); C404(0.49); C412(0.45)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C104(0.81); C404(0.56); C412(0.56)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C104(0.65); C404(0.74); C412(0.90)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C104(1.03); C404(0.62); C412(0.62)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C104(0.86); C404(0.64); C412(0.66)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C104(0.82); C404(0.58); C412(0.56)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C104(0.68); C404(1.14); C412(1.43)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C104(0.83); C404(0.65); C412(0.65)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C104(0.89); C404(0.63); C412(0.58)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C404(0.93); C412(0.93)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C404(0.93); C412(0.93)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C404(0.80); C412(0.80)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C404(0.94); C412(0.94)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C104(0.67); C404(0.50); C412(0.50)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C404(0.86); C412(0.86)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C404(1.08); C412(1.08)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C404(0.93); C412(0.93)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C404(0.88); C412(0.88)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C404(0.67); C412(0.67)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C404(0.99); C412(0.99)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C404(0.98); C412(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C404(1.14); C412(1.14)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C404(0.93); C412(0.93)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C404(0.87); C412(0.87)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C104(0.86); C404(0.86); C412(0.86)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C404(0.93); C412(0.93)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C104(0.72); C404(0.87); C412(0.87)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C104(0.74); C404(0.75); C412(0.75)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C104(0.69); C404(0.84); C412(0.84)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C104(0.51); C404(0.55); C412(0.55)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C104(0.53); C404(0.55); C412(0.55)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C104(0.62); C404(0.70); C412(0.70)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C104(0.62); C404(0.72); C412(0.72)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C104(0.61); C404(0.72); C412(0.72)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C104(0.59); C404(0.64); C412(0.64)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C188(1.06); C104(0.97); C112(1.05); C51(1.17)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C104(0.74); C404(0.60); C412(0.60)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C104(0.87); C404(0.82); C412(0.82)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y221(0.70)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y221(0.74)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y221(0.76)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y221(0.78)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y221(0.80)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C112(1.75)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C112(1.80)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C112(1.13)  LDD0082  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C112(0.99)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
E3 ubiquitin-protein ligase ARIH2 (ARIH2) RBR family O95376
E3 ubiquitin-protein ligase RBX1 (RBX1) RING-box family P62877
RING-box protein 2 (RNF7) RING-box family Q9UBF6
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) . Q9NPC3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 1 (ASB1) Ankyrin SOCS box (ASB) family Q9Y576
Ankyrin repeat and SOCS box protein 6 (ASB6) Ankyrin SOCS box (ASB) family Q9NWX5
Ankyrin repeat and SOCS box protein 7 (ASB7) Ankyrin SOCS box (ASB) family Q9H672
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) . Q5T7N3
Suppressor of cytokine signaling 2 (SOCS2) . O14508

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.