Details of the Target

General Information of Target

Target ID LDTP13985
Target Name Small ribosomal subunit protein mS23 (MRPS23)
Gene Name MRPS23
Gene ID 51649
Synonyms
Small ribosomal subunit protein mS23; 28S ribosomal protein S23, mitochondrial; MRP-S23; S23mt
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDR
VVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNI
QCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mS23 family
Subcellular location
Mitochondrion
Uniprot ID
Q9Y3D9
Ensemble ID
ENST00000313608.13
HGNC ID
HGNC:14509
ChEMBL ID
CHEMBL4295990

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K73(6.88); K93(2.86)  LDD0277  [1]
Probe 1
 Probe Info  		Y75(11.46); Y78(13.36)  LDD3495  [2]
FBP2
 Probe Info  		3.54  LDD0053  [3]
Acrolein
 Probe Info  		H142(0.00); H66(0.00)  LDD0221  [4]
5E-2FA
 Probe Info  		H66(0.00); H176(0.00); H153(0.00); H146(0.00)  LDD2235  [5]
ATP probe
 Probe Info  		K150(0.00); K93(0.00)  LDD0199  [6]
m-APA
 Probe Info  		H66(0.00); H176(0.00); H153(0.00); H146(0.00)  LDD2231  [5]
Ox-W18
 Probe Info  		N.A.  LDD2175  [7]
Crotonaldehyde
 Probe Info  		H142(0.00); H146(0.00)  LDD0219  [4]
TER-AC
 Probe Info  		N.A.  LDD0426  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		99.73  LDD1948  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa H142(0.00); H66(0.00)  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0008  Tranylcypromine SH-SY5Y 3.54  LDD0053  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587