Details of the Target

General Information of Target

Target ID LDTP19820
Target Name Small ribosomal subunit protein eS4, Y isoform 2 (RPS4Y2)
Gene Name RPS4Y2
Gene ID 140032
Synonyms
RPS4Y2P; Small ribosomal subunit protein eS4, Y isoform 2; 40S ribosomal protein S4, Y isoform 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPPAKEGGRKGPRERSGKSAPGTAQGEERAKGAPATEPPKPGWALTPQGLAAMLPAQRH
RHLLFGDLLEDVGAAASTFPCGSVEPGYRMPDPRPWTQSLELPAERQNRLLGVLKAAEAR
GRVRALRLRYTRMRAEEIALLIQRQKSARAAIRLELFLPPQLKPARIPDPLDRQERRRVE
TILEENVDGTIFPR
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS4 family
Uniprot ID
Q8TD47
Ensemble ID
ENST00000629237.2
HGNC ID
HGNC:18501

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C41(4.92)  LDD2157  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C41(5.67)  LDD3332  [3]
AZ-9
 Probe Info  		10.00  LDD2154  [4]
HHS-482
 Probe Info  		Y54(0.82)  LDD0285  [5]
HHS-465
 Probe Info  		Y149(10.00); Y54(4.43)  LDD2237  [6]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [4]
 LDCM0123  JWB131 DM93 Y54(0.82)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y54(0.78)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y54(1.04)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y54(1.73)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y54(1.45)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y54(1.22)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y54(0.48)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y54(1.05)  LDD0292  [5]
 LDCM0022  KB02 42-MG-BA C41(1.07)  LDD2244  [3]
 LDCM0023  KB03 A204 C41(6.19)  LDD2669  [3]
 LDCM0024  KB05 MKN45 C41(5.67)  LDD3332  [3]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.