General Information of Experiment

Probe Name AZ-9  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
Competitor Name AZ-11  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cells (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09477  A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) 10.0
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 10.0
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 10.0
 LDTP01767  Aldehyde dehydrogenase 1A1 (ALDH1A1) 10.0
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) 10.0
 LDTP03946  Glycine--tRNA ligase (GARS1) 10.0
 LDTP06192  Neutral alpha-glucosidase AB (GANAB) 10.0
 LDTP03169  Nucleoside diphosphate kinase B (NME2) 10.0
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 10.0
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 10.0
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) 10.0
 LDTP02733  Pyruvate kinase PKM (PKM) 10.0
 LDTP05007  GTP-binding nuclear protein Ran (RAN) 8.6
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 8.1
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 10.0
 LDTP02010  Annexin A1 (ANXA1) 10.0
 LDTP02199  Annexin A2 (ANXA2) 10.0
 LDTP02929  Galectin-3 (LGALS3) 10.0
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 10.0
 LDTP01976  Statherin (STATH) 10.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03624  Neural cell adhesion molecule L1 (L1CAM) 10.0
Other
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03027  Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) 10.0
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) 10.0
 LDTP05360  Large ribosomal subunit protein eL20 (RPL18A) 10.0
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6) 10.0
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) 10.0
 LDTP01379  Ribosomal L1 domain-containing protein 1 (RSL1D1) 10.0
 LDTP19820  Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2) 10.0
 LDTP04109  Small ribosomal subunit protein uS4 (RPS9) 10.0
 LDTP02205  Tubulin beta chain (TUBB) 10.0
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19) 9.7
 LDTP17097  Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2) 9.0
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 6.8
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) 5.8
 LDTP02292  U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) 5.5

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.