Details of the Target

General Information of Target

Target ID LDTP17238
Target Name Coiled-coil domain-containing protein 18 (CCDC18)
Gene Name CCDC18
Gene ID 343099
Synonyms
Coiled-coil domain-containing protein 18; Sarcoma antigen NY-SAR-24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCK
KIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQAL
HLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADG
DKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGIS
LPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNL
GYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQ
PNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWK
KISYTNDS
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Uniprot ID
Q5T9S5
Ensemble ID
ENST00000343253.11
HGNC ID
HGNC:30370

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.42  LDD0448  [1]
P2
 Probe Info  		2.12  LDD0449  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C430(0.97); C433(0.97); C434(0.97)  LDD0532  [3]
CY-1
 Probe Info  		N.A.  LDD0246  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
ATP probe
 Probe Info  		N.A.  LDD0035  [6]
IPM
 Probe Info  		C85(0.00); C766(0.00); C577(0.00)  LDD0147  [7]
TFBX
 Probe Info  		C577(0.00); C630(0.00); C280(0.00)  LDD0148  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C430(1.05); C434(1.05); C433(0.93)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C430(0.99); C434(0.98); C433(0.98)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C430(0.95); C434(0.98); C433(0.98)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C430(1.09); C434(1.15); C433(1.15)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C430(1.13); C434(1.05); C433(1.05)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C430(1.11); C434(1.03); C433(1.03)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C430(1.14); C434(1.28); C433(1.28)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C430(1.13); C434(1.20); C433(1.20)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C430(1.11); C434(1.23); C433(1.23)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C430(1.13); C434(1.23); C433(1.23)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C430(0.98); C434(1.05); C433(1.05)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C430(1.19); C433(1.19); C434(1.19)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C430(1.00); C434(1.09); C433(1.09)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C430(1.03); C434(0.93); C433(0.93)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C430(0.96); C434(0.99); C433(0.99)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C430(1.26); C434(1.05); C433(1.05)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C430(1.44); C434(0.82); C433(0.82)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C430(1.09); C434(0.94); C433(0.94)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C430(0.87); C434(0.75); C433(0.75)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C430(1.03); C434(0.93); C433(0.93)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C430(0.83); C434(0.74); C433(0.74)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C430(1.06); C434(0.88); C433(0.88)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C430(1.17); C433(1.17); C434(1.17)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C430(0.90); C434(0.80); C433(0.80)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C430(1.04); C434(1.07); C433(1.07)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C430(1.05); C434(1.10); C433(1.10)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C430(1.07); C434(0.82); C433(0.82)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C430(0.95); C434(0.95); C433(0.95)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C430(1.15); C434(1.01); C433(1.01)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C430(1.53); C434(1.24); C433(1.24)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C430(1.23); C434(1.00); C433(1.00)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C430(1.10); C434(1.10); C433(1.08)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C430(1.40); C434(1.40); C433(1.15)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C430(1.06); C434(1.06); C433(1.01)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C430(1.20); C434(1.20); C433(1.04)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C430(1.37); C434(1.37); C433(1.20)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C430(1.01); C434(1.01); C433(1.00)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C430(1.08); C434(1.08); C433(0.92)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C430(1.03); C434(1.03); C433(0.97)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C430(1.17); C434(1.17); C433(1.05)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C430(1.20); C434(1.20); C433(1.05)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C430(1.14); C434(1.14); C433(0.99)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C430(1.13); C434(1.13); C433(0.94)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C430(1.10); C434(1.10); C433(1.02)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C430(1.13); C434(1.13); C433(1.00)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C430(1.16); C434(1.16); C433(1.00)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C430(1.00); C433(1.00); C434(1.00)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C430(0.88); C433(0.88); C434(0.88)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C430(0.91); C433(0.91); C434(0.91)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C430(1.19); C433(1.19); C434(1.19)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C430(1.03); C433(1.03); C434(1.03)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C430(0.93); C433(0.93); C434(0.93)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C430(1.17); C433(1.17); C434(1.17)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C430(0.90); C433(0.90); C434(0.90)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C430(0.81); C433(0.81); C434(0.81)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C430(1.06); C433(1.06); C434(1.06)