Details of the Target

General Information of Target

Target ID LDTP01048
Target Name General vesicular transport factor p115 (USO1)
Gene Name USO1
Gene ID 8615
Synonyms
VDP; General vesicular transport factor p115; Protein USO1 homolog; Transcytosis-associated protein; TAP; Vesicle-docking protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQ
AMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQ
QENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSRE
VIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL
KNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGAT
SSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNP
PRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS
AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTN
ILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGL
CALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPN
FPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR
EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE
GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS
ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA
TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT
DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD
HI
Target Bioclass
Other
Family
VDP/USO1/EDE1 family
Subcellular location
Cytoplasm, cytosol
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Uniprot ID
O60763
Ensemble ID
ENST00000264904.8
HGNC ID
HGNC:30904
ChEMBL ID
CHEMBL4295669

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.E19G DBIA    Probe Info 
CAL27 SNV: p.R660G DBIA    Probe Info 
COLO792 SNV: p.S245F DBIA    Probe Info 
HCT15 SNV: p.Q672P DBIA    Probe Info 
HEC1 SNV: p.Q257R DBIA    Probe Info 
IM95 SNV: p.L174S DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.D267V DBIA    Probe Info 
LNCaP clone FGC SNV: p.V277A DBIA    Probe Info 
NCIH2172 SNV: p.H587Q DBIA    Probe Info 
NCIH2291 SNV: p.R592I DBIA    Probe Info 
NCIH23 SNV: p.E528Ter DBIA    Probe Info 
SNGM SNV: p.R288C DBIA    Probe Info 
SW1783 SNV: p.R736Ter DBIA    Probe Info 
TOV21G SNV: p.Q105H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.21  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K25(8.89); K574(1.66); K580(8.12); K586(4.91)  LDD0277  [5]
Probe 1
 Probe Info  		Y255(15.64); Y701(32.74)  LDD3495  [6]
DBIA
 Probe Info  		C307(5.04)  LDD3310  [7]
BTD
 Probe Info  		C303(0.66)  LDD1700  [8]
DA-P3
 Probe Info  		6.77  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C678(4.49)  LDD0168  [10]
HHS-482
 Probe Info  		Y606(2.44)  LDD0289  [11]
HHS-475
 Probe Info  		Y718(0.64); Y655(0.78); Y606(0.92)  LDD0264  [12]
HHS-465
 Probe Info  		Y606(10.00); Y655(9.87)  LDD2237  [13]
ATP probe
 Probe Info  		K25(0.00); K858(0.00); K861(0.00); K656(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C678(0.00); C344(0.00); C303(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C678(0.00); C344(0.00); C303(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C303(0.00); C27(0.00)  LDD0027  [19]
WYneC
 Probe Info  		N.A.  LDD0014  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0005  [20]
NHS
 Probe Info  		K626(0.00); K858(0.00); K821(0.00)  LDD0010  [20]
SF
 Probe Info  		N.A.  LDD0028  [22]
VSF
 Probe Info  		N.A.  LDD0007  [20]
1c-yne
 Probe Info  		K251(0.00); K596(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
AOyne
 Probe Info  		6.30  LDD0443  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C678(0.81)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C303(0.71)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C303(0.50)  LDD2117  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C678(1.06)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C303(0.63)  LDD2132  [8]
 LDCM0025  4SU-RNA HEK-293T C678(4.49)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C678(2.58)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C303(0.81); C383(2.65)  LDD0812  [27]
