Details of the Target
General Information of Target
Target ID | LDTP10308 | |||||
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Target Name | Dynein light chain 2, cytoplasmic (DYNLL2) | |||||
Gene Name | DYNLL2 | |||||
Gene ID | 140735 | |||||
Synonyms |
DLC2; Dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2 |
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3D Structure | ||||||
Sequence |
MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMER
MASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDE LKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFF EDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYAS HSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGK LTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVD LHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSIC KHVLVKDIKIIVLDLR |
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Target Bioclass |
Other
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Family |
Dynein light chain family
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Subcellular location |
Cytoplasm, cytoskeleton
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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C-Sul Probe Info |
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6.45 | LDD0066 | [1] | |
STPyne Probe Info |
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K36(5.87); K43(8.13); K9(6.25) | LDD0277 | [2] | |
Probe 1 Probe Info |
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Y41(30.22) | LDD3495 | [3] | |
m-APA Probe Info |
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14.77 | LDD0403 | [4] | |
DBIA Probe Info |
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C56(2.20) | LDD3310 | [5] | |
HHS-482 Probe Info |
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Y32(0.91) | LDD0285 | [6] | |
HHS-475 Probe Info |
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Y65(0.72); Y32(0.87); Y41(1.02) | LDD0264 | [7] | |
HHS-465 Probe Info |
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Y50(10.00) | LDD2237 | [8] | |
N1 Probe Info |
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C56(0.00); H55(0.00); W54(0.00); R60(0.00) | LDD0245 | [9] | |
4-Iodoacetamidophenylacetylene Probe Info |
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N.A. | LDD0038 | [10] | |
IA-alkyne Probe Info |
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N.A. | LDD0036 | [10] | |
Lodoacetamide azide Probe Info |
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N.A. | LDD0037 | [10] | |
BTD Probe Info |
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N.A. | LDD0004 | [11] | |
IPM Probe Info |
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N.A. | LDD0025 | [12] | |
TFBX Probe Info |
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N.A. | LDD0027 | [12] | |
Compound 10 Probe Info |
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N.A. | LDD2216 | [13] | |
NHS Probe Info |
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N.A. | LDD0010 | [11] | |
SF Probe Info |
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K44(0.00); Y41(0.00) | LDD0028 | [14] | |
1c-yne Probe Info |
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N.A. | LDD0228 | [15] | |
Acrolein Probe Info |
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C56(0.00); H68(0.00) | LDD0217 | [16] | |
Cinnamaldehyde Probe Info |
