Details of the Target

General Information of Target

Target ID LDTP11033
Target Name A-kinase anchor protein 9 (AKAP9)
Gene Name AKAP9
Gene ID 10142
Synonyms
AKAP350; AKAP450; KIAA0803; A-kinase anchor protein 9; AKAP-9; A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9; Protein yotiao
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEMKKTAIRLPKGKQKPIKTEWNSRCVLFTYFQGDISSVVDEHFSRALSNIKSPQELTP
SSQSEGVMLKNDDSMSPNQWRYSSPWTKPQPEVPVTNRAANCNLHVPGPMAVNQFSPSLA
RRASVRPGELWHFSSLAGTSSLEPGYSHPFPARHLVPEPQPDGKREPLLSLLQQDRCLAR
PQESAARENGNPGQIAGSTGLLFNLPPGSVHYKKLYVSRGSASTSLPNETLSELETPGKY
SLTPPNHWGHPHRYLQHL
Target Bioclass
Other
Subcellular location
Golgi apparatus
Function
Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.; [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.
Uniprot ID
Q99996
Ensemble ID
ENST00000356239.8
HGNC ID
HGNC:379

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K2539(10.00); K3187(0.72)  LDD0277  [2]
Probe 1
 Probe Info  		Y1798(21.33); Y1927(13.81); Y3839(4.10)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C74(2.62); C1966(2.09); C3067(3.44); C1493(4.03)  LDD0168  [4]
DBIA
 Probe Info  		C3581(6.22); C1405(4.64); C2877(12.51); C3521(5.06)  LDD0209  [5]
FBP2
 Probe Info  		19.75  LDD0320  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
CY4
 Probe Info  		D2269(0.00); D2275(0.00); S2268(0.00); S2272(0.00)  LDD0247  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C3521(0.00); C1954(0.00); C2765(0.00); C1144(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		C1405(0.00); C3521(0.00); C1367(0.00); C2765(0.00)  LDD0005  [12]
NPM
 Probe Info  		N.A.  LDD0016  [12]
VSF
 Probe Info  		C3063(0.00); C3521(0.00); C1676(0.00)  LDD0007  [12]
YN-1
 Probe Info  		N.A.  LDD0447  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		14.30  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C74(2.62); C1966(2.09); C3067(3.44); C1493(4.03)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1966(2.71)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C2571(1.01); C1481(1.21); C2010(1.22); C3521(0.94)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C2571(1.02); C1481(1.05); C2010(1.07); C3521(0.87)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C2571(1.01); C1481(1.09); C2010(1.20); C3521(0.95)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C2571(0.99); C1481(0.96); C2010(0.93); C3521(0.90)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C2571(0.98); C1481(1.04); C2010(1.01); C3521(0.91)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C2571(1.09); C1481(0.97); C2010(1.09); C3521(0.90)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C2571(0.97); C1481(1.12); C2010(1.29); C3521(1.00)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C2571(0.98); C1481(1.01); C2010(1.03); C3521(1.06)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C2571(1.11); C1481(1.38); C2010(1.20); C3521(0.98)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C2571(0.99); C1481(1.00); C2010(1.06); C3521(0.86)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C2571(1.04); C1481(1.00); C2010(0.93); C3521(0.95)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C2571(0.91); C1481(1.25); C2010(1.08); C3521(1.01)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C2571(0.96); C1481(1.02); C2010(1.03); C3521(0.95)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C2571(1.11); C1481(0.99); C2010(1.06); C3521(1.02)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C2571(0.98); C1481(0.99); C2010(1.07); C3521(1.04)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C2571(0.93); C1481(1.10); C2010(1.26); C3521(1.05)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C2571(0.87); C1481(0.99); C2010(1.06); C3521(0.94)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C2571(0.96); C1481(1.08); C2010(1.35); C3521(1.00)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C2571(0.99); C1481(1.05); C2010(0.94); C3521(0.96)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C2571(1.09); C1481(1.09); C2010(1.10); C3521(0.99)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C2571(1.11); C1481(1.14); C2010(1.31); C3521(1.00)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C2571(0.81); C1481(1.09); C2010(1.02); C3521(0.99)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C2571(1.00); C1481(1.04); C2010(1.02); C3521(1.00)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C2571(0.92); C1481(1.02); C2010(1.04); C3521(0.98)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C2571(0.99); C1481(1.15); C2010(1.29); C3521(0.92)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