Details of the Target

General Information of Target

Target ID LDTP06186
Target Name Protein RRP5 homolog (PDCD11)
Gene Name PDCD11
Gene ID 22984
Synonyms
KIAA0185; Protein RRP5 homolog; NF-kappa-B-binding protein; NFBP; Programmed cell death protein 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANLEESFPRGGTRKIHKPEKAFQQSVEQDNLFDISTEEGSTKRKKSQKGPAKTKKLKIE
KRESSKSAREKFEILSVESLCEGMRILGCVKEVNELELVISLPNGLQGFVQVTEICDAYT
KKLNEQVTQEQPLKDLLHLPELFSPGMLVRCVVSSLGITDRGKKSVKLSLNPKNVNRVLS
AEALKPGMLLTGTVSSLEDHGYLVDIGVDGTRAFLPLLKAQEYIRQKNKGAKLKVGQYLN
CIVEKVKGNGGVVSLSVGHSEVSTAIATEQQSWNLNNLLPGLVVKAQVQKVTPFGLTLNF
LTFFTGVVDFMHLDPKKAGTYFSNQAVRACILCVHPRTRVVHLSLRPIFLQPGRPLTRLS
CQNLGAVLDDVPVQGFFKKAGATFRLKDGVLAYARLSHLSDSKNVFNPEAFKPGNTHKCR
IIDYSQMDELALLSLRTSIIEAQYLRYHDIEPGAVVKGTVLTIKSYGMLVKVGEQMRGLV
PPMHLADILMKNPEKKYHIGDEVKCRVLLCDPEAKKLMMTLKKTLIESKLPVITCYADAK
PGLQTHGFIIRVKDYGCIVKFYNNVQGLVPKHELSTEYIPDPERVFYTGQVVKVVVLNCE
PSKERMLLSFKLSSDPEPKKEPAGHSQKKGKAINIGQLVDVKVLEKTKDGLEVAVLPHNI
RAFLPTSHLSDHVANGPLLHHWLQAGDILHRVLCLSQSEGRVLLCRKPALVSTVEGGQDP
KNFSEIHPGMLLIGFVKSIKDYGVFIQFPSGLSGLAPKAIMSDKFVTSTSDHFVEGQTVA
AKVTNVDEEKQRMLLSLRLSDCGLGDLAITSLLLLNQCLEELQGVRSLMSNRDSVLIQTL
AEMTPGMFLDLVVQEVLEDGSVVFSGGPVPDLVLKASRYHRAGQEVESGQKKKVVILNVD
LLKLEVHVSLHQDLVNRKARKLRKGSEHQAIVQHLEKSFAIASLVETGHLAAFSLTSHLN
DTFRFDSEKLQVGQGVSLTLKTTEPGVTGLLLAVEGPAAKRTMRPTQKDSETVDEDEEVD
PALTVGTIKKHTLSIGDMVTGTVKSIKPTHVVVTLEDGIIGCIHASHILDDVPEGTSPTT
KLKVGKTVTARVIGGRDMKTFKYLPISHPRFVRTIPELSVRPSELEDGHTALNTHSVSPM
EKIKQYQAGQTVTCFLKKYNVVKKWLEVEIAPDIRGRIPLLLTSLSFKVLKHPDKKFRVG
QALRATVVGPDSSKTLLCLSLTGPHKLEEGEVAMGRVVKVTPNEGLTVSFPFGKIGTVSI
FHMSDSYSETPLEDFVPQKVVRCYILSTADNVLTLSLRSSRTNPETKSKVEDPEINSIQD
IKEGQLLRGYVGSIQPHGVFFRLGPSVVGLARYSHVSQHSPSKKALYNKHLPEGKLLTAR
VLRLNHQKNLVELSFLPGDTGKPDVLSASLEGQLTKQEERKTEAEERDQKGEKKNQKRNE
KKNQKGQEEVEMPSKEKQQPQKPQAQKRGGRECRESGSEQERVSKKPKKAGLSEEDDSLV
DVYYREGKEEAEETNVLPKEKQTKPAEAPRLQLSSGFAWNVGLDSLTPALPPLAESSDSE
EDEKPHQATIKKSKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSI
LWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLTKV
FERAVQYNEPLKVFLHLADIYAKSEKFQEAGELYNRMLKRFRQEKAVWIKYGAFLLRRSQ
AAASHRVLQRALECLPSKEHVDVIAKFAQLEFQLGDAERAKAIFENTLSTYPKRTDVWSV
YIDMTIKHGSQKDVRDIFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQAVKAKALE
YVEAKSSVLED
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.; Involved in the biogenesis of rRNA.
