Details of the Target

General Information of Target

Target ID LDTP11701
Target Name 5'-3' exoribonuclease 2 (XRN2)
Gene Name XRN2
Gene ID 22803
Synonyms
5'-3' exoribonuclease 2; EC 3.1.13.-; DHM1-like protein; DHP protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG
SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE
MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV
ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR
CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD
ARYEAACNRLANKAVQRGSADNVTVMVVRIGH
Target Bioclass
Enzyme
Family
5'-3' exonuclease family, XRN2/RAT1 subfamily
Subcellular location
Nucleus, nucleolus
Function
Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.
Uniprot ID
Q9H0D6
Ensemble ID
ENST00000377191.5
HGNC ID
HGNC:12836

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.K373E DBIA    Probe Info 
AU565 SNV: p.P148L DBIA    Probe Info 
CCK81 SNV: p.V79A DBIA    Probe Info 
COLO678 SNV: p.E727K DBIA    Probe Info 
JHH7 SNV: p.D627V .
JM1 SNV: p.Y554Ter DBIA    Probe Info 
NCIH1155 SNV: p.A442T DBIA    Probe Info 
NCIH716 SNV: p.E727K .
PC14 SNV: p.I208T DBIA    Probe Info 
PC9 SNV: p.I208T .
RKO SNV: p.V22M DBIA    Probe Info 
SH4 SNV: p.P449A DBIA    Probe Info 
SNU1 SNV: p.Y563H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.15  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0448  [2]
TH211
 Probe Info  		Y909(20.00); Y938(20.00)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K640(5.26); K641(10.00); K782(3.66); K796(7.14)  LDD0277  [5]
Probe 1
 Probe Info  		Y377(9.36); Y462(102.29); Y666(9.84)  LDD3495  [6]
BTD
 Probe Info  		C29(1.06)  LDD2092  [7]
AHL-Pu-1
 Probe Info  		C736(2.68)  LDD0168  [8]
HHS-482
 Probe Info  		Y642(0.89)  LDD0285  [9]
HHS-475
 Probe Info  		Y642(0.76)  LDD0264  [10]
HHS-465
 Probe Info  		Y462(3.74)  LDD2237  [11]
DBIA
 Probe Info  		C557(0.89)  LDD0078  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C276(0.00); C159(0.00); C736(0.00); C296(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C736(0.00); C296(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C715(0.00); C296(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C276(0.00); C159(0.00); C736(0.00); C296(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		C296(0.00); C736(0.00)  LDD2226  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
IPM
 Probe Info  		N.A.  LDD0005  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
TFBX
 Probe Info  		N.A.  LDD0148  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [22]
1c-yne
 Probe Info  		K68(0.00); K756(0.00); K590(0.00); K189(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		C159(0.00); C296(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
NAIA_5
 Probe Info  		C159(0.00); C736(0.00); C296(0.00); C21(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		9.09  LDD0475  [25]
FFF probe14
 Probe Info  		18.65  LDD0477  [25]
FFF probe3
 Probe Info  		5.80  LDD0465  [25]
FFF probe4
 Probe Info  		20.00  LDD0466  [25]
JN0003
 Probe Info  		20.00  LDD0469  [25]
STS-2
 Probe Info  		1.00  LDD0139  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C29(1.24); C21(0.74)  LDD2117  [7]
 LDCM0025  4SU-RNA HEK-293T C736(2.68)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C736(2.95)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C159(1.40); C228(1.03); C230(1.03); C263(1.17)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C159(0.92); C228(0.54); C230(0.54); C263(1.14)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C159(0.93); C228(1.69); C230(1.69); C263(0.80)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C159(0.81); C228(1.10); C230(1.10); C263(0.80)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C159(0.84); C228(1.65); C230(1.65); C263(1.07)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C159(0.69); C228(1.53); C230(1.53); C263(1.13)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C159(0.74); C228(1.66); C230(1.66); C263(1.02)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C159(0.82); C228(1.57); C230(1.57); C263(1.47)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C159(0.92); C228(1.70); C230(1.70); C263(1.11)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C159(0.94); C228(1.90); C230(1.90); C263(0.51)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C159(0.95); C228(1.88); C230(1.88); C263(0.99)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C159(0.92); C228(1.97); C230(1.97); C263(0.68)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C159(0.98); C228(0.52); C230(0.52); C263(1.76)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C159(0.95); C228(1.57); C230(1.57); C263(1.11)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C159(0.71); C228(1.00); C230(1.00); C263(0.60)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C159(0.59); C228(0.95); C230(0.95); C263(1.20)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C159(0.83); C228(0.99); C230(0.99); C263(1.12)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C159(0.79); C228(0.94); C230(0.94); C263(1.00)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C159(0.64); C228(0.79); C230(0.79); C263(0.94)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C159(0.74); C228(0.85); C230(0.85); C263(0.96)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C159(0.91); C228(1.01); C230(1.01); C263(1.30)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C159(1.15); C228(0.96); C230(0.96); C263(1.18)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C159(0.90); C228(0.91); C230(0.91); C263(0.97)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C159(1.25); C228(0.64); C230(0.64); C263(1.79)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C159(0.79); C228(0.95); C230(0.95); C263(1.00)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C159(1.31); C228(1.45); C230(1.45); C263(1.74)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