Details of the Target
General Information of Target
| Target ID | LDTP02084 | |||||
|---|---|---|---|---|---|---|
| Target Name | Plasminogen activator inhibitor 2 (SERPINB2) | |||||
| Gene Name | SERPINB2 | |||||
| Gene ID | 5055 | |||||
| Synonyms |
PAI2; PLANH2; Plasminogen activator inhibitor 2; PAI-2; Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor |
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| 3D Structure | ||||||
| Sequence |
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF
NEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGN YLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGK IPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREK LNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKM AEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMV DVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP |
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| Target Bioclass |
Other
|
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| Family |
Serpin family, Ov-serpin subfamily
|
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| Subcellular location |
Cytoplasm
|
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| Function | Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
P1 Probe Info |
 |
1.73 | LDD0448 | [1] | |
|
P2 Probe Info |
 |
2.70 | LDD0449 | [1] | |
|
P3 Probe Info |
 |
4.04 | LDD0450 | [1] | |
|
BTD Probe Info |
 |
C145(0.02) | LDD2096 | [2] | |
|
IPM Probe Info |
 |
C79(4.84); C405(1.56); C161(1.49) | LDD1701 | [2] | |
|
DBIA Probe Info |
 |
C79(1.07) | LDD0078 | [3] | |
|
MPP-AC Probe Info |
 |
N.A. | LDD0428 | [4] | |
|
TPP-AC Probe Info |
 |
N.A. | LDD0427 | [4] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
VE-P Probe Info |
 |
N.A. | LDD0396 | [5] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0020 | ARS-1620 | HCC44 | C79(1.07) | LDD0078 | [3] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C405(0.84); C161(0.82) | LDD1702 | [2] |
| LDCM0022 | KB02 | 42-MG-BA | C79(1.48) | LDD2244 | [6] |
| LDCM0023 | KB03 | MDA-MB-231 | C79(4.84); C405(1.56); C161(1.49) | LDD1701 | [2] |
| LDCM0024 | KB05 | Hs 936.T | C161(2.72) | LDD3313 | [6] |
| LDCM0503 | Nucleophilic fragment 14b | MDA-MB-231 | C145(0.02) | LDD2096 | [2] |
| LDCM0525 | Nucleophilic fragment 25b | MDA-MB-231 | C145(0.18); C161(0.49) | LDD2118 | [2] |
| LDCM0529 | Nucleophilic fragment 27b | MDA-MB-231 | C145(0.04) | LDD2122 | [2] |
| LDCM0531 | Nucleophilic fragment 28b | MDA-MB-231 | C145(0.07) | LDD2124 | [2] |
The Interaction Atlas With This Target
References