Details of the Target

General Information of Target

Target ID LDTP08564
Target Name E3 ubiquitin-protein ligase UBR1 (UBR1)
Gene Name UBR1
Gene ID 197131
Synonyms
E3 ubiquitin-protein ligase UBR1; EC 2.3.2.27; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLE
KQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPT
CVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRC
PLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDH
VIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHV
EVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDA
KLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQ
MFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLK
YILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQM
QLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRV
SEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVV
AEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEA
FNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEP
MPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSK
TQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAID
TDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLE
KLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERK
RKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRI
ALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEA
LDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLC
KSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIF
FNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPML
TWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVR
LLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFH
LITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVS
LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDT
VRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDE
RKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEG
KARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQM
LFGFNWQLL
Target Bioclass
Enzyme
Family
UBR1 family
Subcellular location
Cytoplasm, cytosol
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Uniprot ID
Q8IWV7
Ensemble ID
ENST00000290650.9
HGNC ID
HGNC:16808

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.C1119Y DBIA    Probe Info 
CCK81 SNV: p.I484T DBIA    Probe Info 
CHL1 SNV: p.P530S DBIA    Probe Info 
EFO27 SNV: p.S673N; p.Q1637Ter DBIA    Probe Info 
HCC15 SNV: p.I879F DBIA    Probe Info 
HCT15 Substitution: p.E753L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.F379LfsTer15
SNV: p.S1734T		 DBIA    Probe Info 
KELLY SNV: p.K1042R DBIA    Probe Info 
LS180 Deletion: p.L1708FfsTer21 DBIA    Probe Info 
MEWO Substitution: p.L1708F DBIA    Probe Info 
NCIH23 Insertion: p.N1582KfsTer8 DBIA    Probe Info 
OVK18 Deletion: p.N1043TfsTer54 DBIA    Probe Info 
PF382 SNV: p.H1250Q DBIA    Probe Info 
RH41 SNV: p.S1178N DBIA    Probe Info 
SKOV3 Deletion: p.F379LfsTer15 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.72  LDD0402  [1]
Probe 1
 Probe Info  		Y327(11.92); Y1077(35.88)  LDD3495  [2]
BTD
 Probe Info  		C180(0.38)  LDD2091  [3]
Acrolein
 Probe Info  		C477(0.00); C350(0.00); H408(0.00)  LDD0222  [4]
DBIA
 Probe Info  		C1603(1.00)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C279(0.00); C180(0.00); C1603(0.00); C112(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C279(0.00); C180(0.00); C574(0.00); C1685(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C279(0.00); C574(0.00); C1685(0.00); C99(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		C1603(0.00); C180(0.00)  LDD0005  [8]
TFBX
 Probe Info  		C1369(0.00); C1603(0.00); C1204(0.00)  LDD0148  [10]
NAIA_5
 Probe Info  		C279(0.00); C251(0.00); C1369(0.00); C589(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C343
 Probe Info  		18.77  LDD2005  [11]
C346
 Probe Info  		13.64  LDD2007  [11]
C419
 Probe Info  		10.85  LDD2074  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1603(0.69); C1569(0.58); C1577(0.58); C180(1.01)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1603(0.75); C1569(0.93); C1577(0.93); C180(1.23)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1685(0.70); C180(1.08); C336(0.72); C339(0.72)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1685(0.66); C180(1.41); C336(0.75); C339(0.75)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1685(0.65); C180(1.05); C336(0.76); C339(0.76)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1685(0.65); C180(1.32); C336(0.58); C339(0.58)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1685(0.88); C180(1.15); C336(0.73); C339(0.73)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1685(0.52); C180(1.54); C336(0.63); C339(0.63)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1685(0.65); C180(1.76); C336(0.65); C339(0.65)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1685(0.72); C180(1.62); C336(0.67); C339(0.71)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1685(0.57); C180(1.16); C336(0.76); C339(0.75)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1685(0.85); C180(1.13); C336(0.96); C339(0.85)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1603(0.69); C1569(0.98); C1577(0.98); C180(1.23)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1685(0.64); C180(1.15); C336(0.76); C339(0.74)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1685(0.57); C180(1.19); C336(0.81); C339(0.76)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1685(0.60); C180(1.26); C336(0.70); C339(0.72)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1569(1.04); C1577(1.04); C180(1.29); C336(1.00)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1569(0.81); C1577(0.81); C180(0.81); C336(0.87)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1569(0.80); C1577(0.80); C180(1.22); C336(0.83)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1569(0.77); C1577(0.77); C180(1.20); C336(0.83)