Details of the Target

General Information of Target

Target ID LDTP07672
Target Name E3 ubiquitin-protein ligase LRSAM1 (LRSAM1)
Gene Name LRSAM1
Gene ID 90678
Synonyms
TAL; E3 ubiquitin-protein ligase LRSAM1; EC 2.3.2.27; Leucine-rich repeat and sterile alpha motif-containing protein 1; RING-type E3 ubiquitin transferase LRSAM1; Tsg101-associated ligase; hTAL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL
IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP
RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL
DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD
RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK
EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE
NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS
MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET
ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS
ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL
SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR
PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY
HSS
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
Uniprot ID
Q6UWE0
Ensemble ID
ENST00000300417.11
HGNC ID
HGNC:25135

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.R525Q DBIA    Probe Info 
TOV21G SNV: p.A81S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K463(10.00)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C23(11.02)  LDD0170  [3]
DBIA
 Probe Info  		C397(15.86)  LDD0204  [4]
IPM
 Probe Info  		C23(3.10); C75(1.32)  LDD1701  [5]
CY-1
 Probe Info  		Q340(0.00); Q344(0.00); Q347(0.00)  LDD0246  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C397(0.00); C75(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
aONE
 Probe Info  		N.A.  LDD0002  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		12.70  LDD0443  [13]
NAIA_5
 Probe Info  		C23(0.00); C75(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		6.96  LDD1779  [14]
C201
 Probe Info  		24.08  LDD1877  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C23(11.02)  LDD0170  [3]
 LDCM0561  Abegg_cp(-)-10 HeLa C397(2.46)  LDD0312  [10]
 LDCM0214  AC1 HCT 116 C193(0.43); C205(0.43); C23(0.70); C397(1.07)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C193(0.64); C205(0.64); C23(1.04); C397(1.20)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C193(0.52); C205(0.52); C23(1.15); C39(0.53)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C193(0.49); C205(0.49); C23(1.06); C39(0.61)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C193(0.45); C205(0.45); C23(0.89); C39(0.47)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C193(0.46); C205(0.46); C23(1.23); C39(0.54)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C193(0.54); C205(0.54); C23(0.94); C39(0.59)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C193(0.42); C205(0.42); C23(1.06); C39(0.55)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C193(0.50); C205(0.50); C23(1.25); C39(0.52)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C193(0.47); C205(0.53); C23(0.88); C39(0.51)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C193(0.53); C205(0.54); C23(0.96); C39(0.58)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C193(0.54); C205(0.57); C23(0.76); C39(0.74)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C193(0.66); C205(0.66); C23(1.03); C397(1.16)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C193(0.59); C205(0.58); C23(0.98); C39(0.58)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C193(0.56); C205(0.57); C23(0.86); C39(0.64)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C193(0.48); C205(0.48); C23(0.88); C39(0.50)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C193(1.03); C205(1.03); C23(0.90); C39(1.02)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C193(0.85); C205(0.85); C23(0.92); C39(0.97)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C193(0.80); C205(0.80); C23(1.04); C39(0.92)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C193(0.78); C205(0.78); C23(0.74); C39(0.98)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C193(0.80); C205(0.80); C23(0.84); C39(0.94)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C193(0.78); C205(0.78); C23(0.87); C39(1.11)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C193(0.86); C205(0.86); C23(0.87); C39(0.94)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C193(0.77); C205(0.77); C23(0.94); C397(1.09)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C193(1.01); C205(1.01); C23(0.94); C39(1.05)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C193(0.88); C205(0.88); C23(0.74); C39(0.99)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C193(0.70); C205(0.70); C23(0.81); C39(1.06)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C193(0.76); C205(0.76); C23(0.74); C39(0.97)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C193(0.87); C205(0.87); C23(0.83); C39(0.92)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C193(0.89); C205(0.89); C23(0.85); C39(1.03)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C193(0.77); C205(0.77); C23(0.81); C39(0.99)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C193(0.76); C205(0.76); C23(0.74); C39(1.07)