Details of the Target

General Information of Target

Target ID LDTP05957
Target Name Ras-related protein Rab-31 (RAB31)
Gene Name RAB31
Gene ID 11031
Synonyms
RAB22B; Ras-related protein Rab-31; Ras-related protein Rab-22B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIW
DTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNK
CDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGT
IKVEKPTMQASRRCC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Golgi apparatus, trans-Golgi network
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Uniprot ID
Q13636
Ensemble ID
ENST00000578921.6
HGNC ID
HGNC:9771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.05  LDD0323  [1]
DBIA
 Probe Info  		C49(0.75)  LDD0532  [2]
m-APA
 Probe Info  		H68(0.00); H32(0.00)  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		C120(0.00); C9(0.00)  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		C120(0.00); C9(0.00)  LDD0027  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		C120(0.00); C9(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0561  Abegg_cp(-)-10 HeLa C49(2.74)  LDD0312  [5]
 LDCM0214  AC1 HEK-293T C120(0.97); C9(0.89); C49(1.06)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C49(0.75)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C49(1.05)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C49(1.07)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C49(0.96)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C49(0.91)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C49(1.04)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C49(0.99)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C49(0.94)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C49(0.82)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C49(0.95)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C49(1.00)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C49(0.78)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C49(1.06)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C49(1.11)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C49(1.10)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C49(1.03)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C49(0.95)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C49(1.04)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C49(1.03)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C49(0.88)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C49(1.07)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C49(0.91)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C49(0.84)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C49(0.90)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C49(1.00)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C49(0.97)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C49(0.94)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C49(0.95)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C49(1.01)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C49(0.86)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C49(0.90)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C49(1.07)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C49(0.95)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C49(0.91)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C49(1.02)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C49(1.05)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C49(1.06)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C49(0.98)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C49(1.01)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C49(1.05)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C49(1.07)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C49(0.94)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C49(0.96)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C49(0.74)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C49(0.93)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C49(1.08)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C49(1.00)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C49(0.96)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C49(0.85)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C49(0.68)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C49(0.69)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C49(0.83)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C49(0.87)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C49(0.79)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C49(0.76)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C49(0.91)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C49(0.80)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C49(0.82)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C49(0.80)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C49(0.83)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C49(0.79)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C49(0.67)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C49(0.74)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C49(1.08)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C49(0.83)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C49(1.06)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C120(0.95); C9(0.92); C49(0.97)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C49(0.82)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C49(0.80)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C49(1.14)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C49(0.96)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C49(0.92)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C49(0.88)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C49(0.89)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C49(0.94)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C49(0.92)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C49(0.93)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C120(1.10); C9(1.01); C49(0.99)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C49(0.94)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C49(0.84)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C49(0.85)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C49(0.85)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C49(0.79)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C49(1.11)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C49(1.07)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C49(1.17)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C49(1.14)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C49(1.13)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C120(1.02); C9(0.99); C49(1.01)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C49(0.89)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C49(1.02)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C49(1.01)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C49(1.02)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C49(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C49(0.92)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C49(0.96)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C49(1.01)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C49(0.90)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C49(0.81)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C120(1.04); C9(1.01); C49(1.08)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C49(0.73)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C49(1.15)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C49(0.94)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C49(0.88)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C49(0.83)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C49(0.74)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C49(0.61)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C49(0.90)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C49(0.81)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C49(0.81)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C49(0.83)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C49(0.77)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C49(0.72)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C49(0.75)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C49(0.75)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C49(0.82)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C49(1.01)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C49(0.88)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C49(0.70)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C49(0.79)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C49(0.96)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C49(1.09)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C49(1.37)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C49(0.97)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C49(0.87)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C49(0.72)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C49(0.98)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C49(0.84)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C49(0.92)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C49(0.95)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C49(0.78)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C49(0.82)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C49(0.84)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C49(0.77)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C49(0.74)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C49(0.85)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C49(0.86)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C49(0.97)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C49(0.89)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C49(0.72)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C49(0.94)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C49(1.04)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C49(0.78)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C49(0.85)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C49(0.75)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C49(0