Details of the Target

General Information of Target

Target ID LDTP01557
Target Name RasGAP-activating-like protein 1 (RASAL1)
Gene Name RASAL1
Gene ID 8437
Synonyms
RASAL; RasGAP-activating-like protein 1; RAS protein activator like 1; Ras GTPase-activating-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH
LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI
CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW
DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE
EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD
CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM
PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG
PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILT
PKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRD
FLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETL
SFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNEL
NQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPL
DPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLA
DLDRAHEEFQQQERGKAALGPLGP
Target Bioclass
Other
Function Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
Uniprot ID
O95294
Ensemble ID
ENST00000261729.9
HGNC ID
HGNC:9873

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD2154  [1]
DBIA
 Probe Info  		C386(9.20)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C681(0.00); C137(0.00)  LDD0036  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [1]
 LDCM0632  CL-Sc Hep-G2 C611(0.47)  LDD2227  [4]
 LDCM0625  F8 Ramos C761(1.39); C137(0.76); C386(2.46); C30(0.76)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C761(3.74); C386(3.15); C30(0.68)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C761(1.23); C137(6.73); C386(1.64); C611(4.29)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C761(2.21); C386(0.86); C30(1.03)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C761(0.95); C30(1.05)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C761(1.00); C386(1.12); C30(0.58); C611(0.84)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C761(1.65); C386(1.30); C30(1.00)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C761(0.96); C386(0.48); C30(0.80)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C761(0.95); C30(1.04)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C761(0.82); C386(1.44); C30(0.84)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C761(0.81); C137(0.41); C386(0.74); C30(1.21)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C761(1.17); C386(0.89); C30(0.86)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C761(0.71); C30(0.83)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C761(18.20); C30(0.72)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C761(1.23); C386(0.98); C30(0.78)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C761(0.56); C386(0.61); C30(0.83)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C761(1.21); C137(0.49); C386(1.12); C30(0.62)  LDD2184  [5]
 LDCM0610  Fragment52 Ramos C761(0.93); C30(1.04)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C761(0.76); C30(1.04)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C761(1.40); C137(0.57); C386(1.12); C30(0.66)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C761(2.03); C30(1.00)  LDD2188  [5]
 LDCM0022  KB02 Ramos C761(2.87); C137(0.44); C386(1.87); C30(0.52)  LDD2182  [5]
 LDCM0023  KB03 Jurkat C386(9.20)  LDD0209  [2]
 LDCM0024  KB05 RVH421 C706(1.22)  LDD3320  [6]
 LDCM0131  RA190 MM1.R C761(1.21)  LDD0304  [7]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.