Details of the Target

General Information of Target

Target ID LDTP01139
Target Name Huntingtin-interacting protein 1-related protein (HIP1R)
Gene Name HIP1R
Gene ID 9026
Synonyms
HIP12; KIAA0655; Huntingtin-interacting protein 1-related protein; HIP1-related protein; Huntingtin-interacting protein 12; HIP-12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHH
EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWG
HLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMF
DYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSC
LPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIK
PVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLK
REVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLR
AAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQ
SQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQ
SKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQG
RLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSR
AQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADR
LIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELG
AVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTT
STSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKY
EELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQI
EDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGE
EVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Target Bioclass
Other
Family
SLA2 family
Subcellular location
Cytoplasm, perinuclear region
Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Uniprot ID
O75146
Ensemble ID
ENST00000253083.9
HGNC ID
HGNC:18415

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.N345MfsTer4 .
A101D Insertion: p.A327RfsTer9 DBIA    Probe Info 
A549 SNV: p.E311Ter DBIA    Probe Info 
CAL51 SNV: p.K232N DBIA    Probe Info 
HT115 SNV: p.A71V .
KARPAS422 SNV: p.R53C .
LS180 Deletion: p.N345MfsTer4 DBIA    Probe Info 
NUGC3 Deletion: p.T1035del DBIA    Probe Info 
OPM2 SNV: p.M804T DBIA    Probe Info 
PC14 SNV: p.E308A DBIA    Probe Info 
PC9 SNV: p.E308A .
RKN Deletion: p.A691GfsTer97 DBIA    Probe Info 
SISO SNV: p.Q595H DBIA    Probe Info 
SKMEL2 SNV: p.E21K .
SNU1 SNV: p.E958K DBIA    Probe Info 
SUIT2 Deletion: p.Q574_A583del DBIA    Probe Info 
SW837 SNV: p.S69F DBIA    Probe Info 
T98G SNV: p.A334D DBIA    Probe Info 
TOV21G SNV: p.E435Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.13  LDD0448  [1]
STPyne
 Probe Info  		K274(2.46); K374(4.94); K453(1.19); K489(9.09)  LDD0277  [2]
BTD
 Probe Info  		C938(0.97)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C240(2.39)  LDD0168  [4]
DBIA
 Probe Info  		C105(0.88); C211(0.87); C240(0.88); C650(0.94)  LDD0531  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
ATP probe
 Probe Info  		K37(0.00); K47(0.00)  LDD0199  [7]
CY-1
 Probe Info  		N.A.  LDD0246  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C105(0.00); C240(0.00); C650(0.00); C827(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C650(0.00); C240(0.00); C827(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C650(0.00); C827(0.00); C211(0.00); C240(0.00)  LDD0037  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
NPM
 Probe Info  		N.A.  LDD0016  [10]
TFBX
 Probe Info  		C938(0.00); C240(0.00); C827(0.00)  LDD0148  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
NAIA_5
 Probe Info  		C650(0.00); C105(0.00); C223(0.00); C211(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C938(0.97)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C240(2.39)  LDD0168  [4]
 LDCM0214  AC1 HCT 116 C105(0.88); C211(0.87); C240(0.88); C650(0.94)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C105(0.89); C211(0.70); C240(1.14); C650(1.45)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C105(0.54); C211(0.80); C240(0.93); C650(0.79)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C105(0.67); C211(0.75); C240(0.87); C650(0.85)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C105(0.62); C211(0.98); C240(0.93); C650(0.86)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C105(0.63); C211(0.88); C240(1.09); C650(0.87)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C105(0.69); C211(0.82); C240(0.93); C650(0.82)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C105(0.63); C211(0.76); C240(0.93); C650(0.80)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C105(0.61); C211(0.70); C240(1.00); C650(0.94)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C105(0.61); C211(0.86); C240(1.00); C650(0.90)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C105(0.61); C211(0.83); C240(0.89); C650(0.79)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C105(0.66); C211(0.87); C240(0.81); C650(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C105(0.92); C211(0.73); C240(1.05); C650(1.08)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C105(0.60); C211(0.83); C240(0.89); C650(0.83)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C105(0.62); C211(0.75); C240(0.96); C650(0.79)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C105(0.58); C211(0.70); C240(1.06); C650(0.76)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C105(0.89); C211(1.05); C240(0.97); C650(0.97)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C105(1.00); C211(1.21); C240(0.99); C650(0.98)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C105(1.05); C211(1.03); C240(1.01); C650(1.10)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C105(0.98); C211(1.19); C240(1.11); C650(1.12)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C105(0.97); C211(1.16); C240(0.96); C650(0.87)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C105(0.91); C211(1.05); C240(1.03); C650(0.96)