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C430(0.77); C433(0.77); C434(0.77)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C430(1.02); C433(1.02); C434(1.02)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C430(0.78); C433(0.78); C434(0.78)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C430(0.94); C433(0.94); C434(0.94)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C430(1.05); C433(1.05); C434(1.05)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C430(1.01); C433(1.01); C434(1.01)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C430(1.15); C434(1.15); C433(1.15)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C430(1.21); C434(1.21); C433(1.21)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C430(1.10); C434(1.10); C433(1.10)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C430(1.08); C434(1.08); C433(1.03)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C430(1.15); C434(1.15); C433(1.15)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C430(1.18); C434(1.18); C433(1.18)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C430(1.12); C434(1.12); C433(1.12)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C430(1.31); C434(1.31); C433(1.31)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C430(1.13); C434(1.13); C433(1.13)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C430(0.58); C434(0.58); C433(0.64)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C430(0.65); C434(0.65); C433(0.66)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C430(0.63); C434(0.63); C433(0.61)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C430(0.64); C434(0.64); C433(0.64)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C430(0.62); C434(0.62); C433(0.61)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C430(0.87); C434(0.87); C433(1.07)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C430(0.65); C434(0.65); C433(0.68)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C430(0.69); C434(0.69); C433(0.73)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C430(0.69); C434(0.69); C433(0.66)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C430(0.67); C434(0.67); C433(0.72)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C430(0.73); C434(0.73); C433(0.69)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C630(0.84)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C630(1.03); C766(1.07); C577(1.12)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C630(0.79); C766(1.18)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C630(1.02); C85(0.94)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C630(0.77)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C430(1.02); C434(1.02); C433(0.98)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C630(0.98)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C630(0.81); C577(1.06)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C630(0.97)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C630(0.76)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C630(0.82); C766(1.21); C577(1.13)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C630(0.82); C766(1.10)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C630(1.08); C85(0.84)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C630(1.03)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C630(1.02)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C630(0.84); C577(1.09)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C430(1.01); C434(1.01); C433(0.98)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C630(1.01)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C630(1.08)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C630(0.85); C766(1.19); C577(1.17)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C630(0.88); C766(1.11)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C630(0.84); C85(0.87)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C630(1.09)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C630(0.83)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C430(0.89); C434(0.89); C433(0.89)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C430(1.10); C434(1.10); C433(1.02)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C430(1.04); C434(1.04); C433(0.94)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C430(0.82); C433(0.82); C434(0.82)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C430(0.85); C434(0.85); C433(0.72)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C430(0.98); C434(0.98); C433(0.99)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C430(1.08); C434(1.08); C433(1.07)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C430(1.16); C434(1.16); C433(1.04)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C430(1.14); C434(1.14); C433(1.13)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C430(1.41); C434(1.41); C433(1.19)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C430(1.00); C434(1.00); C433(1.02)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C430(1.12); C434(1.12); C433(1.10)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C430(0.98); C434(1.01); C433(1.00)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C430(1.28); C434(1.22); C433(0.98)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C430(0.84); C433(0.84); C434(0.84)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C430(1.07); C434(1.12); C433(1.01)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C430(1.24); C434(1.04); C433(0.92)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C430(1.59); C434(1.24); C433(1.05)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C430(0.89); C434(0.92); C433(0.98)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C430(0.74); C434(0.82); C433(0.82)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C430(1.13); C434(0.88); C433(0.84)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C430(0.85); C434(0.95); C433(0.92)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C430(0.97); C434(1.16); C433(1.02)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C430(0.89); C434(1.04); C433(0.97)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C430(1.22); C434(0.