Details of the Target

General Information of Target

Target ID LDTP11759
Target Name Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL)
Gene Name IRF2BPL
Gene ID 64207
Synonyms
C14orf4; EAP1; KIAA1865; Probable E3 ubiquitin-protein ligase IRF2BPL; EC 2.3.2.27; Enhanced at puberty protein 1; Interferon regulatory factor 2-binding protein-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEAGEKGRQRKPRPLDPGEG
SKDTDSSAGRRGSTGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGR
QNLSGAAAGEALVGAAGFPPHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQ
CQQEIANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGPPVRIAYMLVV
HGRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGG
ASLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRD
NSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLV
AQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCGC
SPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWENT
YDAADGPSGLSDVMLTAYTAFARLSLHHAATAAPPMGTPLCRFEPRGLPSSVHLYFYDDH
FQGYLVTQAVQPSAQGPAETLEMWLMPQGSLKLLGRSDQASRLQSLEVGTDWDPKERLFR
NFGGLLGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSR
PLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQG
LSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCR
LTSWSSLSPDPKSELGPVKADGRLR
Target Bioclass
Enzyme
Family
IRF2BP family
Subcellular location
Nucleus
Function
Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.
Uniprot ID
Q9H1B7
Ensemble ID
ENST00000238647.5
HGNC ID
HGNC:14282

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K394(7.69)  LDD0277  [2]
ONAyne
 Probe Info  		K394(10.00)  LDD0275  [2]
Probe 1
 Probe Info  		Y459(9.67); Y757(6.33)  LDD3495  [3]
BTD
 Probe Info  		C63(0.84)  LDD2091  [4]
AHL-Pu-1
 Probe Info  		C298(2.50)  LDD0170  [5]
HHS-482
 Probe Info  		Y459(0.69)  LDD0285  [6]
HHS-475
 Probe Info  		Y173(0.72); Y459(0.73); Y415(0.92); Y149(0.95)  LDD0264  [7]
DBIA
 Probe Info  		C14(1.42); C17(1.42); C63(1.00); C742(0.99)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C63(0.00); C764(0.00); C730(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C764(0.00); C385(0.00); C35(0.00); C63(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		N.A.  LDD0005  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		C63(0.00); C730(0.00); C17(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		C63(0.00); C742(0.00)  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		10.80  LDD0443  [16]
NAIA_5
 Probe Info  		C385(0.00); C504(0.00); C63(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C63(0.83)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C63(1.15)  LDD2152  [4]
 LDCM0025  4SU-RNA DM93 C298(2.50)  LDD0170  [5]
 LDCM0561  Abegg_cp(-)-10 HeLa C385(3.16)  LDD0312  [10]
 LDCM0214  AC1 HCT 116 C14(0.84); C17(1.01); C35(0.83); C385(1.18)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C14(0.73); C17(0.73); C38(1.17); C385(1.05)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C14(0.81); C38(0.83); C385(0.80); C445(0.68)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C14(0.92); C38(0.94); C385(0.80); C445(0.72)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C14(0.68); C38(0.92); C385(0.85); C445(0.75)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C14(0.93); C38(1.05); C385(0.89); C445(0.73)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C14(0.78); C38(1.05); C385(0.84); C445(0.76)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C14(0.99); C38(0.95); C385(0.80); C445(0.76)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C14(1.03); C38(1.02); C385(0.74); C445(0.74)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C14(0.97); C38(0.97); C385(0.80); C445(1.38)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C14(0.94); C38(0.74); C385(0.73); C445(0.82)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C14(0.80); C38(0.72); C385(0.77); C445(0.70)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C14(0.81); C17(0.81); C38(1.08); C385(0.99)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C14(0.82); C38(0.97); C385(0.80); C445(0.87)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C14(0.83); C38(0.84); C385(0.85); C445(1.06)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C14(0.78); C38(0.97); C385(0.87); C445(1.11)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C14(1.01); C63(0.83); C739(1.12); C742(1.07)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C14(1.01); C63(0.92); C739(1.53); C742(1.26)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C14(0.93); C63(0.81); C739(1.95); C742(1.51)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C14(0.96); C63(0.84); C739(1.62); C742(1.39)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C14(0.90); C63(0.78); C739(1.50); C742(1.17)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C14(0.89); C63(0.77); C739(1.55); C742(1.22)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C14(0.79); C63(0.80); C739(1.20); C742(1.17)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C14(0.81); C17(0.81); C38(1.34); C385(1.05)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C14(0.96); C63(0.89); C739(1.56); C742(1.31)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C14(0.93); C63(0.92); C739(1.28); C742(1.12)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C14(0.90); C63(0.87); C739(1.46); C742(1.25)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C14(0.83); C63(0.78); C739(1.12); C742(1.10)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C14(0.77); C63(0.75); C739(1.24); C742(1.14)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C14(0.94); C63(0.82); C739(1.26); C742(1.26)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C14(0.99); C63(0.84); C739(1.78); C742(1.40)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C14(0.92); C63(0.82); C739(1.71); C742(1.34)