Details of the Target

General Information of Target

Target ID LDTP02831
Target Name Carbonyl reductase [NADPH] 1 (CBR1)
Gene Name CBR1
Gene ID 873
Synonyms
CBR; CRN; SDR21C1; Carbonyl reductase [NADPH] 1; EC 1.1.1.184; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; EC 1.1.1.196, EC 1.1.1.197; 20-beta-hydroxysteroid dehydrogenase; Alcohol dehydrogenase [NAD(P)+] CBR1; EC 1.1.1.71; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; PG-9-KR; Prostaglandin-E(2) 9-reductase; EC 1.1.1.189; Short chain dehydrogenase/reductase family 21C member 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Cytoplasm
Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
TTD ID
T70518
Uniprot ID
P16152
DrugMap ID
TTVG0SN
Ensemble ID
ENST00000290349.11
HGNC ID
HGNC:1548
ChEMBL ID
CHEMBL5586

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.R74S .
OVK18 SNV: p.M111K .
RT112 SNV: p.T202A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K148(1.34); K157(4.32); K181(9.25); K186(5.13)  LDD0277  [2]
m-APA
 Probe Info  		9.19  LDD0403  [3]
BTD
 Probe Info  		C150(2.27)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C150(2.18)  LDD0168  [5]
HHS-482
 Probe Info  		Y194(1.39)  LDD0285  [6]
HHS-475
 Probe Info  		Y253(0.89)  LDD0264  [7]
DBIA
 Probe Info  		C227(1.63); C226(1.09)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K239(0.00); K242(0.00); K186(0.00); K148(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		C150(0.00); C122(0.00)  LDD0032  [11]
ATP probe
 Probe Info  		K15(0.00); K130(0.00)  LDD0035  [12]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		C227(0.00); C150(0.00); C226(0.00); C122(0.00)  LDD0026  [13]
TFBX
 Probe Info  		C122(0.00); C150(0.00)  LDD0027  [13]
WYneC
 Probe Info  		N.A.  LDD0014  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
Phosphinate-6
 Probe Info  		C150(0.00); C227(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		C150(0.00); C122(0.00); C226(0.00); C227(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		C226(0.00); C227(0.00); C150(0.00)  LDD0218  [17]
W1
 Probe Info  		C227(0.00); C226(0.00)  LDD0236  [18]
NAIA_5
 Probe Info  		C150(0.00); C122(0.00); C227(0.00); C226(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0071  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C150(0.54)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C150(0.93)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C150(0.50)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C150(0.96)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C150(1.03)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C150(1.53)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C150(0.87)  LDD2132  [4]
 LDCM0025  4SU-RNA HEK-293T C150(2.18)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C150(8.06)  LDD0372  [5]
 LDCM0214  AC1 HEK-293T C227(2.71); C226(5.49); C150(1.19)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C227(0.77); C226(1.04)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C227(2.27); C226(1.55)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C227(5.13); C226(2.24)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C227(12.90); C226(4.56)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C227(8.90); C226(3.79)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C227(4.29); C226(2.26)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C227(1.16); C226(0.98)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C227(1.71); C226(1.00)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C227(1.14); C226(1.03)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C227(1.37); C226(1.06)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C227(2.17); C226(1.47)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C227(2.06); C226(1.50)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C227(9.51); C226(3.68)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C227(1.47); C226(1.82)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C227(1.28); C226(1.50)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C227(1.87); C226(1.04); C150(0.89)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C227(3.15); C226(0.96); C150(0.94)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C227(0.81); C226(0.94); C150(0.85)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C227(1.64); C226(1.35); C150(0.96)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C227(1.12); C226(1.42); C150(1.41)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C227(1.71); C226(1.44); C150(1.39)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C227(2.36); C226(1.50); C150(1.46)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C227(1.72); C226(1.36)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C227(1.01); C226(1.30); C150(1.26)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C227(1.33); C226(1.51); C150(1.20)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C227(1.55); C226(1.82); C150(1.48)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C227(1.92); C226(1.81); C150(1.87)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C227(1.51); C226(1.42); C150(1.50)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C227(1.58); C226(1.72); C150(1.80)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C227(3.59); C226(2.22); C150(2.67)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C227(2.47); C226(2.94); C150(2.90)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C227(2.25); C226(0.87); C150(0.85)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C227(1.92); C226(1.32); C150(1.10)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C227(3.44); C226(1.13); C150(1.27)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C227(1.77); C226(0.95); C150(1.14)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C227(1.22); C226(1.08); C150(1.00)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C227(4.37); C226(1.36); C150(1.56)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C227(7.43); C226(1.22); C150(1.33)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C227(4.49); C226(1.27); C150(1.39)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C227(0.89); C226(1.34); C150(1.40)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C227(1.51); C226(1.70); C150(1.99)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C227(8.13); C226(2.08); C150(2.87)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C227(9.65); C226(1.63); C150(1.96)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C227(2.79); C226(2.07)  LDD0857  [8]
