Details of the Target

General Information of Target

Target ID LDTP15093
Target Name Carboxylesterase 5A (CES5A)
Gene Name CES5A
Gene ID 221223
Synonyms
CES7; Carboxylesterase 5A; EC 3.1.1.1; Carboxylesterase-like urinary excreted protein homolog; Cauxin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKEHPEMAEAPQQQLGIPVVKLEKELPWGRGREDPSPETFRLRFRQFRYQEAAGPQEAL
RELQELCRRWLRPELHTKEQILELLVLEQFLTILPREFYAWIREHGPESGKALAAMVEDL
TERALEAKAVPCHRQGEQEETALCRGAWEPGIQLGPVEVKPEWGMPPGEGVQGPDPGTEE
QLSQDPGDETRAFQEQALPVLQAGPGLPAVNPRDQEMAAGFFTAGSQGLGPFKDMALAFP
EEEWRHVTPAQIDCFGEYVEPQDCRVSPGGGSKEKEAKPPQEDLKGALVALTSERFGEAS
LQGPGLGRVCEQEPGGPAGSAPGLPPPQHGAIPLPDEVKTHSSFWKPFQCPECGKGFSRS
SNLVRHQRTHEEKSYGCVECGKGFTLREYLMKHQRTHLGKRPYVCSECWKTFSQRHHLEV
HQRSHTGEKPYKCGDCWKSFSRRQHLQVHRRTHTGEKPYTCECGKSFSRNANLAVHRRAH
TGEKPYGCQVCGKRFSKGERLVRHQRIHTGEKPYHCPACGRSFNQRSILNRHQKTQHRQE
PLVQ
Target Bioclass
Enzyme
Family
Type-B carboxylesterase/lipase family
Subcellular location
Secreted
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
Uniprot ID
Q6NT32
Ensemble ID
ENST00000290567.14
HGNC ID
HGNC:26459

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.L545P .
DETROIT562 SNV: p.D551N .
HCC44 SNV: p.P65S .
HCT116 SNV: p.A255V .
HS936T SNV: p.S136F .
HT SNV: p.P556L .
JURLMK1 SNV: p.H554Y .
LNCaP clone FGC SNV: p.L366R .
LOXIMVI SNV: p.P80T .
MCC13 Substitution: p.G30K .
MEWO SNV: p.E480K .
MOLM16 SNV: p.Q10K .
OVTOKO SNV: p.A78T .
PATU8988T SNV: p.T478R .
RKN SNV: p.Q10K .
RVH421 Deletion: p.K298_L303delinsN .
SW1271 SNV: p.G30V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.94  LDD0448  [1]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.