Details of the Target

General Information of Target

Target ID LDTP01057
Target Name Polyglutamine-binding protein 1 (PQBP1)
Gene Name PQBP1
Gene ID 10084
Synonyms
NPW38; Polyglutamine-binding protein 1; PQBP-1; 38 kDa nuclear protein containing a WW domain; Npw38; Polyglutamine tract-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSC
GLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRS
HEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHR
REELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLF
QQRPYPSPGAVLRANAEASRTKQQD
Target Bioclass
Other
Subcellular location
Nucleus
Function
Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.
Uniprot ID
O60828
Ensemble ID
ENST00000218224.9
HGNC ID
HGNC:9330

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P2L .
MFE319 SNV: p.R44G .
RL952 Deletion: p.R214GfsTer62 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.24  LDD0402  [1]
FBP2
 Probe Info  		8.81  LDD0323  [2]
STPyne
 Probe Info  		K123(5.26)  LDD0277  [3]
Probe 1
 Probe Info  		Y33(27.24); Y40(24.87); Y209(5.57); Y245(11.11)  LDD3495  [4]
DBIA
 Probe Info  		C60(0.84)  LDD3312  [5]
AHL-Pu-1
 Probe Info  		C60(5.87)  LDD0169  [6]
HHS-475
 Probe Info  		Y245(0.79); Y209(6.96)  LDD0264  [7]
HHS-465
 Probe Info  		Y187(4.83); Y245(1.25)  LDD2237  [8]
Acrolein
 Probe Info  		N.A.  LDD0221  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
IPM
 Probe Info  		N.A.  LDD2156  [13]
SF
 Probe Info  		Y245(0.00); Y146(0.00); Y187(0.00)  LDD0028  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
AOyne
 Probe Info  		12.80  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C60(5.87)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C60(1.06)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C60(0.88)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C60(0.95)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C60(0.93)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C60(1.07)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C60(1.12)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C60(0.96)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C60(0.91)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C60(0.82)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C60(0.99)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C60(0.96)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C60(1.01)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C60(1.09)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C60(1.12)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C60(1.04)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C60(0.96)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C60(0.95)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C60(1.08)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C60(0.87)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C60(0.95)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C60(0.92)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C60(1.06)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C60(1.10)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C60(0.99)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C60(0.96)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C60(0.96)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C60(1.01)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C60(0.91)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C60(1.05)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C60(0.95)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C60(1.11)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C60(0.93)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C60(1.16)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C60(0.97)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C60(1.04)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C60(1.06)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C60(0.91)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C60(0.93)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C60(1.12)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C60(1.01)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C60(1.10)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C60(1.02)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C60(0.93)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C60(0.87)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C60(1.03)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C60(0.85)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C60(1.02)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C60(0.92)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C60(1.07)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C60(0.95)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C60(0.95)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C60(0.91)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C60(1.09)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C60(1.01)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C60(0.91)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C60(0.87)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C60(1.08)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C60(1.03)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C60(0.98)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C60(1.27)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C60(1.07)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C60(0.97)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C60(1.04)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C60(1.06)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 12.81  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C60(1.77)  LDD2214  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C60(0.97)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C60(0.90)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C60(0.83)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C60(0.93)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C60(0.95)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C60(0.93)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C60(0.82)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C60(0.97)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C60(0.94)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C60(0.95)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C60(0.91)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C60(0.94)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C60(0.93)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C60(0.93)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C60(0.99)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C60(1.11)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C60(1.04)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C60(0.97)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C60(0.97)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C60(0.96)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C60(0.93)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C60(1.05)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C60(0.99)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C60(0.98)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C60(0.91)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C60(0.93)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C60(0.97)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C60(0.79)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C60(0.85)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C60(0.79)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C60(0.88)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C60(0.86)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C60(0.79)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C60(0.93)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C60(1.11)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C60(0.91)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C60(0.96)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C60(0.98)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C60(0.87)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C60(0.98)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C60(1.13)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C60(0.91)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C60(0.95)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C60(1.04)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C60(1.11)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C60(1.02)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C60(0.80)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C60(1.10)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C60(1.04)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C60(0.95)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C60(0.92)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C60(0.84)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C60(0.94)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C60(0.99)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C60(0.81)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C60(0.84)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C60(0.86)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C60(1.13)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C60(0.98)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C60(1.02)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C60(1.00)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C60(0.76)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C60(0.93)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C60(0.98)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C60(0.84)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C60(1.04)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C60(0.73)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C60(0.85)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C60(0.96)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C60(1.12)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C60(0.97)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C60(0.93)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C60(1.03)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C60(0.99)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C60(0.81)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C60(0.86)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C60(0.82)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C60(0.86)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C60(0.79)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C60(0.88)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C60(0.94)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C60(0.94)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C60(0.86)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C60(0.97)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C60(0.88)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C60(1.12)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C60(0.85)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C60(0.89)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C60(1.06)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C60(0.78)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C60(1.04)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C60(0.80)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C60(0.94)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C60(1.00)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C60(1.03)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C60(0.95)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C60(1.00)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C60(0.96)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C60(1.11)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C60(1.06)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C60(0.93)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C60(0.91)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C60(1.07)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C60(0.56)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C60(0.81)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C60(0.96)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C60(0.97)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C60(0.93)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C60(0.90)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C60(1.01)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C60(0.92)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C60(0.80)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C60(0.85)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C60(0.96)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C60(0.88)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C60(0.75)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C60(0.84)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C60(0.77)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C60(0.97)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C60(0.96)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C60(0.80)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C60(0.85)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C60(0.88)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C60(0.96)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C60(0.89)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C60(0.96)  LDD1698  [18]
 LDCM0625  F8 Ramos C60(0.83)  LDD2187  [20]
 LDCM0573  Fragment11 Ramos C60(0.10)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C60(16.33)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C60(0.62)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C60(1.47)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C60(3.00)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C60(7.72)  LDD2195  [20]
 LDCM0578  Fragment27 Ramos C60(5.64)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C60(0.54)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C60(9.23)  LDD2199  [20]
 LDCM0590  Fragment32 Ramos C60(5.21)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C60(0.85)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C60(7.18)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C60(0.86)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C60(0.99)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C60(3.02)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C60(2.15)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C60(2.71)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C60(20.00)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y245(0.79); Y209(6.96)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y245(0.98)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y245(2.38); Y209(4.08)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y245(1.27); Y209(9.75)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y245(0.47); Y209(3.03)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C60(0.93)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C60(0.96)  LDD1497  [18]
 LDCM0024  KB05 HMCB C60(0.84)  LDD3312  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
WW domain-binding protein 11 (WBP11) . Q9Y2W2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578