Details of the Target

General Information of Target

Target ID LDTP13856
Target Name Little elongation complex subunit 1 (ICE1)
Gene Name ICE1
Gene ID 23379
Synonyms
KIAA0947; Little elongation complex subunit 1; Interactor of little elongator complex ELL subunit 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM
TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM
FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD
VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA
EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG
MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET
CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM
WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK
AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT
RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
Target Bioclass
Enzyme
Family
ICE1 family
Subcellular location
Nucleus
Function
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.
Uniprot ID
Q9Y2F5
Ensemble ID
ENST00000296564.9
HGNC ID
HGNC:29154

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C2094(5.45); C1969(2.89); C1717(3.27)  LDD0168  [1]
Acrolein
 Probe Info  		N.A.  LDD0224  [2]
DBIA
 Probe Info  		C1817(1.43); C1063(1.02); C1076(1.02); C1485(0.93)  LDD0078  [3]
IA-alkyne
 Probe Info  		C20(0.00); C1817(0.00)  LDD0162  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		C265(0.00); C752(0.00); C1254(0.00); C123(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		C1817(0.00); C752(0.00)  LDD0018  [7]
NAIA_5
 Probe Info  		C228(0.00); C1817(0.00); C265(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C2094(5.45); C1969(2.89); C1717(3.27)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2094(2.54)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C1783(1.09); C2001(0.99)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1063(1.02); C1076(1.02); C1783(1.09)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1063(0.73); C1076(0.73)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1063(0.76); C1076(0.76)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1063(0.89); C1076(0.89)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1063(1.37); C1076(1.37)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1063(1.27); C1076(1.27)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1063(1.28); C1076(1.28)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1063(1.04); C1076(1.04)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1063(1.03); C1076(1.28)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1063(0.98); C1076(0.67)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1063(1.01); C1076(0.79)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1063(1.28); C1076(1.28); C1783(1.06)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1063(0.92); C1076(0.79)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1063(0.91); C1076(0.75)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1063(1.00); C1076(1.11)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1817(1.18); C2001(0.80)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1817(1.22); C2001(0.99)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1817(1.36); C2001(1.00)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1817(1.28); C2001(1.00)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1817(1.18); C2001(0.76)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1817(1.11); C2001(0.84)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1817(1.23); C2001(0.82)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1063(0.83); C1076(0.83); C1783(1.02)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1817(1.05); C2001(1.03)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1817(1.10); C2001(1.00)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1817(1.21); C2001(0.77)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1817(0.97); C2001(0.78)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1817(1.16); C2001(0.79)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1817(1.30); C2001(0.84)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1817(1.47); C2001(1.10)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1817(1.36); C2001(0.88)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1063(0.14); C1076(0.14)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1063(0.10); C1076(0.10)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1063(0.10); C1076(0.10)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1063(0.17); C1076(0.17)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1063(0.12); C1076(0.12)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1063(0.11); C1076(0.11)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1063(0.17); C1076(0.17)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1063(0.13); C1076(0.13)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1063(0.14); C1076(0.14)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1063(0.17); C1076(0.17)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1063(0.26); C1076(0.26)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1063(0.14); C1076(0.14)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1063(1.43); C1076(1.43); C1783(1.10)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1063(0.14); C1076(0.14)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1063(0.17); C1076(0.17)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1063(0.11); C1076(0.11)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1063(0.80); C1076(0.80); C1817(1.31)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1063(0.54); C1076(0.54); C1817(1.60)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1063(0.58); C1076(0.58); C1817(1.28)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1063(0.66); C1076(0.66); C1817(1.62)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1063(0.72); C1076(0.72); C1817(1.78)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1063(0.64); C1076(0.64); C1817(2.43)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1063(1.22); C1076(1.22); C1817(2.05)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1063(0.72); C1076(0.72); C1783(1.00)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C1063(0.66); C1076(0.66); C1817(1.23)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1063(0.58); C1076(0.58); C1817(1.38)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1063(0.72); C1076(0.72); C1817(1.54)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1063(0.69); C1076(0.69); C1817(2.57)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1063(0.67); C1076(0.67