Details of the Target

General Information of Target

Target ID LDTP05975
Target Name Laminin subunit gamma-2 (LAMC2)
Gene Name LAMC2
Gene ID 3918
Synonyms
LAMB2T; LAMNB2; Laminin subunit gamma-2; Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPALWLGCCLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNT
DGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGF
HMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGN
PEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVF
SSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPL
MPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYI
DNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQG
GGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVV
CNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLK
CIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGP
NCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQAL
QDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTH
RLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTR
ETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIE
ADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLG
NWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDL
QVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSE
IEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITE
AQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQINSQLRP
MMSELEERARQQRGHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
TTD ID
T75613
Uniprot ID
Q13753
DrugMap ID
TTNS7H3
Ensemble ID
ENST00000264144.5
HGNC ID
HGNC:6493
ChEMBL ID
CHEMBL2364187

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.D784N .
CAL51 SNV: p.N85D DBIA    Probe Info 
HLF SNV: p.P577L .
JURKAT SNV: p.G802R .
MDAMB453 SNV: p.Q1005H .
NB1 SNV: p.Y265C .
OPM2 SNV: p.N451D .
OVK18 SNV: p.S580T .
PATU8988T SNV: p.V817L .
TKKK SNV: p.R80L .
UACC62 SNV: p.P595L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [1]
P8
 Probe Info  		10.00  LDD0451  [1]
DBIA
 Probe Info  		C575(1.49); C585(1.49); C81(0.96); C84(0.96)  LDD0078  [2]
IA-alkyne
 Probe Info  		C37(0.00); C541(0.00); C116(0.00); C393(0.00)  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C309(1.03)  LDD1507  [4]
 LDCM0215  AC10 HCT 116 C309(1.24)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C309(0.71); C609(1.13); C612(1.13)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C309(0.74); C609(1.13); C612(1.13)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C309(0.75); C609(1.04); C612(1.04)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C309(0.82); C609(1.36); C612(1.36)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C309(0.80); C609(0.97); C612(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C309(0.79); C609(1.39); C612(1.39)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C309(0.77); C609(1.57); C612(1.57)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C309(0.92); C609(1.14); C612(1.14)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C309(0.72); C609(1.08); C612(1.08)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C309(0.63); C609(0.95); C612(0.95)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C309(0.83)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C309(0.66); C609(1.16); C612(1.16)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C309(0.66); C609(1.35); C612(1.35)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C309(0.77); C609(1.32); C612(1.32)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C309(0.76); C609(0.95); C612(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C309(0.79); C609(0.97); C612(1.07)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C309(0.84); C609(0.91); C612(0.91)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C309(0.82); C609(1.16); C612(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C309(0.87); C609(0.88); C612(0.96)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C309(0.89); C609(0.97); C612(0.91)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C309(0.92); C609(1.24); C612(0.84)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C309(1.11)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C309(0.75); C609(0.99); C612(0.85)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C309(0.83); C609(0.78); C612(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C309(0.81); C609(0.94); C612(0.83)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C309(0.85); C609(0.88); C612(0.99)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C309(0.93); C609(0.91); C612(0.93)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C309(0.85); C609(1.04); C612(0.89)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C309(0.90); C609(1.20); C612(0.91)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C309(0.96); C609(1.10); C612(1.04)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C609(0.90); C612(0.90)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C609(0.78); C612(0.78)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C609(0.89); C612(0.89)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C609(1.01); C612(1.01)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C609(0.87); C612(0.87)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C609(0.82); C612(0.82)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C609(1.18); C612(1.18)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C609(1.00); C612(1.00)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C609(1.20); C612(1.20)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C609(1.13); C612(1.13)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C609(1.23); C612(1.23)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C609(1.19); C612(1.19)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C309(0.92)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C609(1.24); C612(1.24)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C609(1.60); C612(1.60)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C609(0.94); C612(0.94)  LDD0579  [2]
 LDCM0270  AC15 HCT 116 C309(1.09)  LDD0587  [2]
 LDCM0276  AC17 HEK-293T C309(1.01)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C309(1.00)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C309(1.12)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C309(0.99)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C309(0.95)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C309(1.01)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C309(1.00)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C309(0.97)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C309(0.98)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C609(0.77); C612(0.77); C309(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C609(0.74); C612(0.74); C309(1.07)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C609(0.96); C612(0.96); C309(1.15)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C609(0.73); C612(0.73); C309(1.44)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C609(1.03); C612(1.03); C309(1.09)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C309(0.95)  LDD1529  [4]