C159(1.05); C228(1.01); C230(1.01); C263(1.12)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C159(1.28); C228(1.50); C230(1.50); C263(1.30)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C159(1.28); C228(1.12); C230(1.12); C263(1.32)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C159(1.01); C228(1.10); C230(1.10); C263(1.09)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C159(0.96); C228(1.26); C230(1.26); C263(1.22)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C159(1.20); C228(1.10); C230(1.10); C263(1.28)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C159(0.95); C228(0.97); C230(0.97); C263(1.76)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C159(1.20); C228(1.49); C230(1.49); C263(1.18)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C159(0.95); C228(0.95); C230(0.95); C263(0.97)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C159(1.10); C228(1.35); C230(1.35); C263(0.98)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C159(1.01); C228(1.30); C230(1.30); C263(0.66)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C159(0.99); C228(1.26); C230(1.26); C263(0.83)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C159(0.80); C228(0.73); C230(0.73); C263(0.64)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C159(0.84); C228(0.74); C230(0.74); C263(0.98)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C159(0.85); C228(0.95); C230(0.95); C263(0.73)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C159(0.98); C228(0.78); C230(0.78); C263(0.90)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C159(0.77); C228(0.99); C230(0.99); C263(0.59)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C159(0.83); C228(0.79); C230(0.79); C263(0.57)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C159(1.02); C228(0.73); C230(0.73); C263(1.65)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C159(0.79); C228(0.83); C230(0.83); C263(0.61)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C159(0.81); C228(0.63); C230(0.63); C263(0.64)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C159(1.16); C228(1.45); C230(1.45); C263(0.82)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C557(0.52); C228(0.72); C230(0.72); C159(0.82)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C228(0.23); C230(0.23); C547(0.40); C159(0.68)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C228(0.52); C230(0.52); C547(0.65); C159(0.67)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C228(0.43); C230(0.43); C547(0.52); C159(0.61)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C228(0.18); C230(0.18); C547(0.37); C159(0.41)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C228(0.15); C230(0.15); C547(0.29); C159(0.33)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C228(0.20); C230(0.20); C547(0.39); C159(0.42)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C228(0.56); C230(0.56); C547(0.60); C159(0.73)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C228(0.50); C230(0.50); C159(0.69); C263(0.71)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C159(0.59); C263(0.67); C266(0.67); C228(0.69)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C228(0.20); C230(0.20); C547(0.35); C159(0.37)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C228(0.13); C230(0.13); C547(0.32); C159(0.35)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C159(0.48); C228(0.28); C230(0.28); C263(0.80)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C159(0.51); C228(0.28); C230(0.28); C263(0.83)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C159(0.74); C228(0.93); C230(0.93); C263(0.88)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C159(0.70); C228(1.04); C230(1.04); C263(0.74)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C228(0.81); C230(0.81); C547(0.87); C276(0.92)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C228(0.37); C230(0.37); C547(0.43); C159(0.45)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C159(0.67); C228(0.72); C230(0.72); C296(0.78)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C557(0.83); C228(0.84); C230(0.84); C547(0.88)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C547(0.81); C159(0.86); C557(0.89); C228(0.90)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C547(0.74); C296(0.75); C228(0.80); C230(0.80)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C296(0.74); C547(0.92); C276(0.98); C159(1.16)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C296(0.85); C276(0.86); C228(0.91); C230(0.91)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C159(0.81); C296(0.88); C276(0.92); C557(1.01)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C228(0.66); C230(0.66); C547(0.71); C276(0.82)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C228(0.48); C230(0.48); C547(0.57); C159(0.68)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C228(0.39); C230(0.39); C547(0.58); C159(0.64)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C228(0.38); C230(0.38); C547(0.58); C159(0.65)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C228(0.55); C230(0.55); C159(0.57); C547(0.58)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C547(0.96); C228(1.09); C230(1.09); C266(1.10)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C228(0.42); C230(0.42); C557(0.56); C159(0.59)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C228(0.50); C230(0.50); C159(0.62); C547(0.64)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C228(0.25); C230(0.25); C547(0.39); C557(0.47)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C228(0.33); C230(0.33); C547(0.49); C557(0.50)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C228(0.23); C230(0.23); C547(0.39); C557(0.50)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C296(0.92); C159(1.11); C276(1.16); C736(1.26)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C159(1