 LDCM0260  AC140 HEK-293T C227(4.24); C226(1.31); C150(1.14)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C227(1.36); C226(1.61); C150(1.61)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C227(2.86); C226(1.35); C150(1.47)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C227(2.07); C226(1.82); C150(1.19)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C227(14.90); C226(1.52); C150(1.68)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C227(4.14); C226(2.90); C150(1.51)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C227(9.08); C226(5.96); C150(1.62)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C227(3.85); C226(2.95); C150(1.95)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C227(7.05); C226(4.83); C150(1.19)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C227(2.97); C226(2.29); C150(1.06)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C227(0.94); C226(1.30)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C227(1.76); C226(1.50); C150(1.35)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C227(3.60); C226(2.28); C150(1.35)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C227(2.35); C226(1.92); C150(1.25)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C227(1.90); C226(1.68); C150(1.47)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C227(3.95); C226(2.73); C150(1.09)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C227(1.67); C226(1.39); C150(1.20)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C227(1.32); C226(1.59); C150(1.75)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C227(3.06); C226(2.87); C150(2.13)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C227(6.97); C226(4.38); C150(1.72)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C227(1.19); C226(1.25); C150(1.41)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C227(0.75); C226(1.07); C150(1.22)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C227(3.35); C226(6.90); C150(1.22)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C227(1.48); C226(1.70); C150(1.41)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C227(1.72); C226(1.49); C150(1.40)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C227(8.39); C226(4.93); C150(1.38)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C227(2.40); C226(2.31); C150(1.45)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C227(3.15); C226(2.11); C150(1.26)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C226(1.21)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C226(1.40)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C226(1.52)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C226(1.26)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C226(1.23)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C227(2.20); C226(4.43); C150(1.01)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C226(1.30)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C226(0.96)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C226(1.16)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C226(1.33)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C226(1.21)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C227(12.60); C226(18.40); C150(0.83)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C227(2.26); C226(2.60); C150(0.99)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C227(9.61); C226(14.00); C150(1.07)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C227(11.30); C226(17.10); C150(1.00)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C227(1.22); C226(1.18); C150(0.95)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C227(1.36); C226(2.13); C150(1.01)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C227(1.74); C226(1.74); C150(1.11)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C227(2.74); C226(3.11); C150(1.12)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C227(1.70); C226(1.92); C150(1.07)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C227(2.52); C226(2.67); C150(1.25)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C227(1.78); C226(1.73); C150(1.24)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C227(4.95); C226(6.92); C150(1.14)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C227(1.31); C226(1.19); C150(1.09)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C227(6.71); C226(0.87); C150(2.09)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C227(1.29); C226(1.29); C150(1.69)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C227(3.67); C226(3.23); C150(1.60)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C227(1.60); C226(2.67); C150(1.32)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C227(1.81); C226(1.81); C150(1.40)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C227(3.43); C226(3.08); C150(1.32)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C227(1.18); C226(1.06); C150(1.81)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C227(2.20); C226(2.22); C150(1.07)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C227(1.32); C226(1.25); C150(1.51)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C227(3.73); C226(3.23); C150(1.40)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C227(4.92); C226(4.91); C150(1.44)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C227(1.05); C226(1.05)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C227(1.05); C226(1.14)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C227(1.00); C226(0.95)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C227(1.06); C226(0.96)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C227(1.21); C226(1.35)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C227(1.34); C226(1.42)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C227(2.05); C226(1.87)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C227(1.66); C226(1.48)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C227(1.14); C226(1.36)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C227(2.06); C226(1.94)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C227(2.40); C226(2.08)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C227(1.88); C226(1.47)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C227(3.11); C226(3.01); C150(