Details of the Target

General Information of Target

Target ID LDTP03993
Target Name Probable helicase with zinc finger domain (HELZ)
Gene Name HELZ
Gene ID 9931
Synonyms
DRHC; KIAA0054; Probable helicase with zinc finger domain; EC 3.6.4.-; Down-regulated in human cancers protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNL
KVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPL
CEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQ
LPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNP
QARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQ
LDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNL
HVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPL
TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGI
TFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDH
FQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYG
GNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVT
IGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPES
RPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLL
NQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRP
QSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIH
GSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWK
LTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPS
PPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPD
GAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSS
SLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSS
PESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVL
QHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPL
SLFQELSLGSSSGSNGFYSYFK
Target Bioclass
Enzyme
Family
DNA2/NAM7 helicase family
Subcellular location
Nucleus
Function May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Uniprot ID
P42694
Ensemble ID
ENST00000358691.10
HGNC ID
HGNC:16878

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1937 SNV: p.E1303Q DBIA    Probe Info 
HDQP1 SNV: p.T587S .
HT SNV: p.G315R .
HT115 SNV: p.A488T; p.R1278Q .
HUH7 SNV: p.G498D DBIA    Probe Info 
IGROV1 SNV: p.R997H DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y73H DBIA    Probe Info 
L428 SNV: p.P1673L .
LN18 SNV: p.A1644P .
MCC13 SNV: p.S572F; p.P1369L; p.P1444L; p.S1623F .
MEWO SNV: p.W406Ter DBIA    Probe Info 
MOLT4 SNV: p.Y706N IA-alkyne    Probe Info 
NCIH1155 SNV: p.S1564T DBIA    Probe Info 
NCIH2286 Substitution: p.G341L .
OVK18 SNV: p.P1289S .
RKO SNV: p.P1839T .
RL952 SNV: p.Q1352H DBIA    Probe Info 
RPMI8226 SNV: p.C1784R .
SNGM SNV: p.S1526N DBIA    Probe Info 
SW756 SNV: p.K1086Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K56(0.46)  LDD0277  [1]
Probe 1
 Probe Info  		Y1573(7.26)  LDD3495  [2]
HPAP
 Probe Info  		3.36  LDD0062  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C100(11.00); C101(11.00); C1770(3.78); C1784(3.78)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1055(0.00); C184(0.00); C601(0.00); C256(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C1071(0.00); C601(0.00); C193(0.00); C863(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C863(0.00); C601(0.00); C256(0.00); C1055(0.00)  LDD0037  [6]
IPM
 Probe Info  		C1770(0.00); C10(0.00); C256(0.00); C1784(0.00)  LDD2156  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
AOyne
 Probe Info  		14.30  LDD0443  [10]
NAIA_5
 Probe Info  		C1055(0.00); C184(0.00); C199(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C100(0.98); C101(0.98); C10(1.18); C14(1.18)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C100(1.17); C101(1.18); C10(1.38); C14(1.38)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C100(1.26); C101(1.26); C10(0.55); C14(0.55)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C100(1.25); C101(1.25); C10(0.60); C14(0.60)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C100(1.24); C101(1.24); C10(0.62); C14(0.62)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C100(1.31); C101(1.31); C10(0.49); C14(0.49)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C100(1.14); C101(1.14); C10(0.52); C14(0.52)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C100(1.16); C101(1.16); C10(0.52); C14(0.52)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C100(1.31); C101(1.31); C10(0.51); C14(0.51)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C100(1.21); C101(1.21); C10(0.96); C14(0.95)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C100(1.33); C101(1.33); C10(0.75); C14(0.92)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C100(1.22); C101(1.22); C10(0.80); C14(0.76)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C100(1.32); C101(1.29); C10(1.56); C14(1.56)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C100(1.38); C101(1.38); C10(0.78); C14(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C100(1.39); C101(1.39); C10(0.79); C14(0.62)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C100(1.52); C101(1.52); C10(0.88); C14(0.64)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C100(0.97); C101(0.97); C10(0.95); C14(0.95)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C100(0.99); C101(0.98); C10(0.80); C14(0.86)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C100(0.97); C101(0.92); C10(0.81); C14(0.86)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C100(1.33); C101(1.21); C10(0.79); C14(0.82)