General Information of Target

Target ID LDTP10308
Target Name Dynein light chain 2, cytoplasmic (DYNLL2)
Gene Name DYNLL2
Gene ID 140735
Synonyms
DLC2; Dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMER
MASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDE
LKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFF
EDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYAS
HSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGK
LTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVD
LHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSIC
KHVLVKDIKIIVLDLR
Target Bioclass
Other
Family
Dynein light chain family
Subcellular location
Cytoplasm, cytoskeleton
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Uniprot ID
Q96FJ2
Ensemble ID
ENST00000579991.3
HGNC ID
HGNC:24596

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info 
6.45  LDD0066  [1]
STPyne
 Probe Info 
K36(5.87); K43(8.13); K9(6.25)  LDD0277  [2]
Probe 1
 Probe Info 
Y41(30.22)  LDD3495  [3]
m-APA
 Probe Info 
14.77  LDD0403  [4]
DBIA
 Probe Info 
C56(2.20)  LDD3310  [5]
HHS-482
 Probe Info 
Y32(0.91)  LDD0285  [6]
HHS-475
 Probe Info 
Y65(0.72); Y32(0.87); Y41(1.02)  LDD0264  [7]
HHS-465
 Probe Info 
Y50(10.00)  LDD2237  [8]
N1
 Probe Info 
C56(0.00); H55(0.00); W54(0.00); R60(0.00)  LDD0245  [9]
4-Iodoacetamidophenylacetylene
 Probe Info 
N.A.  LDD0038  [10]
IA-alkyne
 Probe Info 
N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [10]
BTD
 Probe Info 
N.A.  LDD0004  [11]
IPM
 Probe Info 
N.A.  LDD0025  [12]
TFBX
 Probe Info 
N.A.  LDD0027  [12]
Compound 10
 Probe Info 
N.A.  LDD2216  [13]
NHS
 Probe Info 
N.A.  LDD0010  [11]
SF
 Probe Info 
K44(0.00); Y41(0.00)  LDD0028  [14]
1c-yne
 Probe Info 
N.A.  LDD0228  [15]
Acrolein
 Probe Info 
C56(0.00); H68(0.00)  LDD0217  [16]
Cinnamaldehyde
 Probe Info 
N.A.  LDD0220  [16]
Crotonaldehyde
 Probe Info 
C56(0.00); H55(0.00)  LDD0219  [16]
Methacrolein
 Probe Info 
C56(0.00); H55(0.00)  LDD0218  [16]
AOyne
 Probe Info 
15.00  LDD0443  [17]
NAIA_5
 Probe Info 
N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info 
9.48  LDD0475  [19]
FFF probe3
 Probe Info 
6.46  LDD0464  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0561  Abegg_cp(-)-10 HeLa C56(4.07)  LDD0312  [12]
 LDCM0237  AC12 HEK-293T C24(1.27)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C24(1.13)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C24(1.11)  LDD1513  [20]
 LDCM0280  AC20 HEK-293T C24(0.95)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C24(1.01)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C24(1.05)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C24(1.07)  LDD1522  [20]
 LDCM0288  AC28 HEK-293T C24(1.14)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C24(1.07)  LDD1528  [20]
 LDCM0291  AC30 HEK-293T C24(1.12)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C24(1.00)  LDD1531  [20]
 LDCM0297  AC36 HEK-293T C24(1.28)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C24(0.93)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C24(1.16)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C24(1.21)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C24(1.11)  LDD1540  [20]
 LDCM0306  AC44 HEK-293T C24(1.13)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C24(1.06)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C24(0.99)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C24(1.21)  LDD1548  [20]
 LDCM0312  AC5 HEK-293T C24(1.02)  LDD1551  [20]
 LDCM0315  AC52 HEK-293T C24(1.12)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C24(0.99)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C24(1.17)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C24(1.17)  LDD1557  [20]
 LDCM0323  AC6 HEK-293T C24(1.15)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C24(1.04)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C24(0.81)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C24(1.09)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C24(1.12)  LDD1566  [20]
 LDCM0334  AC7 HEK-293T C24(0.90)  LDD1568  [20]
 LDCM0248  AKOS034007472 HEK-293T C24(1.03)  LDD1511  [20]
 LDCM0156  Aniline NCI-H1299 14.77  LDD0403  [4]
 LDCM0108  Chloroacetamide HeLa C56(0.00); H55(0.00); H68(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C24(0.83)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C24(0.83)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C24(0.99)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C24(1.13)  LDD1574  [20]
 LDCM0372  CL103 HEK-293T C24(1.27)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C24(1.05)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C24(0.89)  LDD1578  [20]
 LDCM0376  CL107 HEK-293T C24(1.40)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C24(1.16)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C24(1.09)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C24(1.58)  LDD1583  [20]
 LDCM0381  CL111 HEK-293T C24(1.15)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C24(0.89)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C24(1.12)  LDD1587  [20]
 LDCM0385  CL115 HEK-293T C24(1.23)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C24(1.08)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C24(1.01)  LDD1591  [20]
 LDCM0389  CL119 HEK-293T C24(1.14)  LDD1593  [20]
 LDCM0391  CL120 HEK-293T C24(1.06)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C24(1.17)  LDD1596  [20]
 LDCM0394  CL123 HEK-293T C24(1.18)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C24(1.05)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C24(0.91)  LDD1600  [20]
 LDCM0398  CL127 HEK-293T C24(1.12)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C24(1.19)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C24(0.99)  LDD1604  [20]
 LDCM0402  CL15 HEK-293T C24(1.14)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C24(1.11)  LDD1607  [20]
 LDCM0408  CL20 HEK-293T C24(1.13)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C24(0.87)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C24(1.26)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C24(1.11)  LDD1615  [20]
 LDCM0413  CL25 HEK-293T C24(0.91)  LDD1617  [20]