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1569(0.90); C1577(0.90); C180(0.96); C336(0.90)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1569(1.00); C1577(1.00); C180(0.85); C336(1.03)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1569(0.79); C1577(0.79); C180(1.15); C336(0.94)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1603(0.66); C1569(0.96); C1577(0.96); C180(1.09)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1569(0.86); C1577(0.86); C180(1.18); C336(0.79)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1569(1.06); C1577(1.06); C180(1.04); C336(0.99)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1569(0.83); C1577(0.83); C180(1.61); C336(0.91)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1569(0.93); C1577(0.93); C180(0.77); C336(1.00)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1569(1.12); C1577(1.12); C180(1.04); C336(1.00)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1569(0.92); C1577(0.92); C180(1.60); C336(0.92)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1569(0.88); C1577(0.88); C180(1.28); C336(0.85)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1569(0.80); C1577(0.80); C180(1.24); C336(0.86)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1569(0.84); C1577(0.84); C336(1.08); C339(1.08)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1569(1.09); C1577(1.09); C336(1.19); C339(1.19)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1569(0.74); C1577(0.74); C336(0.92); C339(0.92)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1569(1.20); C1577(1.20); C336(1.16); C339(1.16)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1569(1.07); C1577(1.07); C336(1.11); C339(1.11)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1569(0.80); C1577(0.80); C336(1.08); C339(1.08)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1569(0.78); C1577(0.78); C336(0.97); C339(0.97)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1569(0.84); C1577(0.84); C336(0.95); C339(0.95)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1569(0.95); C1577(0.95); C336(1.25); C339(1.25)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1569(0.99); C1577(0.99); C336(1.20); C339(1.20)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1569(0.86); C1577(0.86); C336(0.91); C339(0.91)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1569(0.82); C1577(0.82); C336(1.02); C339(1.02)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1603(0.79); C1569(0.97); C1577(0.97); C180(1.10)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1569(0.84); C1577(0.84); C336(1.08); C339(1.08)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1569(0.84); C1577(0.84); C336(1.22); C339(1.22)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1569(0.87); C1577(0.87); C336(1.44); C339(1.44)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C574(0.87); C336(0.94); C339(0.94); C511(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C574(0.58); C339(0.74); C336(0.75); C511(0.91)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C574(0.69); C336(0.85); C339(0.85); C511(0.92)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C574(0.63); C336(0.77); C339(0.78); C279(0.89)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C574(0.61); C339(0.73); C336(0.75); C180(0.91)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C574(0.62); C336(0.76); C339(0.79); C511(0.84)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C574(0.51); C339(0.71); C336(0.72); C279(0.73)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C279(0.40); C99(0.76); C336(0.79); C339(0.79)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C574(0.62); C336(0.84); C339(0.85); C180(0.89)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C574(0.68); C336(0.84); C339(0.85); C180(0.98)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C574(0.44); C336(0.77); C339(0.77); C180(0.78)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C574(0.67); C279(0.74); C336(0.82); C339(0.86)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C180(1.06); C279(0.90); C336(0.96); C339(0.93)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C180(0.91); C279(0.75); C336(0.85); C339(0.85)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C180(1.03); C279(1.19); C336(0.91); C339(0.89)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C180(0.92); C279(1.33); C336(1.02); C339(1.02)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C574(0.98); C336(0.99); C339(0.99); C1577(1.00)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C511(0.79); C574(0.79); C336(0.87); C339(0.87)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C279(0.87); C350(0.88); C511(0.89); C574(0.92)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1569(0.74); C1577(0.74); C1603(0.90); C993(0.97)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C350(0.83); C574(0.87); C511(0.90); C1577(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C511(0.83); C574(0.85); C350(0.88); C180(0.98)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C336(0.87); C339(0.87); C511(0.88); C350(0.89)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C279(0.78); C511(0.88); C350(0.91); C477(0.95)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C279(0.93); C477(0.94); C574(0.94); C511(0.94)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C279(0.67); C511(0.79); C574(0.86); C993(0.87)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C279(0.56); C1569(0.68); C1577(0.68); C336(0.88)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C279(0.66); C336(0.74); C1569(0.78); C1577(0.78)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C279(0.64); C99(0.76); C574(0.84); C993(0.88)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C279(0.66); C872(0.69); C1569(0.70); C1577(0.70)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1