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C100(0.96); C101(1.04); C10(0.87); C14(0.87)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C100(0.93); C101(0.96); C10(1.00); C14(1.03)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C100(1.03); C101(1.00); C10(0.93); C14(0.95)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C100(1.05); C101(1.02); C10(1.22); C14(1.22)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C100(1.04); C101(0.96); C10(0.83); C14(0.85)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C100(0.79); C101(1.00); C10(1.00); C14(1.02)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C100(0.96); C101(0.96); C10(1.00); C14(1.05)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C100(0.87); C101(0.91); C10(0.90); C14(1.11)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C100(0.95); C101(1.09); C10(0.92); C14(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C100(0.99); C101(0.95); C10(0.94); C14(0.99)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C100(0.97); C101(0.95); C10(0.85); C14(0.90)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C100(0.95); C101(1.00); C10(0.90); C14(0.91)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C100(0.87); C101(0.87); C10(1.05); C14(1.05)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C100(1.10); C101(1.10); C10(1.15); C14(1.15)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C100(1.15); C101(1.15); C10(0.97); C14(0.97)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C100(1.01); C101(1.01); C10(0.90); C14(0.90)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C100(1.33); C101(1.33); C10(1.19); C14(1.19)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C100(1.16); C101(1.16); C10(1.09); C14(1.09)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C100(1.22); C101(1.22); C10(1.03); C14(1.03)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C100(1.05); C101(1.05); C10(1.18); C14(1.18)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C100(1.29); C101(1.29); C10(1.12); C14(1.12)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C100(1.19); C101(1.19); C10(1.14); C14(1.14)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C100(1.46); C101(1.46); C10(1.03); C14(1.03)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C100(1.45); C101(1.45); C10(1.13); C14(1.13)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C100(1.11); C101(1.12); C10(1.18); C14(1.18)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C100(1.74); C101(1.74); C10(1.07); C14(1.07)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C100(1.83); C101(1.83); C10(1.09); C14(1.09)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C100(1.31); C101(1.31); C10(1.33); C14(1.33)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C100(1.36); C101(1.36); C863(0.86)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C863(0.95); C100(0.98); C101(1.01)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C100(0.89); C863(0.91); C101(0.97)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C863(0.96); C100(1.15); C101(1.19)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C101(0.93); C100(0.95); C863(1.02)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C863(0.62); C101(1.01); C100(1.12)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C863(0.78); C100(1.06); C101(1.16)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C575(0.98); C585(0.98); C10(1.01); C14(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C100(0.88); C863(0.93); C101(1.13)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C863(0.80); C100(0.99); C101(1.10)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C863(0.64); C100(0.95); C101(1.11)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C863(0.52); C100(1.24); C101(1.77)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C100(1.14); C101(1.26); C863(0.92)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C100(1.03); C101(1.30); C863(0.64)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C100(0.94); C101(1.15); C863(0.79)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C100(1.07); C101(1.18); C863(0.66)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C100(1.13); C101(1.13); C10(1.23); C14(1.23)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C10(0.98); C14(0.98); C100(1.23); C101(1.23)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C10(1.08); C14(1.08); C100(1.26); C101(1.26)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C100(0.94); C101(0.94); C863(1.08); C10(1.14)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C100(1.04); C101(1.04); C10(1.05); C14(1.05)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C10(0.96); C14(0.96); C100(1.30); C101(1.30)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C10(1.04); C14(1.04); C100(1.15); C101(1.15)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C10(0.99); C14(0.99); C100(1.33); C101(1.33)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C100(1.17); C101(1.17); C10(1.17); C14(1.17)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C10(0.71); C14(0.71); C100(0.98); C101(0.98)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C10(0.74); C14(0.74); C863(1.08); C100(1.18)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C10(0.98); C14(0.98); C100(1.16); C101(1.16)