Uniprot ID
Q14690
Ensemble ID
ENST00000369797.8
HGNC ID
HGNC:13408

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.75  LDD0402  [1]
TH211
 Probe Info  		Y1353(20.00); Y1103(8.90)  LDD0260  [2]
BTD
 Probe Info  		C333(1.25); C599(1.08)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C241(20.00)  LDD0170  [4]
DBIA
 Probe Info  		C1154(0.93)  LDD0078  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C361(0.00); C694(0.00); C151(0.00); C1754(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C1754(0.00); C361(0.00); C535(0.00); C694(0.00)  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C1754(0.00); C151(0.00); C81(0.00); C361(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C361(0.00); C599(0.00)  LDD2226  [9]
TFBX
 Probe Info  		C1754(0.00); C151(0.00); C599(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C361(0.00); C1754(0.00)  LDD0021  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
ENE
 Probe Info  		C557(0.00); C510(0.00)  LDD0006  [11]
IPM
 Probe Info  		C361(0.00); C1754(0.00); C333(0.00)  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		Y1791(0.00); K740(0.00); Y578(0.00); Y393(0.00)  LDD0028  [14]
STPyne
 Probe Info  		K1363(0.00); K1364(0.00)  LDD0009  [11]
VSF
 Probe Info  		C1754(0.00); C241(0.00); C361(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C1754(0.00); C1473(0.00)  LDD0018  [15]
1c-yne
 Probe Info  		K764(0.00); K1322(0.00); K1239(0.00); K185(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		H1355(0.00); C361(0.00); C694(0.00); C1754(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C510(0.00); C694(0.00); C241(0.00); H1108(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C241(0.00); C694(0.00)  LDD0218  [16]
W1
 Probe Info  		C241(0.00); C1754(0.00); C535(0.00); C599(0.00)  LDD0236  [17]
AOyne
 Probe Info  		12.10  LDD0443  [18]
NAIA_5
 Probe Info  		C1754(0.00); C81(0.00); C361(0.00); C599(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		8.79  LDD0475  [19]
FFF probe3
 Probe Info  		5.54  LDD0464  [19]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C330(1.02)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C599(0.93); C510(1.14); C1754(0.93); C694(0.62)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C241(20.00)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C241(2.75)  LDD0171  [4]
 LDCM0561  Abegg_cp(-)-10 HeLa C361(2.45)  LDD0312  [10]
 LDCM0214  AC1 HCT 116 C1154(1.31); C1218(1.04); C151(1.41); C1754(1.52)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C241(1.12); C1154(1.02); C1218(0.82); C151(0.94)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C694(0.51); C241(0.75); C1154(0.89); C151(0.29)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C694(0.69); C241(0.79); C1154(0.81); C151(0.37)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C694(0.62); C241(0.74); C1154(0.83); C151(0.35)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C694(0.62); C241(0.59); C1154(0.77); C151(0.39)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C694(1.29); C241(0.67); C1154(0.90); C151(0.42)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C694(0.60); C241(0.56); C1154(0.79); C151(0.48)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C694(0.60); C241(0.58); C1154(0.83); C151(0.35)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C694(0.44); C241(0.69); C1154(0.92); C151(0.37)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C694(0.51); C241(0.64); C1154(0.74); C151(0.34)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C694(0.63); C241(0.74); C1154(0.76); C151(0.55)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C241(1.53); C1154(1.10); C1218(0.73); C151(0.66)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C694(0.47); C241(0.72); C1154(0.76); C151(0.61)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C694(0.57); C241(0.66); C1154(0.74); C151(0.25)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C694(0.63); C241(0.58); C1154(0.81); C151(0.30)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C241(1.02); C1154(1.01); C1218(1.02); C151(1.30)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C241(0.86); C1154(1.03); C1218(1.10); C151(0.98)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C241(0.90); C1154(1.09); C1218(1.05); C151(0.92)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C241(0.91); C1154(1.14); C1218(1.16); C151(1.09)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C241(0.87); C1154(1.08); C1218(1.04); C151(0.95)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C241(0.93); C1154(0.96); C1218(1.03); C151(1.01)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C241(0.90); C1154(1.02); C1218(1.13); C151(0.89)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C241(1.17); C1154(1.08); C1218(0.83); C151(0.86)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C241(0.99); C1154(1.14); C1218(1.15); C151(1.12)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C241(0.91); C1154(0.96); C1218(1.00); C151(0.75)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C241(0.88); C1154(0.95); C