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C14(1.17); C38(0.25); C385(1.32); C63(0.44)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C14(0.83); C38(0.31); C385(1.07); C63(0.58)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C14(0.91); C38(0.34); C385(1.11); C63(0.59)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C14(0.88); C38(0.22); C385(1.32); C63(0.53)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C14(0.78); C38(0.28); C385(1.13); C63(0.66)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C14(0.74); C38(0.23); C385(1.33); C63(0.61)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C14(1.07); C38(0.26); C385(1.07); C63(0.66)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C14(1.21); C38(0.26); C385(1.20); C63(0.61)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C14(0.84); C38(0.25); C385(1.15); C63(0.63)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C14(0.62); C38(0.22); C385(1.04); C63(0.58)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C14(0.99); C38(0.29); C385(1.02); C63(0.77)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C14(1.12); C38(0.28); C385(1.30); C63(0.78)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C14(0.89); C17(0.89); C38(1.06); C385(1.30)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C14(0.88); C38(0.28); C385(1.13); C63(0.74)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C14(0.87); C38(0.29); C385(1.07); C63(0.79)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C14(0.77); C38(0.27); C385(1.26); C63(0.63)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C14(0.81); C17(0.91); C63(0.99); C739(1.00)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C14(0.70); C385(0.79); C63(0.82); C17(0.89)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C63(0.73); C14(0.73); C739(0.85); C17(0.90)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C63(0.63); C14(0.84); C17(0.93); C35(1.05)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C14(0.69); C739(0.90); C63(0.90); C385(0.91)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C14(0.78); C63(0.81); C35(0.91); C385(0.93)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C63(0.84); C14(0.87); C17(0.98); C385(0.99)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C63(0.70); C14(0.75); C17(0.75); C742(0.86)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C63(0.77); C14(0.81); C385(0.94); C739(1.00)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C14(0.74); C17(0.84); C63(0.93); C739(0.96)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C63(0.72); C14(0.83); C385(0.83); C35(1.04)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C63(0.73); C14(0.81); C385(0.93); C35(0.96)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C14(0.79); C17(1.09); C35(1.08); C385(0.94)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C14(0.76); C17(1.00); C35(1.69); C385(0.89)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C14(0.80); C17(0.94); C35(0.97); C385(1.10)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C14(0.85); C17(1.08); C35(1.39); C385(1.06)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C742(0.41); C739(0.46); C17(0.47); C14(0.89)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C742(0.45); C17(0.50); C739(0.52); C38(0.88)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C742(0.37); C739(0.40); C17(0.44); C14(0.83)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C742(0.85); C35(0.86); C739(0.89); C63(0.92)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C742(0.41); C17(0.42); C739(0.47); C14(0.87)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C17(0.39); C742(0.43); C739(0.49); C14(0.79)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C742(0.40); C739(0.40); C17(0.42); C14(0.82)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C742(0.36); C739(0.37); C17(0.37); C38(0.76)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C742(0.31); C739(0.33); C17(0.36); C14(0.87)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C445(0.89); C38(1.03); C385(1.10); C742(1.14)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C385(0.91); C445(0.92); C38(1.22); C742(1.45)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C445(0.84); C385(1.04); C38(1.05); C63(1.24)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C445(0.83); C385(1.02); C38(1.05); C742(1.24)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C445(0.84); C38(0.94); C385(0.95); C742(1.35)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C742(0.75); C739(0.76); C63(0.87); C14(0.94)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C445(0.86); C385(0.93); C38(1.05); C742(1.46)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C445(0.84); C385(0.86); C742(1.01); C38(1.03)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C385(0.85); C445(0.88); C38(1.02); C742(1.53)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C445(0.86); C385(0.96); C38(1.14); C742(1.35)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C445(0.68); C385(0.93); C38(1.02); C742(1.08)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C14(0.82); C385(1.00); C17(1.05); C445(1.08)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C385(0.86); C445(0.91); C17(0.93); C38(0.99)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C385(0.77); C38(0.91); C742(1.00); C445(1.03)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C385(0.77); C38(1.01); C17(1.13); C742(1.15)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C385(0.90); C445(0.99); C17(1.08); C38(1.10)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C63(0.75); C35(0.83); C742(0.83); C739(0.86)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C38(0.88); C385(0.93); C17(1.02); C14(1.03)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C385(0.92); C38(1.03); C742(1.04); C14(1.06)