94); C433(0.89)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C430(1.05); C434(0.97); C433(0.80)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C430(0.94); C434(1.07); C433(0.90)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C430(1.21); C434(1.22); C433(0.87)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C430(1.13); C433(1.13); C434(1.13)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C430(1.07); C433(1.07); C434(1.07)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C430(1.23); C433(1.23); C434(1.23)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C430(1.06); C433(1.06); C434(1.06)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C430(1.01); C433(1.01); C434(1.01)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C430(1.14); C433(1.14); C434(1.14)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C430(1.00); C433(1.00); C434(1.00)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C430(1.30); C433(1.30); C434(1.30)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C430(1.18); C433(1.18); C434(1.18)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C430(1.03); C433(1.03); C434(1.03)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C430(1.51); C433(1.51); C434(1.51)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C430(1.14); C433(1.14); C434(1.14)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C430(1.37); C433(1.37); C434(1.37)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C430(1.38); C433(1.38); C434(1.38)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C430(1.06); C434(1.04); C433(1.04)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C430(0.89); C434(0.94); C433(0.94)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C430(0.99); C433(0.99); C434(0.99)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C430(1.26); C433(1.26); C434(1.26)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C430(1.00); C433(1.00); C434(1.00)  LDD2171  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C630(1.19); C85(0.77)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C630(0.93); C85(1.22)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C430(1.06); C434(1.06); C433(0.92)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C430(1.11); C433(1.11); C434(1.11)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C430(1.44); C433(1.44); C434(1.44)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C430(0.83); C433(0.83); C434(0.83)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C430(0.86); C433(0.86); C434(0.86)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C430(1.59); C434(1.59); C433(1.59)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C430(1.41); C434(1.41); C433(1.41)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C430(1.26); C434(1.26); C433(1.26)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C430(1.16); C434(1.16); C433(1.16)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C430(1.59); C434(1.59); C433(1.59)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C630(0.95)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C430(2.40); C434(2.40); C433(2.40)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C430(1.94); C434(1.94); C433(1.94)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C430(0.83); C434(0.83); C433(0.65)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C430(0.74); C434(0.74); C433(0.72)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C430(1.16); C434(1.16); C433(0.85)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C430(0.79); C434(0.79); C433(0.68)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C430(0.60); C434(0.60); C433(0.57)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C630(0.96); C85(0.77)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C630(0.93)  LDD1592  [9]
 LDCM0390  CL12 HEK-293T C630(1.30)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C630(0.80); C766(1.08)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C630(0.91); C85(0.89)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C630(0.84)  LDD1597  [9]
 LDCM0395  CL124 HEK-293T C630(0.82); C766(1.12)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C430(1.01); C434(1.01); C433(1.01)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C430(1.36); C434(1.36); C433(1.05)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C430(0.98); C434(0.98); C433(0.93)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C430(1.03); C434(1.03); C433(0.93)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C630(1.02); C85(0.86)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C630(0.90)  LDD1605  [9]
 LDCM0403  CL16 HEK-293T C433(0.81)  LDD1001  [3]
 LDCM0404  CL17 HCT 116 C430(1.55); C433(1.55); C434(1.55)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C430(1.08); C433(1.08); C434(1.08)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C430(1.11); C433(1.11); C434(1.11)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C630(0.89)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C430(1.40); C433(1.40); C434(1.40)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C430(1.54); C433(1.54); C434(1.54)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C430(0.93); C433(0.93); C434(0.93)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C430(0.97); C433(0.97); C434(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C430(1.14); C433(1.14); C434(1.14)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C430(1.60); C433(1.60); C434(1.60)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C430(1.02); C433(1.02); C434(1.02)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C430(1.13); C433(1.13); C434(1.13)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C430(1.18); C433(1.18); C434(1.18)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C430(1.18); C433(1.18); C434(1.18)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C430(1.13); C433(1.13); C434(1.13)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C430(1.04); C433(1.04); C434(1.04)  LDD0737  [3]