1218(0.99); C151(1.25)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C241(1.08); C1154(0.99); C1218(1.08); C151(1.19)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C241(0.98); C1154(0.96); C1218(1.08); C151(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C241(0.90); C1154(1.00); C1218(1.03); C151(1.12)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C241(0.86); C1154(1.08); C1218(1.10); C151(0.94)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C241(0.87); C1154(1.01); C1218(1.08); C151(0.88)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C241(0.91); C1154(1.63); C1218(1.09); C330(1.20)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C241(0.99); C1154(1.30); C1218(1.08); C330(0.82)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C241(0.95); C1154(1.19); C1218(0.99); C330(0.98)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C241(0.93); C1154(1.06); C1218(0.91); C330(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C241(1.14); C1154(1.02); C1218(0.98); C330(0.97)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C241(1.09); C1154(1.13); C1218(0.95); C330(1.05)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C241(0.99); C1154(1.06); C1218(0.98); C330(1.15)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C241(0.97); C1154(1.08); C1218(0.93); C330(1.11)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C241(1.04); C1154(1.11); C1218(1.03); C330(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C241(1.14); C1154(1.16); C1218(0.88); C330(1.08)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C241(1.01); C1154(1.17); C1218(1.06); C330(1.12)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C241(1.01); C1154(1.04); C1218(1.05); C330(1.10)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C241(1.55); C1154(1.09); C1218(0.89); C151(0.83)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C241(1.03); C1154(1.04); C1218(1.11); C330(1.12)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C241(0.93); C1154(1.00); C1218(1.03); C330(0.84)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C241(1.14); C1154(1.06); C1218(0.90); C330(1.11)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C694(0.69); C241(0.94); C333(0.86); C330(0.86)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1754(0.63); C694(0.63); C151(0.79); C241(0.83)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1754(0.65); C694(0.70); C151(0.75); C241(0.88)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C694(0.71); C1754(0.94); C241(0.96); C535(1.03)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1754(0.71); C694(0.73); C151(0.78); C241(0.81)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C694(0.79); C535(0.85); C1754(0.87); C241(1.04)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1754(0.74); C694(0.79); C535(0.89); C241(0.93)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C330(0.89); C1754(0.92); C333(0.96); C1154(0.98)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C151(0.81); C535(0.82); C694(0.84); C1754(0.86)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C151(0.65); C1754(0.67); C694(0.72); C241(0.93)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C694(0.61); C1754(0.65); C151(0.75); C535(0.88)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1754(0.89); C694(0.97); C241(0.99); C151(1.13)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C694(0.92); C241(0.87); C1154(1.18); C151(0.87)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C694(0.65); C241(0.74); C1154(1.17); C151(1.00)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C694(0.68); C241(0.85); C1154(1.10); C151(0.76)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C694(0.66); C241(0.80); C1154(1.03); C151(0.82)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1218(0.82); C535(0.85); C241(0.95); C1754(0.96)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1218(0.81); C241(0.90); C535(0.93); C1754(1.01)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C241(0.77); C1218(0.77); C694(0.93); C1154(0.96)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C557(0.97); C1218(1.03); C535(1.08); C1154(1.09)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C510(0.72); C557(0.90); C1218(0.92); C535(0.94)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1218(0.81); C535(0.94); C241(0.94); C1754(0.99)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1218(0.80); C694(0.95); C241(1.01); C557(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C535(0.87); C1218(0.88); C241(0.93); C81(0.97)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1218(0.78); C557(0.88); C241(0.96); C694(0.98)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C535(0.83); C241(0.84); C330(0.84); C333(0.84)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C151(0.71); C241(0.73); C330(0.78); C81(0.88)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C151(0.72); C241(0.79); C535(0.83); C330(0.84)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C151(0.74); C330(0.80); C535(0.87); C241(0.89)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