Details of the Target

General Information of Target

Target ID LDTP15396
Target Name Leucine-rich single-pass membrane protein 2 (LSMEM2)
Gene Name LSMEM2
Gene ID 132228
Synonyms
C3orf45; Leucine-rich single-pass membrane protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESRGKSASSPKPDTKVPQVTTEAKVPPAADGKAPLTKPSKKEAPAEKQQPPAAPTTAPA
KKTSAKADPALLNNHSNLKPAPTVPSSPDATPEPKGPGDGAEEDEAASGGPGGRGPWSCE
NFNPLLVAGGVAVAAIALILGVAFLVRKK
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q8N112
Ensemble ID
ENST00000316436.4
HGNC ID
HGNC:26781

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0455  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-7 (CLDN7) Claudin family O95471
Cardiac phospholamban (PLN) Phospholamban family P26678
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 9 (CXCL9) Intercrine alpha (chemokine CxC) family Q07325
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-7 (STX7) Syntaxin family O15400
B-cell differentiation antigen CD72 (CD72) . P21854
Leucine-rich single-pass membrane protein 1 (LSMEM1) . Q8N8F7
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Pulmonary surfactant-associated protein C (SFTPC) . P11686
Small integral membrane protein 3 (SMIM3) . Q9BZL3
Sperm acrosome membrane-associated protein 1 (SPACA1) . Q9HBV2
Transmembrane protein 143 (TMEM143) . Q96AN5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.