569(0.73); C1577(0.73); C99(0.90); C1603(0.93)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C279(0.51); C1569(0.66); C1577(0.66); C872(0.72)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C279(0.67); C993(0.75); C1569(0.78); C1577(0.78)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C279(0.57); C1569(0.71); C1577(0.71); C336(0.74)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C279(0.58); C574(0.77); C336(0.79); C339(0.81)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C279(0.55); C336(0.74); C574(0.75); C339(0.78)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1603(0.67); C993(0.85); C574(0.92); C99(0.94)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1603(0.61); C180(0.87); C872(0.87); C993(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C872(0.73); C993(0.77); C1603(0.82); C279(0.88)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C872(0.78); C1685(0.94); C336(0.98); C339(0.98)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1603(0.89); C574(0.90); C993(0.96); C336(1.00)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1569(0.68); C1577(0.68); C993(0.93); C1603(0.94)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C872(0.70); C279(0.73); C1603(0.77); C336(0.85)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C872(0.51); C279(0.79); C336(0.84); C339(0.84)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C872(0.72); C1603(0.88); C99(0.90); C336(0.91)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C872(0.51); C1603(0.88); C99(0.90); C336(0.94)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C872(0.56); C993(0.71); C336(0.88); C339(0.88)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C872(0.54); C993(0.69); C279(0.78); C336(0.88)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C872(0.81); C336(0.93); C339(0.93); C350(1.04)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C279(0.92); C872(0.94); C336(0.95); C339(0.95)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C279(0.87); C872(0.94); C336(0.97); C339(0.97)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C872(0.81); C336(0.88); C339(0.88); C279(0.93)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1569(0.61); C1577(0.61); C1603(0.87); C336(0.88)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C279(0.85); C336(0.88); C339(0.88); C872(0.92)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C477(1.01); C872(1.02); C99(1.04); C279(1.10)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C279(0.84); C872(0.94); C574(0.95); C99(0.97)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C279(0.86); C350(0.92); C574(0.94); C872(0.94)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C279(0.78); C574(0.89); C350(0.90); C872(0.90)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C350(0.88); C336(0.98); C339(0.98); C574(1.04)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C279(0.95); C99(1.04); C872(1.04); C350(1.13)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C350(0.58); C574(0.76); C1603(0.79); C1569(0.87)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C279(0.70); C1569(0.80); C1577(0.80); C1603(0.91)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C350(0.73); C279(0.73); C574(0.89); C1569(0.96)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C279(0.36); C336(0.81); C339(0.81); C99(0.83)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C350(0.62); C279(0.65); C1569(0.87); C1577(0.87)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C350(0.66); C279(0.72); C1569(0.78); C1577(0.78)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C279(0.63); C1603(0.72); C350(0.75); C336(0.95)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1603(0.70); C350(0.76); C574(0.78); C279(0.80)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C350(0.69); C1603(0.81); C574(0.85); C279(0.87)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C279(0.85); C350(0.85); C1603(0.87); C1569(0.92)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1569(0.82); C1577(0.82); C1603(0.85); C279(0.92)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1603(0.70); C350(0.78); C1569(0.81); C1577(0.81)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1577(0.74); C574(0.82); C336(0.87); C339(0.87)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C477(0.78); C180(0.88); C350(0.88); C336(0.89)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C279(0.50); C1603(0.80); C99(0.81); C350(0.88)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C336(0.83); C339(0.83); C574(0.90); C99(0.91)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C477(0.79); C336(0.94); C339(0.94); C350(0.95)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C574(0.77); C336(0.81); C339(0.81); C350(0.97)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C336(0.88); C339(0.88); C99(0.89); C350(0.91)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C477(0.80); C350(0.91); C336(0.94); C339(0.94)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C350(0.84); C99(0.97); C336(0.98); C339(0.98)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C477(0.71); C336(0.82); C339(0.82); C350(0.93)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1577(0.76); C477(0.83); C350(0.84); C574(0.87)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1577(0.79); C477(0.82); C350(0.84); C99(0.94)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C336(0.92); C339(0.92); C99(0.92); C574(0.93)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C279(0.48); C1603(0.72); C99(0.75); C350(0.76)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C477(0.65); C350(0.83); C1577(0.84); C336(0.87)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C477(0.86); C99(0.89); C350(0.95); C279(1.01)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C99(0.81); C477(0.82); C350(0.87); C1577(0.92)