C151(0.74); C1754(0.78); C241(0.79); C330(0.84)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1218(1.03); C1154(1.20); C535(1.21); C330(1.32)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1754(0.64); C151(0.65); C330(0.76); C241(0.76)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C151(0.72); C241(0.81); C535(0.85); C330(0.86)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C151(0.68); C1754(0.70); C535(0.79); C330(0.90)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C151(0.68); C241(0.80); C535(0.82); C333(0.84)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C151(0.58); C241(0.69); C694(0.69); C330(0.71)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C694(0.79); C1754(0.84); C535(0.92); C81(0.98)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C694(0.64); C1754(0.72); C535(0.88); C81(0.94)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1754(0.75); C694(0.85); C81(0.89); C535(0.98)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C535(0.85); C694(0.86); C1754(0.89); C81(0.98)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C535(0.84); C694(0.85); C1754(0.88); C241(0.96)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C557(1.06); C1218(1.12); C1154(1.23); C535(1.31)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C694(0.75); C1754(0.90); C81(0.97); C535(1.00)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C694(0.61); C1754(0.74); C81(1.05); C1154(1.06)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C694(0.66); C535(0.85); C1754(0.87); C1154(0.98)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C694(0.64); C1754(0.82); C535(1.04); C1154(1.05)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1754(0.84); C694(0.88); C535(0.98); C81(0.99)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C694(0.66); C1754(0.87); C535(0.91); C241(0.99)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C599(0.53); C510(0.69); C557(0.81); C694(0.85)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C599(0.71); C1218(0.86); C361(0.87); C1754(0.88)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C599(0.46); C510(0.62); C241(0.89); C557(0.89)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C599(0.42); C510(0.54); C694(0.90); C557(0.95)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1218(1.22); C535(1.31); C557(1.34); C1154(1.41)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C599(0.46); C510(0.63); C694(0.86); C557(0.88)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C599(0.42); C510(0.57); C361(0.76); C1218(0.80)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C599(0.44); C510(0.57); C361(0.85); C1218(0.88)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C599(0.45); C510(0.59); C1218(0.81); C557(0.82)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C599(0.53); C510(0.63); C694(0.84); C361(0.91)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C599(0.79); C535(0.88); C361(0.95); C1218(0.96)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C599(0.52); C694(0.70); C510(0.71); C557(0.94)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1754(0.90); C557(1.01); C81(1.07); C330(1.08)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C241(0.79); C1218(0.87); C535(0.90); C694(0.98)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1218(0.93); C1754(0.98); C535(1.04); C1154(1.09)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C151(0.73); C1754(0.84); C535(0.92); C330(0.93)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1754(0.91); C557(0.92); C1218(0.93); C694(1.08)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1218(0.86); C1754(1.05); C599(1.06); C241(1.07)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C694(0.95); C1218(0.96); C1754(1.05); C81(1.16)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1218(0.80); C557(0.85); C599(0.94); C1754(1.04)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1218(0.94); C557(0.97); C1754(1.01); C81(1.05)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C241(0.91); C1218(1.07); C535(1.11); C1154(1.16)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1218(0.84); C241(0.93); C1754(1.03); C535(1.08)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1218(0.95); C535(1.07); C557(1.12); C241(1.12)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C599(0.65); C535(0.91); C1218(0.92); C241(0.94)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C599(0.69); C535(0.91); C81(0.96); C241(0.96)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C330(0.82); C1754(0.83); C333(0.84); C1218(0.87)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C599(0.65); C241(0.81); C535(0.92); C1754(0.98)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C599(0.89); C1218(0.98); C535(1.05); C1754(1.06)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C599(0.67); C241(0.88); C535(0.96); C81(0.96)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C599(0.68); C535(0.96); C241(0.97); C694(1.00)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C599(0.90); C1218(0.91); C535(1.02); C81(1.15)