Details of the Target

General Information of Target

Target ID LDTP06191
Target Name LRP chaperone MESD (MESD)
Gene Name MESD
Gene ID 23184
Synonyms
KIAA0081; MESDC2; MESDM; LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development LRP chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASRWARKAVVLLCASDLLLLLLLLPPPGSCAAEGSPGTPDESTPPPRKKKKDIRDYND
ADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTV
SGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRC
ADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNKREDL
Target Bioclass
Other
Family
MESD family
Subcellular location
Endoplasmic reticulum
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
Uniprot ID
Q14696
Ensemble ID
ENST00000261758.6
HGNC ID
HGNC:13520

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.T125A .
RKN Deletion: p.S4_W6del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y166(18.13); Y58(10.91); Y190(6.02)  LDD0260  [1]
C-Sul
 Probe Info  		6.26  LDD0066  [2]
FBP2
 Probe Info  		3.49  LDD0323  [3]
STPyne
 Probe Info  		K217(6.67)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K222(3.35)  LDD3494  [5]
Probe 1
 Probe Info  		Y58(25.47); Y166(28.61)  LDD3495  [6]
DBIA
 Probe Info  		C180(1.68)  LDD3311  [7]
BTD
 Probe Info  		C180(0.80)  LDD2110  [8]
HHS-482
 Probe Info  		Y166(0.74)  LDD0285  [9]
HHS-475
 Probe Info  		Y166(0.94)  LDD0264  [10]
HHS-465
 Probe Info  		Y58(10.00)  LDD2237  [11]
Acrolein
 Probe Info  		N.A.  LDD0221  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C289
 Probe Info  		25.81  LDD1959  [18]
FFF probe13
 Probe Info  		16.89  LDD0475  [19]
FFF probe2
 Probe Info  		12.84  LDD0463  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C180(0.98)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C180(1.06)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C180(0.96)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C180(0.95)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C180(0.93)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C180(0.90)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C180(0.80)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C180(1.01)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C180(1.02)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C180(1.02)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C180(0.98)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C180(1.03)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C180(0.89)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C180(0.95)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C180(0.95)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C180(0.82)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C180(1.09)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C180(1.07)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C180(0.90)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C180(0.97)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C180(1.12)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C180(0.96)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C180(1.02)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C180(0.98)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C180(0.91)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C180(1.03)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C180(0.98)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C180(0.90)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C180(1.00)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C180(0.86)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C180(1.03)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C180(0.95)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C180(1.02)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C180(0.96)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C180(0.94)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C180(1.00)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C180(0.98)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C180(1.02)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C180(1.11)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C180(1.11)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C180(1.00)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C180(0.87)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C180(0.99)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C180(1.02)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C180(1.05)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C180(0.83)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C180(1.01)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C180(0.90)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C180(0.95)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C180(0.92)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C180(0.81)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C180(0.96)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C180(1.02)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C180(0.98)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C180(0.93)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C180(0.99)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C180(0.95)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C180(1.02)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C180(0.99)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C180(0.93)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C180(1.02)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C180(1.08)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C180(0.92)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C180(0.97)  LDD1514  [20]
 LDCM0367  CL1 HEK-293T C180(0.85)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C180(0.91)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C180(0.93)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C180(1.08)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C180(1.39)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C180(1.00)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C180(1.02)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C180(0.87)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C180(0.78)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C180(1.00)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C180(0.92)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C180(0.97)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C180(0.76)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C180(1.05)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C180(1.05)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C180(1.16)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C180(0.88)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C180(1.01)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C180(1.19)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C180(0.94)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C180(0.88)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C180(0.89)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C180(1.02)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C180(1.04)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C180(0.96)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C180(1.11)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C180(1.01)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C180(1.03)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C180(0.99)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C180(1.07)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C180(0.82)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C180(0.97)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C180(0.96)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C180(0.92)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C180(0.83)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C180(0.97)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C180(1.05)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C180(0.88)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C180(1.03)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C180(1.14)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C180(0.81)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C180(1.00)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C180(0.94)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C180(0.90)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C180(1.06)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C180(1.00)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C180(1.08)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C180(0.74)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C180(1.12)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C180(1.05)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C180(0.85)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C180(1.33)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C180(1.02)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C180(1.04)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C180(1.11)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C180(1.01)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C180(0.91)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C180(1.04)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C180(1.05)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C180(1.03)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C180(1.11)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