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C279(0.60); C336(0.80); C339(0.80); C872(0.85)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C279(0.55); C872(0.70); C336(0.75); C339(0.75)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C279(0.55); C872(0.79); C336(0.86); C339(0.86)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C279(0.58); C872(0.77); C336(0.86); C339(0.86)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C279(0.74); C336(0.89); C339(0.89); C574(0.95)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C279(0.73); C350(0.76); C336(0.87); C339(0.87)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C279(0.64); C350(0.76); C872(0.79); C336(0.92)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C350(0.87); C336(1.04); C339(1.04); C574(1.09)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C279(0.57); C872(0.75); C336(0.77); C339(0.77)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C279(0.64); C872(0.77); C336(0.78); C339(0.78)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C279(0.61); C872(0.87); C336(0.89); C339(0.89)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C279(0.58); C574(0.98); C872(1.06); C336(1.10)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C279(0.67); C350(0.84); C336(0.85); C339(0.85)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C279(0.66); C872(0.81); C574(0.91); C336(0.97)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C279(0.58); C336(0.72); C339(0.72); C872(0.73)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C872(0.41); C336(0.65); C339(0.65); C1685(0.68)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1685(0.60); C872(0.66); C350(0.71); C336(0.76)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1603(0.63); C1569(1.01); C1577(1.01); C180(1.11)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C279(0.59); C1603(0.64); C99(0.86); C336(0.86)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C279(0.38); C336(0.69); C339(0.69); C99(0.70)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C1603(1.00)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C180(0.38)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C477(0.00); C350(0.00); H408(0.00)  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C1603(1.88)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C477(0.75); C279(0.84); C180(1.02); C336(1.03)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1569(0.64); C1577(0.64); C279(0.71); C574(0.90)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1569(0.63); C1577(0.63); C99(0.84); C336(0.95)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C279(0.45); C99(0.79); C350(0.80); C1603(0.82)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C279(0.52); C1603(0.80); C99(0.89); C336(0.91)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C279(0.55); C99(0.71); C1603(0.80); C350(0.85)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C279(0.65); C99(0.76); C336(0.80); C339(0.80)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C279(0.70); C350(0.83); C574(0.85); C336(0.90)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C279(0.58); C574(0.80); C350(0.84); C336(0.88)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C279(0.71); C574(0.75); C336(0.77); C339(0.77)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C279(0.65); C574(0.80); C350(0.88); C336(0.91)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C279(0.78); C1577(0.82); C336(0.85); C339(0.85)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1569(0.61); C1577(0.61); C279(0.76); C574(0.81)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C279(0.71); C574(0.79); C350(0.80); C336(0.88)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C350(0.81); C336(0.87); C339(0.87); C574(0.90)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C279(0.74); C99(0.80); C1569(0.81); C1577(0.81)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C279(0.57); C1569(0.66); C1577(0.66); C336(0.74)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1569(0.59); C1577(0.59); C279(0.62); C872(0.69)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C279(0.66); C1569(0.77); C1577(0.77); C336(0.79)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C279(0.60); C336(0.71); C339(0.79); C1569(0.85)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C99(0.67); C872(0.94); C993(1.06); C350(1.08)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C872(0.81); C336(0.89); C339(0.89); C350(0.96)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C279(0.76); C574(0.76); C336(0.83); C339(0.83)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1569(0.74); C1577(0.74); C574(0.79); C279(0.98)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C872(0.72); C1603(0.78); C99(0.87); C336(0.87)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C350(0.62); C279(0.76); C574(0.83); C872(0.91)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C872(0.88); C336(0.92); C339(0.92); C279(0.93)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C872(0.73); C99(0.80); C279(0.82); C350(0.86)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C279(0.79); C872(0.88); C336(0.89); C339(0.89)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C350(0.81); C1569(0.92); C1577(0.92); C1603(0.93)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1603(0.83); C350(0.87); C279(1.00); C1569(1.04)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C350(0.77); C1603(0.81); C1569(0.99); C1577(0.99)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C279(0.76); C350(0.77); C574(0.86); C336(0.90)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1569(0.60); C1577(0.60); C574(0.91); C279(0.92)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C279(0.75); C1569(0.92); C1577(0.92); C477(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1569(0.64); C1577(0.64); C