Details of the Target

General Information of Target

Target ID LDTP16118
Target Name Arginine and glutamate-rich protein 1 (ARGLU1)
Gene Name ARGLU1
Gene ID 55082
Synonyms
Arginine and glutamate-rich protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAGVAAGRQAEDVLPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREE
ENYSFLPLVHNIIKCMDKDSPEVHQDLNALKSKFQEMRKLISTMPGIHLSPEQQQQQLQS
LREQVRTKNELLQKYKSLCMFEIPKE
Target Bioclass
Other
Family
UPF0430 family
Subcellular location
Nucleus
Function Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.
Uniprot ID
Q9NWB6
Ensemble ID
ENST00000400198.8
HGNC ID
HGNC:25482

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC44 SNV: p.E73G .
HEC1B SNV: p.R166C .
JURKAT SNV: p.A213T .
SKMEL30 SNV: p.K106Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		2.23  LDD0449  [1]
C-Sul
 Probe Info  		8.04  LDD0066  [2]
STPyne
 Probe Info  		K260(2.44)  LDD0277  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.