Details of the Target

General Information of Target

Target ID LDTP01323
Target Name 26S proteasome non-ATPase regulatory subunit 10 (PSMD10)
Gene Name PSMD10
Gene ID 5716
Synonyms
26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC
DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
TTD ID
T53890
Uniprot ID
O75832
DrugMap ID
TT2H4LN
Ensemble ID
ENST00000217958.8
HGNC ID
HGNC:9555
ChEMBL ID
CHEMBL2331054

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.A80V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBP2
 Probe Info  		2.96  LDD0323  [2]
TH211
 Probe Info  		Y160(15.97); Y138(14.43)  LDD0257  [3]
TH214
 Probe Info  		Y138(20.00)  LDD0258  [3]
Probe 1
 Probe Info  		Y138(18.26)  LDD3495  [4]
BTD
 Probe Info  		C107(0.35)  LDD2116  [5]
HHS-475
 Probe Info  		Y160(0.96); Y138(0.96)  LDD0264  [6]
HHS-465
 Probe Info  		Y138(9.94); Y160(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C107(1.20)  LDD0078  [8]
5E-2FA
 Probe Info  		H137(0.00); H144(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K30(0.00); K116(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C180(0.00); C107(0.00); C48(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [13]
Lodoacetamide azide
 Probe Info  		C180(0.00); C107(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
SF
 Probe Info  		K221(0.00); Y160(0.00); Y138(0.00)  LDD0028  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
Acrolein
 Probe Info  		H137(0.00); C180(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C107(0.00); C4(0.00); C11(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y138(1.59)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe2
 Probe Info  		6.20  LDD0463  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C107(3.69)  LDD0371  [23]
 LDCM0214  AC1 HEK-293T C107(1.03)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C107(0.89)  LDD0813  [8]
 LDCM0216  AC100 HCT 116 C107(1.09)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C107(1.22)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C107(1.47)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C107(1.02)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C107(1.23)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C107(1.24)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C107(1.02)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C107(0.89)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C107(1.34)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C107(1.49)  LDD0542  [8]
 LDCM0226  AC11 HEK-293T C107(1.00)  LDD0824  [8]
 LDCM0227  AC110 HCT 116 C107(1.60)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C107(1.46)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C107(1.09)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C107(0.96)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C107(1.02)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C107(1.10)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C107(1.18)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C107(1.18)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C107(1.15)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C107(1.13)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C107(1.07)  LDD0835  [8]
 LDCM0238  AC120 HCT 116 C107(1.42)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C107(0.92)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C107(1.02)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C107(1.17)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C107(1.08)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C107(1.17)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C107(1.10)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C107(0.94)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C107(0.69)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C107(1.09)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C107(0.75)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C107(0.84)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C107(1.26)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C107(1.01)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C107(0.84)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C107(0.93)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C107(1.06)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C107(1.24)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C107(1.19)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C107(0.82)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C107(1.06)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C107(0.81)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C107(1.03)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C107(1.39)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C107(1.06)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C107(0.93)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C107(1.37)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C107(1.27)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C107(0.86)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C107(0.60)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C107(0.85)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C107(1.04)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C107(1.23)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C107(1.02)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C107(0.93)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C107(0.56)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C107(1.09)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C107(0.91)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C107(0.77)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C107(1.11)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C107(1.00)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C107(1.04)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C107(0.86)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C107(1.25)  LDD0877  [8]
 LDCM0280  AC20 HCT 116 C107(0.99)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C107(0.96)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C107(0.89)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C107(0.82)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C107(0.83)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C107(1.05)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C107(1.30)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C107(1.36)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C107(1.37)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C107(1.39)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C107(1.17)  LDD0888  [8]
 LDCM0291  AC30 HCT 116 C107(1.63)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C107(1.41)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C107(1.16)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C107(1.29)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C107(1.14)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C107(1.14)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C107(1.28)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C107(1.16)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C107(1.13)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C107(0.96)  LDD0617  [8]
 LDCM0301  AC4 HEK-293T C107(1.06)  LDD0899  [8]
 LDCM0302  AC40 HCT 116 C107(0.88)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C107(1.20)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C107(1.00)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C107(1.26)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C107(1.02)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C107(0.89)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C107(0.95)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C107(0.79)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C107(0.97)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C107(0.65)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C107(1.32)  LDD0910  [8]
 LDCM0313  AC50 HCT 116 C107(0.55)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C107(0.74)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C107(1.01)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C107(0.64)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C107(0.78)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C107(0.49)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C107(0.42)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C107(1.08)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C107(1.25)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C107(1.47)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C107(0.97)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C107(1.51)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C107(1.18)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C107(1.18)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C107(1.58)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C107(1.18)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C107(1.33)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C107(1.72)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C107(1.02)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C107(0.58)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C107(0.59)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C107(0.97)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C107(0.38)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C107(0.66)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C107(0.74)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C107(0.32)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C107(0.32)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C107(0.32)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C107(0.49)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C107(0.37)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C107(0.71)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C107(0.75)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C107(1.04)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C107(0.53)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C107(0.77)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C107(0.27)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C107(0.90)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C107(1.07)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C107(1.21)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C107(1.13)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C107(0.96)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C107(1.01)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C107(1.06)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C107(0.84)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C107(0.86)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C107(0.83)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C107(1.13)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C107(1.25)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C107(1.26)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C107(1.01)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C107(1.06)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C107(0.71)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C107(1.12)  LDD0683  [8]