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C385(0.89); C742(0.99); C38(1.00); C445(1.16)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C385(0.77); C38(0.91); C445(1.11); C742(1.23)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C742(0.82); C385(0.85); C38(0.92); C445(1.08)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C385(0.95); C742(1.01); C38(1.16); C14(1.24)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C14(0.74); C38(0.76); C17(0.82); C445(0.85)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C14(0.78); C445(0.83); C17(0.90); C38(0.95)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C445(0.71); C14(0.73); C38(1.00); C17(1.03)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C445(0.69); C14(0.85); C17(1.10); C63(1.10)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C63(0.70); C35(0.77); C742(0.78); C739(0.84)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C445(0.69); C14(0.79); C63(0.98); C17(1.01)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C445(0.66); C14(0.81); C17(0.96); C63(1.02)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C445(0.73); C14(0.82); C38(0.89); C17(1.08)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C445(0.89); C38(0.99); C14(1.04); C17(1.16)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C445(0.80); C14(0.86); C38(1.14); C17(1.15)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C14(0.81); C17(0.85); C38(1.03); C445(1.10)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C445(0.72); C14(0.81); C17(1.03); C38(1.16)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C445(0.86); C38(1.03); C14(1.16); C17(1.16)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C445(0.75); C38(1.12); C14(1.18); C17(1.18)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C445(0.67); C38(0.96); C14(1.26); C17(1.26)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C38(0.92); C63(0.94); C742(0.96); C445(1.07)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C445(0.76); C14(1.01); C17(1.01); C38(1.36)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C38(0.82); C445(0.87); C63(1.21); C14(1.26)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C445(0.68); C38(1.00); C14(1.15); C17(1.15)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C38(0.90); C14(1.03); C17(1.03); C445(1.19)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C38(0.89); C14(0.98); C17(0.98); C445(1.15)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C38(0.63); C445(0.85); C742(0.93); C739(1.16)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C38(0.61); C445(0.78); C742(0.88); C739(1.06)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C38(0.55); C445(0.79); C742(1.04); C14(1.19)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C63(0.96); C35(0.98); C739(1.00); C445(1.08)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C17(0.87); C14(0.89); C63(0.89); C739(1.03)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C742(0.83); C38(0.90); C14(0.95); C17(0.95)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C445(0.87); C17(0.90); C14(0.96); C739(0.96)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C17(0.75); C739(0.76); C63(0.80); C742(0.82)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C63(0.83); C17(0.85); C14(1.02); C445(1.02)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C14(0.87); C17(0.98); C63(1.07); C445(1.14)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C17(0.58); C14(0.78); C63(0.93); C445(1.15)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C14(0.72); C17(0.78); C63(0.96); C35(1.07)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C17(0.82); C14(0.84); C739(1.02); C445(1.03)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C14(0.72); C63(0.85); C17(0.88); C445(1.01)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C14(0.60); C17(0.64); C445(0.94); C739(0.99)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C14(0.57); C17(0.60); C739(0.89); C742(0.95)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C742(0.85); C14(0.98); C17(0.98); C63(0.98)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C14(0.80); C17(0.90); C445(1.06); C63(1.09)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C35(0.22); C14(0.78); C63(0.79); C17(0.79)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C14(0.69); C17(0.69); C35(0.84); C63(1.07)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C385(0.54); C14(1.02); C17(1.10); C38(1.51)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C385(0.47); C17(1.05); C14(1.08); C38(1.38)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C385(0.33); C14(0.99); C17(1.01); C742(1.12)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C385(0.40); C14(1.08); C38(1.09); C742(1.27)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C385(0.41); C742(1.19); C38(1.28); C63(1.39)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C385(0.40); C14(1.04); C17(1.32); C63(1.35)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C385(0.70); C14(1.09); C63(1.27); C17(1.36)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C385(0.52); C742(0.69); C14(0.95); C17(1.03)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C385(0.47); C14(1.05); C17(1.09); C38(1.59)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C385(0.53); C14(1.11); C17(1.23); C38(1.42)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C385(0.42); C14(1.00); C63(1.09); C17(1.15)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C385(0.62); C38(1.00); C14(1.03); C63(1.17)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C385(0.71); C14(0.91); C17(1.14); C38(1.24)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C385(0.50); C14(1.04); C17(1.12); C38(1.16)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C385(0.37); C14(1.00); C17(1.23); C38(1.44)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C385(0.74); C445(0.76); C14(0.99); C38(1.08)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C739(0.67); C38(0.69); C14(0.79); C445(0.81)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C14(0.65); C17(0.65); C38(1.04); C385(1.16)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C742(0.83); C385(0.90); C14(1.02); C17(1.02)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C14(0.78); C17(0.78); C63(0.83); C742(0.92)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.13  