Details of the Target

General Information of Target

Target ID LDTP06387
Target Name Splicing factor 3A subunit 2 (SF3A2)
Gene Name SF3A2
Gene ID 8175
Synonyms
SAP62; Splicing factor 3A subunit 2; SF3a66; Spliceosome-associated protein 62; SAP 62
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVT
KQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIA
FKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNG
LPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG
VHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPP
APGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG
VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
Target Bioclass
Other
Family
SF3A2 family
Subcellular location
Nucleus
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.
Uniprot ID
Q15428
Ensemble ID
ENST00000221494.10
HGNC ID
HGNC:10766

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		2.03  LDD0449  [1]
TH211
 Probe Info  		Y54(20.00)  LDD0260  [2]
C-Sul
 Probe Info  		8.90  LDD0066  [3]
STPyne
 Probe Info  		K118(10.00); K77(3.42)  LDD0277  [4]
ONAyne
 Probe Info  		K10(5.00); K118(8.33)  LDD0275  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
Probe 1
 Probe Info  		Y45(20.76); Y155(89.38)  LDD3495  [6]
DBIA
 Probe Info  		C59(1.58)  LDD3314  [7]
BTD
 Probe Info  		C56(1.93)  LDD2093  [8]
AHL-Pu-1
 Probe Info  		C56(2.02)  LDD0172  [9]
HHS-475
 Probe Info  		Y155(0.69); Y54(0.94); Y45(1.05)  LDD0264  [10]
HHS-465
 Probe Info  		Y155(10.00)  LDD2237  [11]
ATP probe
 Probe Info  		K76(0.00); K77(0.00); K10(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C59(0.00); C56(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C59(0.00); C56(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C59(0.00); C56(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
ENE
 Probe Info  		N.A.  LDD0006  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
1c-yne
 Probe Info  		K10(0.00); K91(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		H50(0.00); C56(0.00)  LDD0217  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [20]
HHS-482
 Probe Info  		Y155(0.66)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C59(1.15)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C59(1.40); C56(1.24)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C56(1.45)  LDD2152  [8]
 LDCM0025  4SU-RNA HEK-293T C56(2.02)  LDD0172  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C56(2.30)  LDD0173  [9]
 LDCM0214  AC1 HEK-293T C59(0.78)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C59(0.96)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C59(0.98)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C59(0.92)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C59(1.25)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C59(1.05)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C59(0.75)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C59(0.97)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C59(0.80)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C59(1.12)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C59(1.07)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C59(0.99)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C59(0.98)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C59(1.11)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C59(1.20)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C59(0.63)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C59(1.18)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C59(0.98)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C59(0.85)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C59(1.20)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C59(0.94)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C59(1.12)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C59(1.77)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C59(1.20)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C59(0.60)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C59(1.08)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C59(0.96)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C59(0.75)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C59(1.39)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C59(1.02)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C59(1.17)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C59(0.82)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C59(1.15)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C59(1.07)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C59(0.90)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C59(0.99)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C59(0.78)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C59(0.99)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C59(1.05)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C59(1.32)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C59(0.93)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C59(1.02)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C59(1.24)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C59(1.01)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C59(1.06)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C59(0.82)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C59(0.99)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C59(0.97)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C59(1.21)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C59(0.80)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C59(0.73)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C59(0.96)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C59(0.93)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C59(0.86)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C59(0.89)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C59(1.12)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C59(0.87)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C59(1.01)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C59(0.87)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C59(1.10)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C59(1.13)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C59(0.95)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C59(0.65)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C59(1.04)  LDD1514  [22]
 LDCM0108  Chloroacetamide HeLa C56(0.00); H50(0.00)  LDD0222  [19]
 LDCM0367  CL1 HEK-293T C59(1.00)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C59(0.83)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C59(0.97)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C59(0.96)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C59(1.10)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C59(0.93)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C59(0.87)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C59(0.88)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C59(1.23)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C59(0.84)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C59(0.95)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C59(1.40)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C59(1.18)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C59(0.98)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C59(1.05)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C59(0.99)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C59(0.98)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C59(1.65)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C59(0.83)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C59(1.01)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C59(0.88)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C59(0.86)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C59(0.84)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C59(1.12)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C59(1.21)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C59(0.89)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C59(1.10)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C59(0.95)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C59(1.13)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C59(0.85)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C59(0.86)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C59(0.76)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C59(0.99)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C59(1.02)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C59(1.04)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C59(0.72)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C59(1.01)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C59(0.56)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C59(0.91)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C59(1.04)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C59(0.79)