Details of the Target

General Information of Target

Target ID LDTP15199
Target Name TOG array regulator of axonemal microtubules protein 2 (TOGARAM2)
Gene Name TOGARAM2
Gene ID 165186
Synonyms
FAM179A; TOG array regulator of axonemal microtubules protein 2; Crescerin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIKEAGAIISTRHCNPQNGDRCVAALARVECTHFLWPMCIGEVAHVSAEITYTSKHSVEV
QVNMMSENILTGAKKLTNKATLWYAPLSLTNVDKVLEEPPVVYFRQEQEEEGQKRYKTQK
LERMETNWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHSFVHEGVTMKVMDEVA
GILAARHCKTNLVTASMEAINFDNKIRKGCIKTISGRMTFTSNKSVEIEVLVDADCVVDS
SQKRYRAASVFT
Target Bioclass
Other
Family
Crescerin family
Uniprot ID
Q6ZUX3
Ensemble ID
ENST00000379558.5
HGNC ID
HGNC:33715

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.I439T .
DU145 SNV: p.D531Y .
HCT15 SNV: p.R92M .
JURKAT SNV: p.V532M .
LS123 SNV: p.S442R .
LS180 SNV: p.I216T .
MDAMB157 Substitution: p.S386L .
MFE319 SNV: p.I834T; p.L933P .
OCILY3 SNV: p.L644I .
OVK18 SNV: p.K480E .
TOV21G SNV: p.P945H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.60  LDD0448  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060