Details of the Target

General Information of Target

Target ID LDTP03220
Target Name NAD-dependent malic enzyme, mitochondrial (ME2)
Gene Name ME2
Gene ID 4200
Synonyms
NAD-dependent malic enzyme, mitochondrial; NAD-ME; EC 1.1.1.38; Malic enzyme 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIET
QDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLAC
SQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP
VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMK
AITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK
PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS
YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALS
NPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVIL
CNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMA
FRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
Target Bioclass
Enzyme
Family
Malic enzymes family
Subcellular location
Mitochondrion matrix
Function NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
Uniprot ID
P23368
Ensemble ID
ENST00000321341.11
HGNC ID
HGNC:6984

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 SNV: p.H125Y DBIA    Probe Info 
TOV21G SNV: p.P78L DBIA    Probe Info 
YSCCC SNV: p.S387Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y347(20.00); Y361(20.00); Y231(16.77)  LDD0260  [1]
STPyne
 Probe Info  		K156(10.00); K26(1.76)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C185(0.78)  LDD2123  [4]
AHL-Pu-1
 Probe Info  		C428(3.61)  LDD0168  [5]
EA-probe
 Probe Info  		C120(0.93)  LDD2210  [6]
HHS-475
 Probe Info  		Y347(0.75)  LDD0264  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
DBIA
 Probe Info  		C198(0.49); C202(0.49); C441(1.50)  LDD0531  [9]
ATP probe
 Probe Info  		K156(0.00); K346(0.00)  LDD0199  [10]
CY-1
 Probe Info  		D233(0.00); D236(0.00)  LDD0246  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C428(0.00); C441(0.00); C274(0.00); C120(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		C428(0.00); C120(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C428(0.00); C441(0.00); C198(0.00); C202(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [15]
KY-26
 Probe Info  		N.A.  LDD0301  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
SF
 Probe Info  		K357(0.00); Y82(0.00)  LDD0028  [18]
AOyne
 Probe Info  		6.50  LDD0443  [19]
NAIA_5
 Probe Info  		C441(0.00); C481(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		K26(0.00); Y347(0.00)  LDD2240  [21]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.11  LDD1725  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
FFF probe3
 Probe Info  		20.00  LDD0464  [23]
STS-1
 Probe Info  		N.A.  LDD0136  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C428(3.61)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C428(3.44)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C198(0.49); C202(0.49); C441(1.50)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C441(0.92)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C190(0.53); C441(0.62)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C190(0.57); C441(0.62)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C190(0.86); C441(0.66)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C190(0.43); C441(0.41)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C190(0.84); C441(0.70)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C190(0.68); C441(0.50)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C190(0.37); C441(0.45)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C190(0.49); C441(0.45)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C190(0.43); C441(0.65)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C190(0.93); C441(0.92)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C441(1.25)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C190(0.41); C441(0.65)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C190(0.45); C441(0.56)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C190(0.47); C441(0.44)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C190(1.40); C441(1.16)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C190(1.02); C441(1.04)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C190(1.04); C441(0.99)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C190(0.88); C441(1.29)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C190(1.28); C441(1.21)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C190(1.05); C441(1.18)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C190(1.08); C441(1.14)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C441(1.47)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C190(1.05); C441(1.13)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C190(1.06); C441(1.31)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C190(1.16); C441(1.09)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C190(1.38); C441(1.21)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C190(0.94); C441(1.32)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C190(1.00); C441(1.17)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C190(1.11); C441(1.17)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C190(1.11); C441(1.36)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C441(1.20)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C441(1.49)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C441(1.14)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C441(1.25)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C441(1.06)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C441(1.16)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C441(0.82)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C441(0.85)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C441(0.88)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C441(0.98)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C441(0.67)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C441(0.71)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C441(1.60)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C441(0.60)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C441(0.65)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C441(1.06)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C198(0.94); C202(0.94); C441(0.95)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C198(0.54); C202(0.54); C441(0.87)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C198(0.74); C202(0.74); C441(0.92)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C198(0.44); C202(0.44); C441(0.62)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C198(0.56); C202(0.56); C441(0.62)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C198(0.26); C202(0.26); C441(0.56)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C198(0.44); C202(0.44); C441(0.55)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C441(1.27)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C441(0.96); C198(1.08); C202(1.08)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C441(0.88); C198(0.93); C202(0.93)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