Details of the Target

General Information of Target

Target ID LDTP08216
Target Name Protein polybromo-1 (PBRM1)
Gene Name PBRM1
Gene ID 55193
Synonyms
BAF180; PB1; Protein polybromo-1; hPB1; BRG1-associated factor 180; BAF180; Polybromo-1D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDY
KDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLF
NNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNG
SYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMR
TPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDY
YQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVM
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHY
NEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQE
LIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHV
GDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKS
DYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSN
GEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPE
ETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELE
GGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK
INMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGP
VDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQ
VGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAE
SNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNI
RQAYNLENV
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.
TTD ID
T00973
Uniprot ID
Q86U86
DrugMap ID
TTH8ZRL
Ensemble ID
ENST00000296302.11
HGNC ID
HGNC:30064
ChEMBL ID
CHEMBL1795184

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y217(7.92)  LDD0257  [1]
STPyne
 Probe Info  		K1308(1.96); K278(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y134(14.42)  LDD3495  [3]
BTD
 Probe Info  		C880(1.00)  LDD2096  [4]
HHS-475
 Probe Info  		Y417(0.91); Y217(1.03)  LDD0264  [5]
Acrolein
 Probe Info  		H599(0.00); H1606(0.00)  LDD0223  [6]
DBIA
 Probe Info  		C1233(1.11); C1244(1.08); C1257(1.08)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1233(0.00); C799(0.00); C1059(0.00); C543(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C69(0.00); C50(0.00)  LDD0032  [9]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [10]
IPIAA_L
 Probe Info  		C50(0.00); C799(0.00)  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C1233(0.00); C1059(0.00); C1047(0.00); C69(0.00)  LDD0037  [8]
IPM
 Probe Info  		C951(0.00); C1163(0.00)  LDD0147  [11]
NPM
 Probe Info  		N.A.  LDD0016  [12]
OSF
 Probe Info  		N.A.  LDD0029  [13]
SF
 Probe Info  		N.A.  LDD0028  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Crotonaldehyde
 Probe Info  		C1059(0.00); C951(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		C1059(0.00); C1163(0.00)  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [14]
NAIA_5
 Probe Info  		C543(0.00); C69(0.00)  LDD2223  [15]
HHS-465
 Probe Info  		Y217(0.00); K416(0.00); Y417(0.00)  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		16.00  LDD0475  [17]
FFF probe6
 Probe Info  		6.56  LDD0467  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C880(1.28); C1047(0.97); C1163(0.95)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C50(2.22)  LDD0371  [18]
 LDCM0026  4SU-RNA+native RNA HEK-293T C50(5.94)  LDD0372  [18]
 LDCM0561  Abegg_cp(-)-10 HeLa C1163(2.15)  LDD0311  [11]
 LDCM0214  AC1 HCT 116 C1047(1.57); C1163(1.25); C1233(1.07); C1244(0.89)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1224(1.29); C1228(1.29); C1035(1.32); C1047(0.95)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1059(0.76); C1163(0.89); C1233(0.92); C1244(0.91)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1059(0.82); C1163(0.80); C1233(1.09); C1244(0.95)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1059(0.78); C1163(0.87); C1233(0.95); C1244(0.82)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1059(0.83); C1163(0.96); C1233(1.05); C1244(1.23)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1059(0.84); C1163(0.97); C1233(0.96); C1244(0.90)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1059(0.87); C1163(0.80); C1233(1.21); C1244(0.95)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1059(1.00); C1163(0.88); C1233(1.03); C1244(1.26)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1059(1.00); C1163(0.86); C1233(0.95); C1244(1.15)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1059(0.81); C1163(0.82); C1233(1.01); C1244(0.74)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1059(0.71); C1163(0.80); C1233(0.97); C1244(0.85)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1224(1.24); C1228(1.24); C1035(1.33); C1047(0.96)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1059(0.88); C1163(0.87); C1233(0.92); C1244(0.80)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1059(0.84); C1163(0.82); C1233(0.98); C1244(0.91)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1059(0.90); C1163(0.83); C1233(0.96); C1244(0.97)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1059(1.00); C1163(1.37); C1233(1.04); C1244(0.90)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1059(1.17); C1163(1.17); C1233(1.40); C1244(1.04)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1059(1.38); C1163(1.63); C1233(1.45); C1244(1.06)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1059(1.08); C1163(1.04); C1233(1.26); C1244(0.89)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1059(1.06); C1163(1.30); C1233(1.21); C1244(0.95)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1059(1.06); C1163(1.29); C1233(1.43); C1244(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1059(1.08); C1163(1.14); C1233(1.21); C1244(1.03)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1224(0.94); C1228(0.94); C1035(1.23); C1047(1.04)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1059(0.80); C1163(1.26); C1233(1.57); C1244(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1059(1.13); C1163(1.15); C1233(1.09); C1244(0.95)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1059(0.99); C1163(1.25); C1233(1.25); C1244(1.10)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1059(1.01); C1163(1.33); C1233(1.17); C1244(1.21)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1059(1.15); C1163(1.27); C1233(1.08); C1244(0.89)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1059(1.13); C1163(1.14); C1233(1.39); C1244(0.94)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1059(1.07); C1163(0.98); C1233(1.31); C1244(1.12)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1059(1.03); C1163(1.34); C1233(1.39); C1244(1.13)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1224(1.55); C1047(1.26); C1059(1.34); C1233(1.50)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1224(0.96); C1047(1.69); C1059(1.57); C1233(1.32)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1224(0.97); C1047(1.18); C1059(1.56); C1233(1.28)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1224(0.98); C1047(1.27); C1059(1.37); C1233(1.03)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1224(0.83); C1047(1.20); C1059(1.13); C1233(1.14)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1224(1.48); C1047(1.16); C1059(1.31); C1233(1.09)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1224(1.29); C1047(1.21); C1059(0.96); C1233(0.93)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1224(1.40); C1047(1.07); C1059(1.14); C1233(1.10)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1224(1.44); C1047(0.96); C1059(1.52); C1233(1.00)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1224(1.01); C1047(1.17); C1059(1.27); C1233(1.20)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1224(1.09); C1047(1.24); C1059(1.25); C1233(1.09)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1224(1.90); C1047(1.21); C1059(1.93); C1233(1.12)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1224(1.10); C1228(1.10); C1035(1.50); C1047(1.15)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1224(1.30); C1047(1.25); C1059(1.71); C1233(1.10)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1224(1.25); C1047(1.16); C1059(1.26); C1233(1.07)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1224(0.90); C1047(1.33); C1059(1.28); C1233(1.14)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1224(0.86); C1228(0.86); C1244(0.75); C1257(0.75)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C69(0.42); C543(0.45); C951(0.92); C1224(1.25)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C543(0.55); C69(0.64); C951(0.85); C1257(0.90)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C543(0.51); C69(0.57); C1257(1.01); C1244(1.09)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C69(0.44); C543(0.48); C951(1.00); C1224(1.07)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C69(0.44); C543(0.56); C951(1.07); C1244(1.13)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C69(0.45); C543(0.49); C1244(1.02); C1257(1.09)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C543(0.89); C69(0.93); C1047(1.07); C1233(1.10)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C543(0.54); C69(0.72); C1244(0.91); C1257(0.94)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C543(0.57); C69(0.80); C1224(0.89); C1228(0.89)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C69(0.47); C543(0.50); C1257(0.87); C1244(0.89)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C69(0.47); C543(0.58); C1257(1.08); C1244(1.23)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1224(1.30); C1228(1.30); C1059(1.55); C1163(1.43)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1224(1.05); C1228(1.05); C1059(1.60); C1163(1.56)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1224(1.02); C1228(1.02); C1059(1.05); C1163(1.10)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1224(0.85); C1228(0.85); C1059(1.10); C1163(1.09)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C543(0.63); C1244(0.91); C1257(0.91); C1035(0.92)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