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C599(0.62); C1218(0.96); C535(0.96); C241(1.12)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C599(0.75); C1218(0.86); C535(0.93); C241(0.95)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C599(0.57); C1218(0.83); C241(0.86); C1754(0.94)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C599(0.56); C1218(0.92); C535(0.97); C241(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C599(0.65); C241(0.93); C1218(0.95); C535(0.96)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C241(0.88); C333(0.93); C1218(0.94); C330(0.95)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1754(0.96); C81(0.96); C599(0.99); C241(1.04)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C599(0.65); C81(0.71); C535(0.90); C1218(0.93)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C599(0.75); C1218(0.96); C535(1.04); C1754(1.29)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C361(0.60); C535(0.75); C1754(0.77); C330(0.81)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C361(0.53); C1754(0.72); C535(0.73); C330(0.79)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1754(0.66); C535(0.70); C330(0.72); C361(0.74)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C330(0.63); C333(0.71); C535(0.76); C361(0.78)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C361(0.67); C535(0.76); C330(0.82); C1754(0.83)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C330(0.69); C535(0.69); C361(0.74); C557(0.76)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C361(0.69); C535(0.74); C330(0.75); C333(0.78)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C557(0.73); C535(0.77); C330(0.78); C333(0.79)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C361(0.53); C1754(0.64); C330(0.64); C535(0.71)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C330(0.65); C1754(0.68); C535(0.69); C361(0.69)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C535(0.68); C361(0.69); C330(0.69); C333(0.77)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C330(0.52); C1754(0.58); C333(0.73); C361(0.73)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C535(0.68); C1754(0.70); C361(0.75); C330(0.76)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C361(0.64); C330(0.65); C1754(0.69); C535(0.78)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C361(0.65); C330(0.66); C1754(0.67); C535(0.69)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C151(0.44); C694(0.56); C1754(0.69); C241(0.78)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C151(0.40); C694(0.48); C1754(0.54); C241(0.68)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C330(1.02)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C241(1.25); C1154(0.95); C1218(0.83); C151(0.85)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C330(0.84); C1218(0.85); C151(0.87); C333(0.89)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C241(0.94); C535(0.97); C330(1.00); C1218(1.03)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C1154(0.93)  LDD0078  [5]
 LDCM0102  BDHI 8 Jurkat C1754(4.20)  LDD0204  [21]
 LDCM0108  Chloroacetamide HeLa H1355(0.00); C694(0.00); C599(0.00); H772(0.00)  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C557(0.77); C1218(0.81); C694(0.85); C510(0.86)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C694(0.81); C1154(0.98); C557(0.98); C330(1.02)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1218(0.98); C535(1.08); C557(1.17); C81(1.19)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C151(0.54); C1754(0.88); C333(0.88); C1218(0.92)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C151(0.55); C333(0.83); C1218(0.85); C535(0.91)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C151(0.74); C333(0.83); C1218(0.85); C1754(0.88)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C151(0.71); C333(0.80); C1754(0.87); C330(0.91)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C535(0.77); C241(0.84); C81(0.99); C1754(1.05)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C535(0.90); C241(0.98); C1218(1.06); C81(1.12)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C241(0.91); C1218(1.04); C1754(1.12); C81(1.14)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C241(0.88); C1218(1.03); C330(1.10); C81(1.11)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1218(0.80); C241(0.89); C1754(0.96); C1154(0.96)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C535(0.85); C557(0.93); C1154(1.09); C694(1.12)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C241(0.80); C535(0.95); C557(0.98); C1154(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C333(0.93); C81(0.94); C241(0.95); C694(0.97)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C151(0.71); C535(0.75); C1754(0.81); C510(0.83)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C151(0.64); C1754(0.70); C330(0.76); C241(0.84)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C151(0.57); C1754(0.69); C241(0.72); C330(0.80)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C151(0.66); C1754(0.79); C535(0.80); C241(0.81)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C151(0.63); C694(0.79); C535(0.83); C330(0.83)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C694(0.62); C535(0.89); C1754(1.07); C510(1.12)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1754(0.95); C535(0.97); C333(1.04); C694(1.05)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1754(0.86); C694(1.00); C81(1.01); C535(1.01)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1154(1.01); C535(1.02); C694(1.12); C81(1.17)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C694(0.76); C1754(0.84); C535(0.97); C1154(0.98)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C361(0.62); C1154(0.66); C599(0.72); C1218(0.