0.98)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C227(3.40); C226(3.98); C150(1.06)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C227(1.27); C226(1.22)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C227(1.59); C226(1.56); C150(1.28)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C227(2.25); C226(2.78); C150(1.24)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C227(1.24); C226(1.27); C150(1.21)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C227(1.45); C226(1.75); C150(1.42)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C227(2.42); C226(2.62); C150(1.31)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C227(2.01); C226(3.12); C150(1.49)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C227(2.45); C226(2.48); C150(1.12)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C227(2.18); C226(2.22); C150(1.22)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C227(1.06); C226(1.09); C150(1.45)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C227(1.35); C226(1.10); C150(1.06)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C227(1.52); C226(1.65)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C227(1.45); C226(1.59); C150(1.48)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C227(1.93); C226(1.94); C150(1.22)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C227(2.61); C226(2.80); C150(2.08)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C227(1.27); C226(1.31); C150(1.15)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C227(3.80); C226(3.08); C150(1.60)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C227(1.62); C226(4.26); C150(1.46)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C227(3.06); C226(2.30); C150(1.31)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C227(3.08); C226(2.64); C150(1.39)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C227(2.24); C226(2.09); C150(1.60)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C227(1.35); C226(1.33); C150(2.75)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C227(2.70); C226(2.49); C150(1.80)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C227(1.45); C226(1.52); C150(1.48)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C227(1.37); C226(1.46); C150(1.31)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C227(1.67); C226(1.72); C150(1.92)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C227(1.46); C226(1.48); C150(1.66)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C227(1.75); C226(1.57); C150(1.56)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C227(2.45); C226(2.03); C150(1.94)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C227(2.33); C226(2.28); C150(1.80)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C227(3.63); C226(1.85)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C227(8.70); C226(3.23)  LDD0964  [8]
 LDCM0545  Acetamide MDA-MB-231 C150(0.71)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C150(0.75)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C227(5.75); C226(3.44)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C227(2.71); C226(2.09)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C227(0.94); C226(1.21)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 9.19  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C227(1.63); C226(1.09)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C150(0.73)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C122(0.00); C226(0.00); C227(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C122(1.41)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C227(0.95); C226(1.11); C150(1.63)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C227(1.13); C226(2.24); C150(5.18)  LDD0966  [8]
 LDCM0369  CL100 HEK-293T C227(1.00); C226(1.09); C150(1.43)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C227(0.88); C226(2.19)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C227(0.96); C226(1.11)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C227(1.08); C226(1.26)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C227(0.96); C226(2.32)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C227(0.83); C226(2.21); C150(1.13)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C227(0.86); C226(1.74); C150(1.05)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C227(0.81); C226(0.91); C150(1.09)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C227(0.88); C226(1.32); C150(1.13)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C227(1.00); C226(2.37); C150(1.23)  LDD0976  [8]
 LDCM0379  CL11 HEK-293T C227(1.00); C226(3.26); C150(2.75)  LDD0977  [8]
 LDCM0380  CL110 HEK-293T C227(0.74); C226(3.14); C150(1.31)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C227(0.85); C226(1.68); C150(1.14)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C226(2.40)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C226(1.15)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C226(1.33)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C226(2.12)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C226(1.61)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C227(0.96); C226(0.90); C150(0.86)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C227(1.16); C226(1.23); C150(1.07)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C227(1.25); C226(1.36); C150(1.17)  LDD0987  [8]
 LDCM0390  CL12 HEK-293T C227(5.45); C226(2.00); C150(1.12)  LDD0988  [8]
 LDCM0391  CL120 HEK-293T C227(1.12); C226(1.14); C150(1.11)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C227(0.95); C226(1.24); C150(1.50)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C227(0.96); C226(1.11); C150(1.47)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C227(1.03); C226(1.76); C150(1.42)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C227(0.96); C226(1.56); C150(2.01)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C227(2.28); C226(1.74)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C227(0.83); C226(1.44)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C227(2.83); C226(1.23)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C227(1.08); C226(1.13)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C227(0.98); C226(1.68); C150(1.23)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C227(0.98); C226(2.41); C150(1.57)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C227(1.07); C226(1.30); C150(1.61)  LDD1000  [8]
