Details of the Target

General Information of Target

Target ID	LDTP17467
Target Name	Coiled-coil domain-containing protein 81 (CCDC81)
Gene Name	CCDC81
Gene ID	60494
Synonyms	Coiled-coil domain-containing protein 81
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MHSLKKVTFEDVAIDFTQEEWAMMDTSKRKLYRDVMLENISHLVSLGYQISKSYIILQLE QGKELWREGREFLQDQNPDRESALKKKHMISMHPITRKDASTSMTMENSLILEDPFECND SGEDCTHSSTITQRLLTHSGKKPYVSKQCGKSLRNLFSPKPHKQIHTKGKSYQCNLCEKA YTNCFRLRRHKMTHTGERPYACHLCGKAFTQCSHLRRHEKTHTGERPYKCHQCGKAFIQS FNLRRHERTHLGKKCYECDKSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFSLSSDLR
Target Bioclass	Other
Subcellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Uniprot ID	Q6ZN84
Ensemble ID	ENST00000354755.5
HGNC ID	HGNC:26281

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
BICR22	SNV: p.R157K	.
DU145	SNV: p.N493K	.
HT115	SNV: p.R335Q	.
LS180	SNV: p.E26G	.
MFE319	SNV: p.K492R	.
SNGM	SNV: p.E293K; p.Q380Ter	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
P1 Probe Info			10.00	LDD0448	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
SLP adapter and CSK-interacting membrane protein (SCIMP)				.	Q6UWF3

References

1	Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.