 LDCM0215  AC10 HEK-293T C303(0.93); C388(0.41); C391(0.41); C678(0.92)  LDD0813  [27]
 LDCM0216  AC100 HEK-293T C303(0.88); C383(1.15); C388(0.22); C391(0.22)  LDD0814  [27]
 LDCM0217  AC101 HEK-293T C303(0.94); C383(0.88); C388(0.33); C391(0.33)  LDD0815  [27]
 LDCM0218  AC102 HEK-293T C303(0.83); C383(0.93); C388(0.22); C391(0.22)  LDD0816  [27]
 LDCM0219  AC103 HEK-293T C303(0.71); C383(0.72); C388(0.15); C391(0.15)  LDD0817  [27]
 LDCM0220  AC104 HEK-293T C303(0.59); C383(1.07); C388(0.27); C391(0.27)  LDD0818  [27]
 LDCM0221  AC105 HEK-293T C303(0.84); C383(1.32); C388(1.90); C391(1.90)  LDD0819  [27]
 LDCM0222  AC106 HEK-293T C303(1.04); C383(1.50); C388(0.53); C391(0.53)  LDD0820  [27]
 LDCM0223  AC107 HEK-293T C303(0.89); C383(1.22); C388(0.20); C391(0.20)  LDD0821  [27]
 LDCM0224  AC108 HEK-293T C303(1.12); C383(1.46); C388(0.50); C391(0.50)  LDD0822  [27]
 LDCM0225  AC109 HEK-293T C303(1.06); C383(1.78); C388(0.29); C391(0.29)  LDD0823  [27]
 LDCM0226  AC11 HEK-293T C303(1.01); C388(0.86); C391(0.86); C678(0.92)  LDD0824  [27]
 LDCM0227  AC110 HEK-293T C303(0.59); C383(0.26); C388(0.07); C391(0.07)  LDD0825  [27]
 LDCM0228  AC111 HEK-293T C303(0.32); C383(0.08); C388(0.06); C391(0.06)  LDD0826  [27]
 LDCM0229  AC112 HEK-293T C303(0.48); C383(0.17); C388(0.05); C391(0.05)  LDD0827  [27]
 LDCM0230  AC113 HEK-293T C303(0.94); C383(0.95); C478(0.77)  LDD0828  [27]
 LDCM0231  AC114 HEK-293T C303(0.83); C383(0.79); C478(0.94)  LDD0829  [27]
 LDCM0232  AC115 HEK-293T C303(1.06); C383(0.85); C478(1.29)  LDD0830  [27]
 LDCM0233  AC116 HEK-293T C303(0.87); C383(1.01); C478(0.87)  LDD0831  [27]
 LDCM0234  AC117 HEK-293T C303(0.75); C383(0.91); C478(0.73)  LDD0832  [27]
 LDCM0235  AC118 HEK-293T C303(0.69); C383(0.69); C478(0.64)  LDD0833  [27]
 LDCM0236  AC119 HEK-293T C303(0.71); C383(0.73); C478(0.67)  LDD0834  [27]
 LDCM0237  AC12 HEK-293T C303(0.77); C388(0.93); C391(0.93); C678(0.81)  LDD0835  [27]
 LDCM0238  AC120 HEK-293T C303(0.70); C383(0.82); C478(0.88)  LDD0836  [27]
 LDCM0239  AC121 HEK-293T C303(0.68); C383(0.58); C478(0.73)  LDD0837  [27]
 LDCM0240  AC122 HEK-293T C303(0.56); C383(0.38); C478(0.52)  LDD0838  [27]
 LDCM0241  AC123 HEK-293T C303(0.60); C383(0.37); C478(0.44)  LDD0839  [27]
 LDCM0242  AC124 HEK-293T C303(0.67); C383(0.74); C478(0.65)  LDD0840  [27]
 LDCM0243  AC125 HEK-293T C303(0.55); C383(0.39); C478(0.47)  LDD0841  [27]
 LDCM0244  AC126 HEK-293T C303(0.42); C383(0.12); C478(0.17)  LDD0842  [27]
 LDCM0245  AC127 HEK-293T C303(0.31); C383(0.07); C478(0.10)  LDD0843  [27]
 LDCM0246  AC128 HEK-293T C303(0.96); C383(0.87); C678(1.08)  LDD0844  [27]
 LDCM0247  AC129 HEK-293T C303(0.73); C383(0.99); C678(0.57)  LDD0845  [27]
 LDCM0249  AC130 HEK-293T C303(0.76); C383(0.89); C678(0.63)  LDD0847  [27]
 LDCM0250  AC131 HEK-293T C303(0.82); C383(1.07); C678(0.58)  LDD0848  [27]
 LDCM0251  AC132 HEK-293T C303(0.81); C383(1.03); C678(0.65)  LDD0849  [27]
 LDCM0252  AC133 HEK-293T C303(0.70); C383(0.76); C678(0.50)  LDD0850  [27]
 LDCM0253  AC134 HEK-293T C303(0.69); C383(1.05); C678(0.51)  LDD0851  [27]
 LDCM0254  AC135 HEK-293T C303(0.56); C383(0.77); C678(0.48)  LDD0852  [27]
 LDCM0255  AC136 HEK-293T C303(0.59); C383(0.83); C678(0.49)  LDD0853  [27]
 LDCM0256  AC137 HEK-293T C303(0.58); C383(0.48); C678(0.45)  LDD0854  [27]
 LDCM0257  AC138 HEK-293T C303(0.52); C383(0.27); C678(0.38)  LDD0855  [27]
 LDCM0258  AC139 HEK-293T C303(0.50); C383(0.58); C678(0.40)  LDD0856  [27]
 LDCM0259  AC14 HEK-293T C303(0.95); C388(0.32); C391(0.32); C678(0.92)  LDD0857  [27]
 LDCM0260  AC140 HEK-293T C303(0.66); C383(0.75); C678(0.54)  LDD0858  [27]
 LDCM0261  AC141 HEK-293T C303(0.58); C383(0.48); C678(0.37)  LDD0859  [27]
 LDCM0262  AC142 HEK-293T C303(0.66); C383(0.72); C678(0.48)  LDD0860  [27]
 LDCM0263  AC143 HEK-293T C303(0.45); C383(0.99); C388(1.03); C391(1.03)  LDD0861  [27]
 LDCM0264  AC144 HEK-293T C303(0.60); C383(0.46); C388(0.46); C391(0.46)  LDD0862  [27]