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C14(1.42); C17(1.42); C63(1.00); C742(0.99)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C63(0.84)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C730(0.00); C63(0.00); C758(0.00); C742(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C63(0.08)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C739(0.87); C742(0.95); C385(1.01); C445(1.04)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C385(0.89); C445(0.96); C17(1.15); C14(1.22)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C14(0.83); C63(0.88); C35(0.89); C742(0.93)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C63(0.66); C14(1.02); C17(1.02); C742(1.04)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C742(0.78); C63(0.82); C38(0.87); C14(1.14)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C742(0.72); C63(0.82); C38(1.15); C445(1.16)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C742(0.71); C63(0.80); C38(0.88); C14(1.10)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C17(0.42); C742(0.49); C739(0.59); C14(0.74)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C742(0.37); C739(0.43); C17(0.43); C14(0.78)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C742(0.45); C17(0.47); C739(0.49); C14(0.79)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C742(0.33); C739(0.34); C17(0.46); C14(0.88)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C742(0.43); C17(0.44); C739(0.49); C14(0.77)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C742(0.92); C739(0.95); C445(1.01); C385(1.20)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C17(0.35); C742(0.36); C739(0.42); C14(0.67)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C17(0.40); C742(0.42); C739(0.49); C14(0.66)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C445(0.85); C385(0.96); C742(0.96); C38(1.03)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C445(0.63); C385(0.98); C38(1.12); C742(1.39)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C445(0.68); C38(0.84); C385(1.01); C742(1.16)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C445(0.74); C385(0.90); C742(1.03); C38(1.12)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C445(0.82); C385(0.91); C38(0.94); C742(1.09)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C17(1.07); C385(1.08); C742(1.09); C38(1.10)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C38(0.93); C742(1.07); C385(1.10); C445(1.10)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C445(0.84); C742(1.00); C38(1.02); C385(1.06)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C445(1.04); C385(1.21); C742(1.22); C739(1.35)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C385(0.81); C17(1.13); C38(1.16); C742(1.23)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C445(0.77); C14(0.80); C17(0.85); C63(1.21)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C38(0.75); C14(0.76); C445(0.82); C17(0.87)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C14(0.65); C17(0.78); C445(0.82); C38(0.85)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C14(0.75); C445(0.78); C17(0.96); C38(1.01)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C38(0.74); C445(0.76); C14(1.03); C17(1.03)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C445(0.55); C38(0.73); C14(0.92); C17(0.92)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C445(0.59); C14(1.08); C17(1.08); C38(1.16)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C445(0.63); C63(0.94); C14(1.13); C17(1.13)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C739(0.89); C742(0.93); C385(0.99); C445(1.01)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C739(0.93); C742(0.93); C445(0.94); C14(0.94)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C742(0.85); C739(0.86); C445(0.92); C14(1.05)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C14(0.90); C17(0.90); C445(1.08); C63(1.08)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C445(0.87); C739(0.94); C742(0.94); C63(1.07)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C445(0.88); C63(1.07); C739(1.09); C742(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C445(0.94); C14(0.99); C17(0.99); C739(1.07)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C445(1.02); C742(1.03); C14(1.04); C739(1.05)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C445(0.96); C14(1.01); C17(1.01); C739(1.12)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C445(0.90); C739(0.97); C742(0.97); C14(1.03)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C739(0.94); C742(0.94); C445(0.99); C14(1.73)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C445(0.98); C739(1.07); C742(1.07); C14(1.22)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C14(0.82); C17(0.82); C739(0.90); C742(0.90)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C14(0.96); C17(0.96); C445(1.02); C63(1.64)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C14(1.03); C17(1.03); C445(1.01); C63(1.45)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C14(1.02); C17(1.02); C445(1.04); C63(1.10)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C14(1.32); C17(1.32); C445(0.92); C63(1.35)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C14(1.46); C17(1.46); C445(0.95); C63(1.25)