Details of the Target
General Information of Target
| Target ID | LDTP07370 | |||||
|---|---|---|---|---|---|---|
| Target Name | Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) | |||||
| Gene Name | MCTP2 | |||||
| Gene ID | 55784 | |||||
| Synonyms |
Multiple C2 and transmembrane domain-containing protein 2 |
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| 3D Structure | ||||||
| Sequence |
MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA
LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL |
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| Target Bioclass |
Transporter and channel
|
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| Family |
MCTP family
|
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| Subcellular location |
Membrane
|
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| Function | Might play a role in the development of cardiac outflow tract. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A375 | SNV: p.E737D | DBIA Probe Info | |||
| HCC1395 | SNV: p.K651N | . | |||
| HCT116 | SNV: p.R324C | . | |||
| HCT15 | SNV: p.A807V | . | |||
| HT3 | SNV: p.L757F | . | |||
| HUH7 | SNV: p.P79H | . | |||
| IPC298 | SNV: p.E121K | . | |||
| MEC1 | SNV: p.P584T | . | |||
| MOLT4 | SNV: p.A62T | . | |||
| NCIH1703 | SNV: p.V701L | . | |||
| OVK18 | SNV: p.S33R | . | |||
| SKMEL24 | SNV: p.E402K | . | |||
| UACC62 | SNV: p.V207A | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C604(2.71) | LDD3310 | [1] | |
|
IA-alkyne Probe Info |
 |
C497(14.60) | LDD0525 | [2] | |
|
IPM Probe Info |
 |
N.A. | LDD0147 | [3] | |
|
TFBX Probe Info |
 |
C497(0.00); C212(0.00); C604(0.00); C865(0.00) | LDD0148 | [3] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0217 | [4] | |
|
Methacrolein Probe Info |
 |
N.A. | LDD0218 | [4] | |
Competitor(s) Related to This Target
References