279(0.87); C574(1.02)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1685(0.75); C350(0.78); C872(0.86); C1569(0.87)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1685(0.63); C1569(0.70); C1577(0.70); C350(0.73)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1569(0.42); C1577(0.42); C1685(0.50); C350(0.50)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1685(0.57); C1569(0.61); C1577(0.61); C350(0.65)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1685(0.84); C477(0.85); C350(0.91); C279(0.92)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C350(0.60); C279(0.60); C872(0.66); C1685(0.67)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1569(0.53); C1577(0.53); C1685(0.54); C350(0.59)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1569(0.48); C1577(0.48); C1685(0.50); C279(0.64)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C279(0.63); C872(0.67); C99(0.68); C350(0.72)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1569(0.58); C1577(0.58); C1685(0.59); C180(0.88)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1569(0.66); C1577(0.66); C1685(0.59); C180(0.99)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1569(0.76); C1577(0.76); C1685(0.75); C180(1.09)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1569(0.74); C1577(0.74); C1685(0.78); C180(0.96)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1569(0.63); C1577(0.63); C1685(0.51); C180(1.30)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1569(0.59); C1577(0.59); C1685(0.66); C180(0.82)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1603(0.91); C1569(0.95); C1577(0.95); C1685(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1569(0.76); C1577(0.76); C1685(0.68); C180(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1569(0.80); C1577(0.92); C180(1.52); C279(0.74)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1569(0.46); C1577(0.63); C180(1.57); C279(0.82)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1569(0.50); C1577(0.59); C180(1.51); C279(0.72)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1569(0.52); C1577(0.67); C180(1.33); C279(0.75)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1569(0.65); C1577(0.74); C180(1.27); C279(0.61)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1569(0.67); C1577(0.78); C180(1.08); C279(0.77)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1569(0.61); C1577(0.77); C180(2.09); C279(0.72)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1569(0.64); C1577(0.78); C180(1.09); C279(0.84)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1603(1.31); C1569(0.98); C1577(0.98); C1685(1.18)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1569(0.70); C1577(0.78); C180(1.32); C279(0.69)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1569(0.65); C1577(0.76); C180(1.16); C279(0.78)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1569(0.41); C1577(0.59); C180(1.38); C279(0.77)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1569(0.54); C1577(0.76); C180(1.09); C279(0.86)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1569(0.44); C1577(0.64); C180(1.41); C279(0.78)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1569(0.44); C1577(0.60); C180(1.29); C279(0.74)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1569(1.75); C1577(1.32); C1685(1.48); C180(1.10)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1569(1.31); C1577(1.07); C1685(1.19); C180(0.94)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1569(2.12); C1577(1.51); C1685(1.59); C180(0.93)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1569(1.36); C1577(1.19); C1685(1.00); C180(1.06)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1603(1.13); C1569(0.88); C1577(0.88); C1685(1.08)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1569(1.59); C1577(1.28); C1685(1.57); C180(1.09)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1569(1.34); C1577(1.20); C1685(0.92); C180(1.07)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1569(1.46); C1577(1.21); C1685(1.07); C180(1.23)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1569(1.53); C1577(1.39); C1685(1.74); C180(1.14)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1569(1.59); C1577(1.22); C1685(1.39); C180(1.56)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1569(1.41); C1577(1.13); C1685(1.33); C180(1.20)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1569(1.34); C1577(1.13); C1685(0.93); C180(1.05)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1569(1.40); C1577(1.17); C1685(1.14); C180(1.23)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1569(1.42); C1577(1.18); C1685(1.33); C180(1.00)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1569(1.21); C1577(1.04); C1685(1.08); C180(0.96)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1603(1.94); C1569(0.59); C1577(0.59); C1685(0.99)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1569(1.39); C1577(1.12); C1685(1.06); C180(1.19)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1569(0.97); C1577(0.97); C180(1.16); C279(0.94)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1569(0.86); C1577(0.86); C180(1.23); C279(1.00)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1569(0.73); C1577(0.73); C180(1.14); C279(0.94)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1569(0.69); C1577(0.69); C180(0.98); C279(0.96)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1569(0.83); C1577(0.83); C180(1.06); C279(1.15)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1569(0.69); C1577(0.69); C180(1.21); C279(0.80)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1569(0.76); C1577(0.76); C180(0.93); C279(0.99)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1569(0.61); C1577(0.61); C180(1.04); C279(0.89)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1569(0.67); C1577