1224(0.50); C1228(0.50); C543(0.58); C1059(0.87)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C543(0.70); C1224(0.77); C1228(0.77); C1244(0.78)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C543(0.74); C1244(0.84); C1257(0.84); C1233(0.86)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C543(0.72); C1163(0.86); C1035(0.92); C1244(0.98)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C1224(0.60); C1228(0.60); C543(0.65); C1163(0.93)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1224(0.60); C1228(0.60); C543(0.68); C1163(0.83)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C543(0.72); C1224(0.82); C1228(0.82); C1244(0.88)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C1224(0.74); C1228(0.74); C1244(0.79); C1257(0.79)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C69(0.78); C1244(0.78); C1257(0.78); C1233(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1244(0.77); C1257(0.77); C69(0.84); C1233(1.00)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C1244(0.81); C1257(0.81); C69(0.88); C951(1.06)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C1244(0.81); C1257(0.81); C69(0.88); C1233(1.04)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1244(0.77); C1257(0.77); C1047(0.88); C69(0.92)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C543(0.81); C1244(0.92); C1257(0.92); C69(1.03)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1244(0.73); C1257(0.73); C69(0.80); C1233(0.98)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1244(0.80); C1257(0.80); C1233(0.98); C69(0.98)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C69(0.89); C1244(0.96); C1257(0.96); C1233(1.17)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C69(0.79); C1244(0.85); C1257(0.85); C951(1.06)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C1047(0.86); C69(0.98); C1244(1.08); C1257(1.08)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1059(0.85); C951(0.96); C1233(1.04); C1163(1.05)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C1163(0.91); C951(0.93); C1233(0.93); C1059(0.94)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1059(0.89); C951(0.95); C69(0.96); C1035(1.03)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C69(0.83); C1059(0.94); C1233(1.00); C951(1.01)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C69(0.74); C1059(0.82); C1163(0.95); C1035(0.96)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C543(0.79); C69(0.92); C1233(1.00); C1047(1.06)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C69(0.44); C1059(0.97); C1035(1.08); C951(1.11)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C69(0.87); C1163(0.90); C1059(0.92); C951(0.97)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C69(0.87); C1163(0.96); C951(1.03); C1059(1.05)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C69(0.74); C951(1.04); C1163(1.05); C1059(1.06)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C69(0.91); C1047(0.98); C1059(1.00); C951(1.06)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C69(0.80); C1059(0.97); C1047(1.07); C1035(1.13)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C543(0.58); C1244(0.75); C1257(0.75); C951(1.00)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C1244(0.78); C1257(0.78); C543(0.80); C69(0.90)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C543(0.59); C1244(0.83); C1257(0.83); C1035(0.93)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1244(0.73); C1257(0.73); C543(0.74); C1059(0.96)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C543(0.81); C69(0.84); C1244(1.01); C1257(1.01)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C543(0.55); C69(0.92); C1244(0.93); C1257(0.93)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C543(0.66); C1244(0.81); C1257(0.81); C1035(0.88)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C543(0.67); C1244(0.78); C1257(0.78); C69(0.88)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1244(0.67); C1257(0.67); C1047(0.80); C69(0.87)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C543(0.70); C1244(0.74); C1257(0.74); C1047(0.90)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1047(0.80); C1244(0.86); C1257(0.86); C69(0.96)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C69(0.84); C543(0.85); C1047(0.86); C1244(0.88)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1244(1.16); C1257(1.16); C1233(1.17); C951(1.19)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C951(1.07); C1059(1.25); C1035(1.33); C1233(1.39)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1233(1.15); C1244(1.16); C1257(1.16); C1059(1.24)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1244(0.93); C1257(0.93); C1233(1.06); C543(1.08)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C1244(1.15); C1257(1.15); C1233(1.32); C1035(1.34)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1244(1.11); C1257(1.11); C951(1.15); C1059(1.18)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