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C23(1.00); C397(1.34); C75(1.27)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C23(0.80); C397(0.84); C75(1.07)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C23(0.87); C397(1.24); C75(1.18)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C23(0.76); C397(0.87); C75(1.28)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C23(1.08); C397(0.96); C75(1.18)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C23(1.06); C397(1.17); C75(1.24)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C23(0.99); C397(1.14); C75(1.32)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C23(1.04); C397(1.28); C75(1.19)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C23(1.02); C397(1.01); C75(1.18)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C23(0.88); C397(1.05); C75(1.30)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C23(0.88); C397(1.22); C75(1.44)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C23(0.91); C397(1.21); C75(1.24)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C193(0.62); C205(0.62); C23(1.06); C397(1.10)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C23(1.06); C397(1.24); C75(1.45)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C23(0.90); C397(1.22); C75(1.46)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C23(0.87); C397(0.98); C75(1.24)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C418(0.83); C193(0.84); C205(0.84); C75(1.02)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C193(0.64); C205(0.64); C418(0.87); C75(0.97)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C193(0.80); C205(0.80); C75(0.87); C23(0.94)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C193(0.55); C205(0.55); C418(0.80); C75(0.91)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C193(0.63); C205(0.63); C23(0.96); C75(0.97)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C193(0.70); C205(0.70); C418(1.06); C23(1.06)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C193(0.60); C205(0.60); C418(0.95); C397(1.13)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C193(0.73); C205(0.73); C23(1.08); C75(1.10)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C418(0.76); C193(0.77); C205(0.77); C75(0.97)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C193(0.76); C205(0.76); C75(0.94); C418(0.96)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C193(0.69); C205(0.69); C418(0.81); C23(0.94)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C193(0.70); C205(0.70); C418(0.85); C75(0.90)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C193(0.63); C205(0.63); C23(1.01); C397(1.11)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C193(0.74); C205(0.74); C23(1.08); C397(1.08)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C193(0.98); C205(0.98); C23(1.16); C397(0.96)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C193(0.97); C205(0.97); C23(1.23); C397(0.86)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C23(0.87); C193(0.94); C205(0.94); C418(1.03)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C193(0.68); C205(0.68); C23(0.87); C75(1.15)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C23(0.90); C193(0.90); C205(0.90); C397(1.04)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C193(0.62); C205(0.62); C23(0.85); C75(0.97)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C23(0.88); C193(0.98); C205(0.98); C397(1.08)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C23(0.86); C193(0.93); C205(0.93); C418(1.03)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C23(0.92); C193(0.99); C205(0.99); C397(1.01)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C23(0.84); C193(0.89); C205(0.89); C397(1.11)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C23(0.90); C397(1.05); C193(1.08); C205(1.08)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C193(0.82); C205(0.82); C23(0.85); C75(0.96)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C193(0.71); C205(0.71); C23(0.85); C75(0.93)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C193(0.73); C205(0.73); C23(0.96); C75(0.97)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C193(0.74); C205(0.74); C75(0.96); C23(0.96)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C193(0.74); C205(0.74); C75(1.01); C397(1.16)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C193(0.56); C205(0.56); C23(0.77); C75(0.92)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C193(0.84); C205(0.84); C75(1.08); C23(1.13)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C193(0.56); C205(0.56); C23(0.90); C75(0.94)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C193(0.61); C205(0.61); C75(0.98); C23(1.02)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C193(0.72); C205(0.72); C23(0.84); C75(1.01)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C193(0.66); C205(0.66); C23(1.01); C75(1.12)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C23(0.79); C75(0.82); C418(0.94); C397(0.96)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C75(0.86); C23(0.92); C397(0.92); C418(0.96)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C75(0.82); C23(0.85); C418(0.88); C193(0.89)