Details of the Target

General Information of Target

Target ID LDTP01976
Target Name Statherin (STATH)
Gene Name STATH
Gene ID 6779
Synonyms
Statherin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFLVFAFILALMVSMIGADSSEEKFLRRIGRFGYGYGPYQPVPEQPLYPQPYQPQYQQY
TF
Target Bioclass
Transporter and channel
Family
Histatin/statherin family
Subcellular location
Secreted
Function
Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
Uniprot ID
P02808
Ensemble ID
ENST00000246895.9
HGNC ID
HGNC:11369

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD2155  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0151  AZ-11 HeLa 10.00  LDD2155  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Derlin-3 (DERL3) Derlin family Q96Q80
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
Transcription factor A, mitochondrial (TFAM) . Q00059
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Fertilization-influencing membrane protein (FIMP) . Q96LL3
Mucin-7 (MUC7) . Q8TAX7
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.