Details of the Target

General Information of Target

Target ID LDTP15958
Target Name Protein FAM234A (FAM234A)
Gene Name FAM234A
Gene ID 83986
Synonyms
C16orf9; ITFG3; Protein FAM234A; Protein ITFG3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTA
NSLILVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKNDVKE
ESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSV
ILLVVALAMLIIDLRMKSFLAIPNLVIFAVLLFFSSLETPKNPIAFACFFICLITDPFLD
IYFSGLSVTERWKPFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSI
FGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTHRTDYNSLDRIMASKGMRHFCLISEQLV
FFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPT
NFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSK
LKAFLELRTVDGPRHDTYILYYSGHTHGTGEWALAGGDTLRLDTLIEWWREKNGSFCSRL
IIVLDSENSTPWVKEVRKINDQYIAVQGAELIKTVDIEEADPPQLGDFTKDWVEYNCNSS
NNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHLANWLCGL
NLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLVKS
Target Bioclass
Other
Family
FAM234 family
Subcellular location
Membrane
Uniprot ID
Q9H0X4
Ensemble ID
ENST00000301678.7
HGNC ID
HGNC:14163

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.W149C .
CCK81 SNV: p.A9T; p.S211R .
HCT15 SNV: p.G298R .
HEC1B SNV: p.E310G .
NCIH196 SNV: p.G339D .
NCIH661 SNV: p.A49T .
REH SNV: p.D306N; p.W362Ter; p.G499D .
RKO SNV: p.H240Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.83  LDD0323  [1]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580