1233(1.22); C951(1.38); C1059(1.46); C1035(1.46)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1244(1.11); C1257(1.11); C1233(1.27); C951(1.30)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C1244(1.02); C1257(1.02); C1059(1.04); C1233(1.34)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C1244(1.01); C1257(1.01); C951(1.45); C1059(1.46)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1244(1.03); C1257(1.03); C951(1.30); C1059(1.35)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1233(1.06); C1244(1.16); C1257(1.16); C1059(1.48)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C69(0.87); C1047(0.95); C951(1.06); C1244(1.13)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C1047(0.68); C69(0.80); C1035(1.11); C1059(1.12)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C543(0.78); C1244(0.93); C1257(0.93); C1047(0.95)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C69(0.83); C1047(0.89); C1035(0.98); C1059(1.05)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C1047(0.80); C69(0.93); C951(1.01); C1035(1.06)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C69(1.04); C1035(1.05); C1047(1.06); C951(1.12)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C69(0.82); C1233(0.91); C1047(0.98); C1059(1.33)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C1047(0.92); C69(0.96); C1233(1.15); C1059(1.27)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C1047(0.78); C69(0.88); C1233(1.10); C1059(1.24)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C1047(0.79); C69(0.83); C1035(1.09); C1059(1.14)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C1047(0.78); C69(0.83); C1035(1.04); C1233(1.12)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C1047(0.82); C951(0.98); C1035(1.00); C1244(1.05)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C69(0.97); C1244(0.98); C1257(0.98); C1047(1.03)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C543(0.63); C1047(0.90); C69(0.94); C1244(0.98)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C1047(0.78); C69(0.80); C1233(0.96); C1035(1.08)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C69(0.65); C1047(0.89); C1059(1.04); C1233(1.13)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C1047(0.73); C69(0.85); C1233(1.20); C951(1.58)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C543(0.77); C1244(0.84); C1257(0.84); C1047(1.24)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C543(0.60); C1244(0.93); C1257(0.93); C1035(1.15)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C543(0.72); C1244(0.79); C1257(0.79); C1035(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C543(0.65); C1244(0.86); C1257(0.86); C1035(0.95)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1035(0.92); C1059(0.92); C1244(0.94); C1257(0.94)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C543(0.60); C1244(0.79); C1257(0.79); C1035(0.85)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C543(0.78); C1244(0.97); C1257(0.97); C1059(1.14)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C543(0.70); C1035(0.74); C1244(0.82); C1257(0.82)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C543(0.78); C1244(0.83); C1257(0.83); C1047(0.94)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C543(0.74); C1244(0.75); C1257(0.75); C1035(0.98)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C543(0.80); C1244(0.91); C1257(0.91); C1035(0.95)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1244(0.63); C1257(0.63); C543(0.66); C1047(0.89)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1244(0.72); C1257(0.72); C543(0.98); C951(1.00)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C543(0.69); C1244(0.79); C1257(0.79); C1035(0.99)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C543(0.70); C1244(0.83); C1257(0.83); C1035(0.98)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C543(0.60); C1163(0.95); C1059(0.99); C1233(1.00)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C543(0.68); C1163(0.76); C1059(0.86); C1233(0.93)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C1224(1.01); C1228(1.01); C1035(1.24); C1047(1.16)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C543(0.80); C69(0.98); C1224(1.09); C1228(1.09)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C69(0.82); C1244(1.02); C1257(1.02); C1047(1.21)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C1233(1.11); C1244(1.08); C1257(1.08)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C1233(0.83); C1244(0.89); C1257(0.89); C69(0.89)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C1244(0.78); C1257(0.78); C69(1.09); C1224(1.14)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C543(0.70); C69(0.76); C1244(0.86); C1257(0.86)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C543(0.85); C69(0.89); C1047(1.02); C1244(1.07)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1233(0.97); C1224(0.98); C1228(0.98); C1047(0.99)