 LDCM0291  AC30 HCT 116 C609(1.13); C612(1.13); C309(1.37)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C609(0.87); C612(0.87); C309(1.05)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C609(1.04); C612(1.04); C309(1.16)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C609(0.95); C612(0.95); C309(1.06)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C309(0.99); C609(1.24); C612(1.24)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C309(0.93)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C309(0.96)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C309(0.97)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C309(0.91)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C309(0.98)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C309(0.94)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C309(1.08)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C309(1.02)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C309(1.06)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C309(0.94)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C309(0.95)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C309(0.96)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C309(1.21)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C309(1.07)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C309(0.95)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C309(1.05)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C309(1.00)  LDD1551  [4]
 LDCM0313  AC50 HCT 116 C309(1.15)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C309(1.00)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C309(1.03)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C309(1.11)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C309(1.17)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C309(1.06)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C309(1.17)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C609(1.16); C612(1.16)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C609(1.27); C612(1.27)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C609(1.18); C612(1.18)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C309(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C609(1.26); C612(1.26)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C609(1.04); C612(1.04)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C609(1.50); C612(1.50)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C609(1.46); C612(1.46)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C609(1.46); C612(1.46)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C609(1.23); C612(1.23)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C609(1.40); C612(1.40)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C609(1.31); C612(1.31)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C309(0.89)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C309(0.86)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C309(1.20)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C309(0.92)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C309(0.90)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C309(0.79)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C309(0.94)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C309(0.93)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C309(0.77)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C309(0.87)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C309(0.84)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C309(0.88)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C309(0.90)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C309(0.94)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C309(0.92)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C309(0.89)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C309(0.79)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C609(1.76); C612(1.76)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C609(1.73); C612(1.73)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C609(1.46); C612(1.46)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C609(1.44); C612(1.44)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C609(1.23); C612(1.23)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C609(1.64); C612(1.64)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C609(1.49); C612(1.49)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C609(1.22); C612(1.22)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C609(1.63); C612(1.63)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C609(1.63); C612(1.63)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C609(1.29); C612(1.29)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C609(1.40); C612(1.40)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C609(1.37); C612(1.37)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C609(1.42); C612(1.42)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C609(1.61); C612(1.61)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C309(1.08); C609(1.32); C612(1.32)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C309(0.68); C609(1.05); C612(1.05)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C309(1.31)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C309(0.97)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C309(1.10)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C575(1.49); C585(1.49); C81(0.96); C84(0.96)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C309(1.28)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C309(1.79)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C309(1.03)  LDD1573  [4]
 LDCM0370  CL101 HCT 116 C309(0.96)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C309(0.91)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C309(0.88)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C309(1.20)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C309(1.07)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C309(0.95)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C309(0.92)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C309(0.99)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C309(1.07)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C309(1.27)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C309(1.29)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C309(1.12)  LDD1585  [4]
 LDCM0382  CL112 HCT 116 C609(0.85); C612(0.85); C309(1.13)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C309(0.92); C609(1.27); C612(1.27)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C309(0.90); C609(1.26); C612(1.26)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C309(1.24); C609(1.39); C612(1.39)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C309(0.95); C609(1.02); C612(1.02)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C309(1.11)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C309(1.03)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C309(0.94)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C309(1.17)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C309(1.03)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C309(0.91)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C309(1.05)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C309(1.06)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C309(1.07)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C609(1.25); C612(1.25)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C609(1.25); C612(1.25)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C609(1.31); C612(1.31)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C609(0.97); C612(0.97)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C309(1.10)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C309(0.92)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C309(1.67)  LDD1606  [4]