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C599(0.50); C510(0.60); C694(0.84); C557(0.86)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C599(0.66); C510(0.70); C557(0.82); C1218(0.85)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C599(0.52); C510(0.65); C694(0.75); C557(0.95)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C333(0.92); C241(0.96); C330(0.97); C599(0.98)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1754(0.85); C241(0.85); C557(0.93); C599(1.02)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1754(0.86); C557(0.91); C599(0.97); C241(0.98)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1754(0.99); C1218(1.01); C1154(1.05); C535(1.06)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C535(0.89); C1154(1.00); C557(1.08); C81(1.17)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C557(0.88); C694(0.90); C1218(0.91); C81(0.92)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C557(0.70); C535(0.85); C694(0.93); C330(0.95)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C330(0.83); C333(0.89); C599(0.93); C361(0.94)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C599(0.80); C1218(0.82); C330(0.83); C557(0.85)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1218(0.83); C330(0.89); C535(0.92); C361(0.98)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C557(0.79); C1218(0.81); C330(0.85); C599(0.85)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C557(0.81); C333(0.84); C1218(0.84); C330(0.87)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1218(0.81); C599(0.82); C330(0.88); C1154(0.90)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1218(0.77); C330(0.89); C535(0.89); C599(0.93)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1218(0.80); C535(1.04); C330(1.10); C241(1.10)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C599(0.87); C557(0.89); C241(0.89); C1154(0.93)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1154(0.96); C1218(1.01); C535(1.08); C330(1.08)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C694(1.22); C241(0.94); C1154(0.89); C1218(1.01)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C694(0.93); C241(0.95); C1154(0.95); C1218(1.01)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C694(0.97); C241(1.04); C1154(0.82); C1218(0.96)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C694(1.04); C241(1.06); C1154(0.83); C1218(0.99)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C694(1.22); C241(1.24); C1154(0.87); C1218(0.94)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C694(1.04); C1154(1.03); C1218(0.91); C330(0.92)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C694(1.25); C241(1.03); C1154(0.89); C1218(0.90)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C241(20.00); C1154(1.06); C1218(0.92); C151(0.83)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C241(0.75); C1154(1.15); C1218(0.97); C151(0.73)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C241(1.14); C1154(1.05); C1218(0.97); C151(0.70)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C241(0.87); C1154(1.18); C1218(1.03); C151(1.05)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C241(0.81); C1154(1.13); C1218(1.03); C151(0.78)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C241(0.50); C1154(1.10); C1218(0.96); C151(1.48)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C241(0.50); C1154(1.18); C1218(0.99); C151(1.33)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C241(0.57); C1154(1.17); C1218(1.00); C151(0.92)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C694(0.93); C1154(0.83); C1218(1.04); C330(0.91)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C241(0.94); C1154(1.07); C1218(0.89); C151(1.04)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C241(0.63); C1154(1.12); C1218(1.00); C151(1.14)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C241(0.90); C1154(1.53); C1218(0.97); C151(1.11)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C241(0.69); C1154(1.24); C1218(0.80); C151(0.90)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C241(0.61); C1154(1.13); C1218(0.87); C151(0.75)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C241(0.56); C1154(1.17); C1218(0.94); C151(0.86)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C694(0.74); C241(0.75); C1154(0.78); C1218(0.90)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