 LDCM0421  CL32 HEK-293T C430(1.01); C434(1.01); C433(1.01)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C430(3.56); C434(3.56); C433(3.56)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C430(1.35); C434(1.35); C433(1.35)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C430(1.10); C434(1.10); C433(1.10)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C430(1.34); C434(1.34); C433(1.34)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C430(1.42); C434(1.42); C433(1.42)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C430(2.79); C434(2.79); C433(2.79)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C630(1.09); C766(1.04)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C430(1.01); C434(1.01); C433(1.01)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C430(1.57); C434(1.57); C433(1.57)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C430(0.93); C434(0.93); C433(0.93)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C430(1.04); C434(1.04); C433(1.04)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C430(1.18); C434(1.18); C433(1.18)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C430(2.29); C434(2.29); C433(2.29)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C630(0.87); C85(1.01)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C630(0.85)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C630(1.37)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C630(0.86); C85(0.74)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C630(0.76); C577(1.12)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C630(0.92)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C630(0.75); C766(1.02)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C630(0.72); C577(1.14)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C630(0.73)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C630(0.99)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C630(0.84); C766(1.47); C577(1.03)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C630(0.96); C766(1.07)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C630(0.93); C85(1.13)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C630(0.87)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C630(0.34)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C630(0.96)  LDD1655  [9]
 LDCM0453  CL61 HCT 116 C430(1.42); C433(1.42); C434(1.42)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C430(1.03); C433(1.03); C434(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C430(1.13); C433(1.13); C434(1.13)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C430(0.95); C433(0.95); C434(0.95)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C430(1.32); C433(1.32); C434(1.32)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C430(1.01); C433(1.01); C434(1.01)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C430(1.16); C433(1.16); C434(1.16)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C430(0.89); C433(0.89); C434(0.89)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C430(1.54); C433(1.54); C434(1.54)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C630(0.94)  LDD1665  [9]
 LDCM0463  CL70 HCT 116 C430(1.25); C433(1.25); C434(1.25)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C430(1.08); C433(1.08); C434(1.08)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C430(1.11); C433(1.11); C434(1.11)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C430(1.07); C433(1.07); C434(1.07)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C430(1.36); C433(1.36); C434(1.36)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C430(1.00); C434(1.00); C433(1.00)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C430(2.43); C434(2.43); C433(2.43)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C430(1.02); C434(1.02); C433(1.02)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C430(1.10); C434(1.10); C433(1.10)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C630(0.71); C766(0.82); C577(1.09)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C430(1.07); C434(1.07); C433(1.07)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C430(1.02); C434(1.02); C433(1.02)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C430(1.07); C434(1.07); C433(1.07)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C430(0.96); C434(0.96); C433(0.96)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C430(1.47); C434(1.47); C433(1.47)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C430(1.16); C434(1.16); C433(1.16)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C430(1.18); C434(1.18); C433(1.18)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C430(1.51); C434(1.51); C433(1.51)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C430(1.42); C434(1.42); C433(1.42)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C430(1.09); C434(1.09); C433(1.09)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C630(1.03); C766(1.34)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C430(2.88); C434(2.88); C433(2.88)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C430(1.12); C434(1.12); C433(0.88)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C430(3.28); C434(3.28); C433(1.99)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C430(1.53); C434(1.53); C433(1.17)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C430(1.95); C434(1.95); C433(1.30)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C430(4.47); C434(4.47); C433(2.52)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C430(1.21); C434(1.21); C433(0.97)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C430(1.86); C434(1.86); C433(1.33)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C430(1.69); C434(1.69); C433(1.28)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C430(1.45); C434(1.45); C433(1.19)  LDD1092  [3]
 LDCM0468  Fragment33 HCT 116 C430(0.96); C433(0.96); C434(0.96)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C430(1.22); C434(1.22); C433(1.22)  LDD1025  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 CC-LP-1 C630(1.35)  LDD2298  [10]
 LDCM0023  KB03 CC-LP-1 C630(1.55)  LDD2715  [10]
 LDCM0024  KB05 SG231 C630(2.48)  LDD3418  [10]
 LDCM0021  THZ1 HCT 116 C430(1.00); C433(1.00); C434(1.00)  LDD2173  [3]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840