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C105(1.03); C211(1.03); C240(1.08); C650(1.03)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C105(0.91); C211(0.76); C240(1.06); C650(1.28)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C105(0.97); C211(1.05); C240(0.97); C650(0.99)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C105(1.09); C211(0.95); C240(0.91); C650(1.34)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C105(1.03); C211(1.02); C240(1.11); C650(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C105(1.03); C211(0.97); C240(0.93); C650(1.14)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C105(1.03); C211(1.05); C240(1.00); C650(1.26)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C105(1.06); C211(1.15); C240(1.00); C650(0.93)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C105(1.04); C211(1.18); C240(1.06); C650(1.27)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C105(1.00); C211(1.10); C240(1.03); C650(1.28)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C105(1.18); C211(1.18); C650(1.44); C87(1.27)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C105(1.14); C211(1.15); C650(1.42); C87(1.17)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C105(1.20); C211(1.08); C650(1.60); C87(1.13)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C105(1.07); C211(1.16); C650(1.16); C87(1.00)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C105(1.12); C211(1.06); C650(1.42); C87(1.17)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C105(1.13); C211(0.93); C650(1.45); C87(1.13)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C105(1.18); C211(1.06); C650(1.49); C87(1.03)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C105(1.20); C211(1.07); C650(1.28); C87(1.06)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C105(1.17); C211(0.96); C650(1.37); C87(1.02)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C105(1.13); C211(0.94); C650(1.18); C87(1.02)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C105(1.08); C211(1.01); C650(1.52); C87(1.08)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C105(1.18); C211(1.17); C650(1.68); C87(1.05)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C105(0.86); C211(0.68); C240(1.28); C650(1.15)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C105(1.21); C211(1.18); C650(1.58); C87(1.17)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C105(1.27); C211(1.13); C650(1.58); C87(1.14)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C105(1.08); C211(0.95); C650(1.65); C87(1.01)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C105(0.92); C211(1.08); C240(1.03); C650(0.67)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C105(0.88); C87(0.95); C211(1.00); C650(1.10)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C211(0.83); C87(0.88); C105(0.90); C650(1.13)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C105(0.84); C87(0.92); C211(0.97); C240(1.02)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C87(0.88); C211(0.93); C105(1.05); C650(1.20)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C105(1.06); C87(1.08); C650(1.09); C211(1.24)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C87(0.93); C105(0.96); C211(1.13); C240(1.19)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C87(0.82); C211(0.85); C105(0.89); C240(1.19)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C87(0.88); C105(0.90); C211(0.97); C240(1.15)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C87(0.77); C105(0.81); C211(0.85); C240(1.14)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C87(0.86); C105(0.92); C211(0.96); C240(1.30)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C105(1.01); C211(1.30); C240(1.33); C87(1.35)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C105(0.87); C211(1.05); C240(1.23); C650(1.38)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C105(0.85); C211(1.10); C240(1.24); C650(1.34)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C105(0.88); C211(1.07); C240(1.05); C650(1.33)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C105(0.85); C211(1.13); C240(1.23); C650(1.23)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C87(0.96); C240(0.97); C105(1.04); C650(1.08)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C211(0.97); C87(1.04); C105(1.05); C240(1.17)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C87(0.94); C105(1.02); C240(1.02); C211(1.07)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C211(0.93); C240(1.00); C105(1.00); C87(1.02)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C87(0.96); C240(1.00); C211(1.03); C105(1.14)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C240(1.02); C87(1.03); C105(1.05); C211(1.13)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C240(0.92); C87(0.98); C105(1.00); C211(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C240(0.92); C87(0.94); C105(1.02); C650(1.15)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C240(0.91); C650(0.95); C87(0.95); C105(1.05)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C105(0.85); C211(0.88); C240(1.00); C87(1.20)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C211(0.88); C105(0.90); C240(1.09); C87(1.14)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C105(0.85); C211(0.89); C87(1.08); C240(1.11)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C105(0.90); C211(0.97); C240(1.13); C87(1.37)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C105(0.88); C211(0.94); C240(1.06); C87(1.07)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C211(0.88); C240(0.93); C105(0.95); C87(0.99)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C105(0.90); C211(0.91); C87(1.09); C240(1.15)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C105(0.82); C211(0.93); C240(1.15); C87(1.22)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C211(0.86); C105(0.87); C87(0.97); C240(1.43)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C105(0.83); C87(0.86); C211(0.94); C240(1.21)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C87(0.81); C105(0.91); C211(1.03); C240(1.43)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C240(0.85); C211(0.91); C87(0.98); C105(1.00)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C211(0.83); C240(0.89); C87(1.01); C105(1.03)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C240(0.88); C211(0.90); C87(0.96); C105(0.99)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C240(0.91); C87(1.02); C105(1.02); C211(1.06)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C211(0.86); C240(0.95); C87(0.99); C105(1.02)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C240(0.89); C211(0.94); C105(0.99); C87(1.01)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C211(0.91); C87(1.05); C105(1.09); C240(1.09)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C87(0.89); C211(0.90); C240(1.00); C105(1.02)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C240(1.00); C211(1.02); C105(1.03); C87(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C211(0.97); C87(0.98); C240(1.00); C105(1.07)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C87(0.94); C211(0.95); C105(1.04); C240(1.12)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C211(0.92); C87(1.01); C105(1.02); C240(1.04)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C87(0.89); C240(0.92); C650(0.99); C105(1.01)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C650(0.99); C105(1.03); C240(1.04); C211(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C87(0.97); C650(0.97); C240(1.03); C105(1.07)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C87(0.93); C650(1.07); C105(1.17); C211(1.33)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C211(0.98); C650(0.99); C240(1.01); C105(1.04)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C87(0.82); C650(0.92); C105(1.06); C240(1.09)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C87(0.77); C240(0.91); C650(0.92); C105(0.98)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C87(0.82); C240(0.95); C211(0.99); C105(1.00)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C87(0.76); C650(0.87); C105(1.04); C240(1.11)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C87(0.81); C240(1.05); C105(1.06); C650(1.09)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C87(0.79); C105(1.09); C211(1.14); C650(1.21)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C87(0.78); C650(1.13); C105(1.24); C211(1.45)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C105(0.91); C211(0.93); C650(0.96); C87(1.05)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C211(0.92); C650(0.95); C105(0.96); C87(0.96)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C211(0.88); C105(0.92); C87(0.95); C650(0.97)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C211(0.74); C105(0.88); C87(0.91); C650(1.06)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C105(0.86); C211(0.88); C87(0.99); C650(1.03)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C211(0.79); C87(0.85); C105(0.89); C650(1.17)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C211(0.86); C105(0.96); C87(1.00); C650(1.16)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C211(0.77); C105(0.91); C87(0.92); C650(1.08)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C211(0.92); C105(1.00); C87(1.01); C650(1.06)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C211(0.88); C87(1.01); C650(1.05); C105(1.11)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C211(0.86); C105(0.95); C650(1.00); C87(1.06)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C211(0.95); C105(1.08); C650(1.18); C87(1.19)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C211(1.02); C105(1.04); C240(1.11); C87(1.15)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C105(1.08); C211(1.12); C87(1.23); C240(1.24)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C211(0.79); C105(0.95); C87(0.99); C240(1.08)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C211(1.03); C105(1.11); C650(1.21); C240(1.51)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C240(1.12); C211(1.15); C105(1.17); C87(1.18)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C87(1.06); C105(1.07); C211(1.13); C240(1.16)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C211(1.28); C105(1.29); C87(1.41); C240(1.44)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C105(1.34); C211(1.43); C87(1.43); C650(1.70)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C211(1.38); C105(1.40); C87(1.58); C650(1.78)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C105(1.10); C211(1.12); C240(1.17); C87(1.33)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C105(1.02); C211(1.12); C87(1.25); C240(1.37)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C105(0.97); C211(0.99); C240(1.08); C87(1.10)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C105(1.09); C211(1.15); C87(1.19); C240(1.22)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C211(0.67); C105(0.87); C87(0.93); C650(1.13)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C105(0.98); C87(1.16); C211(1.18); C240(1.28)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C650(0.91); C105(1.04); C211(1.10); C87(1.19)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C211(1.36); C105(1.45); C87(1.58); C240(1.86)