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C75(0.79); C23(0.95); C193(1.05); C205(1.05)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C75(0.78); C23(0.86); C193(0.98); C205(0.98)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C193(0.47); C205(0.47); C23(0.69); C75(0.85)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C23(0.84); C75(0.89); C418(1.00); C193(1.00)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C193(0.91); C205(0.91); C75(0.92); C23(0.92)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C23(0.87); C193(0.93); C205(0.93); C75(0.96)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C193(0.89); C205(0.89); C75(0.99); C23(1.03)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C23(0.84); C75(0.90); C418(0.93); C193(0.99)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C23(0.77); C193(0.91); C205(0.91); C75(0.92)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C193(0.83); C205(0.83); C23(0.89); C39(0.95)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C193(0.84); C205(0.84); C39(0.89); C52(0.89)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C39(0.68); C52(0.68); C193(0.71); C205(0.71)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C23(0.79); C39(0.90); C52(0.90); C193(0.92)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C193(0.45); C205(0.45); C23(0.72); C75(0.91)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C23(0.71); C193(0.87); C205(0.87); C39(0.95)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C23(0.75); C193(0.89); C205(0.89); C397(0.94)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C23(0.73); C193(0.87); C205(0.87); C75(1.01)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C23(0.67); C193(0.83); C205(0.83); C39(0.89)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C23(0.77); C39(0.86); C52(0.86); C193(0.98)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C23(0.65); C193(0.88); C205(0.88); C39(1.06)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C23(0.88); C193(0.95); C205(0.95); C75(1.25)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C193(0.50); C205(0.50); C75(0.88); C397(1.17)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C193(0.53); C205(0.53); C75(1.00); C39(1.11)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C193(0.59); C205(0.59); C75(0.92); C39(1.19)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C193(0.73); C205(0.73); C75(0.98); C397(1.14)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C193(0.43); C205(0.43); C75(1.06); C397(1.25)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C193(0.40); C205(0.40); C75(0.84); C39(1.11)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C193(0.62); C205(0.62); C75(0.95); C397(1.23)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C193(0.43); C205(0.43); C75(1.03); C418(1.12)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C193(0.46); C205(0.46); C75(1.00); C397(1.45)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C193(0.58); C205(0.58); C75(0.87); C397(1.21)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C193(0.46); C205(0.46); C75(1.10); C397(1.20)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C193(0.39); C205(0.39); C75(1.03); C397(1.29)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C193(0.69); C205(0.69); C75(1.05); C23(1.05)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C193(0.66); C205(0.66); C75(0.96); C397(1.00)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C193(0.77); C205(0.77); C75(0.93); C418(0.97)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C193(0.77); C205(0.77); C75(0.84); C397(1.00)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C193(0.76); C205(0.76); C75(0.85); C23(0.94)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C193(0.75); C205(0.75); C75(0.85); C23(1.00)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C193(0.76); C205(0.76); C75(0.93); C23(1.26)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C193(0.70); C205(0.70); C75(0.90); C23(1.19)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C193(0.84); C205(0.84); C75(0.95); C23(1.20)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C193(0.82); C205(0.82); C75(0.86); C23(0.95)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C193(0.71); C205(0.71); C23(1.14); C397(1.14)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C193(0.62); C205(0.62); C23(0.98); C75(0.99)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C193(0.81); C205(0.81); C75(0.95); C418(1.07)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C193(0.64); C205(0.64); C75(0.97); C397(1.07)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C193(0.89); C205(0.89); C75(1.02); C23(1.05)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C75(0.82); C193(0.84); C205(0.84); C397(0.93)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C75(0.88); C193(0.98); C205(0.98); C397(1.43)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C193(0.92); C205(0.92); C39(1.09); C52(1.09)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C39(0.88); C52(0.88); C193(0.93); C205(0.93)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C193(0.76); C205(0.76); C39(0.87); C52(0.87)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