C2571(0.99); C1481(1.01); C2010(1.07); C3521(0.90)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C2571(1.12); C1481(1.06); C2010(1.35); C3521(0.99)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C2571(1.12); C1481(1.07); C2010(0.95); C3521(0.89)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C2571(1.14); C1481(1.25); C2010(1.33); C3521(0.90)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C2571(0.98); C1481(0.96); C2010(0.98); C3521(0.92)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C2571(1.08); C1481(1.10); C2010(1.08); C3521(0.87)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C2571(0.97); C1481(1.01); C2010(0.91); C3521(0.91)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C2571(0.96); C1481(0.99); C2010(1.07); C3521(0.93)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C2571(1.02); C1481(1.11); C2010(1.29); C3521(1.05)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C2571(0.96); C1481(1.07); C2010(1.08); C3521(0.97)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C2571(1.02); C1481(1.09); C2010(1.38); C3521(0.98)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C2571(1.11); C1481(0.97); C2010(0.93); C3521(0.90)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C2571(0.97); C1481(1.24); C2010(1.21); C3521(1.00)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C2571(0.84); C1481(0.94); C2010(0.99); C3521(0.94)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C2571(1.09); C1481(0.99); C2010(1.10); C3521(1.00)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C2571(0.94); C1481(1.06); C2010(1.03); C3521(0.89)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C2571(0.87); C1481(1.13); C2010(1.27); C3521(0.99)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C2571(0.99); C1481(1.23); C2010(1.25); C3521(0.98)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C2571(1.04); C1481(1.06); C2010(1.05); C3521(0.88)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C2571(0.98); C1481(1.03); C2010(1.37); C3521(0.97)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C2571(0.94); C1481(1.15); C2010(0.98); C3521(0.92)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C2571(1.03); C1481(1.16); C2010(1.23); C3521(0.94)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C2571(1.15); C1481(1.02); C2010(0.98); C3521(0.90)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C2571(1.10); C1481(1.10); C2010(1.07); C3521(0.90)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C2571(0.95); C1481(1.10); C2010(1.10); C3521(0.92)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C2571(1.00); C1481(1.10); C2010(1.26); C3521(0.96)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C2571(0.94); C1481(1.03); C2010(1.04); C3521(0.87)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C2571(1.14); C1481(1.03); C2010(1.28); C3521(0.99)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C2571(1.07); C1481(1.14); C2010(0.99); C3521(0.95)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C2571(1.03); C1481(1.19); C2010(0.97); C3521(0.94)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C2571(1.05); C1481(1.24); C2010(1.26); C3521(0.97)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C2571(0.99); C1481(1.06); C2010(0.98); C3521(0.92)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C2571(1.11); C1481(1.14); C2010(1.09); C3521(0.95)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C2571(0.90); C1481(1.02); C2010(1.06); C3521(0.93)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C2571(1.00); C1481(0.98); C2010(1.05); C3521(0.91)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C2571(0.83); C1481(0.97); C2010(1.07); C3521(0.93)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C2571(1.00); C1481(1.16); C2010(1.08); C3521(0.94)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C2571(1.02); C1481(1.15); C2010(1.28); C3521(1.00)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C2571(0.86); C1481(1.06); C2010(1.02); C3521(0.95)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C2010(20.00); C3521(20.00); C2125(1.49); C1782(0.92)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C2571(0.91); C1481(1.13); C2010(0.99); C3521(0.89)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C2571(0.73); C1481(0.97); C2010(0.76); C3521(0.84)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C2571(1.22); C1481(1.08); C2010(1.00); C3521(0.76)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C2571(0.94); C1481(1.15); C2010(1.08); C3521(0.97)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C2571(0.89); C1481(0.96); C2010(1.04); C3521(1.01)