 LDCM0265  AC145 HEK-293T C303(0.58); C383(0.43); C388(0.40); C391(0.40)  LDD0863  [27]
 LDCM0266  AC146 HEK-293T C303(0.54); C383(0.41); C388(0.33); C391(0.33)  LDD0864  [27]
 LDCM0267  AC147 HEK-293T C303(0.47); C383(0.29); C388(0.29); C391(0.29)  LDD0865  [27]
 LDCM0268  AC148 HEK-293T C303(0.74); C383(0.43); C388(0.34); C391(0.34)  LDD0866  [27]
 LDCM0269  AC149 HEK-293T C303(0.97); C383(1.44); C388(0.95); C391(0.95)  LDD0867  [27]
 LDCM0270  AC15 HEK-293T C303(0.72); C388(0.15); C391(0.15); C678(0.71)  LDD0868  [27]
 LDCM0271  AC150 HEK-293T C303(0.65); C383(0.73); C388(0.61); C391(0.61)  LDD0869  [27]
 LDCM0272  AC151 HEK-293T C303(0.68); C383(0.57); C388(0.57); C391(0.57)  LDD0870  [27]
 LDCM0273  AC152 HEK-293T C303(0.69); C383(0.80); C388(0.71); C391(0.71)  LDD0871  [27]
 LDCM0274  AC153 HEK-293T C303(0.69); C383(0.68); C388(0.51); C391(0.51)  LDD0872  [27]
 LDCM0621  AC154 HEK-293T C303(0.74); C383(0.80); C388(1.17); C391(1.17)  LDD2162  [27]
 LDCM0622  AC155 HEK-293T C303(0.71); C383(1.00); C388(0.91); C391(0.91)  LDD2163  [27]
 LDCM0623  AC156 HEK-293T C303(0.56); C383(0.28); C388(0.33); C391(0.33)  LDD2164  [27]
 LDCM0624  AC157 HEK-293T C303(0.33); C383(0.12); C388(0.26); C391(0.26)  LDD2165  [27]
 LDCM0276  AC17 HEK-293T C303(0.60)  LDD0874  [27]
 LDCM0277  AC18 HEK-293T C303(0.69)  LDD0875  [27]
 LDCM0278  AC19 HEK-293T C303(0.74)  LDD0876  [27]
 LDCM0279  AC2 HEK-293T C303(0.81); C383(0.85)  LDD0877  [27]
 LDCM0280  AC20 HEK-293T C303(0.54)  LDD0878  [27]
 LDCM0281  AC21 HEK-293T C303(0.58)  LDD0879  [27]
 LDCM0282  AC22 HEK-293T C303(0.59)  LDD0880  [27]
 LDCM0283  AC23 HEK-293T C303(0.52)  LDD0881  [27]
 LDCM0284  AC24 HEK-293T C303(0.64)  LDD0882  [27]
 LDCM0285  AC25 HEK-293T C303(0.87); C383(0.76)  LDD0883  [27]
 LDCM0286  AC26 HEK-293T C303(0.76); C383(0.63)  LDD0884  [27]
 LDCM0287  AC27 HEK-293T C303(0.71); C383(0.83)  LDD0885  [27]
 LDCM0288  AC28 HEK-293T C303(0.72); C383(0.55)  LDD0886  [27]
 LDCM0289  AC29 HEK-293T C303(0.55); C383(0.63)  LDD0887  [27]
 LDCM0290  AC3 HEK-293T C303(1.12); C383(1.14)  LDD0888  [27]
 LDCM0291  AC30 HEK-293T C303(0.76); C383(0.72)  LDD0889  [27]
 LDCM0292  AC31 HEK-293T C303(0.83); C383(0.88)  LDD0890  [27]
 LDCM0293  AC32 HEK-293T C303(0.77); C383(0.76)  LDD0891  [27]
 LDCM0294  AC33 HEK-293T C303(0.69); C383(0.72)  LDD0892  [27]
 LDCM0295  AC34 HEK-293T C303(0.85); C383(0.93)  LDD0893  [27]
 LDCM0296  AC35 HEK-293T C303(0.95); C383(0.52); C388(0.59); C391(0.59)  LDD0894  [27]
 LDCM0297  AC36 HEK-293T C303(0.90); C383(0.70); C388(0.49); C391(0.49)  LDD0895  [27]
 LDCM0298  AC37 HEK-293T C303(0.79); C383(0.69); C388(0.35); C391(0.35)  LDD0896  [27]
 LDCM0299  AC38 HEK-293T C303(0.82); C383(0.69); C388(0.56); C391(0.56)  LDD0897  [27]
 LDCM0300  AC39 HEK-293T C303(0.88); C383(0.72); C388(0.53); C391(0.53)  LDD0898  [27]
 LDCM0301  AC4 HEK-293T C303(1.08); C383(0.92)  LDD0899  [27]
 LDCM0302  AC40 HEK-293T C303(0.86); C383(0.64); C388(0.97); C391(0.97)  LDD0900  [27]
 LDCM0303  AC41 HEK-293T C303(0.81); C383(0.60); C388(0.60); C391(0.60)  LDD0901  [27]
 LDCM0304  AC42 HEK-293T C303(0.82); C383(0.76); C388(0.89); C391(0.89)  LDD0902  [27]
 LDCM0305  AC43 HEK-293T C303(0.64); C383(0.79); C388(1.16); C391(1.16)  LDD0903  [27]
 LDCM0306  AC44 HEK-293T C303(0.77); C383(0.58); C388(0.35); C391(0.35)  LDD0904  [27]
 LDCM0307  AC45 HEK-293T C303(0.75); C383(0.63); C388(0.46); C391(0.46)  LDD0905  [27]
 LDCM0308  AC46 HEK-293T C303(1.02); C383(0.55); C388(0.55); C391(0.55)  LDD0906  [27]
 LDCM0309  AC47 HEK-293T C303(0.91); C383(0.56); C388(0.53); C391(0.53)  LDD0907  [27]
 LDCM0310  AC48 HEK-293T C303(0.78); C383(0.50); C388(0.68); C391(0.68)  LDD0908  [27]
 LDCM0311  AC49 HEK-293T C303(0.84); C383(0.60); C388(1.22); C391(1.22)  LDD0909  [27]
 LDCM0312  AC5 HEK-293T C303(0.89); C383(0.89)  LDD0910  [27]
 LDCM0313  AC50 HEK-293T C303(0.81); C383(0.55); C388(0.64); C391(0.64)  LDD0911  [27]