C193(1.05); C205(1.05); C397(1.11); C39(1.12)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C39(0.96); C52(0.96); C193(0.97); C205(0.97)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C397(1.04); C23(1.11); C193(1.15); C205(1.15)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C39(0.91); C52(0.91); C23(1.05); C193(1.06)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C23(0.99); C75(1.00); C397(1.03); C193(1.31)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C23(0.93); C193(1.04); C205(1.04); C397(1.21)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C193(1.02); C205(1.02); C23(1.10); C397(1.21)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C39(0.93); C52(0.93); C193(1.06); C205(1.06)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C193(0.87); C205(0.87); C23(0.97); C39(1.10)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C39(0.56); C52(0.56); C193(0.60); C205(0.60)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C193(0.86); C205(0.86); C39(0.90); C52(0.90)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C193(0.99); C205(0.99); C23(1.07); C39(1.08)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C193(0.37); C205(0.37); C39(0.43); C52(0.43)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C193(0.53); C205(0.53); C39(0.58); C52(0.58)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C193(0.78); C205(0.78); C23(1.00); C397(1.00)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C193(0.70); C205(0.70); C75(0.90); C418(1.05)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C193(0.68); C205(0.68); C75(1.09); C23(1.37)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0102  BDHI 8 Jurkat C397(15.86)  LDD0204  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C23(20.00); C23(2.76); C397(1.86); C75(0.96)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C75(0.89); C397(0.89); C193(0.98); C205(0.98)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C23(0.61); C193(0.65); C205(0.65); C75(0.98)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C193(0.49); C205(0.49); C23(0.72); C418(0.83)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C193(0.65); C205(0.65); C23(1.15); C75(1.19)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C193(0.74); C205(0.74); C23(0.97); C397(1.01)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C193(0.85); C205(0.85); C23(0.97); C75(1.00)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C193(0.73); C205(0.73); C23(1.01); C75(1.04)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C193(0.77); C205(0.77); C75(1.02); C23(1.04)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C193(0.59); C205(0.59); C23(0.98); C75(1.07)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C193(0.73); C205(0.73); C23(0.87); C75(1.06)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C193(0.87); C205(0.87); C23(0.91); C75(1.12)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C193(0.81); C205(0.81); C23(0.92); C397(1.09)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C23(0.63); C193(0.80); C205(0.80); C75(0.95)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C193(0.74); C205(0.74); C23(0.85); C75(1.04)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C193(0.83); C205(0.83); C23(1.02); C397(1.11)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C193(0.84); C205(0.84); C75(0.91); C23(0.91)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C193(0.64); C205(0.64); C23(1.00); C75(1.04)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C193(0.72); C205(0.72); C75(0.90); C23(1.10)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C193(0.65); C205(0.65); C75(0.96); C397(1.04)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C193(0.81); C205(0.81); C75(0.88); C23(1.00)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C23(0.85); C75(1.02); C418(1.03); C193(1.16)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C23(0.83); C75(0.86); C397(0.99); C193(0.99)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C23(0.88); C193(0.95); C205(0.95); C418(0.99)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C23(0.60); C193(0.89); C205(0.89); C75(1.01)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C75(0.89); C23(1.00); C193(1.03); C205(1.03)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C23(0.90); C75(1.08); C397(1.14); C39(1.44)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C193(0.74); C205(0.74); C39(0.79); C52(0.79)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C23(0.80); C193(0.82); C205(0.82); C75(0.91)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C23(0.81); C193(0.91); C205(0.91); C75(1.06)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C193(0.66); C205(0.66); C75(0.81); C397(1.00)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C193(0.51); C205(0.51); C75(0.87); C418(1.03)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C193(0.61); C205(0.61); C75(0.89); C418(0.96)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C193(0.64); C205(0.64); C75(0.92); C39(1.10)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C193(0.64); C205(0.64); C23(0.87); C75(0.95)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C23(0.78); C