.92)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C49(1.01)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C49(0.89)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C49(0.93)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C49(0.86)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C49(0.76)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C49(1.06)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C49(1.06)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C49(0.84)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C49(0.76)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C49(0.82)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C49(20.00)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C49(0.89)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C49(0.97)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C120(0.91); C9(1.01); C49(0.98)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C49(0.68)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C49(0.69)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C49(0.83)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C49(0.69)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C49(1.04)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C49(0.98)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C49(1.10)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C49(1.13)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C49(1.05)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C49(0.95)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C49(1.05)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C49(0.95)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C49(0.84)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C49(0.80)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C49(0.80)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C49(0.92)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C49(0.84)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C49(0.78)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C49(0.97)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C49(0.96)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C49(0.97)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C49(1.16)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C49(0.76)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C49(0.92)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C49(0.85)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C49(0.83)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C49(1.03)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C49(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C49(0.86)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C49(0.87)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C49(1.14)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C49(0.94)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C49(1.15)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C120(1.26); C9(1.05); C49(1.08)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C120(1.21); C9(0.97); C49(1.00)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C120(1.17); C9(0.98); C49(1.08)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C120(1.24); C9(0.96); C49(0.96)  LDD1610  [8]
 LDCM0407  CL2 HCT 116 C49(0.94)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C120(1.18); C9(0.94); C49(1.06)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C120(1.15); C9(0.93); C49(1.16)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C120(1.09); C9(0.97); C49(1.09)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C120(1.11); C9(1.05); C49(0.90)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C120(1.01); C9(1.14); C49(1.14)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C120(1.26); C9(0.98); C49(1.00)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C120(1.17); C9(1.06); C49(1.03)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C120(1.17); C9(1.01); C49(1.10)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C120(1.06); C9(1.00); C49(1.02)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C120(1.10); C9(0.99); C49(1.13)  LDD1621  [8]
 LDCM0418  CL3 HCT 116 C49(1.16)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C120(1.04); C9(0.94); C49(1.05)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C49(0.81)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C49(0.99)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C49(0.79)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C49(0.69)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C49(0.75)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C49(0.62)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C49(0.68)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C49(0.69)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C49(1.11)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C49(0.74)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C49(0.70)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C49(0.67)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C49(0.73)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C49(0.77)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C49(0.69)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C49(0.85)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C49(0.91)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C49(0.86)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C49(1.07)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C49(1.12)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C49(0.90)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C49(1.12)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C49(1.09)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C49(1.13)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C49(1.16)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C49(0.91)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C49(1.16)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C49(0.84)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C49(1.09)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C49(0.88)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C49(0.86)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C49(0.82)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C120(0.99); C9(0.99); C49(0.89)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C120(1.10); C9(1.00); C49(0.94)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C120(1.11); C9(0.98); C49(1.14)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C120(1.26); C9(0.99); C49(1.04)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C120(1.07); C9(0.97); C49(1.02)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C120(1.16); C9(0.88); C49(1.08)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C120(1.11); C9(0.98); C49(1.02)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C120(1.04); C9(0.96); C49(1.00)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C120(1.07); C9(0.98); C49(0.99)  LDD1664  [8]
 LDCM0462  CL7 HCT 116 C49(1.15)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C120(1.11); C9(0.98); C49(1.04)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C120(1.08); C9(0.97); C49(0.91)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C120(1.09); C9(1.06); C49(1.06)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C120(1.04); C9(0.96); C49(0.89)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C120(1.09); C9(1.08); C49(1.04)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C120(1.12); C9(1.04); C49(1.05)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C120(0.94); C9(0.87); C49(1.08)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C120(1.21); C9(0.97); C49(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C120(1.18); C9(0.98); C49(1.02)  LDD1675  [8]
 LDCM0473  CL8 HCT 116 C49(0.83)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C120(1.16); C9(1.05); C49(0.96)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C120(1.14); C9(1.01); C49(1.05)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C120(1.07); C9(0.96); C49(1.05)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C120(1.10); C9(1.04); C49(0.90)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C120(1.07); C9(1.01); C49(1.16)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C120(0.98); C9(0.95); C49(0.98)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C120(0.98); C9(0.96); C49(1.02)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C120(1.04); C9(1.02); C49(1.06)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C120(0.98); C9(0.97); C49(1.02)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C120(0.95); C9(0.93); C49(1.02)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C49(0.94)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C120(0.98); C9(0.98); C49(1.25)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C120(1.08); C9(1.04); C49(1.02)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C120(1.05); C9(0.91); C49(1.05)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C120(1.06); C9(0.99); C49(1.08)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C120(1.07); C9(0.91); C49(1.02)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C120(1.11); C9(0.93); C49(1.08)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C120(1.04); C9(0.97); C49(1.16)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C120(1.14); C9(0.96); C49(0.96)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C120(1.10); C9(0.97); C49(0.95)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C120(0.99); C9(0.97); C49(1.03)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C120(1.09); C9(1.02); C49(1.12)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C120(4.37)  LDD1702  [9]
 LDCM0468  Fragment33 HEK-293T C120(1.08); C9(0.93); C49(1.04)  LDD1671  [8]
 LDCM0427  Fragment51 HCT 116 C49(0.49)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C120(0.96); C9(0.96); C49(0.89)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C120(1.08); C9(0.95); C49(1.01)  LDD1497  [8]
 LDCM0024  KB05 HMCB C23(2.55); C49(1.96); C9(2.29)  LDD3312  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ALS2 C-terminal-like protein (ALS2CL) . Q60I27

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840