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C863(1.05); C10(1.08); C14(1.08); C100(1.40)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C10(0.73); C14(0.73); C863(1.09); C100(1.50)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C100(0.91); C101(0.91); C863(0.96); C575(1.25)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C10(0.64); C14(0.64); C863(1.11); C100(1.56)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C10(0.79); C14(0.79); C863(1.14); C100(1.24)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C10(0.75); C14(0.75); C863(1.28); C100(1.40)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C10(0.67); C14(0.67); C100(0.99); C101(0.99)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C10(0.89); C14(0.89); C100(1.10); C101(1.10)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C863(0.91); C100(0.97); C101(0.97)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C100(0.91); C101(0.91); C863(0.93)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C100(0.85); C101(0.85); C863(0.95)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C100(0.94); C101(0.94); C863(1.12)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C100(0.97); C101(0.97); C863(1.09)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C100(0.93); C101(0.93); C863(1.03); C575(1.23)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C863(0.99); C100(1.11); C101(1.11)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C863(0.92); C100(0.98); C101(0.98)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C100(1.01); C101(1.01); C863(1.05)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C863(1.05); C100(1.16); C101(1.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C100(1.03); C101(1.03); C863(1.04)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C863(1.02); C100(1.13); C101(1.13)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C863(1.02); C575(1.08); C585(1.08); C101(1.11)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C575(0.89); C585(0.89); C863(0.93); C100(1.00)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C575(0.86); C585(0.86); C101(0.89); C863(1.00)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C575(0.79); C585(0.79); C101(1.08); C100(1.10)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C100(0.97); C101(0.97); C863(1.13); C575(1.13)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C575(0.98); C585(0.98); C101(0.99); C100(1.01)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C575(0.71); C585(0.71); C863(0.95); C101(1.02)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C575(0.75); C585(0.75); C101(0.91); C863(0.99)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C575(0.89); C585(0.89); C863(0.96); C101(1.76)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C101(0.91); C575(1.01); C585(1.01); C100(1.06)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C575(1.03); C585(1.03); C863(1.20); C101(1.34)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C575(0.74); C585(0.74); C863(1.24); C101(1.37)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C100(0.84); C101(0.84); C80(0.88); C10(0.92)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C863(1.05); C80(1.05); C100(1.05); C101(1.05)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C10(0.70); C14(0.70); C863(1.11); C80(1.12)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C575(0.93); C585(0.93); C10(0.99); C14(0.99)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C575(0.78); C585(0.78); C863(0.86); C80(0.93)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C575(0.77); C585(0.77); C863(0.84); C100(1.06)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C10(0.80); C14(0.80); C863(0.93); C80(1.05)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C10(0.53); C14(0.53); C863(0.90); C80(0.93)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C10(0.74); C14(0.74); C80(0.84); C575(0.87)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C10(0.84); C14(0.84); C863(0.94); C100(0.99)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C10(0.79); C14(0.79); C575(0.83); C585(0.83)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C10(0.64); C14(0.64); C575(0.85); C585(0.85)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C10(0.74); C14(0.74); C100(1.08); C101(1.08)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C10(0.84); C14(0.84); C100(0.88); C101(0.88)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C575(0.88); C585(0.88); C10(1.06); C14(1.06)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C100(0.84); C101(0.84); C10(0.95); C14(0.95)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C10(0.96); C14(0.96); C100(0.99); C101(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C100(0.84); C101(0.84); C10(1.00); C14(1.00)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C10(0.85); C14(0.85); C100(1.07); C101(1.07)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C10(0.96); C14(0.96); C100(1.04); C101(1.04)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C10(0.83); C14(0.83); C100(0.95); C101(0.95)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C10(0.80); C14(0.80); C100(0.87); C101(0.87)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C10(0.75); C14(0.75); C100(0.94); C101(0.94)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