Details of the Target

General Information of Target

Target ID LDTP12155
Target Name Pleckstrin homology domain-containing family A member 2 (PLEKHA2)
Gene Name PLEKHA2
Gene ID 59339
Synonyms
TAPP2; Pleckstrin homology domain-containing family A member 2; PH domain-containing family A member 2; Tandem PH domain-containing protein 2; TAPP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHRFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEAL
ACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLS
PGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGIS
QWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWL
PARALVEEALAQRFQVDPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQ
WRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALS
MARATLAQRSYLPQIS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Uniprot ID
Q9HB19
Ensemble ID
ENST00000617275.5
HGNC ID
HGNC:14336

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
NAIA_5
 Probe Info  		C81(20.00)  LDD2227  [2]
HPAP
 Probe Info  		3.02  LDD0063  [3]
DBIA
 Probe Info  		C191(1.02)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C228(0.00); C11(0.00); C332(0.00); C191(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C11(0.00); C332(0.00); C253(0.00); C228(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C11(0.00); C332(0.00); C191(0.00); C253(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NAIA_4
 Probe Info  		C191(0.00); C332(0.00)  LDD2226  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		C191(0.00); C332(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		C191(0.00); C332(0.00)  LDD2213  [7]
Methacrolein
 Probe Info  		C191(0.00); C253(0.00)  LDD0218  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C228(0.90); C191(0.28)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C191(0.86)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C191(0.97)  LDD1105  [4]
 LDCM0230  AC113 PaTu 8988t C232(1.16); C81(1.24)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C232(1.05); C81(0.89)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C232(0.90); C81(0.97)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C232(1.18); C81(0.97)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C232(1.62); C81(1.40)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C232(1.16); C81(1.00)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C232(1.03); C81(0.95)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C191(0.84)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C232(0.79); C81(1.00)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C232(1.14); C81(0.96)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C232(1.01); C81(0.75)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C232(1.04); C81(0.92)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C232(0.93); C81(1.05)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C232(0.98); C81(1.16)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C232(1.09); C81(0.90)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C232(0.90); C81(0.84)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C191(0.63)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C191(0.59)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C191(0.56)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C191(0.61)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C191(0.55)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C191(0.56)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C191(0.64)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C191(0.71)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C191(0.70)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C191(0.65)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C191(0.55)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C191(0.49)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C191(0.85)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C191(0.83)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C191(0.80)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C191(0.40)  LDD1141  [4]
 LDCM0270  AC15 PaTu 8988t C191(1.22)  LDD1149  [4]
 LDCM0276  AC17 HCT 116 C191(1.47)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C191(0.78)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C191(0.60)  LDD0595  [4]
 LDCM0279  AC2 PaTu 8988t C228(0.81); C191(0.49)  LDD1158  [4]
 LDCM0280  AC20 HCT 116 C191(0.75)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C191(1.69)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C191(2.06)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C191(1.64)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C191(0.92)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C191(0.41)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C191(0.51)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C191(0.33)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C191(0.50)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C191(0.38)  LDD0606  [4]
 LDCM0290  AC3 PaTu 8988t C228(0.77); C191(0.34)  LDD1169  [4]
 LDCM0291  AC30 HCT 116 C191(0.26)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C191(0.61)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C191(0.36)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C191(0.36)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C191(0.44)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C228(0.96); C232(1.49); C81(1.15)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C228(0.89); C232(1.73); C81(0.83)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C228(0.64); C232(1.61); C81(1.11)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C228(0.95); C232(1.64); C81(0.86)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C228(0.97); C232(1.53); C81(1.00)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C228(0.85); C191(0.33)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C228(0.84); C232(1.57); C81(1.13)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C228(0.76); C232(1.11); C81(1.20)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C228(0.78); C232(1.00); C81(1.26)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C228(0.82); C232(1.35); C81(1.16)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C228(0.79); C232(1.46); C81(1.25)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C228(0.82); C232(1.30); C81(1.68)  LDD1186  [4]