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N.A. | LDD0220 | [16] | |
Crotonaldehyde Probe Info |
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C56(0.00); H55(0.00) | LDD0219 | [16] | |
Methacrolein Probe Info |
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C56(0.00); H55(0.00) | LDD0218 | [16] | |
AOyne Probe Info |
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15.00 | LDD0443 | [17] | |
NAIA_5 Probe Info |
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N.A. | LDD2223 | [18] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
FFF probe13 Probe Info |
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9.48 | LDD0475 | [19] | |
FFF probe3 Probe Info |
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6.46 | LDD0464 | [19] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0561 | Abegg_cp(-)-10 | HeLa | C56(4.07) | LDD0312 | [12] |
LDCM0237 | AC12 | HEK-293T | C24(1.27) | LDD1510 | [20] |
LDCM0259 | AC14 | HEK-293T | C24(1.13) | LDD1512 | [20] |
LDCM0270 | AC15 | HEK-293T | C24(1.11) | LDD1513 | [20] |
LDCM0280 | AC20 | HEK-293T | C24(0.95) | LDD1519 | [20] |
LDCM0281 | AC21 | HEK-293T | C24(1.01) | LDD1520 | [20] |
LDCM0282 | AC22 | HEK-293T | C24(1.05) | LDD1521 | [20] |
LDCM0283 | AC23 | HEK-293T | C24(1.07) | LDD1522 | [20] |
LDCM0288 | AC28 | HEK-293T | C24(1.14) | LDD1527 | [20] |
LDCM0289 | AC29 | HEK-293T | C24(1.07) | LDD1528 | [20] |
LDCM0291 | AC30 | HEK-293T | C24(1.12) | LDD1530 | [20] |
LDCM0292 | AC31 | HEK-293T | C24(1.00) | LDD1531 | [20] |
LDCM0297 | AC36 | HEK-293T | C24(1.28) | LDD1536 | [20] |
LDCM0298 | AC37 | HEK-293T | C24(0.93) | LDD1537 | [20] |
LDCM0299 | AC38 | HEK-293T | C24(1.16) | LDD1538 | [20] |
LDCM0300 | AC39 | HEK-293T | C24(1.21) | LDD1539 | [20] |
LDCM0301 | AC4 | HEK-293T | C24(1.11) | LDD1540 | [20] |
LDCM0306 | AC44 | HEK-293T | C24(1.13) | LDD1545 | [20] |
LDCM0307 | AC45 | HEK-293T | C24(1.06) | LDD1546 | [20] |
LDCM0308 | AC46 | HEK-293T | C24(0.99) | LDD1547 | [20] |
LDCM0309 | AC47 | HEK-293T | C24(1.21) | LDD1548 | [20] |
LDCM0312 | AC5 | HEK-293T | C24(1.02) | LDD1551 | [20] |
LDCM0315 | AC52 | HEK-293T | C24(1.12) | LDD1554 | [20] |
LDCM0316 | AC53 | HEK-293T | C24(0.99) | LDD1555 | [20] |
LDCM0317 | AC54 | HEK-293T | C24(1.17) | LDD1556 | [20] |
LDCM0318 | AC55 | HEK-293T | C24(1.17) | LDD1557 | [20] |
LDCM0323 | AC6 | HEK-293T | C24(1.15) | LDD1562 | [20] |
LDCM0324 | AC60 | HEK-293T | C24(1.04) | LDD1563 | [20] |
LDCM0325 | AC61 | HEK-293T | C24(0.81) | LDD1564 | [20] |
LDCM0326 | AC62 | HEK-293T | C24(1.09) | LDD1565 | [20] |
LDCM0327 | AC63 | HEK-293T | C24(1.12) | LDD1566 | [20] |
LDCM0334 | AC7 | HEK-293T | C24(0.90) | LDD1568 | [20] |
LDCM0248 | AKOS034007472 | HEK-293T | C24(1.03) | LDD1511 | [20] |
LDCM0156 | Aniline | NCI-H1299 | 14.77 | LDD0403 | [4] |
LDCM0108 | Chloroacetamide | HeLa | C56(0.00); H55(0.00); H68(0.00) | LDD0222 | [16] |
LDCM0367 | CL1 | HEK-293T | C24(0.83) | LDD1571 | [20] |
LDCM0368 | CL10 | HEK-293T | C24(0.83) | LDD1572 | [20] |
LDCM0369 | CL100 | HEK-293T | C24(0.99) | LDD1573 | [20] |
LDCM0370 | CL101 | HEK-293T | C24(1.13) | LDD1574 | [20] |
LDCM0372 | CL103 | HEK-293T | C24(1.27) | LDD1576 | [20] |
LDCM0373 | CL104 | HEK-293T | C24(1.05) | LDD1577 | [20] |
LDCM0374 | CL105 | HEK-293T | C24(0.89) | LDD1578 | [20] |
LDCM0376 | CL107 | HEK-293T | C24(1.40) | LDD1580 | [20] |
LDCM0377 | CL108 | HEK-293T | C24(1.16) | LDD1581 | [20] |