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C2571(1.08); C1481(0.97); C2010(1.11); C3521(0.94)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C2571(1.16); C1481(1.07); C2010(0.99); C3521(0.84)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C2571(0.96); C1481(1.01); C2010(1.03); C3521(0.98)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C2571(0.93); C1481(1.04); C2010(1.04); C3521(0.99)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C2571(1.03); C1481(1.01); C2010(1.13); C3521(0.94)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C2571(0.98); C1481(1.04); C2010(1.09); C3521(0.86)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C2571(0.89); C1481(1.05); C2010(1.07); C3521(0.98)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C2571(1.19); C1481(1.03); C2010(0.83); C3521(0.90)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C2571(1.03); C1481(1.10); C2010(1.01); C3521(1.01)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C2571(1.02); C1481(1.03); C2010(1.02); C3521(0.98)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C2571(1.11); C1481(1.06); C2010(1.01); C3521(0.82)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C2571(0.97); C1481(1.07); C2010(1.09); C3521(0.92)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C2571(0.75); C1481(1.06); C2010(0.98); C3521(0.93)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C2571(1.07); C1481(1.02); C2010(1.10); C3521(0.99)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C2571(1.22); C1481(1.11); C2010(1.07); C3521(0.92)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C2571(0.96); C1481(1.07); C2010(1.11); C3521(0.93)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C2571(1.01); C1481(1.10); C2010(1.10); C3521(0.95)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C2571(0.99); C1481(1.04); C2010(1.06); C3521(0.91)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C2571(0.89); C1481(1.02); C2010(0.78); C3521(0.90)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C2571(1.09); C1481(1.09); C2010(1.02); C3521(0.88)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C2571(0.94); C1481(1.08); C2010(1.08); C3521(0.95)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C2571(1.04); C1481(1.02); C2010(1.06); C3521(0.89)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C2571(0.92); C1481(0.96); C2010(0.96); C3521(0.88)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C2571(0.94); C1481(1.09); C2010(1.02); C3521(0.78)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C2571(0.87); C1481(1.15); C2010(1.06); C3521(0.97)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C2571(0.88); C1481(1.05); C2010(1.08); C3521(0.94)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C2571(0.99); C1481(1.08); C2010(1.09); C3521(0.98)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C2571(1.04); C1481(1.07); C2010(0.99); C3521(0.85)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C2571(1.00); C1481(1.40); C2010(1.03); C3521(1.05)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C2571(0.82); C1481(1.05); C2010(1.11); C3521(0.84)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C2571(0.98); C1481(1.01); C2010(0.95); C3521(0.92)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C2571(1.13); C1481(1.18); C2010(0.97); C3521(0.86)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C2571(0.96); C1481(1.25); C2010(0.99); C3521(0.91)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C2571(0.81); C1481(1.03); C2010(0.97); C3521(0.79)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C2571(1.04); C1481(1.07); C2010(0.81); C3521(0.94)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C2571(0.78); C1481(1.04); C2010(1.11); C3521(0.84)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C2571(1.13); C1481(1.13); C2010(0.98); C3521(0.85)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C2571(1.03); C1481(1.18); C2010(0.53); C3521(0.92)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C2571(0.89); C1481(0.93); C2010(0.89); C3521(0.89)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C2571(1.09); C1481(0.99); C2010(0.87); C3521(0.98)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C2571(0.92); C1481(1.09); C2010(0.79); C3521(0.97)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C2571(0.88); C1481(1.09); C2010(0.99); C3521(0.86)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C2571(0.94); C1481(1.07); C2010(1.07); C3521(0.93)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C2571(1.00); C1481(1.02); C2010(1.10); C3521(0.95)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C2571(1.00); C1481(1.10); C2010(0.99); C3521(0.81)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C2571(0.94); C1481(1.09); C2010(1.09); C3521(0.93)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C2571(0.92); C1481(0.87); C2010(1.12); C3521(0.91)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C2571(0.93); C1481(1.04); C2010(0.97); C3521(0.88)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C2571(0.87); C1481(1.12); C2010(0.78); C3521(0.95)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C2571(0.96); C1481(1.03); C2010(0.97); C3521(0.89)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C2571(0.92); C1481(1.05); C2010(0.46); C3521(0.86)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C2571(0.97); C1481(0.95); C2010(0.82); C3521(0.92)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C2571(0.99); C1481(0.92); C2010(0.83); C3521(1.02)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C2571(0.83); C1481(0.86); C2010(0.80); C3521(1.00)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C2571(0.90); C1481(1.20); C2010(1.00); C3521(0.94)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C2571(0.97); C1481(1.05); C2010(1.03); C3521(0.97)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C2571(1.10); C1481(1.13); C2010(0.98); C3521(0.86)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C2571(1.17); C1481(1.10); C2010(1.07); C3521(0.86)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C2571(0.86); C1481(1.00); C2010(1.04); C3521(1.01)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C2571(0.90); C1481(1.06); C2010(0.90); C3521(0.89)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C2571(1.03); C1481(1.01); C2010(0.75); C3521(0.95)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C2571(0.98); C1481(1.00); C2010(0.99); C3521(0.96)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C2571(0.92); C1481(1.13); C2010(0.56); C3521(1.06)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C2571(1.10); C1481(0.99); C2010(0.84); C3521(0.96)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C2571(1.02); C1481(0.88); C2010(0.82); C3521(0.92)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C2571(0.90); C1481(0.87); C2010(0.73); C3521(1.02)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C2571(0.99); C1481(1.16); C2010(1.05); C3521(0.87)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C2571(1.05); C1481(1.21); C2010(1.12); C3521(0.98)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C2571(0.86); C1481(1.01); C2010(1.05); C3521(0.92)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C2571(1.26); C1481(1.11); C2010(1.02); C3521(0.71)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C2571(0.95); C1481(1.09); C2010(1.03); C3521(0.82)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C2571(0.81); C1481(0.94); C2010(0.88); C3521(0.75)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C2571(1.06); C1481(1.04); C2010(0.71); C3521(0.92)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C2571(1.10); C1481(0.99); C2010(0.97); C3521(0.85)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C2571(1.03); C1481(1.23); C2010(0.56); C3521(0.92)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C2571(1.09); C1481(0.95); C2010(0.84); C3521(0.89)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C2571(1.02); C1481(0.91); C2010(0.88); C3521(0.86)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C2571(0.88); C1481(1.05); C2010(0.87); C3521(0.79)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C2571(0.90); C1481(1.06); C2010(0.79); C3521(0.92)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C2571(0.87); C1481(1.15); C2010(1.16); C3521(0.90)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C2571(0.98); C1481(1.00); C2010(1.08); C3521(0.92)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C2571(1.06); C1481(1.08); C2010(1.17); C3521(0.95)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C2571(0.98); C1481(1.09); C2010(0.93); C3521(0.68)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C2571(0.98); C1481(1.14); C2010(1.20); C3521(0.94)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C2571(0.86); C1481(1.02); C2010(0.96); C3521(0.81)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C2571(1.03); C1481(1.05); C2010(0.83); C3521(0.97)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C2571(1.06); C1481(0.98); C2010(0.98); C3521(0.84)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C2571(1.12); C1481(1.18); C2010(0.54); C3521(0.93)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C2571(1.13); C1481(1.13); C2010(0.80); C3521(0.96)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