Details of the Target

General Information of Target

Target ID LDTP09477
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15)
Gene Name ADAMTS15
Gene ID 170689
Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 15; ADAM-TS 15; ADAM-TS15; ADAMTS-15; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF
QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC
GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW
NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC
QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR
RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD
GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT
VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS
AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
Uniprot ID
Q8TE58
Ensemble ID
ENST00000299164.4
HGNC ID
HGNC:16305

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K512(8.28)  LDD0277  [1]
AZ-9
 Probe Info  		10.00  LDD2155  [2]
DBIA
 Probe Info  		C480(1.04)  LDD1507  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C480(1.04)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C480(1.07)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C480(0.97)  LDD1510  [3]
 LDCM0276  AC17 HEK-293T C480(1.10)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C480(0.95)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C480(0.99)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C480(1.07)  LDD1520  [3]
 LDCM0285  AC25 HEK-293T C480(1.05)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C480(1.01)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C480(1.03)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C480(1.02)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C480(1.05)  LDD1529  [3]
 LDCM0294  AC33 HEK-293T C480(1.16)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C480(1.01)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C480(1.08)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C480(1.09)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C480(0.98)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C480(1.16)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C480(1.00)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C480(1.02)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C480(1.19)  LDD1546  [3]
 LDCM0311  AC49 HEK-293T C480(1.07)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C480(0.97)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C480(1.00)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C480(1.10)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C480(1.18)  LDD1555  [3]
 LDCM0320  AC57 HEK-293T C480(0.97)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C480(1.04)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C480(0.94)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C480(1.16)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C480(1.03)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C480(1.02)  LDD1570  [3]
 LDCM0151  AZ-11 HeLa 10.00  LDD2155  [2]
 LDCM0369  CL100 HEK-293T C480(0.93); C174(1.04); C933(1.10)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C480(1.03)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C480(1.11)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C480(0.98); C174(1.10); C933(1.10)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C480(1.37)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C480(1.08)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C480(1.15); C174(1.01); C933(1.15)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C480(0.97)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C480(0.94)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C480(1.03); C174(1.04); C933(1.11)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C480(1.17)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C480(1.04)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C480(1.10); C174(1.08); C933(1.13)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C480(1.21)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C480(1.05)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C480(1.08); C174(1.07); C933(1.09)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C480(1.23)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C480(0.93)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C480(1.11); C174(1.08); C933(0.99)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C480(0.98)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C480(0.93)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C480(0.97); C174(0.96); C933(1.11)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C480(1.11)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C480(0.90)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C480(1.06); C174(1.12); C933(1.29)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C480(1.14)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C480(1.08)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C480(1.05)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C480(1.06)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C480(0.93)  LDD1613  [3]
 LDCM0414  CL26 HEK-293T C480(1.05)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C480(1.05)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C480(1.10); C174(0.92); C933(0.94)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C480(1.07)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C480(0.91)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C480(1.05)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C480(1.08)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C480(0.97)  LDD1626  [3]
 LDCM0428  CL39 HEK-293T C480(0.93)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C480(0.97); C174(1.15); C933(1.11)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C480(1.10); C174(1.13); C933(0.98)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C480(1.04)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C480(1.05)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C480(0.99)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C480(1.10)  LDD1639  [3]
 LDCM0440  CL5 HEK-293T C480(1.03)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C480(1.15)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C480(1.08); C174(1.26); C933(1.05)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C480(1.13)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C480(1.02)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C480(1.33)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C480(1.17)  LDD1651  [3]
 LDCM0454  CL62 HEK-293T C480(1.16)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C480(0.97)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C480(0.91); C174(1.15); C933(1.15)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C480(1.15)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C480(1.05)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C480(1.02)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C480(1.05)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C480(0.89)  LDD1665  [3]
 LDCM0467  CL74 HEK-293T C480(1.28)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C480(1.09); C174(1.18); C933(1.06)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C480(1.00)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C480(1.00)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C480(0.84)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C480(1.05)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C480(1.16)  LDD1678  [3]
 LDCM0480  CL86 HEK-293T C480(1.03)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C480(0.95)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C480(0.92); C174(1.03); C933(1.03)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C480(1.11)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C480(1.04)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C480(1.01)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C480(0.91)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C480(0.93)  LDD1691  [3]
 LDCM0493  CL98 HEK-293T C480(0.99)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C480(0.96)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C480(1.04)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C480(0.96)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C480(1.24)  LDD1631  [3]
 LDCM0022  KB02 BRX211 C933(3.07); C480(1.60)  LDD2268  [4]
 LDCM0023  KB03 BRX211 C933(5.60); C480(3.11)  LDD2685  [4]
 LDCM0024  KB05 BRX211 C933(3.89)  LDD3102  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840