 LDCM0308  AC46 HCT 116 C191(1.19)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C191(1.26)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C191(1.38)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C191(1.20)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C228(0.87); C191(0.36)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C191(1.29)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C191(3.01)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C191(1.04)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C191(0.99)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C191(1.29)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C191(1.29)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C191(1.75)  LDD0636  [4]
 LDCM0320  AC57 PaTu 8988t C81(0.93)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C81(0.84)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C81(0.93)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C191(0.84)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C81(0.94)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C81(1.40)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C81(0.33)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C81(0.56)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C81(1.06)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C81(1.04)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C81(0.89)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C81(0.91)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C191(1.26)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C191(1.14)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C191(0.71)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C191(1.58)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C191(1.37)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C191(1.38)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C191(1.51)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C191(1.81)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C191(2.02)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C191(1.80)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C191(2.18)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C191(1.25)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C191(1.40)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C191(0.81)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C191(2.22)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C191(1.47)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C191(1.99)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C191(0.97)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C191(1.15)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C191(0.81)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C191(1.27)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C191(0.87)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C191(0.90)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C191(1.03)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C191(0.78)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C191(1.36)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C191(1.10)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C191(0.74)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C191(0.91)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C191(0.81)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C191(1.08)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C191(1.45)  LDD0681  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C191(0.90)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C191(1.04)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C191(1.01)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C191(1.02)  LDD0078  [4]
 LDCM0102  BDHI 8 Jurkat C81(12.17)  LDD0204  [9]
 LDCM0632  CL-Sc Hep-G2 C81(20.00)  LDD2227  [2]
 LDCM0367  CL1 HEK-293T C253(1.02)  LDD1571  [10]
 LDCM0369  CL100 PaTu 8988t C228(0.74); C191(0.39)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C191(0.80)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C191(0.86)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C191(1.12)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C191(0.88)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C191(1.98)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C191(0.58)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C191(0.56)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C191(0.83)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C191(1.30)  LDD0695  [4]
 LDCM0380  CL110 HCT 116 C191(0.69)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C191(0.62)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C191(0.67)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C191(0.37)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C191(0.29)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C191(0.61)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C191(0.38)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C228(0.81); C232(1.24); C81(1.18)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C228(0.78); C232(1.18); C81(1.29)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C228(0.81); C232(1.36); C81(1.18)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C253(1.03)  LDD1594  [10]
 LDCM0391  CL120 PaTu 8988t C228(0.68); C232(1.18); C81(1.16)  LDD1270  [4]
 LDCM0392  CL121 HCT 116 C191(0.80)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C191(0.81)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C191(1.24)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C191(1.30)  LDD0712  [4]
 LDCM0396  CL125 PaTu 8988t C81(1.03)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C81(0.84)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C81(0.81)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C81(0.91)  LDD1278  [4]