.04); C296(1.15); C263(1.21); C266(1.21)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C296(1.05); C159(1.13); C736(1.20); C547(1.21)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C736(0.94); C276(0.99); C159(1.01); C263(1.03)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C736(0.79); C228(0.85); C230(0.85); C159(0.88)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C547(0.70); C228(0.89); C230(0.89); C557(1.15)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C228(0.78); C230(0.78); C159(0.80); C736(0.80)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C296(0.88); C263(0.90); C266(0.90); C159(0.93)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C159(0.84); C557(0.85); C228(0.86); C230(0.86)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C263(0.88); C266(0.88); C159(0.91); C557(0.94)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C228(0.87); C230(0.87); C159(0.88); C547(0.91)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C228(0.74); C230(0.74); C547(0.75); C159(0.78)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C263(0.72); C266(0.72); C276(0.86); C159(0.89)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C263(0.77); C266(0.77); C276(0.79); C159(0.81)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C263(0.67); C266(0.67); C736(0.72); C276(0.95)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C228(0.56); C230(0.56); C159(0.59); C276(0.59)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C547(0.65); C228(0.82); C230(0.82); C557(1.09)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C557(0.60); C228(0.65); C230(0.65); C159(0.66)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C228(0.90); C230(0.90); C263(0.95); C266(0.95)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C263(0.79); C266(0.79); C276(0.79); C159(0.85)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C159(0.62); C557(0.67); C263(0.79); C266(0.79)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C557(0.77); C263(0.79); C266(0.79); C228(0.80)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C159(0.53); C557(0.65); C296(0.73); C276(0.83)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C557(0.58); C159(0.61); C263(0.67); C266(0.67)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C159(0.43); C296(0.81); C266(0.82); C557(0.86)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C159(0.48); C266(0.63); C228(0.73); C230(0.73)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C159(0.42); C557(0.55); C266(0.77); C263(0.78)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C228(0.51); C230(0.51); C547(0.65); C159(0.72)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C557(0.51); C159(0.56); C266(1.00); C263(1.01)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C159(0.62); C557(0.80); C296(0.88); C228(0.95)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C159(0.38); C557(0.56); C263(0.89); C296(1.01)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C557(0.62); C159(0.64); C296(0.99); C263(1.06)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C159(0.36); C557(0.52); C263(0.96); C296(0.97)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C159(0.45); C557(0.62); C228(0.69); C230(0.69)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C159(0.50); C557(0.78); C228(0.78); C230(0.78)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C159(0.24); C557(0.41); C263(0.76); C228(0.77)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C547(0.66); C159(0.72); C228(0.75); C230(0.75)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C159(0.52); C547(0.58); C228(0.73); C230(0.73)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C228(0.69); C230(0.69); C547(0.85); C159(0.90)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C547(0.39); C159(0.42); C228(0.50); C230(0.50)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C159(0.84); C296(0.88); C547(0.89); C263(0.92)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C159(0.54); C228(0.55); C230(0.55); C547(0.65)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C159(0.43); C228(0.45); C230(0.45); C547(0.47)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C159(0.40); C547(0.46); C263(0.74); C266(0.74)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C159(0.44); C228(0.45); C230(0.45); C547(0.54)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C159(0.49); C547(0.54); C263(0.75); C266(0.75)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C547(0.48); C159(0.51); C228(0.56); C230(0.56)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C159(0.86); C547(0.90); C263(0.91); C266(0.91)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C228(0.65); C230(0.65); C159(0.70); C547(0.71)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C228(0.55); C230(0.55); C159(0.78); C547(0.79)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C159(0.56); C547(0.63); C263(0.63); C266(0.63)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C228(0.93); C230(0.93); C263(0.94); C266(0.94)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C159(0.39); C547(0.48); C263(0.56); C266(0.56)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C557(0.46); C263(0.48); C266(0.48); C547(0.51)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C557(0.47); C263(0.52); C266(0.52); C159(0.64)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C228(0.48); C230(0.48); C159(0.70); C263(0.71)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C557(0.58); C159(0.69); C228(0.72); C230(0.72)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C263(0.90); C266(0.90); C557(0.93); C159(0.94)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C557(0.61); C263(0.76); C266(0.76); C159(0.80)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C557(0.51); C159(0.62); C263(0.69); C266(0.69)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C159(0.97); C557(1.00); C263(1.11); C266(1.11)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C557(0.47); C547(0.53); C159(0.67); C228(0.78)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C557(0.50); C263(0.54); C266(0.54); C547(0.59)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C557(0.71); C159(0.74); C263(0.88); C266(0.88)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C228(0.69); C230(0.69); C263(0.87); C266(0.87)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C557(0.84); C159(0.93); C263(0.93); C266(0.93)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C263(0.66); C266(0.66); C228(0.73); C230(0.73)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C557(0.45); C159(0.59); C547(0.66); C263(0.68)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C547(0.27); C557(0.32); C263(0.55); C266(0.55)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C263(0.64); C266(0.64); C557(0.70); C547(0.82)  LDD0683  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C29(0.62)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C159(1.12); C228(0.83); C230(0.83); C263(1.33)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C228(0.70); C230(0.70); C547(0.80); C557(0.97)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C228(0.34); C230(0.34); C547(0.36); C159(0.55)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 C296(0.00); C736(0.00)  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C557(0.89)  LDD0078  [12]
 LDCM0108  Chloroacetamide HeLa C159(0.00); C296(0.00); C557(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C296(20.00)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C276(0.65); C159(1.05); C266(1.10); C263(1.13)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C557(0.56); C228(0.60); C230(0.60); C547(0.66)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C547(0.72); C228(0.77); C230(0.77); C557(1.03)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C228(0.51); C230(0.51); C547(0.59); C557(0.76)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C228(0.69); C230(0.69); C547(0.88); C557(1.01)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C547(0.84); C228(0.85); C230(0.85); C557(1.07)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C228(0.71); C230(0.71); C547(0.88); C276(0.92)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C228(0.54); C230(0.54); C547(0.56); C159(0.71)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C228(0.42); C230(0.42); C159(0.47); C547(0.50)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C228(0.35); C230(0.35); C547(0.42); C159(0.47)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C228(0.30); C230(0.30); C159(0.36); C547(0.44)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C547(0.62); C159(0.63); C228(0.66); C230(0.66)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C228(0.58); C230(0.58); C547(0.59); C276(0.62)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C228(0.51); C230(0.51); C547(0.52); C159(0.54)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C159(0.69); C228(0.73); C230(0.73); C557(0.77)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C159(0.73); C276(0.77); C296(0.82); C228(0.82)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C228(0.30); C230(0.30); C547(0.47); C159(0.49)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C228(0.50); C230(0.50); C159(0.56); C263(0.62)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C228(0.40); C230(0.40); C557(0.61); C159(0.62)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C228(0.52); C230(0.52); C557(0.59); C547(0.60)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C159(0.58); C228(0.59); C230(0.59); C547(0.62)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C159(0.86); C296(0.92); C228(0.93); C230(0.93)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C228(0.81); C230(0.81); C159(0.81); C557(0.90)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C557(0.50); C276(0.51); C547(0.54); C228(0.55)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C296(0.82); C736(0.84); C228(0.89); C230(0.89)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C557(0.59); C263(0.67); C266(0.67); C159(0.74)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C263(0.71); C266(0.71); C276(0.75); C557(0.77)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C276(0.60); C263(0.63); C266(0.63); C557(0.64)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C557(0.57); C159(0.64); C263(0.65); C266(0.65)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C266(0.85); C296(0.91); C228(0.91); C230(0.91)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C159(0.61); C228(0.74); C230(0.74); C276(0.90)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C159(0.61); C228(0.80); C230(0.80); C266(0.84)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C159(0.50); C266(0.69); C263(0.78); C557(0.82)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C557(0.66); C276(0.75); C228(0.79); C230(0.79)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C557(0.69); C276(0.83); C228(0.92); C230(0.92)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C276(0.65); C557(0.73); C547(0.81); C228(0.88)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C263(0.68); C266(0.68); C547(0.69); C557(0.70)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C263(0.70); C266(0.71); C159(0.90); C736(0.96)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C276(0.64); C557(0.73); C263(0.78); C266(0.78)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C547(0.75); C557(0.75); C276(0.77); C263(0.83)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C557(1.03); C276(1.09); C228(1.14); C230(1.14)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C557(0.50); C159(0.54); C276(0.55); C547(0.62)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C276(0.43); C547(0.44); C159(0.59); C557(0.64)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C159(0