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C543(0.83); C1233(0.94); C951(1.02); C1244(1.04)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C543(0.80); C1233(0.97); C1224(1.02); C1228(1.02)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C543(0.68); C1224(0.82); C1228(0.82); C1244(0.94)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C543(0.69); C1224(1.04); C1228(1.04); C1059(1.20)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C543(0.62); C1224(0.86); C1228(0.86); C1163(1.11)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C543(0.58); C1244(1.02); C1257(1.02); C1035(1.16)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C543(0.67); C1244(0.89); C1257(0.89); C1163(0.91)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C69(0.63); C1244(0.95); C1257(0.95); C1233(1.08)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C543(0.68); C1224(0.86); C1228(0.86); C1035(0.97)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C543(0.65); C1224(0.86); C1228(0.86); C1163(0.87)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C1244(0.83); C1257(0.83); C69(0.90); C1059(0.91)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1244(0.82); C1257(0.82); C69(0.82); C1233(1.03)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1244(0.65); C1257(0.65); C1233(0.88); C69(0.92)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C1244(0.81); C1257(0.81); C69(0.83); C1233(1.01)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1244(0.74); C1257(0.74); C1233(1.00); C951(1.04)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C69(0.80); C1059(0.92); C1047(1.19); C1163(1.21)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C69(0.82); C1059(0.93); C951(1.04); C1163(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1059(0.90); C69(0.97); C1035(1.05); C1233(1.06)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C69(0.71); C1244(1.08); C1257(1.08); C951(1.22)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C69(0.63); C1059(0.92); C951(0.97); C1035(0.98)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C69(0.77); C951(0.80); C543(0.82); C1059(0.86)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1244(0.66); C1257(0.66); C1047(0.87); C543(0.88)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C543(0.73); C1244(0.74); C1257(0.74); C69(0.79)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C543(0.67); C1244(0.77); C1257(0.77); C1047(0.92)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C1244(0.96); C1257(0.96); C1233(0.99); C1059(1.01)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C1244(0.98); C1257(0.98); C1059(0.99); C951(1.02)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1244(1.05); C1257(1.05); C1233(1.08); C1035(1.13)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1059(1.14); C1035(1.22); C1233(1.23); C951(1.27)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C1244(0.90); C1257(0.90); C1233(1.01); C69(1.13)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C1244(0.72); C1257(0.72); C951(0.86); C69(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C1244(0.83); C1257(0.83); C1233(0.94); C951(1.11)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C1244(1.00); C1257(1.00); C1163(1.00); C1233(1.01)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C1244(0.87); C1257(0.87); C1163(0.98); C1224(0.99)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C951(1.04); C1244(1.05); C1257(1.05); C1233(1.12)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C951(1.00); C1233(1.09); C1163(1.30); C69(1.34)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C1244(0.80); C1257(0.80); C1233(0.84); C1163(0.91)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1233(1.02); C951(1.08); C1163(1.12); C1224(1.19)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C69(0.88); C1233(1.13); C1163(1.16); C951(1.18)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1244(1.23); C1257(1.23); C951(1.33); C1233(1.35)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C1244(1.03); C1257(1.03); C1233(1.04); C951(1.05)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C1244(0.96); C1257(0.96); C69(0.99); C951(1.11)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1224(1.36); C1228(1.36); C1163(1.47); C1233(1.08)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1224(1.20); C1228(1.20); C1163(1.13); C1233(1.01)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1224(1.25); C1228(1.25); C1163(1.15); C1233(1.08)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1224(1.13); C1228(1.13); C1163(1.11); C1233(0.98)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1224(1.30); C1228(1.30); C1163(1.24); C1233(1.10)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C1224(0.97); C1228(0.97); C1163(1.02); C1233(0.97)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1224(1.06); C1228(1.06); C1163(1.07); C1233(0.93)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1163(1.07); C1244(1.13); C1257(1.13); C543(0.94)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1163(1.34); C1244(1.48); C1257(1.48); C543(0.97)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1163(1.03); C1244(1.16); C1257(1.16); C543(0.88)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1163(1.08); C1244(1.49); C1257(1.49); C543(0.83)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1163(1.23); C1244(1.39); C1257(1.39); C543(0.89)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1163(1.16); C1244(1.26); C1257(1.26); C543(0.84)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1163(1.16); C1244(1.39); C1257(1.39); C543(1.02)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1163(1.46); C1244(1.19); C1257(1.19); C543(1.08)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C1224(0.96); C1228(0.96); C1163(0.90); C1233(0.96)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1163(1.05); C1244(1.20); C1257(1.20); C543(0.75)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1163(1.21); C1244(1.16); C1257(1.16); C543(1.14)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1163(1.47); C1244(1.43); C1257(1.43); C543(1.01)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1163(1.08); C1244(1.47); C1257(1.47); C543(1.02)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1163(1.12); C1244(1.39); C1257(1.39); C543(1.12)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1163(1.42); C1244(1.50); C1257(1.50); C543(0.81)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1224(0.64); C1228(0.64); C1059(0.95); C1233(0.76)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1224(0.69); C1228(0.69); C1059(0.87); C1233(0.74)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1224(0.64); C1228(0.64); C1059(0.86); C1233(0.72)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1224(0.78); C1228(0.78); C1059(0.88); C1233(0.84)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C1224(1.08); C1228(1.08); C1163(1.08); C1233(1.03)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1224(0.70); C1228(0.70); C1059(1.24); C1233(0.77)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1224(0.68); C1228(0.68); C1059(1.04); C1233(0.82)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1224(0.62); C1228(0.62); C1059(1.07); C1233(0.79)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1224(0.63); C1228(0.63); C1059(1.30); C1233(0.73)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1224(0.63); C1228(0.63); C1059(1.02); C1233(0.74)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1224(0.61); C1228(0.61); C1059(0.94); C1233(0.75)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1224(0.76); C1228(0.76); C1059(0.81); C1233(0.76)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1224(0.61); C1228(0.61); C1059(1.23); C1233(0.70)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1224(0.67); C1228(0.67); C1059(0.96); C1233(0.71)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1224(0.74); C1228(0.74); C1059(0.89); C1233(0.82)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C1224(1.09); C1228(1.09); C1163(1.22); C1233(0.96)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1224(0.79); C1228(0.79); C1059(0.79); C1233(0.75)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1224(1.00); C1228(1.00); C1047(1.10); C1059(1.37)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1224(0.83); C1228(0.83); C1047(0.95); C1059(1.34)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1224(0.93); C1228(0.93); C1047(1.44); C1059(1.35)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1224(1.14); C1228(1.14); C1047(1.13); C1059(1.24)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1224(1.02); C1228(1.02); C1047(1.24); C1059(1.54)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1224(1.29); C1228(1.29); C1047(1.30); C1059(1.66)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1224(1.06); C1228(1.06); C1047(1.26); C1059(1.46)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1224(0.96); C1228(0.96); C1047(0.74); C1059(1.55)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1224(1.13); C1228(1.13); C1047(1.23); C1059(1.39)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C1224(1.42); C1228(1.42); C1163(1.20); C1233(1.10)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1224(0.94); C1228(0.94); C1047(1.05); C1059(1.22)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1224(1.00); C1228(1.00); C1047(0.89); C1059(1.30)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1224(0.88); C1228(0.88); C1047(1.12); C1059(1.16)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1224(0.95); C1228(0.95); C1047(1.19); C1059(1.11)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1224(1.00); C1228(1.00); C1047(1.41); C1059(1.32)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C1163(1.20); C1233(1.09); C1244(1.11); C1257(1.11)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1163(1.09); C1233(0.99); C1244(1.31); C1257(