C10(0.87); C14(0.87); C100(1.05); C101(1.05)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C10(0.96); C14(0.96); C100(1.13); C101(1.13)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C575(0.96); C585(0.96); C10(1.04); C14(1.04)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C10(0.86); C14(0.86); C100(1.08); C101(1.08)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C100(0.94); C101(0.94); C863(1.34); C10(1.41)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C10(0.83); C14(0.83); C100(1.48); C101(1.48)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C10(0.76); C14(0.76); C80(1.33); C863(1.44)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C10(0.77); C14(0.77); C80(0.83); C863(1.48)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C10(0.81); C14(0.81); C80(0.97); C863(1.14)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C10(0.86); C14(0.86); C863(1.05); C80(1.13)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C10(0.94); C14(0.94); C100(0.98); C863(0.99)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C80(0.82); C10(0.92); C14(0.92); C863(1.01)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C10(0.87); C14(0.87); C863(1.15); C101(1.43)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C100(0.92); C863(0.93); C101(0.97); C10(1.14)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C10(0.89); C14(0.89); C80(1.03); C863(1.39)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C10(0.78); C14(0.78); C80(1.05); C863(1.41)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C10(0.89); C14(0.89); C80(0.95); C863(1.06)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C80(0.91); C10(0.97); C14(0.97); C100(1.19)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C10(0.95); C14(0.95); C863(0.97); C100(1.06)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C10(1.00); C14(1.00); C863(1.04); C80(1.09)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C80(0.71); C10(0.74); C14(0.74); C863(1.40)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C10(0.41); C14(0.41); C100(1.42); C101(1.42)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C10(0.64); C14(0.64); C100(1.31); C101(1.31)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C100(1.20); C101(1.21); C10(1.30); C14(1.30)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C575(1.18); C585(1.18); C100(1.23); C10(1.28)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C575(0.98); C585(0.98); C10(1.00); C14(1.00)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C1770(1.20); C1784(1.20); C10(1.06); C14(1.06)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C1055(1.35)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C10(0.87); C14(0.87); C101(1.21); C100(1.26)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C10(0.78); C14(0.78); C101(2.96); C100(3.03)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C10(0.92); C14(0.92); C863(0.92); C100(1.04)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C10(1.05); C14(1.05); C575(1.07); C585(1.07)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C10(0.89); C14(0.89); C575(1.22); C585(1.22)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C575(1.11); C585(1.11); C100(1.21); C101(1.26)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C575(1.03); C585(1.03); C100(1.07); C101(1.13)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C10(1.10); C14(1.10); C100(1.59); C101(1.59)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C10(1.17); C14(1.17); C100(1.33); C101(1.33)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C100(1.14); C101(1.14); C10(1.29); C14(1.29)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C100(1.19); C101(1.19); C10(1.49); C14(1.49)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C10(1.13); C14(1.13); C100(1.50); C101(1.50)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C10(0.83); C14(0.83); C101(2.00); C100(2.16)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C100(1.37); C101(1.37); C10(1.39); C14(1.39)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C10(0.97); C14(0.97); C100(2.02); C101(2.02)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C10(0.80); C14(0.80); C863(0.87); C100(1.32)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C10(0.73); C14(0.73); C863(1.12); C100(1.38)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C10(0.63); C14(0.63); C863(0.98); C100(1.93)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C10(1.01); C14(1.01); C863(1.10); C100(1.44)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C10(0.78); C14(0.78); C863(1.14); C100(1.25)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C863(1.16); C100(1.31); C101(1.31)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C863(0.97); C100(1.04); C101(1.04)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C100(0.99); C101(0.99); C863(1.07)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C10(0.75); C14(0.75); C101(1.65); C100(1.70)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C100(0.98); C101(0.98); C863(1.02)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C863(0.87); C575(1.09); C585(1.09); C100(1.39)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C575(0.86); C585(0.86); C863(1.07); C101(1.36)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