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C59(1.08)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C59(1.06)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C59(0.89)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C59(1.11)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C59(1.21)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C59(0.78)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C59(1.06)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C59(0.86)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C59(1.18)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C59(0.99)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C59(0.84)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C59(1.20)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C59(0.59)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C59(0.89)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C59(0.93)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C59(0.95)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C59(1.14)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C59(1.18)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C59(1.10)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C59(0.85)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C59(0.85)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C59(1.13)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C59(0.82)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C59(0.89)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C59(0.96)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C59(0.83)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C59(0.97)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C59(1.17)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C59(1.40)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C59(0.98)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C59(1.06)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C59(0.81)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C59(0.98)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C59(0.96)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C59(0.65)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C59(0.88)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C59(1.06)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C59(1.03)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C59(1.07)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C59(0.87)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C59(0.83)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C59(0.83)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C59(1.01)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C59(1.00)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C59(0.82)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C59(0.86)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C59(1.08)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C59(0.68)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C59(0.95)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C59(1.05)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C59(1.03)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C59(1.01)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C59(0.96)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C59(0.94)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C59(0.99)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C59(1.18)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C59(0.87)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C59(0.97)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C59(1.08)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C59(0.72)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C59(0.96)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C59(1.12)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C59(0.83)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C59(0.79)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C59(0.93)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C59(0.85)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C59(1.11)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C59(0.93)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C59(0.72)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C59(0.72)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C59(0.90)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C59(1.18)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C59(0.64)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C59(0.93)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C59(0.92)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C59(1.02)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C59(0.83)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C59(1.12)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C59(1.09)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C59(0.92)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C59(0.82)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C59(0.90)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C59(0.88)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C59(0.80)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C59(0.89)  LDD1698  [22]
 LDCM0625  F8 Ramos C56(1.58)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C56(0.51)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C56(1.40)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C56(0.56)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C56(0.76)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C56(1.10)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C56(0.69)  LDD2195  [23]
 LDCM0578  Fragment27 Ramos C56(0.63)  LDD2197  [23]
 LDCM0588  Fragment30 Ramos C56(0.95)  LDD2199  [23]
 LDCM0590  Fragment32 Ramos C56(0.71)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C59(0.75)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C56(1.92)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C56(0.72)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C59(1.16)  LDD1631  [22]
 LDCM0569  Fragment7 Ramos C56(1.46)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C56(0.51)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y155(0.69); Y54(0.94); Y45(1.05)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y54(0.69); Y45(0.70); Y155(0.73)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y155(0.70); Y54(0.77); Y45(1.99)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y155(0.76); Y54(0.96); Y45(1.78)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y155(0.66); Y54(1.82); Y45(2.53)  LDD0268  [10]
 LDCM0107  IAA HeLa H50(0.00); C56(0.00)  LDD0221  [19]
 LDCM0022  KB02 Ramos C56(0.83)  LDD2182  [23]
 LDCM0023  KB03 Ramos C56(1.22)  LDD2183  [23]
 LDCM0024  KB05 IGR37 C59(1.58)  LDD3314  [7]
 LDCM0109  NEM HeLa H50(0.00); K10(0.00)  LDD0223  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C56(1.93)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C59(1.39)  LDD2094  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C59(0.76)  LDD2100  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C59(0.59)  LDD2114  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C59(1.75); C56(1.79)  LDD2119  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C59(1.40); C56(1.46)  LDD2123  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C59(1.65)  LDD2129  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C59(0.80)  LDD2134  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C56(1.12)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C59(0.82); C56(1.14)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C56(0.86)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C56(0.58)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C56(1.84)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C56(1.35)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C59(1.28)  LDD2147  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C59(0.28)  LDD2150  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DHX15 (DHX15) DEAD box helicase family O43143
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
PHD finger-like domain-containing protein 5A (PHF5A) PHF5 family Q7RTV0
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 1 (SF1) BBP/SF1 family Q15637
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein lin-54 homolog (LIN54) Lin-54 family Q6MZP7
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Small nuclear ribonucleoprotein E (SNRPE) SnRNP Sm proteins family P62304
Small nuclear ribonucleoprotein F (SNRPF) SnRNP Sm proteins family P62306
U2 small nuclear ribonucleoprotein A' (SNRPA1) U2 small nuclear ribonucleoprotein A family P09661
BEN domain-containing protein 2 (BEND2) . Q8NDZ0
Cytoplasmic protein NCK2 (NCK2) . O43639
Protein TFG (TFG) . Q92734
Splicing factor 3A subunit 1 (SF3A1) . Q15459
Splicing factor 45 (RBM17) . Q96I25

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578