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C14(1.14); C17(1.26); C385(0.95); C445(1.05)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C14(1.36); C17(1.36); C445(1.17); C63(1.24)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C35(0.93); C38(0.99); C445(0.99); C63(0.98)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C14(1.04); C17(1.04); C35(1.20); C38(1.05)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C14(0.67); C17(0.67); C35(0.69); C38(1.15)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C14(0.84); C17(0.84); C35(0.93); C38(1.35)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C14(0.79); C17(0.79); C35(1.11); C38(1.16)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C14(0.81); C17(0.81); C35(1.06); C38(1.37)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C14(0.71); C17(0.71); C35(1.03); C38(0.99)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C14(0.85); C17(0.85); C35(1.04); C38(1.24)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C14(1.33); C17(1.29); C385(1.08); C445(0.96)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C14(0.93); C17(0.93); C35(0.92); C38(1.18)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C14(0.76); C17(0.76); C35(1.13); C38(1.05)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C14(0.82); C17(0.82); C35(0.95); C38(1.09)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C14(0.78); C17(0.78); C35(1.16); C38(1.04)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C14(0.84); C17(0.84); C35(1.04); C38(1.21)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C14(0.90); C17(0.90); C35(0.97); C38(1.10)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C14(0.90); C17(0.90); C385(1.03); C445(1.08)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C14(1.06); C17(1.06); C385(0.96); C445(0.89)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C14(1.00); C17(1.00); C385(1.01); C445(1.04)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C14(0.91); C17(0.91); C385(1.09); C445(0.98)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C14(1.09); C17(1.08); C385(1.20); C445(1.10)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C14(1.04); C17(1.04); C385(0.99); C445(0.85)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C14(1.02); C17(1.02); C385(1.03); C445(1.02)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C14(1.21); C17(1.21); C385(0.97); C445(0.87)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C14(1.02); C17(1.02); C385(0.94); C445(0.90)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C14(1.13); C17(1.13); C385(0.93); C445(1.01)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C14(1.02); C17(1.02); C385(0.97); C445(0.93)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C14(1.12); C17(1.12); C385(0.87); C445(0.86)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C14(0.83); C17(0.83); C385(0.91); C445(0.88)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C14(1.03); C17(1.03); C385(1.03); C445(1.07)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C14(1.04); C17(1.04); C385(1.04); C445(0.99)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C14(0.98); C17(1.07); C385(1.07); C445(0.98)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C14(1.00); C17(1.00); C385(1.01); C445(0.93)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C14(1.17); C17(1.32); C38(1.43); C385(0.85)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C14(1.13); C17(1.27); C38(1.36); C385(0.84)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C14(1.01); C17(1.00); C38(1.22); C385(0.90)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C14(0.94); C17(0.94); C38(0.90); C385(0.78)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C14(1.02); C17(1.02); C38(1.13); C385(0.83)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C14(1.21); C17(1.25); C38(1.07); C385(0.90)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C14(1.05); C17(1.08); C38(1.36); C385(0.84)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C14(0.98); C17(1.09); C38(1.50); C385(0.73)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C14(1.15); C17(1.31); C38(1.36); C385(1.03)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C14(1.27); C17(1.24); C385(1.22); C445(1.03)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C14(1.11); C17(1.22); C38(1.56); C385(0.84)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C14(1.08); C17(1.11); C38(1.44); C385(0.80)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C14(1.00); C17(1.11); C38(1.10); C385(0.96)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C14(1.15); C17(1.34); C38(1.20); C385(0.91)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C14(1.04); C17(1.14); C38(1.05); C385(0.79)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C14(0.75); C17(0.78); C35(0.87); C385(1.13)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C14(0.88); C17(0.88); C35(0.64); C385(1.21)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C14(0.89); C17(0.93); C35(0.93); C385(1.19)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C14(0.81); C17(0.86); C35(0.99); C385(0.91)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C14(0.93); C17(0.98); C385(0.98); C445(0.93)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C14(1.07); C17(1.00); C35(0.87); C385(0.96)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C14(1.07); C17(1.04); C35(0.91); C385(1.22)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C14(0.89); C17(0.95); C35(1.08); C385(1.04)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C14(1.02); C17(0.96); C35(1.00); C385(0.90)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C14(0.78); C17(0.86); C35(1.08); C385(1.09)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C14(1.09); C17(1.08); C35(0.99); C385(1.05)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