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C105(0.95); C240(0.97); C650(1.10); C211(1.22)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C240(0.95); C105(1.02); C650(1.04); C87(1.22)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C650(0.89); C105(0.97); C240(1.13); C87(1.19)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C105(1.01); C650(1.01); C240(1.05); C87(1.16)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C105(1.01); C240(1.01); C650(1.03); C87(1.06)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C105(0.97); C650(1.03); C240(1.06); C211(1.12)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C105(0.99); C240(1.02); C650(1.05); C87(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C105(1.04); C650(1.14); C240(1.16); C211(1.18)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C105(1.14); C240(1.17); C87(1.18); C650(1.21)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C240(1.04); C650(1.07); C105(1.08); C87(1.08)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C650(0.90); C87(0.95); C105(0.96); C240(1.07)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C650(0.89); C105(0.95); C87(1.18); C240(1.33)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C87(0.88); C105(0.93); C650(1.06); C211(1.06)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C105(0.98); C87(1.07); C650(1.15); C211(1.31)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C87(1.06); C105(1.07); C650(1.09); C240(1.36)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C105(0.78); C211(0.88); C87(0.93); C650(0.97)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C105(0.63); C211(0.79); C650(0.79); C87(0.87)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C105(0.96); C211(0.78); C240(1.13); C650(1.26)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C211(0.73); C105(0.92); C87(0.92); C240(1.15)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C211(0.88); C87(0.90); C105(1.00); C240(1.46)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C240(0.43); C223(0.29)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C240(0.86); C211(0.87); C87(0.90); C105(0.90)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C105(0.82); C240(0.91); C650(0.92); C211(0.93)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C240(0.88); C211(0.92); C650(0.95); C105(0.97)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C211(0.70); C87(0.81); C105(0.87); C650(0.94)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C211(0.77); C87(0.82); C105(0.86); C240(1.05)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C211(0.69); C87(0.85); C240(0.90); C105(0.97)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C87(0.85); C211(0.89); C105(0.94); C240(1.05)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C105(0.99); C87(1.02); C211(1.08); C650(1.10)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C211(1.06); C105(1.12); C87(1.24); C240(1.37)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C211(1.02); C105(1.05); C87(1.09); C240(1.29)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C211(1.17); C650(1.21); C105(1.30); C240(1.68)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C87(0.89); C105(0.99); C240(1.08); C650(1.18)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C240(0.74); C211(0.95); C105(0.98); C87(1.06)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C211(0.99); C87(1.01); C105(1.02); C650(1.08)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C87(0.94); C240(1.00); C105(1.01); C211(1.13)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C105(0.89); C211(0.94); C240(1.00); C87(1.14)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C105(0.87); C87(0.93); C211(1.01); C240(1.26)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C87(0.79); C105(0.81); C211(0.99); C240(1.11)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C87(0.80); C105(0.83); C211(0.88); C240(1.20)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C87(0.74); C105(0.85); C211(0.85); C240(1.17)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C211(1.09); C240(1.22); C87(1.23); C105(1.24)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C211(0.92); C240(1.02); C87(1.03); C105(1.07)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C211(0.94); C87(0.96); C105(1.03); C240(1.05)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C105(0.96); C240(0.97); C211(1.00); C87(1.06)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C87(0.91); C211(0.92); C240(1.00); C105(1.04)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C105(0.72); C87(0.88); C240(0.89); C650(1.00)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C87(0.80); C105(0.99); C650(1.03); C240(1.03)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C211(0.93); C240(0.93); C87(0.95); C105(1.03)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C87(0.80); C105(1.09); C211(1.12); C240(1.16)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C211(0.75); C105(0.96); C87(0.98); C650(1.05)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C650(0.77); C211(0.80); C105(0.83); C87(1.03)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C211(0.68); C87(0.83); C105(0.88); C650(0.98)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C211(0.86); C105(0.98); C87(1.07); C650(1.13)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C240(0.76); C87(0.89); C105(0.90); C211(0.90)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C87(0.81); C105(0.83); C650(0.87); C240(0.87)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C240(0.56); C105(0.83); C87(0.83); C211(0.84)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C211(0.76); C105(0.87); C87(0.90); C650(1.02)