 LDCM0248  AKOS034007472 HEK-293T C107(1.06)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C107(0.89)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C107(1.02)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C107(1.20)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C180(0.00); H137(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C4(2.47); C107(0.64)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C107(1.21)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C107(0.94)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C107(1.06)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C107(1.01)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C107(0.82)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C107(0.80)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C107(0.73)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C107(0.96)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C107(0.84)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C107(0.82)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C107(0.91)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C107(0.89)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C107(1.06)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C107(0.79)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C107(1.02)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C107(1.11)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C107(1.26)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C107(1.35)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C107(1.87)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C107(1.37)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C107(0.70)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C107(1.14)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C107(1.09)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C107(1.04)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C107(1.11)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C107(1.37)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C107(0.95)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C107(0.64)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C107(0.61)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C107(1.22)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C107(1.54)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C107(1.50)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C107(1.19)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C107(1.05)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C107(1.04)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C107(0.82)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C107(1.33)  LDD1001  [8]
 LDCM0404  CL17 HCT 116 C107(0.99)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C107(1.05)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C107(1.00)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C107(1.00)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C107(1.36)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C107(0.90)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C107(1.47)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C107(1.28)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C107(1.05)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C107(1.06)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C107(1.04)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C107(1.13)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C107(1.06)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C107(1.29)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C107(1.01)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C107(1.06)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C107(0.97)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C107(1.07)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C107(0.83)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C107(0.99)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C107(1.40)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C107(1.05)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C107(1.22)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C107(1.05)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C107(1.08)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C107(0.84)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C107(1.14)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C107(1.35)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C107(0.80)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C107(0.93)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C107(0.68)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C107(0.98)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C107(1.42)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C107(1.09)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C107(0.95)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C107(0.89)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C107(0.98)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C107(0.91)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C107(1.06)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C107(1.47)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C107(0.96)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C107(0.91)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C107(1.05)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C107(1.06)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C107(1.01)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C107(0.98)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C107(0.88)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C107(1.05)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C107(0.79)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C107(0.77)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C107(0.86)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C107(0.74)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C107(0.84)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C107(0.75)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C107(0.86)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C107(1.56)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C107(0.97)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C107(0.85)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C107(0.96)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C107(0.93)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C107(1.31)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C107(1.00)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C107(0.95)  LDD0784  [8]
 LDCM0469  CL76 HEK-293T C107(1.12)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C107(1.09)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C107(0.90)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C107(1.09)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C107(1.04)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C107(1.25)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C107(1.12)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C107(1.13)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C107(1.17)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C107(1.18)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C107(1.63)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C107(1.32)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C107(1.45)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C107(1.29)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C107(1.00)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C107(1.00)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C107(0.96)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C107(1.29)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C107(1.07)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C107(1.26)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C107(1.41)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C107(1.17)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C107(1.71)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C107(1.57)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C107(1.02)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C107(0.91)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C107(0.97); C180(1.09)  LDD1698  [24]
 LDCM0625  F8 Ramos C107(3.41)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C107(0.78)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C107(0.94)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C107(0.65)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C107(0.96)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C107(0.57)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C107(0.53)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C107(0.96)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C107(1.16)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C107(0.99)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C107(0.66)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C107(1.06)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C107(1.04)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C107(0.65)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C107(0.99)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C107(0.95)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C107(0.74)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C107(1.65)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C107(1.49)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C107(1.59)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C107(0.61)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C107(0.59)  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y160(0.96); Y138(0.96)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y138(0.77); Y160(0.85)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y138(0.48); Y160(0.89)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y138(0.80); Y160(0.89)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y138(0.78); Y160(0.91)  LDD0268  [6]
 LDCM0107  IAA HeLa C180(0.00); H137(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C107(1.05)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C107(1.08)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C107(0.99)  LDD0082  [8]
 LDCM0109  NEM HeLa H137(0.00); C180(0.00)  LDD0223  [20]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C107(0.35)  LDD2116  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C4(1.12); C107(0.52)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C4(1.59); C107(0.64); C4(0.58)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C107(1.10)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 6B (PSMC4) AAA ATPase family P43686
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) . Q9NWT6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 1 (CLIC1) Chloride channel CLIC family O00299
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock 70 kDa protein 1A (HSPA1A) Heat shock protein 70 family P0DMV8
Cytoplasmic protein NCK2 (NCK2) . O43639
G-rich sequence factor 1 (GRSF1) . Q12849
Melanoma-associated antigen 4 (MAGEA4) . P43358

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.