C2571(0.94); C1481(0.91); C2010(0.85); C3521(0.94)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C2571(1.04); C1481(0.92); C2010(0.88); C3521(0.95)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C2571(0.94); C1481(1.01); C2010(0.81); C3521(0.95)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C2571(0.90); C1481(1.13); C2010(1.04); C3521(0.91)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C2571(0.97); C1481(1.08); C2010(1.04); C3521(0.94)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C2571(1.08); C1481(1.02); C2010(0.99); C3521(0.78)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C2571(0.80); C1481(1.12); C2010(1.03); C3521(0.98)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C2571(0.85); C1481(1.02); C2010(0.98); C3521(0.81)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C2571(1.11); C1481(0.98); C2010(0.83); C3521(0.91)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C2571(0.95); C1481(0.98); C2010(0.74); C3521(0.82)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C2571(1.08); C1481(0.94); C2010(1.01); C3521(0.84)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C2571(1.07); C1481(1.22); C2010(0.63); C3521(0.97)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C2571(0.97); C1481(0.91); C2010(0.86); C3521(0.91)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C2571(1.04); C1481(0.92); C2010(0.83); C3521(0.81)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C2571(0.88); C1481(0.92); C2010(0.79); C3521(0.93)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C2571(0.94); C1481(1.25); C2010(1.04); C3521(0.90)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C2571(1.01); C1481(1.10); C2010(1.09); C3521(0.89)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C2571(0.91); C1481(1.11); C2010(1.08); C3521(0.95)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C2571(1.10); C1481(1.05); C2010(1.00); C3521(0.88)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C2571(0.95); C1481(1.22); C2010(1.13); C3521(0.94)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C2571(1.11); C1481(1.26); C2010(0.56); C3521(0.89)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C2571(0.79); C1481(1.17); C2010(0.84); C3521(0.80)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C2571(0.95); C1481(1.09); C2010(0.88); C3521(0.93)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C2571(0.93); C1481(1.03); C2010(0.94); C3521(0.82)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C2571(1.00); C1481(1.17); C2010(0.68); C3521(0.92)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C2571(0.99); C1481(1.00); C2010(0.90); C3521(0.92)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C2571(0.92); C1481(1.01); C2010(0.88); C3521(0.87)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C2571(0.86); C1481(0.99); C2010(0.89); C3521(0.87)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C2571(0.96); C1481(1.19); C2010(1.04); C3521(0.96)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C2571(0.99); C1481(1.02); C2010(1.07); C3521(0.95)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C2571(0.98); C1481(1.13); C2010(1.01); C3521(1.03)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C2571(0.96); C1481(1.02); C2010(1.06); C3521(0.96)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1675(1.70); C1676(1.24)  LDD1702  [16]
 LDCM0468  Fragment33 HEK-293T C2571(0.97); C1481(1.03); C2010(1.09); C3521(0.92)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C2571(0.93); C1481(0.97); C2010(1.06); C3521(0.89)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C1782(1.02); C2571(0.99); C1481(1.21); C2010(0.95)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C3581(6.22); C1405(4.64); C2877(12.51); C3521(5.06)  LDD0209  [5]
 LDCM0024  KB05 G361 C2777(2.85); C2889(6.69)  LDD3311  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0008  Tranylcypromine HeLa 19.75  LDD0320  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Golgin-45 (BLZF1) . Q9H2G9
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein SSX2 (SSX2; SSX2B) SSX family Q16385
General vesicular transport factor p115 (USO1) VDP/USO1/EDE1 family O60763
Gelsolin (GSN) Villin/gelsolin family P06396
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
Melanoma-associated antigen 6 (MAGEA6) . P43360
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Sterile alpha motif domain-containing protein 3 (SAMD3) . Q8N6K7
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
WW domain-containing adapter protein with coiled-coil (WAC) . Q9BTA9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840