Details of the Target

General Information of Target

Target ID LDTP12926
Target Name Aryl-hydrocarbon-interacting protein-like 1 (AIPL1)
Gene Name AIPL1
Gene ID 23746
Synonyms
AIPL2; Aryl-hydrocarbon-interacting protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLA
SPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMS
LHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQ
PSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRRE
GSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKS
NLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGL
LTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSE
YLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWIT
RAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May be important in protein trafficking and/or protein folding and stabilization.
Uniprot ID
Q9NZN9
Ensemble ID
ENST00000250087.9
HGNC ID
HGNC:359

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.L76F .
HCC15 SNV: p.Q163R .
HCT15 SNV: p.I256S; p.C323G .
KATOIII SNV: p.M59R .
KURAMOCHI SNV: p.E139V .
MCC26 SNV: p.V33M .
MEWO SNV: p.W218Ter .
NCIH1155 SNV: p.M326I .
NCIH23 SNV: p.T332M .
TOV21G SNV: p.S78Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.74  LDD0448  [1]
DBIA
 Probe Info  		C207(1.19)  LDD3344  [2]
ATP probe
 Probe Info  		K174(0.00); K176(0.00)  LDD0199  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H146 C207(1.19)  LDD2510  [2]
 LDCM0023  KB03 NCI-H146 C207(1.61)  LDD2927  [2]
 LDCM0024  KB05 NCI-H146 C207(1.19)  LDD3344  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin-like protein 4B (TXNL4B) DIM1 family Q9NX01
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor LBX1 (LBX1) . P52954
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NEDD8 ultimate buster 1 (NUB1) . Q9Y5A7
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.