C863(0.84); C575(1.27); C585(1.27); C101(1.96)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C575(0.86); C585(0.86); C863(1.17); C101(1.51)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C10(0.89); C14(0.89); C80(0.90); C100(1.02)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C575(0.74); C585(0.74); C80(0.78); C863(0.88)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C10(0.77); C14(0.77); C575(0.86); C585(0.86)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C10(0.79); C14(0.79); C575(0.91); C585(0.91)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C10(0.79); C14(0.79); C101(1.30); C100(1.30)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C10(0.79); C14(0.79); C101(1.44); C100(1.48)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C10(0.85); C14(0.85); C101(1.83); C100(1.89)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C10(0.86); C14(0.86); C100(1.13); C101(1.13)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C10(0.79); C14(0.79); C80(1.30); C100(1.73)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C10(0.91); C14(0.91); C100(0.95); C101(0.95)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C10(0.92); C14(0.92); C100(0.93); C101(0.93)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C101(1.01); C100(1.03); C10(1.07); C14(1.07)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C10(0.85); C14(0.85); C100(0.95); C101(0.95)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C10(0.65); C14(0.65); C80(0.85); C100(1.63)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C10(0.85); C14(0.85); C100(1.01); C101(1.01)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C10(0.81); C14(0.81); C80(0.97); C100(1.04)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C10(0.90); C14(0.90); C100(1.06); C101(1.06)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C100(1.41); C101(1.41); C80(0.84); C10(0.83)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C100(1.08); C101(1.08); C80(1.72); C10(0.83)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C100(0.98); C101(0.98); C80(1.52); C10(1.00)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C100(1.06); C101(1.06); C80(1.37); C10(0.85)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C100(0.92); C101(0.92); C80(1.10); C10(0.83)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C100(1.06); C101(1.04); C10(0.91); C14(0.91)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C100(0.87); C101(0.87); C80(1.20); C10(0.97)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C100(1.14); C101(1.14); C10(0.90); C14(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C100(1.19); C101(1.19); C10(0.76); C14(0.76)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C100(2.56); C101(2.56); C10(0.56); C14(0.56)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C100(1.14); C101(1.14); C10(0.66); C14(0.66)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C100(1.01); C101(1.01); C10(0.61); C14(0.61)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C100(1.22); C101(1.22); C10(0.65); C14(0.65)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C100(0.96); C101(0.96); C10(0.62); C14(0.62)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C100(1.08); C101(1.08); C10(0.65); C14(0.65)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C100(1.34); C101(1.33); C10(0.94); C14(0.94)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C100(1.82); C101(1.82); C10(0.72); C14(0.72)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C100(1.32); C101(1.32); C10(0.67); C14(0.67)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C100(1.00); C101(1.00); C10(0.60); C14(0.60)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C100(1.08); C101(1.08); C10(0.63); C14(0.63)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C100(1.05); C101(1.05); C10(0.61); C14(0.61)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C100(1.60); C101(1.60); C10(0.65); C14(0.65)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C100(1.19); C101(1.19); C10(1.12); C14(1.12)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C100(1.04); C101(1.04); C10(1.06); C14(1.06)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C100(0.95); C101(0.95); C10(0.98); C14(0.98)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C100(0.99); C101(0.99); C10(0.86); C14(0.86)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C100(1.07); C101(1.06); C10(0.92); C14(0.92)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C100(0.95); C101(0.95); C10(0.88); C14(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C100(1.02); C101(1.02); C10(1.08); C14(1.08)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C100(1.03); C101(1.03); C10(1.01); C14(1.01)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C100(1.04); C101(1.04); C10(0.83); C14(0.83)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C100(1.15); C101(1.15); C10(0.85); C14(0.85)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C100(0.91); C101(0.91); C10(1.02); C14(1.02)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C100(1.08); C101(1.08); C10(0.94); C14(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C100(1.13); C101(1.13); C10(0.81); C14(0.81)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C100(1.02); C101(1.02); C10(1