193(0.85); C205(0.85); C75(0.90)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C193(0.60); C205(0.60); C23(0.79); C75(1.00)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C193(0.77); C205(0.77); C39(0.95); C52(0.95)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C193(0.61); C205(0.61); C52(0.77); C39(0.85)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C193(0.43); C205(0.43); C52(0.58); C39(0.84)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C193(0.65); C205(0.65); C52(0.85); C23(0.94)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C397(0.81); C193(0.93); C205(0.93); C75(1.04)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C193(0.80); C205(0.80); C39(0.88); C52(0.91)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C193(0.66); C205(0.66); C52(0.79); C39(0.86)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C193(0.78); C205(0.78); C39(0.98); C23(1.10)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C193(0.85); C205(0.85); C52(0.92); C39(0.99)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C193(0.79); C205(0.79); C23(0.81); C39(0.96)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C193(0.70); C205(0.70); C23(0.79); C39(0.91)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C193(0.73); C205(0.73); C23(0.95); C39(0.86)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C193(0.71); C205(0.71); C23(0.89); C39(0.99)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C193(0.71); C205(0.71); C23(0.81); C39(1.03)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C193(0.71); C205(0.71); C23(0.92); C39(1.00)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C193(0.87); C205(0.87); C23(0.93); C397(0.81)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C193(0.78); C205(0.78); C23(0.79); C39(1.04)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C193(0.88); C205(0.88); C23(1.01); C39(0.97)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C193(0.66); C205(0.66); C23(1.20); C397(0.93)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C193(0.58); C205(0.58); C23(0.97); C397(1.12)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C193(0.82); C205(0.82); C23(1.01); C397(1.05)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C193(0.98); C205(0.98); C23(0.91); C397(1.09)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C193(0.82); C205(0.82); C23(1.01); C397(1.07)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C193(1.03); C205(1.03); C23(0.92); C397(0.96)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C193(0.96); C205(0.96); C23(0.80); C397(0.96)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C193(0.93); C205(0.93); C23(1.08); C397(0.89)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C193(0.81); C205(0.81); C23(0.90); C397(1.08)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C193(0.89); C205(0.89); C23(0.89); C397(0.94)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C193(0.91); C205(0.91); C23(0.82); C397(0.91)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C193(0.87); C205(0.87); C23(0.83); C397(1.00)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C193(0.72); C205(0.72); C23(0.80); C397(0.97)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C193(0.81); C205(0.81); C23(0.83); C397(1.15)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C193(1.36); C205(1.36); C23(0.97); C397(0.85)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C193(1.34); C205(1.34); C23(1.11); C397(0.82)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C193(1.24); C205(1.24); C23(0.91); C397(0.86)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C193(1.18); C205(1.18); C23(0.80); C397(0.90)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C193(0.83); C205(0.83); C23(0.78); C397(0.98)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C193(1.44); C205(1.44); C23(0.82); C397(0.86)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C193(1.35); C205(1.35); C23(0.87); C397(0.93)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C193(1.08); C205(1.08); C23(0.73); C397(0.89)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C193(1.35); C205(1.35); C23(0.77); C397(0.81)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C193(1.38); C205(1.38); C23(0.82); C397(0.85)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C193(1.37); C205(1.37); C23(0.81); C397(0.86)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C193(1.15); C205(1.15); C23(0.77); C397(1.00)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C193(1.02); C205(1.02); C23(0.76); C397(0.94)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C193(1.43); C205(1.43); C23(0.85); C397(0.91)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C193(1.29); C205(1.29); C23(0.83); C397(1.01)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C193(0.67); C205(0.67); C23(0.76); C397(0.99)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C193(1.11); C205(1.11); C23(0.84); C397(0.94)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C193(0.89); C205(0.89); C23(0.91); C397(1.04)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C193(0.87); C205(0.87); C23(0.90); C397(1.02)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C193(0.74); C205