 LDCM0400  CL13 HEK-293T C253(1.00)  LDD1604  [10]
 LDCM0403  CL16 HEK-293T C253(1.19)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C253(0.80)  LDD1608  [10]
 LDCM0406  CL19 HEK-293T C253(1.06)  LDD1610  [10]
 LDCM0412  CL24 HEK-293T C253(1.10)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C253(0.99)  LDD1617  [10]
 LDCM0416  CL28 HEK-293T C253(1.18)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C253(0.92)  LDD1621  [10]
 LDCM0420  CL31 HEK-293T C253(1.03)  LDD1624  [10]
 LDCM0425  CL36 HEK-293T C253(1.01)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C253(1.00)  LDD1630  [10]
 LDCM0429  CL4 HEK-293T C253(1.04)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C253(1.04)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C253(0.98)  LDD1635  [10]
 LDCM0433  CL43 HEK-293T C253(1.05)  LDD1637  [10]
 LDCM0436  CL46 PaTu 8988t C232(1.28)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C232(1.20)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C232(1.34)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C232(1.30)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C253(1.14)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C232(1.91)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C232(1.46)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C232(1.25)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C232(1.81)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C232(1.21)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C232(1.41)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C232(0.21)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C232(2.91)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C232(1.94)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C232(3.47)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C232(2.28)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C253(1.08)  LDD1656  [10]
 LDCM0456  CL64 HEK-293T C253(1.09)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C253(1.03)  LDD1660  [10]
 LDCM0459  CL67 HEK-293T C253(1.04)  LDD1662  [10]
 LDCM0462  CL7 HEK-293T C253(0.93)  LDD1665  [10]
 LDCM0465  CL72 HEK-293T C253(1.05)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C253(0.98)  LDD1669  [10]
 LDCM0469  CL76 HEK-293T C253(1.09)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C253(0.80)  LDD1673  [10]
 LDCM0472  CL79 HEK-293T C253(0.96)  LDD1675  [10]
 LDCM0478  CL84 HEK-293T C253(1.06)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C253(1.10)  LDD1682  [10]
 LDCM0482  CL88 HEK-293T C253(0.99)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C253(0.94)  LDD1686  [10]
 LDCM0486  CL91 PaTu 8988t C228(0.77); C191(0.73)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C228(0.78); C191(0.45)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C228(0.81); C191(0.64)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C228(0.83); C191(0.46)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C228(0.86); C191(0.61)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C228(0.90); C191(0.43)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C228(0.84); C191(0.32)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C228(0.95); C191(0.40)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C228(0.76); C191(0.42)  LDD1373  [4]
 LDCM0625  F8 Ramos C253(1.43); C232(1.40); C191(1.13); C81(0.57)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C253(1.44); C232(4.59); C191(1.72); C81(0.79)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C253(1.59); C232(16.95); C191(0.14); C81(0.46)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C253(2.04); C232(1.37); C191(1.08); C81(0.92)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C253(1.25); C232(1.25); C191(0.90); C81(0.76)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C253(1.32); C232(1.31); C191(1.16); C81(1.62)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C253(2.09); C232(1.96); C191(1.60); C81(1.06)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C253(1.11); C232(1.35); C191(0.95); C81(0.76)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C253(1.41); C232(0.91); C191(0.92); C81(0.80)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C253(1.09); C232(1.34); C191(0.85); C81(0.79)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C253(0.55); C232(1.05); C191(0.80); C81(1.28)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C253(1.22); C232(1.34); C191(1.12); C81(0.74)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C253(1.13); C232(0.97); C191(1.02); C81(0.95)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C253(1.48); C232(4.49); C191(1.55); C81(0.65)  LDD2201  [11]
 LDCM0468  Fragment33 Ramos C253(0.92); C232(1.53); C191(0.94); C81(1.07)  LDD2202  [11]
 LDCM0596  Fragment38 Ramos C253(1.24); C232(1.82); C191(0.96); C81(0.93)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C253(1.28); C232(1.41); C191(1.29); C81(1.08)  LDD2184  [11]
 LDCM0610  Fragment52 Ramos C253(1.43); C232(1.84); C191(1.02); C81(0.95)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C253(1.62); C232(1.60); C191(1.39); C81(1.17)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C253(2.72); C232(3.33); C191(1.90); C81(0.84)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C253(2.41); C232(2.40); C191(1.78); C81(1.17)  LDD2188  [11]
 LDCM0022  KB02 Ramos 5.69  LDD0431  [12]
 LDCM0023  KB03 Jurkat C205(9.42); C232(5.33)  LDD0209  [9]
 LDCM0024  KB05 G361 C191(3.06)  LDD3311  [13]
 LDCM0014  Panhematin K562 3.02  LDD0063  [3]
 LDCM0131  RA190 MM1.R C232(1.52)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
PDZ domain-containing protein GIPC1 (GIPC1) GIPC family O14908
PDZ domain-containing protein GIPC2 (GIPC2) GIPC family Q8TF65
PDZ domain-containing protein GIPC3 (GIPC3) GIPC family Q8TF64
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Disks large homolog 2 (DLG2) MAGUK family Q15700
Disks large homolog 3 (DLG3) MAGUK family Q92796
Gamma-1-syntrophin (SNTG1) Syntrophin family Q9NSN8
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Meiosis 1 arrest protein (M1AP) . Q8TC57

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.