); C1817(1.28)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1063(0.54); C1076(0.54); C1817(1.57)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1063(0.68); C1076(0.68); C1817(1.29)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1063(0.73); C1076(0.73); C1817(1.04)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1063(0.29); C1076(0.29); C2001(0.92); C1783(1.02)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1063(0.46); C1076(0.46); C1783(1.05); C2001(1.20)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1063(0.31); C1076(0.31); C2001(0.80); C1783(1.01)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1783(0.94); C2001(1.10)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1063(0.41); C1076(0.41); C2001(0.97); C1783(1.00)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1063(0.37); C1076(0.37); C2001(1.05); C1817(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1063(0.24); C1076(0.24); C1783(0.98); C1817(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1063(0.27); C1076(0.27); C2001(0.75); C1783(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1063(0.28); C1076(0.28); C2001(0.94); C1783(0.99)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1783(1.00); C2001(1.07)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1783(1.00); C2001(1.01)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1783(0.98); C2001(1.09)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1783(1.03); C2001(1.30)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C2001(1.17); C1783(1.18)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1783(1.13); C2001(1.27)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1783(1.03); C2001(1.10)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1783(0.88); C2001(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1783(1.36); C2001(1.42)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C2001(1.15); C1783(1.20)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C2001(1.39); C1783(1.40)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C1063(1.12); C1076(1.12)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C1063(1.50); C1076(1.50)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C1063(1.51); C1076(1.51)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C1063(1.48); C1076(1.48)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C1063(1.49); C1076(1.49)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C1783(1.01); C2001(1.08)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C1063(1.31); C1076(1.31)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C1063(0.77); C1076(0.77)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C1063(0.94); C1076(0.94)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C1063(1.29); C1076(1.29)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C1063(1.04); C1076(1.04)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C1063(1.07); C1076(1.07)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C1817(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1817(1.19)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1817(1.28)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1817(1.39)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1783(1.01); C2001(1.14)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1817(1.65)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1817(1.11)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1817(1.02)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1817(1.40)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1817(1.19)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1817(1.69)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1817(1.82)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1817(1.16)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1817(1.17)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1817(1.16)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1063(0.91); C1076(0.91); C1783(1.21)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1817(1.14)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1817(1.02)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1817(1.36)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1817(1.18)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1817(1.47)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1817(0.89)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1817(0.91)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1817(1.04)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1063(0.72); C1076(0.72); C1783(1.00); C1817(1.20)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1817(0.98); C1063(1.33); C1076(1.33); C1783(2.22)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1783(0.87); C1063(1.00); C1076(1.00)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1817(1.03); C1063(1.04); C1076(1.04); C1783(1.31)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1063(0.68); C1076(0.68); C1817(0.93); C1783(1.64)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1817(1.02); C1063(1.26); C1076(1.26); C1783(2.07)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1063(2.16); C1076(2.16); C1783(2.42); C1817(3.16)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1817(1.26); C1063(1.29); C1076(1.29); C1783(1.73)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1783(1.55); C1817(2.39); C1063(2.76); C1076(2.76)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1817(1.08); C1063(1.17); C1076(1.17); C1783(1.73)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1063(1.19); C1076(1.19); C1817(1.56); C1783(1.69)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1063(1.06); C1076(1.06); C1783(1.16); C1817(1.17)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1063(0.83); C1076(0.83); C1817(0.83); C1783(1.46)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1063(0.80); C1076(0.80); C1783(1.18)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1817(1.17); C1783(1.27); C1063(1.30); C1076(1.30)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1063(0.97); C1076(0.97); C1783(1.45); C1817(1.79)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1817(2.03); C1063(2.54); C1076(2.54); C1783(3.32)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1063(0.18); C1076(0.18); C2001(1.36)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1063(0.14); C1076(0.14); C2001(1.25)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1063(0.13); C1076(0.13); C2001(1.24)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1063(0.16); C1076(0.16); C2001(0.96)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