Details of the Target

General Information of Target

Target ID LDTP03864
Target Name Small ribosomal subunit protein eS19 (RPS19)
Gene Name RPS19
Gene ID 6223
Synonyms
Small ribosomal subunit protein eS19; 40S ribosomal protein S19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAAST
ARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGG
RKLTPQGQRDLDRIAGQVAAANKKH
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS19 family
Subcellular location
Cytoplasm
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
P39019
Ensemble ID
ENST00000593863.5
HGNC ID
HGNC:10402

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
P8
 Probe Info  		10.00  LDD0451  [1]
A-EBA
 Probe Info  		2.75  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
C-Sul
 Probe Info  		7.59  LDD0066  [4]
TH211
 Probe Info  		Y48(13.13); Y54(10.67)  LDD0257  [5]
TH214
 Probe Info  		Y54(20.00)  LDD0258  [5]
TH216
 Probe Info  		Y48(20.00); Y54(10.32)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
AZ-9
 Probe Info  		E13(10.00)  LDD2208  [7]
ONAyne
 Probe Info  		K97(0.00); K143(0.00); K122(0.00); K111(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K43(0.56); K97(1.48); K144(1.76); K143(1.76)  LDD3494  [9]
Probe 1
 Probe Info  		Y48(15.82)  LDD3495  [10]
HHS-482
 Probe Info  		Y48(0.96)  LDD0285  [11]
HHS-475
 Probe Info  		Y54(1.99)  LDD0264  [12]
HHS-465
 Probe Info  		Y48(10.00)  LDD2237  [13]
Acrolein
 Probe Info  		H42(0.00); H91(0.00)  LDD0222  [14]
AMP probe
 Probe Info  		K143(0.00); K144(0.00)  LDD0200  [15]
ATP probe
 Probe Info  		K143(0.00); K144(0.00); K122(0.00); K23(0.00)  LDD0199  [15]
ATP probe
 Probe Info  		K115(0.00); K43(0.00); K111(0.00); K29(0.00)  LDD0035  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
NHS
 Probe Info  		K111(0.00); K29(0.00)  LDD0010  [18]
SF
 Probe Info  		Y48(0.00); K143(0.00); K23(0.00); K122(0.00)  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
Ox-W18
 Probe Info  		W33(0.00); W52(0.00)  LDD2175  [20]
1c-yne
 Probe Info  		K43(0.00); K7(0.00)  LDD0228  [17]
W1
 Probe Info  		N.A.  LDD0236  [21]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H42(0.00); H91(0.00)  LDD0222  [14]
 LDCM0116  HHS-0101 DM93 Y54(1.99)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y54(10.68)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y54(1.10)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y54(1.60)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y54(1.21)  LDD0268  [12]
 LDCM0123  JWB131 DM93 Y48(0.96)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y48(0.51)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y48(1.71)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y48(2.02)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y48(3.05)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y48(0.97)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y48(0.19)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y48(0.87)  LDD0292  [11]
 LDCM0109  NEM HeLa H42(0.00); H91(0.00)  LDD0223  [14]
 LDCM0110  W12 Hep-G2 N10(0.88); D8(0.93)  LDD0237  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Serine/threonine-protein kinase pim-1 (PIM1) CAMK Ser/Thr protein kinase family P11309
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.