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C211(0.83); C105(0.87); C87(0.91); C650(1.68)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C650(0.77); C87(0.80); C211(0.82); C105(0.87)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C87(0.84); C211(0.87); C105(0.89); C650(1.17)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C650(0.77); C240(0.86); C105(0.86); C211(0.88)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C87(0.85); C105(0.94); C211(0.94); C650(1.12)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C211(0.89); C87(0.95); C105(1.02); C650(1.25)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C105(0.98); C211(1.05); C87(1.06); C650(1.56)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C87(0.87); C211(0.88); C105(0.97); C650(1.35)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C211(0.90); C87(0.94); C105(0.97); C650(1.69)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C105(0.89); C211(0.87); C650(0.99); C87(0.98)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C105(0.92); C211(0.85); C650(0.90); C87(0.95)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C105(0.94); C211(0.78); C650(1.29); C87(0.84)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C105(0.89); C211(0.89); C650(0.93); C87(0.86)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C105(0.83); C211(0.84); C650(1.53); C87(0.87)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C105(0.85); C211(0.92); C240(0.80); C650(0.97)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C105(0.78); C211(0.79); C650(1.07); C87(0.88)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C105(1.07); C211(0.99); C240(0.97); C650(1.07)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C105(0.96); C211(0.87); C240(1.05); C650(0.96)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C105(0.97); C211(0.87); C240(1.01); C650(1.16)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C105(0.98); C211(1.08); C240(1.27); C650(1.00)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C105(0.95); C211(1.07); C240(1.07); C650(1.03)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C105(1.01); C211(1.08); C240(1.08); C650(1.03)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C105(1.03); C211(1.16); C240(1.18); C650(1.25)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C105(0.93); C211(0.97); C240(1.17); C650(1.32)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C105(0.85); C211(0.87); C240(0.70); C650(0.87)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C105(0.89); C211(0.93); C240(0.99); C650(1.05)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C105(0.94); C211(1.10); C240(1.06); C650(0.97)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C105(0.87); C211(1.31); C240(1.17); C650(1.12)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C105(0.87); C211(1.26); C240(1.08); C650(1.01)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C105(0.84); C211(1.03); C240(1.14); C650(1.14)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C105(0.94); C211(1.03); C240(1.18); C650(1.12)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C105(0.96); C211(0.87); C240(1.02); C650(0.92)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C105(0.93); C211(0.85); C240(0.97); C650(1.08)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C105(0.89); C211(0.86); C240(0.94); C650(0.98)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C105(0.94); C211(1.08); C240(1.04); C650(1.19)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C105(0.84); C211(0.91); C240(0.83); C650(1.11)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C105(0.90); C211(0.91); C240(0.89); C650(1.09)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C105(0.94); C211(0.90); C240(1.09); C650(0.97)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C105(0.89); C211(0.87); C240(1.36); C650(0.89)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C105(0.85); C211(0.94); C240(0.88); C650(1.06)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C105(0.88); C211(0.90); C240(1.02); C650(1.01)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C105(0.88); C211(0.83); C240(0.80); C650(1.04)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C105(0.93); C211(0.80); C240(0.85); C650(0.97)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C105(0.88); C211(0.79); C240(0.93); C650(0.82)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C105(0.90); C211(0.93); C240(1.11); C650(1.03)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C105(0.97); C211(0.91); C240(1.02); C650(0.99)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C105(0.86); C211(0.81); C240(0.76); C650(0.89)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C105(0.92); C211(0.92); C240(1.04); C650(0.98)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C105(1.04); C211(1.00); C650(1.51); C87(0.96)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C105(0.95); C211(0.93); C650(1.16); C87(1.05)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C105(0.96); C211(0.89); C650(1.20); C87(0.90)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C105(1.07); C211(0.93); C650(1.17); C87(0.92)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C105(1.01); C211(0.94); C650(1.12); C87(0.97)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C105(1.03); C211(1.04); C650(1.20); C87(1.06)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C105(1.05); C211(1.00); C650(1.08); C87(0.99)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C105(1.12); C211(0.93); C650(1.01); C87(0.91)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C105(0.88); C211(0.82); C650(1.02); C87(0.78)