Details of the Target

General Information of Target

Target ID LDTP09790
Target Name RAB6A-GEF complex partner protein 2 (RGP1)
Gene Name RGP1
Gene ID 9827
Synonyms
KIAA0258; RAB6A-GEF complex partner protein 2; Retrograde Golgi transport protein RGP1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYS
LPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRL
VAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEI
DPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMI
IIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLY
PGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNP
VRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFI
PSLLYFGYTALMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID
Target Bioclass
Other
Family
RGP1 family
Subcellular location
Cytoplasm, cytosol
Function
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.
Uniprot ID
Q92546
Ensemble ID
ENST00000378078.5
HGNC ID
HGNC:21965

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.02  LDD0403  [1]
DBIA
 Probe Info  		C101(7.49)  LDD0204  [2]
IA-alkyne
 Probe Info  		C314(6.29)  LDD0513  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		C101(0.00); C90(0.00)  LDD0148  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C101(0.95); C90(1.21)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C208(1.06); C101(0.99); C314(1.15)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C208(1.06); C101(0.89)  LDD1509  [7]
 LDCM0230  AC113 HCT 116 C208(0.99)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C208(1.21)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C208(1.22)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C208(1.32)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C208(1.20)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C208(1.25)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C208(1.20)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C208(1.08); C101(0.98); C314(0.98); C90(1.08)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C208(1.05)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C208(1.13)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C208(1.15)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C208(1.07)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C208(1.03)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C208(1.23)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C208(1.27)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C208(1.27)  LDD0562  [8]
 LDCM0259  AC14 HEK-293T C208(0.96); C101(1.03); C314(0.96); C90(0.99)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C208(1.03); C101(1.00); C314(0.94); C90(1.01)  LDD1513  [7]
 LDCM0276  AC17 HCT 116 C208(1.08)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C208(1.07)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C208(0.96)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C208(1.02); C101(0.99); C314(1.19)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C208(0.94)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C208(0.83)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C208(0.91)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C208(0.78)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C208(0.94)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C101(0.94); C90(1.03)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C208(1.01); C101(1.09); C314(1.06)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C208(1.05); C101(0.96)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C208(1.01); C101(1.05); C314(0.98); C90(0.93)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C208(0.97); C101(1.00); C314(0.93)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C208(1.07); C101(0.98)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C208(0.93); C101(1.03); C314(1.19); C90(0.97)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C208(1.01); C101(1.05); C314(1.03); C90(1.17)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C208(0.94); C101(0.87); C314(0.89)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C101(0.93); C90(1.15)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C208(1.05); C101(1.19); C314(1.12)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C208(1.04); C101(0.95)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C208(1.01); C101(1.02); C314(1.14); C90(1.06)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C208(0.94); C101(0.99); C314(0.79)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C208(0.95); C101(1.35); C314(0.97); C90(0.94)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C208(0.99); C101(1.04); C314(1.02); C90(1.05)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C208(1.02); C101(0.93); C314(1.06); C90(1.09)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C208(0.92); C101(1.03); C314(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C101(0.88); C90(1.02)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C208(1.09); C101(0.91); C314(1.21)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C208(1.05); C101(1.03)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C208(1.03); C101(1.04); C314(1.08); C90(1.22)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C208(1.00); C101(1.02); C314(0.98)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C208(1.48)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C208(1.10)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C208(1.44)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C208(1.22)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C208(0.91); C101(1.03); C314(1.15)  LDD1551  [7]
 LDCM0313  AC50 HCT 116 C208(1.53)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C208(1.30)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C208(1.12)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C208(1.01)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C208(1.56)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C208(1.06)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C208(1.32)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C208(1.16)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C208(1.05)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C208(1.30)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C208(1.01); C101(1.06); C314(1.47); C90(1.07)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C208(1.39)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C208(1.32)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C208(1.46)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C208(1.52)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C208(1.43)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C208(1.32)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C208(1.42)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C208(1.56)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C208(1.49)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C208(0.87)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C208(1.06); C101(1.02); C314(1.11); C90(1.14)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C208(0.85)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C208(0.95)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C208(0.95)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C208(0.97)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C208(0.85)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C208(0.90)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C208(0.68)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C208(0.91)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C208(0.85)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C208(0.82)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C208(1.00); C101(1.06); C314(0.97)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C208(0.77)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C208(0.75)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C208(0.86)  LDD0665  [8]
 LDCM0248  AKOS034007472 HEK-293T C208(0.99); C101(0.86); C314(0.92)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C101(0.92); C90(0.96)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C208(1.02); C101(0.95); C314(0.93)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 14.02  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C101(7.49)  LDD0204  [2]
 LDCM0367  CL1 HCT 116 C208(1.12)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C208(0.87)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C101(1.12); C314(1.10); C90(1.26)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C208(0.97); C101(1.02); C314(1.13)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C208(0.97); C101(0.88); C314(0.99)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C208(0.98); C101(0.96)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C101(1.07); C314(1.08); C90(1.34)  LDD1577  [7]