 LDCM0403  CL16 HCT 116 C612(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C612(0.75)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C612(0.82)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C612(0.92)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C309(1.00)  LDD1611  [4]
 LDCM0408  CL20 HCT 116 C612(0.85)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C612(0.76)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C612(0.93)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C612(1.07)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C612(0.79)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C612(1.01)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C612(1.13)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C612(0.75)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C612(0.91)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C612(0.92)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C309(1.01)  LDD1622  [4]
 LDCM0419  CL30 HCT 116 C612(0.71)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C309(1.04)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C309(0.99)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C309(1.61)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C309(1.12)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C309(1.13)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C309(1.33)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C309(1.13)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C309(0.99)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C309(1.24)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C309(0.99)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C309(1.11)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C309(1.04)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C309(1.00)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C309(0.91)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C309(0.79)  LDD1639  [4]
 LDCM0436  CL46 HCT 116 C609(1.17); C612(1.17)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C609(1.05); C612(1.05)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C609(1.08); C612(1.08)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C609(1.05); C612(1.05)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C309(1.08)  LDD1644  [4]
 LDCM0441  CL50 HCT 116 C609(1.20); C612(1.20)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C609(1.06); C612(1.06)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C609(1.34); C612(1.34)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C609(1.34); C612(1.34)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C609(1.27); C612(1.27)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C609(1.14); C612(1.14)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C609(1.04); C612(1.04)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C609(1.10); C612(1.10)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C609(1.43); C612(1.43)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C609(1.09); C612(1.09)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C309(1.29)  LDD1654  [4]
 LDCM0452  CL60 HCT 116 C609(1.36); C612(1.36)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C309(1.02)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C309(0.97)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C309(0.93)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C309(1.28)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C309(1.01)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C309(1.13)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C309(0.90)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C309(1.02)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C309(1.30)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C309(0.97)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C309(0.98)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C309(1.16)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C309(1.09)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C309(1.21)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C309(1.00)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C309(1.00)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C309(1.31)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C309(0.98)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C309(0.94)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C309(2.83)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C309(0.93)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C309(1.02)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C309(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C309(1.21)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C309(1.23)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C309(1.04)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C309(1.09)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C309(1.05)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C309(1.02)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C309(1.03)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C309(1.17)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C309(3.79)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C309(0.98)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C309(1.38)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C309(1.28)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C309(1.17)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C309(1.85)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C309(1.16)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C309(1.25)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C309(1.15)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C309(1.02)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C309(0.98)  LDD1698  [4]
 LDCM0625  F8 Ramos C309(1.51)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C309(3.10)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C309(0.35)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C309(14.69)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C309(0.78)  LDD2192  [5]
 LDCM0579  Fragment20 Ramos C309(11.82)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C309(1.40)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C309(0.94)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C309(0.77)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C309(0.50)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C309(1.23)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C309(1.29)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C309(14.71)  LDD2201  [5]
 LDCM0468  Fragment33 HEK-293T C309(0.97)  LDD1671  [4]
 LDCM0596  Fragment38 Ramos C309(1.63)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C309(2.34)  LDD2184  [5]
 LDCM0427  Fragment51 HEK-293T C309(1.00)  LDD1631  [4]
 LDCM0610  Fragment52 Ramos C309(0.65)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C309(0.47)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C309(6.44)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C309(6.72)  LDD2188  [5]
 LDCM0022  KB02 HEK-293T C309(0.82)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C309(0.89)  LDD1497  [4]
 LDCM0024  KB05 MEWO C309(1.66)  LDD3319  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bst-1005 Antibody D08DSC

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840