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C105(0.97); C211(0.93); C240(0.88); C650(1.18)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C105(0.99); C211(0.91); C650(1.05); C87(0.97)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C105(1.00); C211(0.99); C650(1.07); C87(0.99)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C105(1.09); C211(1.03); C650(1.12); C87(0.92)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C105(0.97); C211(0.98); C650(1.19); C87(0.84)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C105(0.93); C211(1.01); C650(1.10); C87(0.90)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C105(0.91); C211(0.77); C650(1.00); C87(0.86)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C105(0.93); C211(0.88); C650(0.97); C87(0.94)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C105(0.94); C211(0.78); C650(1.20); C87(0.97)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C105(1.01); C211(1.16); C650(1.10); C87(0.99)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C105(1.01); C211(1.02); C240(0.66); C650(1.00)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C105(0.91); C211(1.02); C650(1.07); C87(0.88)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C105(1.02); C211(0.91); C650(1.03); C87(1.00)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C105(1.08); C211(1.23); C650(1.40); C87(1.14)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C105(1.04); C211(1.03); C650(1.18); C87(1.08)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C105(1.10); C211(1.14); C650(1.08); C87(1.27)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C105(0.94); C211(0.85); C650(1.01); C87(0.98)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C105(1.02); C211(0.87); C650(1.00); C87(0.93)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C105(1.01); C211(1.19); C650(1.05); C87(0.91)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C105(1.01); C211(0.88); C650(1.19); C87(0.97)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C105(1.22); C211(1.13); C650(1.38); C87(1.33)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C105(0.89); C211(0.93); C240(0.78); C650(0.97)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C105(1.03); C211(1.30); C650(1.00); C87(0.88)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C105(0.94); C211(0.87); C240(1.09); C650(1.02)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C105(0.93); C211(0.92); C240(0.84); C650(0.90)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C105(0.98); C211(0.94); C240(0.85); C650(1.23)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C105(0.82); C211(0.84); C240(1.03); C650(0.96)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C105(0.92); C211(0.87); C240(1.10); C650(0.93)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C105(0.90); C211(0.78); C240(0.99); C650(1.05)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C105(0.96); C211(0.97); C240(1.01); C650(0.90)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C105(1.02); C211(0.93); C240(0.87); C650(1.06)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C105(0.95); C211(0.83); C240(0.98); C650(1.01)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C240(1.08)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C87(0.79); C211(1.19); C223(0.93); C105(1.04)  LDD1698  [14]
 LDCM0625  F8 Ramos C105(1.68); C650(1.46); C240(0.91); C223(0.33)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C105(0.52)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C105(0.22); C240(0.49)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C105(0.60); C650(3.66)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C105(1.12)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C105(1.71); C650(1.20); C240(0.92); C223(2.04)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C105(0.55)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C105(0.50)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C105(0.32); C650(1.25)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C105(0.63)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C105(0.67); C240(0.44)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C105(1.16); C650(1.94)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C105(0.89)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C105(0.69); C650(3.74)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C105(1.02); C211(0.94); C650(1.28); C87(0.89)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C105(1.85)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C105(1.06); C650(0.93); C240(0.40); C223(0.95)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C105(0.97); C211(1.16); C240(0.96); C650(0.97)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C105(1.53); C650(0.86)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C105(0.82)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C105(0.78); C240(0.33); C223(0.23)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C105(0.51); C650(0.72)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C105(0.70); C240(0.99); C87(0.81); C223(1.35)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C105(0.90); C240(0.98); C87(0.97); C223(0.82)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C105(1.52); C827(2.18)  LDD3310  [16]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C938(0.97)  LDD2109  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C240(1.29)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C827(1.41)  LDD2136  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Huntingtin-interacting protein 1-related protein (HIP1R) SLA2 family O75146
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840