(0.74); C23(0.92); C397(1.12)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C193(0.75); C205(0.75); C23(0.96); C397(1.15)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C193(0.81); C205(0.81); C23(0.94); C397(0.99)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C193(0.79); C205(0.79); C23(1.12); C397(1.27)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C193(0.79); C205(0.79); C23(1.12); C397(1.14)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C193(0.58); C205(0.58); C23(1.14); C397(1.20)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C193(0.52); C205(0.52); C23(0.97); C397(1.14)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C193(0.79); C205(0.79); C23(0.70); C397(1.09)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C193(0.61); C205(0.61); C23(1.04); C397(1.11)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C193(0.73); C205(0.73); C23(0.96); C397(1.08)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C193(0.92); C205(0.92); C23(1.13); C397(1.13)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C193(0.72); C205(0.72); C23(0.93); C397(1.07)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C193(0.71); C205(0.71); C23(0.96); C397(1.04)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C193(0.74); C205(0.74); C23(0.89); C397(1.04)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C193(0.91); C205(0.91); C23(0.95); C397(1.08)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C193(0.86); C205(0.86); C23(0.80); C397(1.00)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C193(0.91); C205(0.91); C23(0.82); C397(1.13)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C193(0.76); C205(0.76); C23(0.91); C397(1.31)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C193(0.75); C205(0.75); C23(0.82); C397(1.03)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C193(0.84); C205(0.84); C23(0.74); C397(1.26)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C193(0.79); C205(0.79); C23(0.75); C397(1.05)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C193(0.77); C205(0.77); C23(0.74); C397(1.10)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C193(0.88); C205(0.88); C23(0.75); C397(1.11)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C193(0.82); C205(0.82); C23(0.77); C397(1.16)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C193(0.93); C205(0.93); C23(0.75); C397(1.00)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C193(0.81); C205(0.81); C23(0.71); C397(1.14)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C193(0.81); C205(0.81); C23(0.76); C397(1.14)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C193(0.92); C205(0.92); C23(0.77); C397(1.17)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C193(0.85); C205(0.85); C23(0.89); C397(1.04)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C193(1.07); C205(1.07); C23(0.77); C397(1.14)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C193(0.51); C205(0.51); C23(1.08); C397(1.13)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C193(0.58); C205(0.58); C23(1.10); C397(0.95)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C193(0.55); C205(0.55); C23(0.78); C397(1.00)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C193(0.50); C205(0.50); C23(0.76); C397(1.02)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C193(0.49); C205(0.49); C23(0.89); C397(1.17)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C193(0.59); C205(0.59); C23(1.00); C397(1.02)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C193(0.55); C205(0.55); C23(0.92); C397(1.12)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C193(0.50); C205(0.50); C23(0.76); C397(1.05)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C193(0.49); C205(0.49); C23(0.68); C397(1.06)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C397(0.62)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C23(0.92); C418(1.04); C397(1.11); C75(0.95)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(0.96)  LDD1702  [5]
 LDCM0572  Fragment10 Ramos C397(0.33)  LDD2189  [18]
 LDCM0574  Fragment12 Ramos C397(0.77)  LDD2191  [18]
 LDCM0576  Fragment14 Ramos C75(0.84)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C75(1.50); C397(0.69)  LDD2198  [18]
 LDCM0590  Fragment32 Ramos C397(1.00)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C193(0.84); C205(0.84); C23(1.06); C397(1.15)  LDD0785  [16]
 LDCM0427  Fragment51 HCT 116 C193(1.04); C205(1.04); C23(1.13); C397(1.25)  LDD0744  [16]
 LDCM0569  Fragment7 Ramos C75(0.63)  LDD2186  [18]
 LDCM0022  KB02 HEK-293T C418(0.92); C397(0.98); C75(0.95); C23(1.05)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C418(0.89); C397(1.06); C75(1.02); C23(1.07)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C23(2.37)  LDD3310  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 N (UBE2N) Ubiquitin-conjugating enzyme family P61088
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA methyltransferase 1-associated protein 1 (DMAP1) . Q9NPF5
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Telomeric repeat-binding factor 1 (TERF1) . P54274
XIAP-associated factor 1 (XAF1) . Q6GPH4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840