.53); C276(0.56); C557(0.56); C547(0.57)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C557(0.58); C276(0.59); C159(0.67); C547(0.69)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C159(0.64); C263(0.76); C266(0.76); C276(0.42)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C159(0.68); C263(0.69); C266(0.74); C276(0.38)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C159(0.78); C263(0.74); C266(0.78); C276(0.56)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C159(0.80); C263(0.82); C266(0.87); C276(0.65)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C159(0.73); C263(0.77); C266(0.81); C276(0.76)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C159(0.56); C263(0.88); C266(0.94); C276(0.52)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C159(0.99); C228(0.91); C230(0.91); C263(1.10)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C159(0.86); C263(0.85); C266(0.94); C276(0.95)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C159(0.74); C228(0.76); C230(0.76); C263(0.80)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C159(0.69); C228(0.98); C230(0.98); C263(0.78)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C159(0.64); C228(0.65); C230(0.65); C263(0.74)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C159(0.47); C228(0.39); C230(0.39); C263(0.69)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C159(0.51); C228(0.39); C230(0.39); C263(0.80)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C159(0.55); C228(0.33); C230(0.33); C263(0.76)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C159(0.53); C228(0.31); C230(0.31); C263(0.86)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C159(0.52); C228(0.33); C230(0.33); C263(0.86)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C159(0.96); C228(0.96); C230(0.96); C263(1.06)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C159(0.52); C228(0.38); C230(0.38); C263(0.79)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C159(0.58); C228(0.40); C230(0.40); C263(0.85)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C159(0.50); C228(0.26); C230(0.26); C263(0.99)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C159(0.50); C228(0.29); C230(0.29); C263(0.94)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C159(0.60); C228(0.49); C230(0.49); C263(0.92)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C159(0.60); C228(0.41); C230(0.41); C263(0.83)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C159(1.48); C263(0.82); C266(0.82); C296(0.83)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C159(1.30); C263(0.88); C266(0.88); C296(1.10)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C159(1.45); C263(1.06); C266(1.06); C296(0.94)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C159(0.96); C263(1.09); C266(1.09); C296(0.87)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C159(1.00); C228(0.94); C230(0.94); C263(1.48)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C159(1.28); C263(1.02); C266(1.02); C296(1.07)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C159(1.37); C263(1.00); C266(1.00); C296(0.99)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C159(1.31); C263(0.92); C266(0.92); C296(0.96)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C159(1.44); C263(1.01); C266(1.01); C296(0.92)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C159(1.29); C263(0.96); C266(0.96); C296(1.02)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C159(1.26); C263(0.75); C266(0.75); C296(0.98)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C159(1.09); C263(1.03); C266(1.03); C296(0.90)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C159(1.35); C263(1.01); C266(1.01); C296(0.83)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C159(1.31); C263(0.97); C266(0.97); C296(0.91)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C159(1.15); C263(0.94); C266(0.94); C296(1.07)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C159(1.00); C228(0.95); C230(0.95); C263(1.14)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C159(1.16); C263(1.23); C266(1.23); C296(0.97)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C159(0.95); C228(0.78); C230(0.78); C263(1.22)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C159(0.87); C228(0.63); C230(0.63); C263(1.70)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C159(0.71); C228(0.68); C230(0.68); C263(1.33)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C159(0.54); C228(0.58); C230(0.58); C263(1.34)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C159(0.85); C228(0.75); C230(0.75); C263(1.40)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C159(0.45); C228(0.58); C230(0.58); C263(1.38)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C159(0.59); C228(0.79); C230(0.79); C263(1.63)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C159(0.80); C228(0.68); C230(0.68); C263(1.19)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C159(1.01); C228(0.81); C230(0.81); C263(1.77)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C159(0.89); C228(0.74); C230(0.74); C263(1.47)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C159(0.83); C228(0.67); C230(0.67); C263(1.41)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C159(0.62); C228(0.52); C230(0.52); C263(1.57)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C159(0.98); C228(0.66); C230(0.66); C263(1.16)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C159(0.64); C228(0.60); C230(0.60); C263(1.43)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C159(0.67); C228(0.60); C230(0.60); C263(1.54)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C159(0.96); C228(0.81); C230(0.81); C263(0.91)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C159(0.81); C228(0.80); C230(0.80); C263(1.03)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C159(0.81); C228(0.69); C230(0.69); C263(0.75)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C159(0.54); C228(0.51); C230(0.51); C263(0.90)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C159(0.76); C228(0.53); C230(0.53); C263(0.94)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C159(0.92); C228(0.99); C230(0.99); C263(0.97)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C159(0.76); C228(0.63); C230(0.63); C263(1.14)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C159(0.45); C228(0.46); C230(0.46); C263(1.29)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C159(0.44); C228(0.42); C230(0.42); C263(0.97)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C159(0.39); C228(0.38); C230(0.38); C263(0.81)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C159(0.70); C228(0.60); C230(0.60); C263(0.84)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C159(0.78); C228(0.65); C230(0.65); C263(0.93)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C159(0.61); C228(0.57); C230(0.57); C263(1.17)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C159(0.47); C228(0.48); C230(0.48); C263(1.30)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C159(0.41); C228(0.44); C230(0.44); C263(1.15)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C159(0.84); C228(0.74); C230(0.74); C263(1.02)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C159(1.10); C228(1.08); C230(1.08); C263(1.02)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C159(1.05); C228(0.88); C230(0.88); C263(0.93)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C159(1.23); C228(1.05); C230(1.05); C263(1.12)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C159(1.49); C228(1.16); C230(1.16); C263(1.23)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C159(1.10); C228(0.82); C230(0.82); C263(1.05)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C159(1.12); C228(0.79); C230(0.79); C263(0.88)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C159(1.21); C228(0.87); C230(0.87); C263(0.99)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C159(1.08); C228(0.77); C230(0.77); C263(0.99)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C159(1.18); C228(0.67); C230(0.67); C263(0.82)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C159(1.14); C228(0.78); C230(0.78); C263(0.99)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C276(0.95); C557(0.89); C21(0.90); C296(0.94)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C296(0.66)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C159(0.68); C228(0.66); C230(0.66); C263(1.43)  LDD0785  [12]
 LDCM0566  Fragment4 Ramos C296(1.63)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C159(0.52); C228(0.34); C230(0.34); C263(0.68)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y642(0.76)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y642(0.73)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y642(0.79)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y642(0.85)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y642(0.86)  LDD0268  [10]
 LDCM0107  IAA HeLa C159(0.00); C557(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y642(0.89)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y642(1.05)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y642(1.04)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y642(2.49)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y642(1.67)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y642(0.37)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y642(0.75)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y642(0.91)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C276(1.10)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C276(1.14)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C276(0.98)  LDD0082  [12]
 LDCM0109  NEM HeLa H206(0.00); H441(0.00)  LDD0223  [23]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C29(1.06)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C29(0.91)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C29(1.17)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C29(0.87)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C29(0.75); C21(1.15)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C29(1.21)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C29(0.89)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C21(1.12)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C21(0.38)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C29(0.94); C21(0.95); C276(1.23)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C29(0.84); C21(0.80)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C21(0.38)  LDD2110  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C21(0.66)  LDD2115  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C21(1.08)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C29(0.97); C21(0.93)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C29(1.06)  LDD2127  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C29(0.38)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C21(1.02)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C29(1.14)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C29(1.38); C21(1.16)  LDD2137  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C29(0.95)  LDD2141  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C29(3.10); C21(0.12)  LDD2145  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C21(0.54)  LDD2148  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-3' exoribonuclease 2 (XRN2) 5'-3' exonuclease family Q9H0D6
Cryptochrome-2 (CRY2) DNA photolyase class-1 family Q49AN0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDKN2A-interacting protein (CDKN2AIP) CARF family Q9NXV6
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
CDKN2AIP N-terminal-like protein (CDKN2AIPNL) CARF family Q96HQ2
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578