.00); C14(1.00)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C100(0.94); C101(0.94); C10(1.01); C14(1.01)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C100(1.36); C101(1.33); C10(0.87); C14(0.87)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C100(1.03); C101(1.03); C10(0.88); C14(0.88)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C100(0.96); C101(0.96); C10(1.04); C14(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C100(1.09); C101(1.09); C10(0.87); C14(0.87)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C100(1.19); C101(1.19); C10(0.93); C14(0.93)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C100(1.00); C101(1.00); C10(1.01); C14(1.01)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C100(0.90); C101(0.90); C10(1.03); C14(1.03)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C100(1.21); C101(1.21); C10(1.04); C14(1.04)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C100(0.82); C101(0.82); C10(0.90); C14(0.90)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C100(1.19); C101(1.19); C10(1.14); C14(1.14)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C100(1.19); C101(1.19); C10(0.96); C14(0.96)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C100(1.25); C101(1.23); C10(0.82); C14(0.82)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C100(1.08); C101(1.08); C10(1.03); C14(1.03)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C100(1.19); C101(1.19); C10(1.00); C14(1.00)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C100(1.21); C101(1.21); C10(0.97); C14(0.97)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C100(1.43); C101(1.43); C10(0.91); C14(0.91)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C100(1.07); C101(1.07); C10(0.88); C14(0.88)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C100(1.13); C101(1.13); C80(1.03); C10(0.96)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C100(1.36); C101(1.36); C80(0.76); C10(0.84)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C100(1.34); C101(1.34); C80(0.87); C10(0.90)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C100(1.36); C101(1.36); C80(1.01); C10(0.75)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C100(5.35); C101(5.12); C10(0.64); C14(0.64)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C100(0.98); C101(0.98); C80(1.09); C10(1.03)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C100(1.15); C101(1.15); C80(1.00); C10(0.78)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C100(1.53); C101(1.53); C80(0.92); C10(0.84)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C100(1.60); C101(1.60); C80(0.91); C10(0.77)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C100(2.18); C101(2.18); C80(1.02); C10(0.82)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C100(1.22); C101(1.22); C80(0.91); C10(1.01)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C100(1.09); C101(1.09); C80(0.86); C10(0.84)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C100(1.38); C101(1.38); C80(0.78); C10(0.83)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C100(1.47); C101(1.47); C80(0.79); C10(0.88)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C100(2.07); C101(2.07); C80(0.72); C10(0.92)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C100(1.26); C101(1.22); C10(0.82); C14(0.82)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C100(2.08); C101(2.08); C80(1.01); C10(0.69)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C100(1.02); C101(1.02); C10(1.01); C14(1.01)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C100(1.18); C101(1.18); C10(0.76); C14(0.76)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C100(0.93); C101(0.93); C10(0.84); C14(0.84)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C100(1.06); C101(1.06); C10(0.80); C14(0.80)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C100(1.53); C101(1.53); C10(0.71); C14(0.71)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C100(1.02); C101(1.02); C10(0.91); C14(0.91)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C100(1.10); C101(1.10); C10(0.86); C14(0.86)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C100(1.06); C101(1.06); C10(1.13); C14(1.13)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C100(1.02); C101(1.02); C10(1.22); C14(1.22)  LDD0811  [5]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C100, C101(6.18)  LDD0513  [12]
 LDCM0495  E2913 HEK-293T C863(1.01); C256(0.94); C193(1.08); C858(1.10)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C100(1.05); C101(1.05); C10(0.96); C14(0.96)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C100(2.73); C101(2.73); C10(0.66); C14(0.66)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C100(11.00); C101(11.00); C1770(3.78); C1784(3.78)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C100(2.92); C101(2.92); C1770(1.78); C1784(1.78)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C100(20.00); C101(20.00); C1770(2.96); C1784(2.96)  LDD0082  [5]
 LDCM0014  Panhematin HEK-293T 3.36  LDD0062  [3]
 LDCM0021  THZ1 HCT 116 C1770(1.20); C1784(1.20); C10(1.06); C14(1.06)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Iron-sulfur cluster co-chaperone protein HscB (HSCB) HscB family Q8IWL3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402