 LDCM0314  AC51 HEK-293T C303(0.78); C383(0.33); C388(0.26); C391(0.26)  LDD0912  [27]
 LDCM0315  AC52 HEK-293T C303(0.67); C383(0.42); C388(0.25); C391(0.25)  LDD0913  [27]
 LDCM0316  AC53 HEK-293T C303(0.89); C383(0.53); C388(0.59); C391(0.59)  LDD0914  [27]
 LDCM0317  AC54 HEK-293T C303(0.80); C383(0.41); C388(0.23); C391(0.23)  LDD0915  [27]
 LDCM0318  AC55 HEK-293T C303(0.71); C383(0.36); C388(0.42); C391(0.42)  LDD0916  [27]
 LDCM0319  AC56 HEK-293T C303(0.84); C383(0.52); C388(0.53); C391(0.53)  LDD0917  [27]
 LDCM0320  AC57 HEK-293T C303(0.87); C383(0.46)  LDD0918  [27]
 LDCM0321  AC58 HEK-293T C303(0.81); C383(0.74)  LDD0919  [27]
 LDCM0322  AC59 HEK-293T C303(0.98); C383(0.94)  LDD0920  [27]
 LDCM0323  AC6 HEK-293T C303(1.20); C388(1.30); C391(1.30); C678(1.03)  LDD0921  [27]
 LDCM0324  AC60 HEK-293T C303(0.77); C383(0.86)  LDD0922  [27]
 LDCM0325  AC61 HEK-293T C303(0.65); C383(0.55)  LDD0923  [27]
 LDCM0326  AC62 HEK-293T C303(0.84); C383(0.69)  LDD0924  [27]
 LDCM0327  AC63 HEK-293T C303(0.69); C383(0.61)  LDD0925  [27]
 LDCM0328  AC64 HEK-293T C303(0.79); C383(0.49)  LDD0926  [27]
 LDCM0329  AC65 HEK-293T C303(0.71); C383(0.51)  LDD0927  [27]
 LDCM0330  AC66 HEK-293T C303(0.84); C383(0.72)  LDD0928  [27]
 LDCM0331  AC67 HEK-293T C303(0.78); C383(0.67)  LDD0929  [27]
 LDCM0332  AC68 HEK-293T C303(1.26); C383(0.87); C388(0.94); C391(0.94)  LDD0930  [27]
 LDCM0333  AC69 HEK-293T C303(1.43); C383(0.87); C388(0.96); C391(0.96)  LDD0931  [27]
 LDCM0334  AC7 HEK-293T C303(0.94); C388(0.58); C391(0.58); C678(0.79)  LDD0932  [27]
 LDCM0335  AC70 HEK-293T C303(1.36); C383(1.11); C388(0.83); C391(0.83)  LDD0933  [27]
 LDCM0336  AC71 HEK-293T C303(0.98); C383(1.17); C388(0.95); C391(0.95)  LDD0934  [27]
 LDCM0337  AC72 HEK-293T C303(1.22); C383(0.96); C388(1.28); C391(1.28)  LDD0935  [27]
 LDCM0338  AC73 HEK-293T C303(1.41); C383(0.93); C388(0.91); C391(0.91)  LDD0936  [27]
 LDCM0339  AC74 HEK-293T C303(1.73); C383(0.65); C388(0.67); C391(0.67)  LDD0937  [27]
 LDCM0340  AC75 HEK-293T C303(1.28); C383(1.21); C388(0.73); C391(0.73)  LDD0938  [27]
 LDCM0341  AC76 HEK-293T C303(1.11); C383(0.99); C388(1.01); C391(1.01)  LDD0939  [27]
 LDCM0342  AC77 HEK-293T C303(1.24); C383(0.51); C388(0.89); C391(0.89)  LDD0940  [27]
 LDCM0343  AC78 HEK-293T C303(1.09); C383(0.59); C388(0.88); C391(0.88)  LDD0941  [27]
 LDCM0344  AC79 HEK-293T C303(1.23); C383(1.32); C388(1.05); C391(1.05)  LDD0942  [27]
 LDCM0345  AC8 HEK-293T C303(0.70); C388(0.23); C391(0.23); C678(0.59)  LDD0943  [27]
 LDCM0346  AC80 HEK-293T C303(0.82); C383(0.78); C388(0.64); C391(0.64)  LDD0944  [27]
 LDCM0347  AC81 HEK-293T C303(0.94); C383(0.79); C388(0.83); C391(0.83)  LDD0945  [27]
 LDCM0348  AC82 HEK-293T C303(0.67); C383(0.68); C388(0.11); C391(0.11)  LDD0946  [27]
 LDCM0349  AC83 HEK-293T C303(1.10); C383(0.32); C678(1.31)  LDD0947  [27]
 LDCM0350  AC84 HEK-293T C303(0.83); C383(0.37); C678(0.81)  LDD0948  [27]
 LDCM0351  AC85 HEK-293T C303(0.94); C383(0.49); C678(0.64)  LDD0949  [27]
 LDCM0352  AC86 HEK-293T C303(0.82); C383(0.93); C678(1.06)  LDD0950  [27]
 LDCM0353  AC87 HEK-293T C303(0.84); C383(0.63); C678(0.82)  LDD0951  [27]
 LDCM0354  AC88 HEK-293T C303(0.89); C383(0.58); C678(0.85)  LDD0952  [27]
 LDCM0355  AC89 HEK-293T C303(0.76); C383(0.50); C678(0.77)  LDD0953  [27]
 LDCM0357  AC90 HEK-293T C303(0.70); C383(0.50); C678(0.74)  LDD0955  [27]
 LDCM0358  AC91 HEK-293T C303(0.90); C383(0.63); C678(0.72)  LDD0956  [27]
 LDCM0359  AC92 HEK-293T C303(0.93); C383(0.59); C678(1.00)  LDD0957  [27]
 LDCM0360  AC93 HEK-293T C303(0.70); C383(0.55); C678(1.07)  LDD0958  [27]
 LDCM0361  AC94 HEK-293T C303(0.69); C383(0.61); C678(0.77)  LDD0959  [27]
 LDCM0362  AC95 HEK-293T C303(0.81); C383(0.47); C678(0.70)  LDD0960  [27]
 LDCM0363  AC96 HEK-293T C303(0.45); C383(0.62); C678(0.59)  LDD0961  [27]
 LDCM0364  AC97 HEK-293T C303(0.46); C383(0.07); C678(0.48)  LDD0962  [27]