LDCM0378 | CL109 | HEK-293T | C24(1.09) | LDD1582 | [20] |
LDCM0379 | CL11 | HEK-293T | C24(1.58) | LDD1583 | [20] |
LDCM0381 | CL111 | HEK-293T | C24(1.15) | LDD1585 | [20] |
LDCM0382 | CL112 | HEK-293T | C24(0.89) | LDD1586 | [20] |
LDCM0383 | CL113 | HEK-293T | C24(1.12) | LDD1587 | [20] |
LDCM0385 | CL115 | HEK-293T | C24(1.23) | LDD1589 | [20] |
LDCM0386 | CL116 | HEK-293T | C24(1.08) | LDD1590 | [20] |
LDCM0387 | CL117 | HEK-293T | C24(1.01) | LDD1591 | [20] |
LDCM0389 | CL119 | HEK-293T | C24(1.14) | LDD1593 | [20] |
LDCM0391 | CL120 | HEK-293T | C24(1.06) | LDD1595 | [20] |
LDCM0392 | CL121 | HEK-293T | C24(1.17) | LDD1596 | [20] |
LDCM0394 | CL123 | HEK-293T | C24(1.18) | LDD1598 | [20] |
LDCM0395 | CL124 | HEK-293T | C24(1.05) | LDD1599 | [20] |
LDCM0396 | CL125 | HEK-293T | C24(0.91) | LDD1600 | [20] |
LDCM0398 | CL127 | HEK-293T | C24(1.12) | LDD1602 | [20] |
LDCM0399 | CL128 | HEK-293T | C24(1.19) | LDD1603 | [20] |
LDCM0400 | CL13 | HEK-293T | C24(0.99) | LDD1604 | [20] |
LDCM0402 | CL15 | HEK-293T | C24(1.14) | LDD1606 | [20] |
LDCM0403 | CL16 | HEK-293T | C24(1.11) | LDD1607 | [20] |
LDCM0408 | CL20 | HEK-293T | C24(1.13) | LDD1612 | [20] |
LDCM0409 | CL21 | HEK-293T | C24(0.87) | LDD1613 | [20] |
LDCM0410 | CL22 | HEK-293T | C24(1.26) | LDD1614 | [20] |
LDCM0411 | CL23 | HEK-293T | C24(1.11) | LDD1615 | [20] |
LDCM0413 | CL25 | HEK-293T | C24(0.91) | LDD1617 | [20] |
LDCM0415 | CL27 | HEK-293T | C24(1.44) | LDD1619 | [20] |
LDCM0416 | CL28 | HEK-293T | C24(1.00) | LDD1620 | [20] |
LDCM0418 | CL3 | HEK-293T | C24(1.27) | LDD1622 | [20] |
LDCM0421 | CL32 | HEK-293T | C24(1.08) | LDD1625 | [20] |
LDCM0422 | CL33 | HEK-293T | C24(0.79) | LDD1626 | [20] |
LDCM0423 | CL34 | HEK-293T | C24(1.25) | LDD1627 | [20] |
LDCM0424 | CL35 | HEK-293T | C24(1.19) | LDD1628 | [20] |
LDCM0426 | CL37 | HEK-293T | C24(0.92) | LDD1630 | [20] |
LDCM0428 | CL39 | HEK-293T | C24(0.98) | LDD1632 | [20] |
LDCM0429 | CL4 | HEK-293T | C24(1.16) | LDD1633 | [20] |
LDCM0430 | CL40 | HEK-293T | C24(1.01) | LDD1634 | [20] |
LDCM0434 | CL44 | HEK-293T | C24(1.15) | LDD1638 | [20] |
LDCM0435 | CL45 | HEK-293T | C24(0.95) | LDD1639 | [20] |
LDCM0436 | CL46 | HEK-293T | C24(1.21) | LDD1640 | [20] |
LDCM0437 | CL47 | HEK-293T | C24(1.08) | LDD1641 | [20] |
LDCM0439 | CL49 | HEK-293T | C24(1.30) | LDD1643 | [20] |
LDCM0443 | CL52 | HEK-293T | C24(1.02) | LDD1646 | [20] |
LDCM0447 | CL56 | HEK-293T | C24(1.24) | LDD1650 | [20] |
LDCM0448 | CL57 | HEK-293T | C24(0.97) | LDD1651 | [20] |
LDCM0449 | CL58 | HEK-293T | C24(1.16) | LDD1652 | [20] |
LDCM0450 | CL59 | HEK-293T | C24(1.12) | LDD1653 | [20] |
LDCM0453 | CL61 | HEK-293T | C24(1.24) | LDD1656 | [20] |
LDCM0455 | CL63 | HEK-293T | C24(1.10) | LDD1658 | [20] |
LDCM0456 | CL64 | HEK-293T | C24(0.98) | LDD1659 | [20] |
LDCM0460 | CL68 | HEK-293T | C24(1.19) | LDD1663 | [20] |
LDCM0461 | CL69 | HEK-293T | C24(1.04) | LDD1664 | [20] |
LDCM0463 | CL70 | HEK-293T | C24(1.14) | LDD1666 | [20] |
LDCM0464 | CL71 | HEK-293T | C24(1.12) | LDD1667 | [20] |
LDCM0466 | CL73 | HEK-293T | C24(1.08) | LDD1669 | [20] |
LDCM0469 | CL76 | HEK-293T | C24(0.99) | LDD1672 | [20] |
LDCM0473 | CL8 | HEK-293T | C24(0.48) | LDD1676 | [20] |
LDCM0474 | CL80 | HEK-293T | C24(1.29) | LDD1677 | [20] |
LDCM0475 | CL81 | HEK-293T | C24(1.02) | LDD1678 | [20] |
LDCM0476 | CL82 | HEK-293T | C24(1.21) | LDD1679 | [20] |
LDCM0477 | CL83 | HEK-293T | C24(1.37) | LDD1680 | [20] |