C180(0.99)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C180(1.03)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C180(0.80)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C180(1.10)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C180(1.09)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C180(1.03)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C180(1.09)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C180(1.23)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C180(0.93)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C180(1.18)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C180(1.01)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C180(1.10)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C180(0.73)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C180(0.89)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C180(1.06)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C180(0.99)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C180(1.05)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C180(0.91)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C180(1.06)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C180(1.05)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C180(1.04)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C180(0.97)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C180(1.07)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C180(0.95)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C180(0.80)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C180(1.02)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C180(0.93)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C180(0.93)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C180(0.97)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C180(1.06)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C180(0.91)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C180(1.07)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C180(1.12)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C180(1.20)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C180(1.26)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C180(0.97)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C180(1.15)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C180(1.14)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C180(1.01)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C180(0.93)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C180(1.00)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C180(1.08)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C180(0.90)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C180(1.01)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C180(1.06)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C180(1.17)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C180(1.14)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C180(1.04)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C180(1.13)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C180(0.86)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C180(0.96)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C180(1.00)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C180(0.94)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C180(0.99)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C180(0.85)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C180(1.03)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C180(0.93)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C180(1.00)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C180(1.15)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C180(0.83)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C180(0.89)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C180(1.01)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C180(0.94)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C180(0.96)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C180(0.85)  LDD1698  [20]
 LDCM0625  F8 Ramos C180(0.99)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C180(0.55)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C180(0.44)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C180(0.66)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C180(1.08)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C180(0.95)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C180(0.57)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C180(1.14)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C180(1.40)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C180(1.10)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C180(1.11)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C180(1.12)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C180(1.09)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C180(0.62)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C180(1.07)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C180(0.98)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C180(0.83)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C180(1.06)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C180(1.09)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C180(1.06)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C180(0.60)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C180(0.50)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y166(0.94)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y166(0.87)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y166(0.80)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y166(0.85)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y166(0.74)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0123  JWB131 DM93 Y166(0.74)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y166(0.38)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y166(0.79)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y166(2.51)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y166(1.53)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y166(0.74)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y166(0.44)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y166(0.79)  LDD0292  [9]
 LDCM0022  KB02 Ramos C180(0.59)  LDD2182  [21]
 LDCM0023  KB03 Ramos C180(0.59)  LDD2183  [21]
 LDCM0024  KB05 G361 C180(1.68)  LDD3311  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C180(0.80)  LDD2110  [8]
 LDCM0131  RA190 MM1.R C180(1.12)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family G member 8 (ABCG8) ABCG family Q9H221
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) RNA M5U methyltransferase family Q8IZ69
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) Clp1 family Q92989
Cytochrome P450 4F11 (CYP4F11) Cytochrome P450 family Q9HBI6
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Three prime repair exonuclease 2 (TREX2) TREX family Q9BQ50
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Putative serine/threonine-protein kinase SIK1B (SIK1B) CAMK Ser/Thr protein kinase family A0A0B4J2F2
GTP-binding protein GEM (GEM) RGK family P55040
Thymidine phosphorylase (TYMP) Thymidine/pyrimidine-nucleoside phosphorylase family P19971
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
V-type proton ATPase subunit E 2 (ATP6V1E2) V-ATPase E subunit family Q96A05
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) . Q9UBL3
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Copper homeostasis protein cutC homolog (CUTC) CutC family Q9NTM9
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) Cytochrome c oxidase subunit 5A family P20674
Golgin subfamily A member 7 (GOLGA7) ERF4 family Q7Z5G4
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 827 (ZNF827) Krueppel C2H2-type zinc-finger protein family Q17R98
Zinc finger protein 844 (ZNF844) Krueppel C2H2-type zinc-finger protein family Q08AG5
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) . P12319
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Abitram (ABITRAM) ABITRAM family Q9NX38
Acyl-CoA-binding domain-containing protein 7 (ACBD7) ACBD7 family Q8N6N7
Akirin-2 (AKIRIN2) Akirin family Q53H80
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
BLOC-1-related complex subunit 8 (BORCS8) BORCS8 family Q96FH0
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Protein FAM13C (FAM13C) FAM13 family Q8NE31
Cotranscriptional regulator ARB2A (ARB2A) FAM172 family Q8WUF8
Collagen alpha-2(I) chain (COL1A2) Fibrillar collagen family P08123
Histone H2A-Bbd type 2/3 (H2AB2; H2AB3) Histone H2A family P0C5Z0
Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) HSBP1 family C9JCN9
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Small ribosomal subunit protein mS37 (CHCHD1) Mitochondrion-specific ribosomal protein mS37 family Q96BP2
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Nuclear exosome regulator NRDE2 (NRDE2) NRDE2 family Q9H7Z3
Centrosomal AT-AC splicing factor (CENATAC) . Q86UT8
Collagen alpha-1(X) chain (COL10A1) . Q03692
Cytochrome c oxidase assembly protein COX14 (COX14) . Q96I36
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Lymphocyte antigen 96 (LY96) . Q9Y6Y9
Melanoma-associated antigen B4 (MAGEB4) . O15481
Polyamine-modulated factor 1 (PMF1) . Q6P1K2
Protein Njmu-R1 (C17orf75) . Q9HAS0
Tektin-like protein 1 (TEKTL1) . Q8IYK2
Testis-expressed protein 12 (TEX12) . Q9BXU0
Testis-expressed protein 48 (TEX48) . A0A1B0GUV7
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.