C441(0.49); C198(0.51); C202(0.51)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C198(0.18); C202(0.18); C441(0.58)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C198(0.66); C202(0.66); C441(0.76)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C198(0.69); C202(0.69); C441(0.98)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C198(0.88); C202(0.88); C441(0.87)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C198(1.14); C202(1.14); C441(0.78)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C198(0.99); C202(0.99); C441(1.13)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C198(0.73); C202(0.73); C441(0.90)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C441(1.02); C198(1.09); C202(1.09)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C198(0.89); C202(0.89); C441(1.02)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C441(1.05); C198(1.23); C202(1.23)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C198(0.91); C202(0.91); C441(1.11)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C441(1.10); C198(1.17); C202(1.17)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C441(0.96); C198(1.02); C202(1.02)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C198(1.17); C202(1.17); C441(1.35)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C441(0.75); C190(1.00)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C441(0.74); C190(0.88)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C441(1.00); C190(1.18)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C441(0.90); C190(0.93)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C441(0.60); C190(0.80)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C198(0.85); C202(0.85); C441(1.38)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C441(0.45); C190(0.72)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C190(0.80); C441(1.04)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C441(0.62); C190(0.72)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C441(0.36); C190(0.99)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C441(0.38); C190(0.91)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C198(1.35); C202(1.35); C441(1.52)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C198(0.99); C202(0.99); C441(1.21)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C441(1.04); C198(1.07); C202(1.07)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C441(1.12); C198(1.19); C202(1.19)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C198(0.92); C202(0.92); C441(0.97)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C198(0.64); C202(0.64); C441(1.57)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C441(0.76); C198(0.84); C202(0.84)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C198(0.99); C202(0.99); C441(1.10)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C198(0.93); C202(0.93); C441(0.94)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C441(0.72); C198(0.74); C202(0.74)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C441(0.98); C198(1.02); C202(1.02)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C441(0.70); C198(0.77); C202(0.77)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C198(0.82); C202(0.82); C441(1.03)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C198(0.67); C202(0.67); C441(1.01)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C198(0.33); C202(0.33); C441(0.54)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C198(0.33); C202(0.33); C441(0.51)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C198(0.58); C202(0.58); C441(1.50)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C198(0.37); C202(0.37); C441(0.54)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C441(1.15); C198(1.25); C202(1.25)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C198(0.91); C202(0.91); C441(1.19)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C441(0.70); C198(0.72); C202(0.72)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C441(0.68); C198(0.73); C202(0.73)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C198(0.41); C202(0.41); C441(0.46)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C198(0.19); C202(0.19); C441(0.24)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C198(0.43); C202(0.43); C441(1.08); C190(1.48)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C198(0.36); C202(0.36); C441(0.98); C190(1.26)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C198(0.50); C202(0.50); C441(0.74); C190(1.06)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C441(0.71)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C198(0.32); C202(0.32); C441(0.65); C190(1.04)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C198(0.24); C202(0.24); C441(0.80); C190(1.56)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C198(0.38); C202(0.38); C441(0.65); C190(1.41)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C198(0.44); C202(0.44); C441(0.71); C190(1.54)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C198(0.36); C202(0.36); C441(0.69); C190(1.76)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C198(0.48); C202(0.48); C441(0.87); C190(1.37)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C198(0.47); C202(0.47); C441(1.03); C190(1.28)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C198(0.15); C202(0.15); C441(0.56); C190(1.42)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C198(0.66); C202(0.66); C441(0.77); C190(0.83)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C198(0.36); C202(0.36); C441(0.70); C190(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C441(0.95)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C198(0.43); C202(0.43); C441(0.49); C190(0.70)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C198(0.63); C202(0.63); C190(0.96); C441(1.04)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C198(0.60); C202(0.60); C441(0.74); C190(0.84)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C198(0.21); C202(0.21); C441(0.46); C190(0.79)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C198(0.18); C202(0.18); C190(0.78); C441(0.80)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C198(0.12); C202(0.12); C441(0.39); C190(0.57)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C198(0.49); C202(0.49); C441(0.94); C190(1.10)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C198(0.52); C202(0.52); C441(0.68); C190(0.99)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C198(0.39); C202(0.39); C441(0.68); C190(0.97)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C198(0.61); C202(0.61); C441(0.77); C190(0.87)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C441(0.93)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C198(0.55); C202(0.55); C190(1.02); C441(1.09)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C198(0.41); C202(0.41); C190(0.62); C441(0.77)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C198(0.12); C202(0.12); C190(0.33); C441(0.61)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C190(0.31); C198(0.44); C202