LDCM0479 | CL85 | HEK-293T | C24(1.26) | LDD1682 | [20] |
LDCM0481 | CL87 | HEK-293T | C24(1.27) | LDD1684 | [20] |
LDCM0482 | CL88 | HEK-293T | C24(1.26) | LDD1685 | [20] |
LDCM0484 | CL9 | HEK-293T | C24(1.02) | LDD1687 | [20] |
LDCM0487 | CL92 | HEK-293T | C24(1.10) | LDD1690 | [20] |
LDCM0488 | CL93 | HEK-293T | C24(0.97) | LDD1691 | [20] |
LDCM0489 | CL94 | HEK-293T | C24(1.05) | LDD1692 | [20] |
LDCM0490 | CL95 | HEK-293T | C24(0.81) | LDD1693 | [20] |
LDCM0492 | CL97 | HEK-293T | C24(1.15) | LDD1695 | [20] |
LDCM0494 | CL99 | HEK-293T | C24(1.13) | LDD1697 | [20] |
LDCM0495 | E2913 | HEK-293T | C24(1.15) | LDD1698 | [20] |
LDCM0625 | F8 | Ramos | C24(1.22) | LDD2187 | [21] |
LDCM0572 | Fragment10 | Ramos | C24(0.90) | LDD2189 | [21] |
LDCM0573 | Fragment11 | Ramos | C24(0.13) | LDD2190 | [21] |
LDCM0574 | Fragment12 | Ramos | C24(0.81) | LDD2191 | [21] |
LDCM0575 | Fragment13 | Ramos | C24(1.28) | LDD2192 | [21] |
LDCM0576 | Fragment14 | Ramos | C24(1.20) | LDD2193 | [21] |
LDCM0579 | Fragment20 | Ramos | C24(0.67) | LDD2194 | [21] |
LDCM0580 | Fragment21 | Ramos | C24(1.16) | LDD2195 | [21] |
LDCM0582 | Fragment23 | Ramos | C24(1.07) | LDD2196 | [21] |
LDCM0578 | Fragment27 | Ramos | C24(1.23) | LDD2197 | [21] |
LDCM0586 | Fragment28 | Ramos | C24(0.47) | LDD2198 | [21] |
LDCM0588 | Fragment30 | Ramos | C24(1.15) | LDD2199 | [21] |
LDCM0589 | Fragment31 | Ramos | C24(1.43) | LDD2200 | [21] |
LDCM0590 | Fragment32 | Ramos | C24(0.68) | LDD2201 | [21] |
LDCM0468 | Fragment33 | HEK-293T | C24(1.39) | LDD1671 | [20] |
LDCM0596 | Fragment38 | Ramos | C24(1.37) | LDD2203 | [21] |
LDCM0566 | Fragment4 | Ramos | C24(0.79) | LDD2184 | [21] |
LDCM0610 | Fragment52 | Ramos | C24(1.10) | LDD2204 | [21] |
LDCM0614 | Fragment56 | Ramos | C24(0.75) | LDD2205 | [21] |
LDCM0569 | Fragment7 | Ramos | C24(0.65) | LDD2186 | [21] |
LDCM0571 | Fragment9 | Ramos | C24(0.55) | LDD2188 | [21] |
LDCM0116 | HHS-0101 | DM93 | Y65(0.72); Y32(0.87); Y41(1.02) | LDD0264 | [7] |
LDCM0117 | HHS-0201 | DM93 | Y65(0.53); Y32(0.81); Y41(1.22) | LDD0265 | [7] |
LDCM0118 | HHS-0301 | DM93 | Y65(0.69); Y32(0.80); Y41(0.87) | LDD0266 | [7] |
LDCM0119 | HHS-0401 | DM93 | Y65(0.78); Y41(0.95); Y32(1.07) | LDD0267 | [7] |
LDCM0120 | HHS-0701 | DM93 | Y65(0.56); Y32(0.76); Y41(1.08) | LDD0268 | [7] |
LDCM0107 | IAA | HeLa | H55(0.00); H68(0.00); C56(0.00) | LDD0221 | [16] |
LDCM0123 | JWB131 | DM93 | Y32(0.91) | LDD0285 | [6] |
LDCM0124 | JWB142 | DM93 | Y32(1.04) | LDD0286 | [6] |
LDCM0125 | JWB146 | DM93 | Y32(0.87) | LDD0287 | [6] |
LDCM0126 | JWB150 | DM93 | Y32(3.98) | LDD0288 | [6] |
LDCM0127 | JWB152 | DM93 | Y32(2.59) | LDD0289 | [6] |
LDCM0128 | JWB198 | DM93 | Y32(1.08) | LDD0290 | [6] |
LDCM0129 | JWB202 | DM93 | Y32(0.82) | LDD0291 | [6] |
LDCM0130 | JWB211 | DM93 | Y32(1.19) | LDD0292 | [6] |
LDCM0022 | KB02 | HEK-293T | C24(1.10) | LDD1492 | [20] |
LDCM0023 | KB03 | HEK-293T | C24(1.04) | LDD1497 | [20] |
LDCM0024 | KB05 | COLO792 | C56(2.20) | LDD3310 | [5] |
LDCM0109 | NEM | HeLa | H68(0.00); H55(0.00); C56(0.00) | LDD0223 | [16] |
LDCM0131 | RA190 | MM1.R | C24(1.24) | LDD0304 | [22] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transcription factor
Protein name | Family | Uniprot ID | |||
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Homeobox protein MOX-2 (MEOX2) | . | P50222 | |||
Homeobox-containing protein 1 (HMBOX1) | . | Q6NT76 |
Other
References