1063(0.15); C1076(0.15); C2001(0.86)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1063(0.19); C1076(0.19); C2001(0.89)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1063(0.17); C1076(0.17); C2001(0.94)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1063(0.29); C1076(0.29); C2001(0.88)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1063(0.17); C1076(0.17); C2001(1.27)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1063(0.14); C1076(0.14); C2001(1.02)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1063(0.17); C1076(0.17); C2001(1.00)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1063(0.09); C1076(0.09); C2001(1.06)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1063(0.19); C1076(0.19); C2001(0.84)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1063(0.12); C1076(0.12); C2001(1.04)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1063(0.21); C1076(0.21); C2001(1.17)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1063(2.05); C1076(2.05)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1063(0.72); C1076(0.72)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1063(0.88); C1076(0.88); C1783(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1783(1.06); C1063(1.15); C1076(1.15)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1063(0.83); C1076(0.83); C1783(1.73)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1817(1.43); C1063(1.02); C1076(1.02); C1485(0.93)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C752(0.73)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C752(0.28)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C1783(1.02); C2001(2.62)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C1783(1.09); C1063(2.08); C1076(2.08)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1783(0.89); C1063(1.99); C1076(1.99)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1783(1.04); C1063(1.55); C1076(1.55)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1783(0.85); C1063(1.13); C1076(1.13)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1063(0.25); C1076(0.25); C1783(1.06); C2001(1.13)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1063(0.24); C1076(0.24); C2001(0.98); C1817(1.39)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1063(0.22); C1076(0.22); C2001(1.04); C1783(1.15)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1063(0.17); C1076(0.17); C2001(1.15); C1783(1.47)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1063(0.26); C1076(0.26); C2001(0.90); C1783(1.11)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C752(0.32)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C1063(0.22); C1076(0.22); C2001(1.21); C1783(1.22)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1063(0.31); C1076(0.31); C2001(0.98); C1783(1.26)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1783(1.02); C2001(1.22)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1783(1.02); C2001(1.15)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1783(0.79); C2001(0.92)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C2001(1.10); C1783(1.31)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C2001(1.16); C1783(1.16)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C1063(1.31); C1076(1.31)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C1063(0.75); C1076(0.75)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C1063(0.86); C1076(0.86)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C752(0.69)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C1063(0.82); C1076(0.82)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C1817(0.95)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1817(1.01)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1817(1.41)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1817(1.36)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C1817(0.80)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1817(0.79)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1817(0.95)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1817(1.25)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C752(0.70)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C752(0.58)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C752(0.43)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C1063(0.94); C1076(0.94); C1817(0.97); C2001(1.63)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1063(0.84); C1076(0.84); C1817(1.03); C2001(1.14)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1063(0.85); C1076(0.85); C1817(0.96); C2001(1.76)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1063(0.88); C1076(0.88); C1817(0.95); C2001(1.39)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C752(0.71)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C1063(0.82); C1076(0.82); C1817(0.89); C2001(1.52)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1817(0.81); C1063(0.93); C1076(0.93); C2001(2.06)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1063(0.54); C1076(0.54); C1817(0.89); C2001(1.60)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1817(1.00); C1063(1.10); C1076(1.10); C2001(1.15)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1063(0.65); C1076(0.65); C1817(0.97); C2001(1.11)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1063(0.65); C1076(0.65); C1817(1.18); C2001(1.34)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1063(0.89); C1076(0.89); C1817(1.18); C2001(1.14)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1063(0.65); C1076(0.65); C1817(0.96); C2001(1.17)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1063(0.70); C1076(0.70); C1817(1.02); C2001(1.35)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1063(0.68); C1076(0.68); C1817(1.13); C2001(1.80)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C752(0.60)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C1063(0.69); C1076(0.69); C1817(1.07); C2001(2.35)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C1063(0.71); C1076(0.71); C752(0.82)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C1063(0.89); C1076(0.89); C1817(0.94)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1063(0.99); C1076(0.99); C1817(0.94)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1063(0.95); C1076(0.95); C1817(0.88)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1063(0.76); C1076(0.76); C1817(0.89)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1063(1.56); C1076(1.56); C1817(0.61)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1063(0.72); C1076(0.72); C1817(0.89)