 LDCM0365  AC98 HEK-293T C303(1.06); C383(0.77); C388(0.43); C391(0.43)  LDD0963  [27]
 LDCM0366  AC99 HEK-293T C303(0.97); C383(1.11); C388(0.71); C391(0.71)  LDD0964  [27]
 LDCM0248  AKOS034007472 HEK-293T C303(0.86); C388(0.75); C391(0.75); C678(0.88)  LDD0846  [27]
 LDCM0356  AKOS034007680 HEK-293T C303(0.73); C388(0.10); C391(0.10); C678(0.66)  LDD0954  [27]
 LDCM0275  AKOS034007705 HEK-293T C303(0.75); C388(0.22); C391(0.22); C678(0.73)  LDD0873  [27]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0632  CL-Sc Hep-G2 C678(1.15); C678(0.66)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C303(0.40); C388(2.20); C391(2.20); C478(1.36)  LDD0965  [27]
 LDCM0368  CL10 HEK-293T C303(0.27); C388(0.12); C391(0.12); C478(0.23)  LDD0966  [27]
 LDCM0369  CL100 HEK-293T C303(0.67); C383(0.76)  LDD0967  [27]
 LDCM0370  CL101 HEK-293T C303(0.67); C388(0.15); C391(0.15); C678(0.62)  LDD0968  [27]
 LDCM0371  CL102 HEK-293T C303(0.68); C388(0.16); C391(0.16); C678(0.64)  LDD0969  [27]
 LDCM0372  CL103 HEK-293T C303(0.78); C388(0.16); C391(0.16); C678(0.69)  LDD0970  [27]
 LDCM0373  CL104 HEK-293T C303(0.84); C388(0.19); C391(0.19); C678(0.69)  LDD0971  [27]
 LDCM0374  CL105 HEK-293T C303(0.73)  LDD0972  [27]
 LDCM0375  CL106 HEK-293T C303(0.74)  LDD0973  [27]
 LDCM0376  CL107 HEK-293T C303(0.80)  LDD0974  [27]
 LDCM0377  CL108 HEK-293T C303(0.81)  LDD0975  [27]
 LDCM0378  CL109 HEK-293T C303(0.67)  LDD0976  [27]
 LDCM0379  CL11 HEK-293T C303(0.36); C388(0.18); C391(0.18); C478(0.50)  LDD0977  [27]
 LDCM0380  CL110 HEK-293T C303(0.54)  LDD0978  [27]
 LDCM0381  CL111 HEK-293T C303(0.65)  LDD0979  [27]
 LDCM0382  CL112 HEK-293T C303(0.66); C383(0.64)  LDD0980  [27]
 LDCM0383  CL113 HEK-293T C303(0.84); C383(0.68)  LDD0981  [27]
 LDCM0384  CL114 HEK-293T C303(0.55); C383(0.47)  LDD0982  [27]
 LDCM0385  CL115 HEK-293T C303(0.69); C383(0.68)  LDD0983  [27]
 LDCM0386  CL116 HEK-293T C303(0.66); C383(0.64)  LDD0984  [27]
 LDCM0387  CL117 HEK-293T C303(0.97); C383(0.82); C388(0.88); C391(0.88)  LDD0985  [27]
 LDCM0388  CL118 HEK-293T C303(0.89); C383(1.05); C388(0.60); C391(0.60)  LDD0986  [27]
 LDCM0389  CL119 HEK-293T C303(0.77); C383(0.66); C388(0.56); C391(0.56)  LDD0987  [27]
 LDCM0390  CL12 HEK-293T C303(1.16); C388(2.82); C391(2.82); C478(2.43)  LDD0988  [27]
 LDCM0391  CL120 HEK-293T C303(0.80); C383(0.74); C388(0.54); C391(0.54)  LDD0989  [27]
 LDCM0392  CL121 HEK-293T C303(0.84); C383(0.42); C388(0.37); C391(0.37)  LDD0990  [27]
 LDCM0393  CL122 HEK-293T C303(0.85); C383(0.23); C388(0.55); C391(0.55)  LDD0991  [27]
 LDCM0394  CL123 HEK-293T C303(0.77); C383(0.50); C388(0.49); C391(0.49)  LDD0992  [27]
 LDCM0395  CL124 HEK-293T C303(0.96); C383(0.64); C388(0.89); C391(0.89)  LDD0993  [27]
 LDCM0396  CL125 HEK-293T C303(0.84); C383(0.62)  LDD0994  [27]
 LDCM0397  CL126 HEK-293T C303(0.84); C383(0.69)  LDD0995  [27]
 LDCM0398  CL127 HEK-293T C303(0.99); C383(0.84)  LDD0996  [27]
 LDCM0399  CL128 HEK-293T C303(0.91); C383(0.72)  LDD0997  [27]
 LDCM0400  CL13 HEK-293T C303(0.63); C388(1.09); C391(1.09); C478(1.09)  LDD0998  [27]
 LDCM0401  CL14 HEK-293T C303(0.88); C388(1.18); C391(1.18); C478(1.11)  LDD0999  [27]
 LDCM0402  CL15 HEK-293T C303(0.42); C388(0.49); C391(0.49); C478(1.30)  LDD1000  [27]
 LDCM0403  CL16 HEK-293T C303(1.16); C383(1.31); C391(0.96)  LDD1001  [27]
 LDCM0404  CL17 HEK-293T C303(0.81); C383(0.84); C391(0.68)  LDD1002  [27]
 LDCM0405  CL18 HEK-293T C303(0.81); C383(0.66); C391(0.60)  LDD1003  [27]
 LDCM0406  CL19 HEK-293T C303(1.02); C383(0.71); C391(0.61)  LDD1004  [27]
 LDCM0407  CL2 HEK-293T C303(0.93); C388(1.43); C391(1.43); C478(1.82)  LDD1005  [27]
 LDCM0408  CL20 HEK-293T C303(0.75); C383(0.65); C391(0.71)  LDD1006  [27]
 LDCM0409  CL21 HEK-293T C303(0.63); C383(0.48); C391(0.38)  LDD1007  [27]
 LDCM0410  CL22 HEK-293T C303(0.83); C383(0.62); C391(0.34)  LDD1008  [27]