 LDCM0403  CL16 HEK-293T C227(0.98); C226(1.10); C150(1.03)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C227(1.22); C226(1.51); C150(1.22)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C227(1.02); C226(1.21); C150(1.06)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C227(1.06); C226(1.27); C150(1.13)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C227(0.92); C226(1.78); C150(1.09)  LDD1005  [8]
 LDCM0408  CL20 HEK-293T C227(1.00); C226(1.15); C150(1.05)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C227(1.20); C226(1.59); C150(1.16)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C227(0.96); C226(1.39); C150(1.05)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C227(1.04); C226(1.16); C150(1.09)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C227(0.96); C226(1.06); C150(1.00)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C227(1.17); C226(3.23); C150(1.21)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C227(0.94); C226(1.13); C150(1.04)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C227(0.90); C226(1.22); C150(1.13)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C227(1.19); C226(1.58); C150(1.10)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C227(0.92); C226(1.05); C150(1.06)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C227(4.69); C226(1.40); C150(1.23)  LDD1016  [8]
 LDCM0419  CL30 HEK-293T C227(1.03); C226(1.25); C150(1.07)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C227(10.70); C226(1.58); C150(1.34)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C227(6.22); C226(1.49); C150(1.44)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C227(16.30); C226(1.02); C150(2.23)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C227(20.00); C226(1.75); C150(1.14)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C227(15.70); C226(1.36); C150(1.28)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C227(15.90); C226(1.70); C150(1.19)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C227(12.60); C226(2.35); C150(1.37)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C227(16.50); C226(3.41); C150(3.40)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C227(4.90); C226(2.12); C150(1.35)  LDD1027  [8]
 LDCM0430  CL40 HEK-293T C227(2.50); C226(1.46); C150(1.33)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C227(10.60); C226(0.83); C150(2.16)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C227(6.18); C226(2.26); C150(1.94)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C227(2.32); C226(2.04); C150(2.10)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C227(2.00); C226(1.32); C150(1.36)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C227(19.50); C226(3.75); C150(2.21)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C227(1.13); C226(1.13); C150(1.04)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C227(1.23); C226(1.39); C150(0.88)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C227(1.15); C226(1.19); C150(0.94)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C227(1.10); C226(1.34); C150(0.98)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C227(1.32); C226(1.27); C150(1.15)  LDD1038  [8]
 LDCM0441  CL50 HEK-293T C227(1.15); C226(4.07); C150(1.07)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C227(1.27); C226(4.71); C150(1.07)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C227(1.12); C226(1.17); C150(0.93)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C227(1.48); C226(4.78); C150(1.01)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C227(1.31); C226(2.01); C150(1.01)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C227(1.17); C226(1.21); C150(0.92)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C227(1.26); C226(1.36); C150(1.03)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C227(1.46); C226(2.34); C150(1.09)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C227(0.86); C226(1.04); C150(0.89)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C227(1.18); C226(1.30); C150(0.96)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C227(5.18); C226(5.38); C150(1.29)  LDD1049  [8]
 LDCM0452  CL60 HEK-293T C227(1.17); C226(1.78); C150(1.01)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C227(1.30); C226(0.91); C150(1.15)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C227(5.09); C226(1.73); C150(1.03)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C227(1.52); C226(1.45); C150(1.69)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C227(1.43); C226(3.31); C150(1.36)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C227(1.83); C226(1.13); C150(1.22)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C227(2.67); C226(1.65); C150(1.11)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C227(1.26); C226(1.19); C150(0.97)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C227(3.43); C226(1.72); C150(1.16)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C227(1.24); C226(1.71); C150(0.99)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C227(1.66); C226(1.42); C150(1.56)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C227(1.59); C226(1.26); C150(0.98)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C227(4.04); C226(3.31); C150(1.10)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C227(2.51); C226(1.05); C150(1.08)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C227(0.87); C226(3.63); C150(0.98)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C227(1.60); C226(2.82); C150(1.95)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C227(1.32); C226(1.03); C150(1.04)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C227(1.29); C226(4.13); C150(1.37)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C227(1.39); C226(0.98); C150(1.80)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C227(0.90); C226(0.90); C150(1.31)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C226(5.35); C150(0.85)  LDD1071  [8]