 LDCM0415  CL27 HEK-293T C24(1.44)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C24(1.00)  LDD1620  [20]
 LDCM0418  CL3 HEK-293T C24(1.27)  LDD1622  [20]
 LDCM0421  CL32 HEK-293T C24(1.08)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C24(0.79)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C24(1.25)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C24(1.19)  LDD1628  [20]
 LDCM0426  CL37 HEK-293T C24(0.92)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C24(0.98)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C24(1.16)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C24(1.01)  LDD1634  [20]
 LDCM0434  CL44 HEK-293T C24(1.15)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C24(0.95)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C24(1.21)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C24(1.08)  LDD1641  [20]
 LDCM0439  CL49 HEK-293T C24(1.30)  LDD1643  [20]
 LDCM0443  CL52 HEK-293T C24(1.02)  LDD1646  [20]
 LDCM0447  CL56 HEK-293T C24(1.24)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C24(0.97)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C24(1.16)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C24(1.12)  LDD1653  [20]
 LDCM0453  CL61 HEK-293T C24(1.24)  LDD1656  [20]
 LDCM0455  CL63 HEK-293T C24(1.10)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C24(0.98)  LDD1659  [20]
 LDCM0460  CL68 HEK-293T C24(1.19)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C24(1.04)  LDD1664  [20]
 LDCM0463  CL70 HEK-293T C24(1.14)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C24(1.12)  LDD1667  [20]
 LDCM0466  CL73 HEK-293T C24(1.08)  LDD1669  [20]
 LDCM0469  CL76 HEK-293T C24(0.99)  LDD1672  [20]
 LDCM0473  CL8 HEK-293T C24(0.48)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C24(1.29)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C24(1.02)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C24(1.21)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C24(1.37)  LDD1680  [20]
 LDCM0479  CL85 HEK-293T C24(1.26)  LDD1682  [20]
 LDCM0481  CL87 HEK-293T C24(1.27)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C24(1.26)  LDD1685  [20]
 LDCM0484  CL9 HEK-293T C24(1.02)  LDD1687  [20]
 LDCM0487  CL92 HEK-293T C24(1.10)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C24(0.97)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C24(1.05)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C24(0.81)  LDD1693  [20]
 LDCM0492  CL97 HEK-293T C24(1.15)  LDD1695  [20]
 LDCM0494  CL99 HEK-293T C24(1.13)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C24(1.15)  LDD1698  [20]
 LDCM0625  F8 Ramos C24(1.22)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C24(0.90)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C24(0.13)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C24(0.81)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C24(1.28)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C24(1.20)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C24(0.67)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C24(1.16)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C24(1.07)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C24(1.23)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C24(0.47)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C24(1.15)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C24(1.43)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C24(0.68)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C24(1.39)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C24(1.37)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C24(0.79)  LDD2184  [21]
 LDCM0610  Fragment52 Ramos C24(1.10)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C24(0.75)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C24(0.65)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C24(0.55)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y65(0.72); Y32(0.87); Y41(1.02)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y65(0.53); Y32(0.81); Y41(1.22)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y65(0.69); Y32(0.80); Y41(0.87)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y65(0.78); Y41(0.95); Y32(1.07)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y65(0.56); Y32(0.76); Y41(1.08)  LDD0268  [7]
 LDCM0107  IAA HeLa H55(0.00); H68(0.00); C56(0.00)  LDD0221  [16]
 LDCM0123  JWB131 DM93 Y32(0.91)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y32(1.04)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y32(0.87)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y32(3.98)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y32(2.59)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y32(1.08)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y32(0.82)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y32(1.19)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C24(1.10)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C24(1.04)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C56(2.20)  LDD3310  [5]
 LDCM0109  NEM HeLa H68(0.00); H55(0.00); C56(0.00)  LDD0223  [16]
 LDCM0131  RA190 MM1.R C24(1.24)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Serine/threonine-protein kinase tousled-like 1 (TLK1) Ser/Thr protein kinase family Q9UKI8
Septin-4 (SEPTIN4) Septin GTPase family O43236
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Dynein axonemal light chain 4 (DNAL4) Dynein light chain family O96015
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
cAMP-dependent protein kinase inhibitor alpha (PKIA) PKI family P61925
cAMP-dependent protein kinase inhibitor gamma (PKIG) PKI family Q9Y2B9
Ras guanyl-releasing protein 3 (RASGRP3) RASGRP family Q8IV61
Zygote arrest protein 1 (ZAR1) ZAR1 family Q86SH2
Developmental pluripotency-associated protein 3 (DPPA3) . Q6W0C5
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Protein FAM117B (FAM117B) . Q6P1L5
Regulator of DNA class I crossover intermediates 1 (REDIC1) . Q86WS4
Selenocysteine insertion sequence-binding protein 2-like (SECISBP2L) . Q93073
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.