 LDCM0411  CL23 HEK-293T C303(1.04); C383(0.87); C391(0.54)  LDD1009  [27]
 LDCM0412  CL24 HEK-293T C303(0.94); C383(0.78); C391(0.56)  LDD1010  [27]
 LDCM0413  CL25 HEK-293T C303(0.84); C383(0.64); C391(0.66)  LDD1011  [27]
 LDCM0414  CL26 HEK-293T C303(0.71); C383(1.11); C391(0.82)  LDD1012  [27]
 LDCM0415  CL27 HEK-293T C303(0.76); C383(0.43); C391(0.60)  LDD1013  [27]
 LDCM0416  CL28 HEK-293T C303(0.82); C383(0.70); C391(0.63)  LDD1014  [27]
 LDCM0417  CL29 HEK-293T C303(0.92); C383(0.88); C391(0.56)  LDD1015  [27]
 LDCM0418  CL3 HEK-293T C303(0.75); C388(1.80); C391(1.80); C478(1.90)  LDD1016  [27]
 LDCM0419  CL30 HEK-293T C303(0.62); C383(0.41); C391(0.23)  LDD1017  [27]
 LDCM0420  CL31 HEK-293T C303(0.83); C383(0.97); C388(1.52); C391(1.52)  LDD1018  [27]
 LDCM0421  CL32 HEK-293T C303(0.72); C383(0.75); C388(1.39); C391(1.39)  LDD1019  [27]
 LDCM0422  CL33 HEK-293T C303(0.61); C383(0.88); C388(1.45); C391(1.45)  LDD1020  [27]
 LDCM0423  CL34 HEK-293T C303(0.82); C383(0.69); C388(1.26); C391(1.26)  LDD1021  [27]
 LDCM0424  CL35 HEK-293T C303(0.85); C383(0.81); C388(1.37); C391(1.37)  LDD1022  [27]
 LDCM0425  CL36 HEK-293T C303(0.76); C383(0.68); C388(1.00); C391(1.00)  LDD1023  [27]
 LDCM0426  CL37 HEK-293T C303(0.89); C383(0.86); C388(1.32); C391(1.32)  LDD1024  [27]
 LDCM0428  CL39 HEK-293T C303(0.42); C383(0.25); C388(0.19); C391(0.19)  LDD1026  [27]
 LDCM0429  CL4 HEK-293T C303(0.69); C388(1.34); C391(1.34); C478(2.66)  LDD1027  [27]
 LDCM0430  CL40 HEK-293T C303(0.59); C383(0.74); C388(1.00); C391(1.00)  LDD1028  [27]
 LDCM0431  CL41 HEK-293T C303(0.51); C383(0.34); C388(0.27); C391(0.27)  LDD1029  [27]
 LDCM0432  CL42 HEK-293T C303(0.62); C383(0.32); C388(0.20); C391(0.20)  LDD1030  [27]
 LDCM0433  CL43 HEK-293T C303(0.48); C383(0.35); C388(0.20); C391(0.20)  LDD1031  [27]
 LDCM0434  CL44 HEK-293T C303(0.76); C383(0.74); C388(1.68); C391(1.68)  LDD1032  [27]
 LDCM0435  CL45 HEK-293T C303(0.50); C383(0.39); C388(0.38); C391(0.38)  LDD1033  [27]
 LDCM0436  CL46 HEK-293T C303(0.90); C383(0.82); C388(0.53); C391(0.53)  LDD1034  [27]
 LDCM0437  CL47 HEK-293T C303(1.01); C383(0.92); C388(1.53); C391(1.53)  LDD1035  [27]
 LDCM0438  CL48 HEK-293T C303(0.97); C383(0.83); C388(1.32); C391(1.32)  LDD1036  [27]
 LDCM0439  CL49 HEK-293T C303(0.97); C383(0.95); C388(0.70); C391(0.70)  LDD1037  [27]
 LDCM0440  CL5 HEK-293T C303(0.97); C388(0.87); C391(0.87); C478(2.05)  LDD1038  [27]
 LDCM0441  CL50 HEK-293T C303(0.71); C383(0.44); C388(0.17); C391(0.17)  LDD1039  [27]
 LDCM0442  CL51 HEK-293T C303(0.83); C383(0.90); C388(0.51); C391(0.51)  LDD1040  [27]
 LDCM0443  CL52 HEK-293T C303(1.14); C383(0.94); C388(3.17); C391(3.17)  LDD1041  [27]
 LDCM0444  CL53 HEK-293T C303(1.02); C383(1.02); C388(1.57); C391(1.57)  LDD1042  [27]
 LDCM0445  CL54 HEK-293T C303(0.88); C383(0.74); C388(0.75); C391(0.75)  LDD1043  [27]
 LDCM0446  CL55 HEK-293T C303(0.92); C383(0.73); C388(0.43); C391(0.43)  LDD1044  [27]
 LDCM0447  CL56 HEK-293T C303(0.98); C383(0.91); C388(1.12); C391(1.12)  LDD1045  [27]
 LDCM0448  CL57 HEK-293T C303(0.98); C383(0.98); C388(1.08); C391(1.08)  LDD1046  [27]
 LDCM0449  CL58 HEK-293T C303(1.09); C383(0.78); C388(0.86); C391(0.86)  LDD1047  [27]
 LDCM0450  CL59 HEK-293T C303(0.86); C383(0.58); C388(0.27); C391(0.27)  LDD1048  [27]
 LDCM0451  CL6 HEK-293T C303(0.77); C388(0.99); C391(0.99); C478(1.01)  LDD1049  [27]
 LDCM0452  CL60 HEK-293T C303(0.73); C383(0.41); C388(0.15); C391(0.15)  LDD1050  [27]
 LDCM0453  CL61 HEK-293T C303(1.00); C678(0.75)  LDD1051  [27]
 LDCM0454  CL62 HEK-293T C303(0.90); C678(0.80)  LDD1052  [27]
 LDCM0455  CL63 HEK-293T C303(0.76); C678(0.69)  LDD1053  [27]
 LDCM0456  CL64 HEK-293T C303(0.68); C678(0.71)  LDD1054  [27]
 LDCM0457  CL65 HEK-293T C303(0.73); C678(0.72)  LDD1055  [27]
 LDCM0458  CL66 HEK-293T C303(0.69); C678(0.79)  LDD1056  [27]
 LDCM0459  CL67 HEK-293T C303(0.84); C678(0.82)  LDD1057  [27]
 LDCM0460  CL68 HEK-293T C303(0.52); C678(0.57)  LDD1058  [27]