 LDCM0474  CL80 HEK-293T C227(1.43); C226(1.16); C150(1.17)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C227(1.42); C226(1.27); C150(1.20)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C227(1.12); C226(0.95); C150(0.89)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C227(1.27); C226(1.40); C150(1.01)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C227(1.40); C226(2.05); C150(1.55)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C227(1.39); C226(1.07); C150(1.55)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C227(1.39); C226(1.15); C150(1.81)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C227(1.43); C226(1.43); C150(1.39)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C227(1.23); C226(1.04); C150(1.29)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C227(1.15); C226(1.05); C150(1.52)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C226(1.26); C150(1.06)  LDD1082  [8]
 LDCM0485  CL90 HEK-293T C227(1.09); C226(0.89); C150(1.36)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C227(4.24); C226(1.07); C150(1.08)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C227(1.09); C226(1.07); C150(1.44)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C227(1.00); C226(0.98); C150(1.32)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C227(0.88); C226(0.76); C150(1.75)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C227(0.85); C226(0.78); C150(2.02)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C227(5.46); C226(1.01); C150(1.36)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C227(0.94); C226(0.79); C150(1.09)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C227(0.93); C226(0.88); C150(1.19)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C227(0.80); C226(0.85); C150(1.04)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C150(0.95); C122(1.03); C226(1.15); C227(0.86)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C227(0.92)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C227(1.49); C226(2.64); C150(1.72)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C227(4.30); C226(1.50); C150(1.38)  LDD1025  [8]
 LDCM0116  HHS-0101 DM93 Y253(0.89)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y253(0.80)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y253(0.67)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y253(0.84)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y253(0.85)  LDD0268  [7]
 LDCM0107  IAA HeLa C122(0.00); C226(0.00); C227(0.00); C150(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y194(1.39)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y194(2.43)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y194(2.35)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y194(1.99)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y194(4.95)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y194(2.03)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y194(0.67)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y194(1.85)  LDD0292  [6]
 LDCM0022  KB02 HCT 116 C226(3.47); C227(1.42); C150(2.26)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C226(5.08); C227(1.92); C150(2.04)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C226(7.22); C227(5.05); C150(3.35)  LDD0082  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C150(1.21)  LDD2121  [4]
 LDCM0109  NEM HeLa C226(0.00); C122(0.00)  LDD0224  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C150(0.97)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C150(1.13)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C150(0.94)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C150(1.10)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C150(0.99)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C150(0.51)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C150(1.02)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C150(1.52)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C150(0.91)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C150(0.69)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C150(0.58)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C150(0.98)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C150(0.51)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C150(2.78)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C150(1.09)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C150(0.75)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C150(0.90)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C150(0.87)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C150(1.10)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C150(1.01)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C150(0.56)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C150(0.62)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C150(1.25)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C150(1.19)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C150(0.97)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C150(2.27)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C150(0.73)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C150(0.38)  LDD2141  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C150(0.85)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C150(0.48)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C150(0.66)  LDD2150  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C226(0.59)  LDD2207  [22]
 LDCM0131  RA190 MM1.R C227(1.42)  LDD0304  [23]
 LDCM0110  W12 Hep-G2 C227(23.54)  LDD0237  [18]
 LDCM0111  W14 Hep-G2 C227(26.65)  LDD0238  [18]
 LDCM0112  W16 Hep-G2 C227(1.17)  LDD0239  [18]
 LDCM0113  W17 Hep-G2 C227(30.91)  LDD0240  [18]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetohexamide Small molecular drug DB00414
Curcumin Small molecular drug DB11672
Daunorubicin Small molecular drug DB00694
Deutetrabenazine Small molecular drug DB12161
Doxorubicin Small molecular drug DB00997
Fenofibrate Small molecular drug DB01039
Haloperidol Small molecular drug DB00502
Loxoprofen Small molecular drug DB09212
Lubiprostone Small molecular drug DB01046
Rutin Small molecular drug DB01698
Tetrabenazine Small molecular drug DB04844
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N6022 Small molecular drug D09LPV
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amrubicin Small molecular drug DB06263
Quercetin Small molecular drug DB04216
Resveratrol Small molecular drug DB02709
2-(2-{2-[2-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol Polyethyleneglycol Peg400 . DB03556
3-(4-amino-1-tert-butyl-1h-pyrazolo[34-d]Pyrimidin-3-yl)Phenol . DB04463
Curcumin Sulfate . DB14635
Heptaethylene Glycol . DB03394

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.