Details of the Target
General Information of Target
| Target ID | LDTP14866 | |||||
|---|---|---|---|---|---|---|
| Target Name | Adipogenesis regulatory factor (ADIRF) | |||||
| Gene Name | ADIRF | |||||
| Gene ID | 10974 | |||||
| Synonyms |
AFRO; APM2; C10orf116; Adipogenesis regulatory factor; Adipogenesis factor rich in obesity; Adipose most abundant gene transcript 2 protein; Adipose-specific protein 2; apM-2 |
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| 3D Structure | ||||||
| Sequence |
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVL
KPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTP FVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKA KKMIAASWVFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLII LFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHP HEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTI TTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV |
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| Target Bioclass |
Other
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| Subcellular location |
Nucleus
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| Function |
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
P2 Probe Info |
 |
10.00 | LDD0449 | [1] | |
|
P8 Probe Info |
 |
10.00 | LDD0451 | [1] | |
|
STPyne Probe Info |
 |
K70(10.00); K71(5.22) | LDD0277 | [2] | |
The Interaction Atlas With This Target
References