 LDCM0461  CL69 HEK-293T C303(0.74); C678(0.73)  LDD1059  [27]
 LDCM0462  CL7 HEK-293T C303(0.51); C388(0.65); C391(0.65); C478(1.21)  LDD1060  [27]
 LDCM0463  CL70 HEK-293T C303(0.91); C678(0.94)  LDD1061  [27]
 LDCM0464  CL71 HEK-293T C303(0.70); C678(0.74)  LDD1062  [27]
 LDCM0465  CL72 HEK-293T C303(0.80); C678(0.76)  LDD1063  [27]
 LDCM0466  CL73 HEK-293T C303(0.72); C678(0.71)  LDD1064  [27]
 LDCM0467  CL74 HEK-293T C303(0.59); C678(0.54)  LDD1065  [27]
 LDCM0469  CL76 HEK-293T C383(0.57); C478(0.75); C678(0.81)  LDD1067  [27]
 LDCM0470  CL77 HEK-293T C383(0.44); C478(1.09); C678(0.68)  LDD1068  [27]
 LDCM0471  CL78 HEK-293T C383(0.32); C478(0.90); C678(0.72)  LDD1069  [27]
 LDCM0472  CL79 HEK-293T C383(0.35); C478(1.22); C678(0.79)  LDD1070  [27]
 LDCM0473  CL8 HEK-293T C388(0.15); C391(0.15); C478(1.02)  LDD1071  [27]
 LDCM0474  CL80 HEK-293T C383(0.41); C478(0.82); C678(0.88)  LDD1072  [27]
 LDCM0475  CL81 HEK-293T C383(0.48); C478(0.68); C678(0.81)  LDD1073  [27]
 LDCM0476  CL82 HEK-293T C383(0.58); C478(1.04); C678(1.33)  LDD1074  [27]
 LDCM0477  CL83 HEK-293T C383(0.49); C478(0.67); C678(1.08)  LDD1075  [27]
 LDCM0478  CL84 HEK-293T C383(0.48); C478(1.06); C678(0.61)  LDD1076  [27]
 LDCM0479  CL85 HEK-293T C383(0.64); C478(0.90); C678(0.72)  LDD1077  [27]
 LDCM0480  CL86 HEK-293T C383(0.44); C478(1.20); C678(0.81)  LDD1078  [27]
 LDCM0481  CL87 HEK-293T C383(0.56); C478(1.09); C678(0.87)  LDD1079  [27]
 LDCM0482  CL88 HEK-293T C383(0.53); C478(1.15); C678(1.06)  LDD1080  [27]
 LDCM0483  CL89 HEK-293T C383(0.44); C478(1.37); C678(0.80)  LDD1081  [27]
 LDCM0484  CL9 HEK-293T C388(0.82); C391(0.82); C478(0.77)  LDD1082  [27]
 LDCM0485  CL90 HEK-293T C383(0.34); C478(0.62); C678(0.89)  LDD1083  [27]
 LDCM0486  CL91 HEK-293T C303(1.17); C383(2.43)  LDD1084  [27]
 LDCM0487  CL92 HEK-293T C303(0.72); C383(1.39)  LDD1085  [27]
 LDCM0488  CL93 HEK-293T C303(0.87); C383(1.16)  LDD1086  [27]
 LDCM0489  CL94 HEK-293T C303(0.68); C383(0.86)  LDD1087  [27]
 LDCM0490  CL95 HEK-293T C303(0.60); C383(0.67)  LDD1088  [27]
 LDCM0491  CL96 HEK-293T C303(0.80); C383(0.90)  LDD1089  [27]
 LDCM0492  CL97 HEK-293T C303(0.88); C383(1.08)  LDD1090  [27]
 LDCM0493  CL98 HEK-293T C303(0.87); C383(1.09)  LDD1091  [27]
 LDCM0494  CL99 HEK-293T C303(0.97); C383(0.97)  LDD1092  [27]
 LDCM0634  CY-0357 Hep-G2 C678(0.43)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C303(1.02); C678(0.94); C478(0.84); C344(0.96)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C678(1.11)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 6.77  LDD0183  [9]
 LDCM0625  F8 Ramos C303(1.15); C678(1.89); C27(1.44); C478(0.77)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C303(0.64); C678(0.94); C27(1.42); C478(0.68)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C303(0.13); C678(0.18); C27(1.03); C478(0.06)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C303(0.63); C678(0.71); C27(1.24); C478(0.78)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C303(1.02); C678(1.36); C27(1.25); C478(0.88)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C303(0.66); C678(0.65); C27(0.56); C478(1.11)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C303(0.69); C678(0.79); C27(0.50); C478(0.95)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C303(0.54); C678(0.92); C27(0.54); C478(0.96)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C303(0.49); C678(1.46); C27(1.07); C478(1.09)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C303(0.85); C678(2.66); C27(1.35); C478(1.20)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C303(0.98); C678(0.92); C27(1.31); C478(0.91)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C303(0.90); C678(1.41); C27(3.61); C478(1.26)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C303(0.79); C678(1.07); C27(0.91); C478(1.09)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C303(0.59); C678(0.90); C27(0.51); C478(1.04)  LDD2201  [29]