C694(0.73); C241(0.80); C1154(0.79); C1218(1.02)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C694(0.82); C241(0.88); C1154(0.85); C1218(0.82)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C694(1.02); C241(0.92); C1154(0.90); C1218(0.86)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C694(0.96); C1154(0.97); C1218(1.12); C330(0.91)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C694(1.15); C241(0.95); C1154(0.85); C1218(0.85)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C694(0.86); C241(0.89); C1154(0.80); C1218(0.70)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C694(0.69); C241(0.71); C1154(0.68); C1218(0.87)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C694(0.72); C241(0.82); C1154(0.82); C1218(1.06)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C694(0.87); C241(0.75); C1154(0.76); C1218(0.91)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C694(1.12); C241(0.77); C1154(0.80); C1218(0.88)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C694(0.84); C241(0.90); C1154(0.92); C1218(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C694(0.89); C241(0.88); C1154(0.83); C1218(1.09)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C694(0.90); C241(0.81); C1154(0.80); C1218(0.97)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C694(1.10); C241(0.90); C1154(0.88); C1218(0.95)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C694(1.08); C1154(0.96); C1218(1.08); C330(1.04)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C694(0.99); C241(0.87); C1154(0.92); C1218(0.86)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C694(1.44); C241(0.88); C1154(0.96); C1218(1.18)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C694(1.27); C241(0.85); C1154(0.93); C1218(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C694(0.78); C241(0.78); C1154(0.99); C1218(1.03)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C694(0.93); C241(0.86); C1154(1.02); C1218(1.06)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C694(1.11); C241(0.95); C1154(1.07); C1218(1.14)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C694(0.99); C241(0.84); C1154(1.09); C1218(1.04)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C694(1.64); C241(0.92); C1154(1.16); C1218(0.98)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C694(0.88); C241(0.85); C1154(0.94); C1218(1.27)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C694(0.73); C241(0.88); C1154(0.95); C1218(1.08)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C694(1.17); C1154(1.08); C1218(1.18); C330(1.10)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C694(1.07); C241(0.80); C1154(0.89); C1218(1.08)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C694(0.77); C241(0.70); C1154(0.92); C1218(1.09)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C694(0.55); C241(0.74); C1154(0.80); C1218(1.07)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C694(0.73); C241(0.74); C1154(0.89); C1218(1.18)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C694(0.76); C241(0.69); C1154(0.86); C1218(1.09)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C694(1.44); C241(1.11); C1154(1.11); C1218(0.98)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C694(0.92); C241(0.90); C1154(1.09); C1218(1.06)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C694(1.11); C241(0.95); C1154(1.01); C1218(0.96)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C694(1.09); C241(0.81); C1154(1.03); C1218(1.07)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C694(0.82); C1154(1.03); C1218(1.38); C330(2.09)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C694(0.72); C241(1.13); C1154(1.19); C1218(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C694(0.77); C241(0.92); C1154(1.09); C1218(0.99)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C694(1.95); C241(1.28); C1154(1.34); C1218(1.20)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C694(1.70); C241(0.76); C1154(1.25); C1218(0.99)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C694(1.24); C241(0.80); C1154(1.42); C1218(1.23)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C694(0.69); C241(0.93); C1154(1.07); C1218(1.10)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C694(1.11); C241(1.23); C1154(1.14); C1218(0.94)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C694(1.07); C241(0.96); C1154(0.98); C1218(0.94)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C694(0.69); C241(0.87); C1154(1.05); C1218(1.11)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C694(0.89); C241(0.77); C1154(1.41); C1218(1.24)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C694(0.89); C1154(1.01); C1218(0.97); C330(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C694(0.84); C241(0.55); C1154(0.95); C1218(0.98)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1154(1.14); C1218(1.07); C151(0.98); C1754(1.09)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1154(1.19); C1218(1.04); C151(1.10); C1754(0.81)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1154(1.28); C1218(0.99); C151(1.52); C1754(1.01)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1154(1.18); C1218(1.06); C151(1.39); C1754(1.23)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1154(1.07); C1218(1.12); C151(1.04); C1754(1.03)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1154(1.06); C1218(1.05); C151(1.49); C1754(1.05)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1154(1.06); C1218(1.06); C151(1.42); C1754(1.18)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1154(1.24); C1218(1.02); C151(1.10); C1754(1.43)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1154(1.21); C1218(1.12); C151(1.55); C1754(1.56)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C557(1.02); C694(0.98); C1754(0.85); C599(0.87)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C241(3.59); C1754(3.27); C1218(1.23); C694(0.89)  LDD1702  [3]
 LDCM0625  F8 Ramos C151(1.97); C361(1.21)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C151(0.79)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C151(4.33); C361(1.59)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C151(1.03); C361(0.96)  LDD2191  [23]
 LDCM0576  Fragment14 Ramos C151(0.94); C361(1.02)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C151(0.82)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C151(1.02); C361(0.73)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C151(1.14); C361(1.33)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C151(1.02); C361(1.14)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C151(1.63); C361(0.61)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C151(0.80); C361(1.70)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C151(1.01); C361(1.45)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C151(0.59)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C694(1.45); C241(0.86); C1154(0.99); C1218(1.15)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C151(0.99); C361(1.07)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C151(1.28)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C241(1.15); C1154(1.32); C1218(1.13); C151(1.24)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C151(1.17); C361(1.24)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C151(1.37); C361(0.77)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C151(0.89)  LDD2188  [23]
 LDCM0107  IAA HeLa H1355(0.00); H772(0.00); H1760(0.00); H1823(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C694(1.89); C241(1.75); C81(1.33)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C694(2.88); C241(1.43); C81(2.47)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C694(2.70); C241(1.93); C81(1.25)  LDD0082  [5]
 LDCM0109  NEM HeLa H772(0.00); H1337(0.00); H658(0.00)  LDD0223  [16]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C333(2.21); C505(1.09)  LDD2093  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C330(1.80)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C330(1.36); C1754(1.20)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C330(1.20)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C330(0.66)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C330(0.94)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C330(0.90); C599(0.47); C1754(0.63); C694(0.70)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C330(0.69); C599(0.61)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C330(0.89)  LDD2114  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1473(1.01)  LDD2116  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C333(1.46)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C599(0.93); C1754(1.01); C694(0.82)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C330(0.84); C599(0.61); C510(0.79); C1754(0.65)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C330(0.88); C599(1.02); C1154(0.52)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C330(0.73)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C330(1.16)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C330(0.64)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1754(0.98); C694(1.20); C535(0.75)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C330(0.84); C599(0.99); C1754(0.89); C694(0.83)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C333(1.25); C599(1.08)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C330(1.04); C599(0.91); C1754(0.61)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C330(0.66)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1754(0.81)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C333(0.62); C1754(0.79)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C330(0.95)  LDD2147  [3]
 LDCM0131  RA190 MM1.R C361(1.57)  LDD0304  [24]
 LDCM0170  Structure8 Ramos 20.00  LDD0433  [25]
 LDCM0021  THZ1 HCT 116 C535(1.24); C1154(1.21); C81(1.09)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor NF-kappa-B p105 subunit (NFKB1) . P19838

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
21 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
25 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.