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1063(0.83); C1076(0.83); C1817(0.96)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C752(0.61)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C1063(1.12); C1076(1.12); C1817(0.85)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1063(1.58); C1076(1.58); C1817(0.71)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1063(0.91); C1076(0.91); C1817(0.58)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1063(1.03); C1076(1.03); C1817(0.83)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1063(0.68); C1076(0.68); C1817(0.88)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1063(0.66); C1076(0.66); C1817(0.83)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1063(0.90); C1076(0.90); C1817(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1063(0.69); C1076(0.69); C1817(0.96)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1063(0.84); C1076(0.84); C1817(0.96)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1063(0.85); C1076(0.85); C1817(1.10)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C752(0.55)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C1063(0.98); C1076(0.98); C1817(1.22)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1063(0.82); C1076(0.82); C1817(1.29)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1063(1.38); C1076(1.38); C1817(1.22)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1063(1.25); C1076(1.25); C1817(1.25)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1063(1.72); C1076(1.72); C1817(1.32)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1063(0.95); C1076(0.95); C1817(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1063(1.01); C1076(1.01); C1817(1.01)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1063(0.78); C1076(0.78); C1817(1.01)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1063(1.18); C1076(1.18); C1817(1.06)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1063(1.09); C1076(1.09); C1817(1.16)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C752(0.60)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C1063(1.08); C1076(1.08); C1817(1.11)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1063(1.04); C1076(1.04); C1817(1.05); C2001(0.83)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1063(1.18); C1076(1.18); C1817(1.21); C2001(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1063(0.67); C1076(0.67); C1817(1.13); C2001(0.88)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1063(1.32); C1076(1.32); C1817(0.98); C2001(0.92)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1063(1.05); C1076(1.05); C1817(0.91); C2001(1.01)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1063(1.12); C1076(1.12); C1817(0.99); C2001(1.10)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1063(0.87); C1076(0.87); C1817(1.17); C2001(0.97)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1063(0.54); C1076(0.54); C1817(0.93); C2001(0.89)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1063(1.25); C1076(1.25); C1817(1.68); C2001(0.96)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C752(0.45)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C1063(1.50); C1076(1.50); C1817(1.18); C2001(1.06)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1063(0.89); C1076(0.89); C1817(1.03); C2001(0.80)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1063(0.75); C1076(0.75); C1817(1.18); C2001(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1063(1.14); C1076(1.14); C1817(0.98); C2001(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1063(1.03); C1076(1.03); C1817(1.14); C2001(0.98)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1063(0.91); C1076(0.91); C1817(0.87)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1063(0.76); C1076(0.76); C1817(0.85)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1063(0.85); C1076(0.85); C1817(0.78)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1063(0.79); C1076(0.79); C1817(0.81)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C752(1.14)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C1063(0.83); C1076(0.83); C1817(1.05)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1063(0.66); C1076(0.66); C1817(0.92)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1063(0.48); C1076(0.48); C1817(0.68)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1063(0.78); C1076(0.78); C1817(0.94)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1063(0.93); C1076(0.93); C1817(0.93)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1063(0.84); C1076(0.84); C1817(1.02)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1063(0.68); C1076(0.68); C1817(1.36)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1063(0.70); C1076(0.70); C1817(1.78)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1063(0.69); C1076(0.69); C1817(1.07)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1063(0.84); C1076(0.84); C1817(0.90)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C752(1.18)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C1063(0.89); C1076(0.89); C1817(0.71)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1783(0.86); C2001(0.94)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1783(0.93); C2001(0.93)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1783(0.89); C2001(0.92)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1783(0.95); C2001(1.01)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1783(1.04); C2001(0.96)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1783(1.19); C2001(1.65)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1783(1.09); C2001(2.33)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1783(0.93); C2001(1.09)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1783(0.95); C2001(1.12)  LDD0811  [3]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C2094(7.27)  LDD0513  [9]
 LDCM0495  E2913 HEK-293T C265(1.01); C2014(1.34); C2094(1.06); C1969(0.99)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C1063(0.87); C1076(0.87); C1817(1.01); C2001(0.83)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1063(1.23); C1076(1.23); C1817(0.80)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C1063(4.28); C1076(4.28); C1783(1.74)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C1063(2.09); C1076(2.09); C1783(1.77)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C1063(4.39); C1076(4.39); C1783(1.88)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]
 LDCM0021  THZ1 HCT 116 C1817(1.06); C1063(1.02); C1076(1.02)  LDD2173  [3]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402