 LDCM0468  Fragment33 HEK-293T C303(0.31); C678(0.29)  LDD1066  [27]
 LDCM0596  Fragment38 Ramos C303(1.00); C678(1.67); C27(1.53); C478(1.16)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C303(0.87); C678(1.01); C27(1.76); C478(0.66)  LDD2184  [29]
 LDCM0427  Fragment51 HEK-293T C303(0.76); C383(1.43); C388(1.98); C391(1.98)  LDD1025  [27]
 LDCM0610  Fragment52 Ramos C303(1.57); C678(1.13); C27(1.48); C478(1.05)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C303(1.16); C678(1.12); C27(1.38); C478(1.43)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C303(0.61); C678(1.07); C27(0.30); C478(1.10)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C303(0.75); C678(0.90); C27(0.78); C478(1.35)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y718(0.64); Y655(0.78); Y606(0.92)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y606(0.42); Y655(0.75); Y718(10.84)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y655(0.84); Y606(0.91); Y718(1.30)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y718(0.56); Y655(0.82); Y606(0.84)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y655(0.74); Y606(0.82); Y718(1.06)  LDD0268  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0127  JWB152 DM93 Y606(2.44)  LDD0289  [11]
 LDCM0129  JWB202 DM93 Y606(0.65)  LDD0291  [11]
 LDCM0022  KB02 HEK-293T C344(0.92); C303(0.93); C678(0.95); C478(1.12)  LDD1492  [28]
 LDCM0023  KB03 HEK-293T C344(0.96); C303(1.07); C678(0.99); C478(1.03)  LDD1497  [28]
 LDCM0024  KB05 COLO792 C307(5.04)  LDD3310  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C678(1.28)  LDD2102  [8]
 LDCM0109  NEM HeLa H654(0.00); H17(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C303(0.40)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C678(1.77); C303(1.02)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C678(1.01)  LDD2092  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C678(1.01)  LDD2096  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C678(1.09)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C303(0.58)  LDD2099  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C678(1.76)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C303(0.73)  LDD2107  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C303(0.58)  LDD2111  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C678(0.65); C27(1.24)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C678(0.96)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C303(0.71)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C303(0.77)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C678(0.73)  LDD2122  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C678(0.59)  LDD2124  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C678(0.82)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C303(0.32)  LDD2127  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C303(0.65)  LDD2133  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C303(0.87)  LDD2135  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C678(1.07); C303(0.58)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C303(0.66)  LDD1700  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C678(1.04)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C303(0.29)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C678(0.93); C27(0.65)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C678(2.34); C303(1.28)  LDD2153  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C303(0.90)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C678(1.13)  LDD0304  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-phosphohydroxy-L-lysine phospho-lyase (PHYKPL) Class-III pyridoxal-phosphate-dependent aminotransferase family Q8IUZ5
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exportin-7 (XPO7) Exportin family Q9UIA9

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.