(0.67); C180(1.55); C279(1.40)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1603(1.14); C1569(0.70); C1577(0.70); C1685(1.18)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1569(0.65); C1577(0.65); C180(1.05); C279(0.87)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1569(0.72); C1577(0.72); C180(1.23); C279(0.72)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1569(0.84); C1577(0.84); C180(1.31); C279(1.19)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1569(0.79); C1577(0.79); C180(1.06); C279(1.11)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1569(0.79); C1577(0.79); C180(1.03); C279(0.97)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1603(1.45); C1569(0.81); C1577(0.81); C180(1.20)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1603(1.75); C1569(0.85); C1577(0.85); C180(1.33)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1603(1.20); C1569(0.85); C1577(0.85); C180(1.04)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1603(2.12); C1569(0.80); C1577(0.80); C180(1.44)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1603(5.39); C1569(0.66); C1577(0.66); C1685(0.76)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1603(1.37); C1569(0.76); C1577(0.76); C180(1.20)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1603(1.80); C1569(0.80); C1577(0.80); C180(1.37)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1603(1.97); C1569(0.89); C1577(0.89); C180(1.84)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1603(1.72); C1569(0.76); C1577(0.76); C180(2.07)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1603(2.11); C1569(0.75); C1577(0.75); C180(2.02)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1603(1.59); C1569(0.80); C1577(0.80); C180(1.44)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1603(1.04); C1569(0.94); C1577(0.94); C180(1.28)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1603(1.70); C1569(0.86); C1577(0.86); C180(1.51)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1603(1.58); C1569(0.87); C1577(0.87); C180(1.77)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1603(1.95); C1569(0.90); C1577(0.90); C180(1.91)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1603(1.83); C1569(0.85); C1577(0.85); C1685(0.87)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1603(2.15); C1569(1.21); C1577(1.21); C180(3.47)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1603(0.83); C1569(0.70); C1577(0.70); C180(1.03)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1603(0.74); C1569(0.72); C1577(0.72); C180(1.03)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1603(1.03); C1569(0.78); C1577(0.78); C180(1.02)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1603(1.19); C1569(0.61); C1577(0.61); C180(1.09)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1603(0.86); C1569(0.59); C1577(0.59); C180(1.09)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1603(0.89); C1569(0.70); C1577(0.70); C180(1.11)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1603(0.97); C1569(0.73); C1577(0.73); C180(1.11)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1603(1.02); C1569(0.65); C1577(0.65); C180(1.23)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1603(0.91); C1569(0.67); C1577(0.67); C180(1.09)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C589(0.86); C574(0.94); C180(1.16); C993(0.96)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(3.64)  LDD1702  [3]
 LDCM0204  EV-97 T cell C1603(7.56)  LDD0525  [13]
 LDCM0206  EV-99 T cell C1603(15.74)  LDD0521  [13]
 LDCM0625  F8 Ramos C1603(0.65)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C1603(1.75)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C180(0.92)  LDD2190  [14]
 LDCM0575  Fragment13 Ramos C1603(2.45)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C180(1.00); C1603(0.78)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C1603(2.89)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C1603(1.71)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C1603(1.46)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C1603(1.71)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C180(0.54); C1603(0.61)  LDD2198  [14]
 LDCM0589  Fragment31 Ramos C1603(2.48)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C1603(4.66)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C1569(0.82); C1577(0.82); C180(1.22); C279(0.90)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C1603(15.36)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C1603(0.90)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C1569(0.54); C1577(0.79); C180(1.33); C279(0.68)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C1603(2.27)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C1603(0.83)  LDD2186  [14]
 LDCM0022  KB02 HCT 116 C1603(2.50); C477(1.50)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1603(2.94); C477(1.38)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1603(5.88); C477(1.31)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C180(0.73)  LDD2102  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C180(0.96)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C279(1.15)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C279(0.91)  LDD2109  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C180(1.19)  LDD2118  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C279(1.16)  LDD2125  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C180(0.76)  LDD2150  [3]
 LDCM0021  THZ1 HCT 116 C477(1.10); C1603(1.10)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-hexosaminidase subunit beta (HEXB) Glycosyl hydrolase 20 family P07686
Transthyretin (TTR) Transthyretin family P02766
Ubiquitin-conjugating enzyme E2 B (UBE2B) Ubiquitin-conjugating enzyme family P63146
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578