1.31)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1163(0.99); C1233(1.04); C1244(1.20); C1257(1.20)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1163(1.27); C1233(1.25); C1244(1.11); C1257(1.11)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C1224(1.36); C1228(1.36); C1163(1.22); C1233(1.06)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C1163(1.16); C1233(1.18); C1244(1.49); C1257(1.49)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1163(1.15); C1233(1.21); C1244(1.25); C1257(1.25)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1163(1.54); C1233(1.38); C1244(1.42); C1257(1.42)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1163(1.38); C1233(1.31); C1244(1.23); C1257(1.23)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1163(1.59); C1233(1.49); C1244(1.78); C1257(1.78)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1163(1.20); C1233(1.16); C1244(1.07); C1257(1.07)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1163(1.13); C1233(1.13); C1244(1.16); C1257(1.16)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1163(1.20); C1233(1.25); C1244(1.20); C1257(1.20)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1163(1.49); C1233(1.34); C1244(1.28); C1257(1.28)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1163(1.71); C1233(1.54); C1244(1.92); C1257(1.92)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C1224(1.17); C1228(1.17); C1163(1.09); C1233(1.02)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C1163(0.97); C1233(1.01); C1244(0.92); C1257(0.92)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1047(1.42); C1163(1.04); C1233(1.05); C1244(0.92)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1047(1.18); C1163(1.10); C1233(1.06); C1244(0.78)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1047(1.23); C1163(0.97); C1233(1.17); C1244(0.83)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1047(1.07); C1163(1.11); C1233(1.02); C1244(0.77)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1047(0.80); C1163(1.02); C1233(0.78); C1244(0.81)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1047(1.29); C1163(1.11); C1233(1.10); C1244(0.83)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1047(0.98); C1163(1.19); C1233(0.82); C1244(0.90)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1047(1.09); C1163(1.18); C1233(1.03); C1244(0.98)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1047(1.25); C1163(1.14); C1233(1.01); C1244(0.89)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C1233(0.97); C1163(0.94); C1035(0.91); C543(1.01)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C50(1.60)  LDD1702  [4]
 LDCM0625  F8 Ramos C69(0.72)  LDD2187  [20]
 LDCM0573  Fragment11 Ramos C69(20.00)  LDD2190  [20]
 LDCM0576  Fragment14 Ramos C69(1.68)  LDD2193  [20]
 LDCM0468  Fragment33 HCT 116 C1224(1.02); C1228(1.02); C1047(1.06); C1059(1.52)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C1163(1.29); C1244(1.67); C1257(1.67); C543(1.07)  LDD0744  [7]
 LDCM0569  Fragment7 Ramos C69(0.65)  LDD2186  [20]
 LDCM0116  HHS-0101 DM93 Y417(0.91); Y217(1.03)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y217(0.84); Y417(1.25)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y417(1.11); Y217(2.47)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y217(1.15); Y417(2.55)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y217(0.82); Y417(2.19)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C1244(15.62); C1257(15.62); C951(2.82)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1244(20.00); C1257(20.00); C951(1.98)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1244(20.00); C1257(20.00); C951(1.97)  LDD0082  [7]
 LDCM0109  NEM HeLa H599(0.00); H1606(0.00)  LDD0223  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C880(1.00)  LDD2096  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1047(0.82)  LDD2100  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C880(0.55); C1163(0.79)  LDD2109  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C880(0.98)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C880(1.12)  LDD2127  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C880(1.40)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C880(1.37)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C880(0.44); C1163(1.01)  LDD2137  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C880(0.55)  LDD2148  [4]
 LDCM0021  THZ1 HCT 116 C951(1.10); C1244(1.03); C1257(1.03)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromodomain-helicase-DNA-binding protein 7 (CHD7) SNF2/RAD54 helicase family Q9P2D1
Transcription activator BRG1 (SMARCA4) SNF2/RAD54 helicase family P51532
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AT-rich interactive domain-containing protein 2 (ARID2) . Q68CP9

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pfi-3 Small molecular drug D09GNM

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578