C14(1.26); C17(1.16); C35(0.76); C385(1.22)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C14(0.94); C17(1.01); C35(1.01); C385(1.50)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C14(1.06); C17(1.01); C35(0.89); C385(1.04)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C14(1.10); C17(1.11); C35(1.23); C385(1.24)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C14(1.17); C17(1.17); C385(1.03); C445(0.99)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C14(0.67); C17(0.76); C35(1.01); C385(0.76)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C14(0.84); C17(0.89); C35(0.89); C385(1.00)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C14(0.92); C17(1.05); C35(0.98); C385(1.13)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C14(0.83); C17(1.01); C35(0.90); C385(1.05)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C14(1.13); C17(1.19); C35(1.01); C385(1.05)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C14(0.67); C17(0.84); C35(1.00); C385(0.91)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C14(0.87); C17(1.06); C35(1.02); C385(0.99)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C14(0.88); C17(1.08); C35(0.94); C385(1.29)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C14(0.96); C17(1.09); C35(0.86); C385(0.76)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C14(0.94); C17(0.99); C35(0.91); C385(1.26)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C63(0.90)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C63(1.04); C38(0.93); C730(1.00); C35(0.99)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C63(1.42)  LDD1702  [4]
 LDCM0625  F8 Ramos C63(1.31)  LDD2187  [18]
 LDCM0573  Fragment11 Ramos 5.59  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C63(1.02)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C63(0.82)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C63(0.91); 0.87  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C63(1.29)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C63(0.76)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C63(1.00)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C63(0.73)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C63(1.51); 1.58  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C63(0.99)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C63(0.81)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C63(1.98)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C14(0.86); C17(1.00); C38(1.22); C385(0.80)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C63(1.10)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C63(0.73)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C14(0.70); C17(0.70); C35(1.09); C38(1.35)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C63(1.34)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C63(1.90)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C63(1.08)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C63(0.96)  LDD2188  [18]
 LDCM0116  HHS-0101 DM93 Y173(0.72); Y459(0.73); Y415(0.92); Y149(0.95)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y459(0.47); Y173(0.66); Y149(1.08); Y415(1.32)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y173(0.78); Y459(0.80); Y149(0.83); Y415(1.66)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y173(0.76); Y459(0.81); Y149(0.82); Y415(1.53)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y459(0.70); Y173(0.81); Y149(0.87); Y415(1.17)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0123  JWB131 DM93 Y459(0.69)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y149(1.12); Y459(0.99)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y149(0.62); Y459(0.77)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y149(2.65); Y459(1.50)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y149(2.06); Y459(0.92)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y149(0.40); Y459(1.22)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y149(0.44); Y459(0.49)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y149(1.03); Y459(0.80)  LDD0292  [6]
 LDCM0022  KB02 HCT 116 C14(3.65); C63(1.92); C742(1.43); C17(2.31)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C14(5.13); C63(1.33); C742(1.34); C17(2.25)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C14(3.99); C63(1.77); C742(1.51); C17(1.37)  LDD0082  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C63(0.69)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [14]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C63(0.99)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C63(0.96)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C63(0.79)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C63(0.96)  LDD2111  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C63(0.87)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C63(0.80)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C63(1.01)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C63(0.91)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C63(1.07)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C63(1.28)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C63(1.43)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C63(1.28)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C63(0.94)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C63(0.92)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C63(1.94)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C63(1.03)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C63(1.40)  LDD2147  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C63(1.00)  LDD2150  [4]
 LDCM0131  RA190 MM1.R C63(1.43)  LDD0304  [19]
 LDCM0021  THZ1 HCT 116 C742(1.19); C63(1.11); C14(1.07); C17(1.07)  LDD2173  [8]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.