 LDCM0374  CL105 HCT 116 C208(0.93)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C208(0.86)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C208(0.82)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C208(0.96)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C208(0.99)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C208(0.92)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C208(1.01)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C208(1.02)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C101(0.89); C314(1.23); C90(1.04)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C208(0.97); C101(1.10); C314(1.14)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C208(1.13); C101(0.93); C314(0.88)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C208(1.02); C101(0.95)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C101(1.05); C314(1.15); C90(1.23)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C208(0.95); C101(1.01); C314(0.97)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C208(1.05); C101(1.17); C314(0.92)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C208(1.02); C101(0.94)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C208(1.05)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C101(1.20); C314(1.17); C90(1.41)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C208(1.09)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C208(1.18)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C208(1.30)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C208(1.14)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C208(1.24)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C208(1.17)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C208(1.26)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C208(1.10)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C208(0.86)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C208(0.96)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C208(1.11)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C208(1.27)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C208(0.82)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C208(1.23)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C208(1.18)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C208(0.88)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C208(1.50)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C208(1.26)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C208(1.51)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C208(1.19)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C208(1.27)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C208(1.48)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C208(1.27)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C208(1.42)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C208(1.32)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C208(1.51)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C208(0.89)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C208(1.24)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C208(0.93)  LDD0737  [8]
 LDCM0421  CL32 HEK-293T C208(1.07); C101(1.04); C314(1.07); C90(1.34)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C208(1.24); C101(0.76); C314(0.76)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C208(1.04); C101(1.28); C314(1.11); C90(1.13)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C208(1.09); C101(0.93); C314(1.17); C90(1.12)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C208(0.96); C101(0.93); C314(1.11)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C208(0.93); C101(0.97); C314(1.04)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C208(1.02); C101(1.08)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C208(1.16)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C101(1.21); C314(1.03); C90(1.27)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C101(0.81); C90(1.31)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C208(1.00); C101(0.95); C314(1.11)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C208(0.99); C101(1.04)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C208(1.06); C101(1.02); C314(1.06); C90(1.10)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C208(1.06); C101(0.80); C314(1.09)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C208(1.06)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C208(1.11)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C208(1.10)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C208(0.95)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C208(0.86)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C208(1.06)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C208(1.12)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C208(1.14)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C208(0.96)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C208(1.20)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C208(0.97)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C208(0.94)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C208(1.05)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C208(1.02)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C208(1.05)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C208(0.99)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C208(1.09)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C208(1.64)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C208(1.17)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C208(1.27)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C208(1.81)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C208(1.17)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C208(1.48)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C208(1.51)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C208(1.34)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C208(1.32)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C208(0.88)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C208(1.19)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C208(1.17)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C208(1.15)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C208(1.24)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C208(1.55)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C208(1.11)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C208(0.92)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C208(0.91)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C208(1.32)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C208(0.91)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C208(1.53)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C208(0.87)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C208(1.16)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C208(1.11)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C208(0.80)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C208(0.87)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C208(1.11)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C208(0.87)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C208(1.15)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C208(0.82)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C208(1.04)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C208(0.93)  LDD0802  [8]
 LDCM0486  CL91 HEK-293T C208(0.99); C101(0.95)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C208(1.05); C101(0.83); C314(1.02); C90(1.11)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C208(1.06); C101(0.92); C314(0.76)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C208(1.09); C101(1.01); C314(0.87); C90(1.14)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C208(1.33); C101(0.86); C314(1.00); C90(1.23)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C208(1.09); C101(0.93); C314(0.91)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C208(1.04); C101(0.96); C314(1.02)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C208(1.05); C101(0.94); C314(1.08)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C208(1.05); C101(0.88)  LDD1697  [7]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C314(6.29)  LDD0513  [3]
 LDCM0495  E2913 HEK-293T C208(1.07); C101(0.88)  LDD1698  [7]
 LDCM0625  F8 Ramos C314(1.63)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C314(0.81)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C208(0.03); C314(12.56)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C314(0.76)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C314(0.80)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C208(1.46)  LDD2193  [9]
 LDCM0580  Fragment21 Ramos C314(0.82)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C314(0.85)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C314(1.00)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C208(0.24); C314(4.27)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C314(0.68)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C314(2.07)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C314(1.35)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C208(1.19)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C314(0.92)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C208(0.82); C314(1.73)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C208(1.07); C101(0.96); C314(0.99)  LDD1631  [7]
 LDCM0610  Fragment52 Ramos C314(1.15)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C314(1.49)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C208(1.07); C314(10.64)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C314(1.27)  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C208(1.00); C90(0.88); C101(1.04); C314(1.04)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C208(33.34); C101(23.07)  LDD0209  [2]
 LDCM0024  KB05 HEK-293T C208(0.98); C90(0.95); C101(0.87); C314(1.10)  LDD1502  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ret finger protein-like 3 (RFPL3) . O75679

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578