(0.44); C441(0.58)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C190(0.45); C198(0.55); C202(0.55); C441(0.55)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C190(0.43); C198(0.57); C202(0.57); C441(0.63)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C190(0.25); C441(0.73); C198(0.92); C202(0.92)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C190(0.25); C441(0.75); C198(1.16); C202(1.16)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C190(0.22); C441(0.65); C198(0.92); C202(0.92)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C190(0.20); C441(0.57); C198(0.86); C202(0.86)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C190(0.22); C198(1.38); C202(1.38); C441(1.50)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C190(0.48); C198(0.49); C202(0.49); C441(0.72)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C190(0.36); C198(0.70); C202(0.70); C441(0.77)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C190(0.41); C441(0.80); C198(0.94); C202(0.94)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C190(0.43); C198(0.72); C202(0.72); C441(1.07)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C190(0.23); C441(0.59); C198(0.89); C202(0.89)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C190(0.47); C198(0.67); C202(0.67); C441(0.85)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C190(0.21); C441(0.48); C198(0.73); C202(0.73)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C441(0.21); C190(0.44)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C441(0.52); C190(0.59)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C441(1.13)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C441(1.32)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C441(0.67)  LDD0592  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C441(0.83); C198(0.99); C202(0.99)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C198(0.37); C202(0.37); C441(0.84)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C198(0.60); C202(0.60); C441(1.32)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C441(0.98)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C441(0.97)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C441(1.21)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C441(0.98)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C441(0.81); C198(0.92); C202(0.92)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C198(0.47); C202(0.47); C441(0.63)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C198(0.80); C202(0.80); C441(0.81)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C198(0.70); C202(0.70); C441(0.87)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C441(0.79); C198(1.05); C202(1.05)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C198(0.36); C202(0.36); C441(1.29)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C198(0.71); C202(0.71); C441(1.01)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C198(0.80); C202(0.80); C441(0.84)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C441(0.77); C190(0.92)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C441(0.69); C190(0.86)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C441(0.50); C190(0.81)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C441(0.58); C190(1.15)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C441(0.53); C190(1.07)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C441(0.39); C198(0.43); C202(0.43)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C441(0.89); C198(0.90); C202(0.90)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C441(0.85); C198(0.89); C202(0.89)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C198(0.38); C202(0.38); C441(1.06)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C441(1.09); C198(1.11); C202(1.11)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C441(0.58); C198(0.98); C202(0.98)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C198(0.37); C202(0.37); C441(0.52)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C198(0.53); C202(0.53); C441(0.70)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C198(0.52); C202(0.52); C441(0.58)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C198(0.77); C202(0.77); C441(0.94); C190(1.38)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C198(0.72); C202(0.72); C190(0.96); C441(0.96)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C198(0.70); C202(0.70); C441(0.84); C190(1.08)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C198(0.59); C202(0.59); C441(1.04); C190(1.48)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C198(0.32); C202(0.32); C441(1.36)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C198(0.83); C202(0.83); C441(0.95)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C198(0.37); C202(0.37); C441(1.64)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C441(0.43)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C441(0.64)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C441(0.58)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C441(0.57)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C441(0.81); C198(0.95); C202(0.95)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C441(0.52)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C441(0.56)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C441(0.54)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C441(0.75)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C441(0.58)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C441(0.57)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C441(0.74)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C441(0.72)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C441(0.56)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C441(0.59)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C198(0.81); C202(0.81); C441(0.86)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C441(0.60)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C198(0.77); C202(0.77); C441(0.68)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C198(0.41); C202(0.41); C441(0.34)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C198(0.49); C202(0.49); C441(0.40)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C198(0.33); C202(0.33); C441(0.28)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C198(0.42); C202(0.42); C441(0.35)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C198(0.46); C202(0.46); C441(0.41)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C198(0.45); C202(0.45); C441(0.31)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C198(0.42); C202(0.42); C441(0.38)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C198(0.89); C202(0.89); C441(1.22)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C198(0.49); C202(0.49); C441(0.42)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C198(0.59); C202(0.59); C441(0.50)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C198(0.18); C202(0.18); C441(0.16)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C198(0.32); C202(0.32); C441(0.28)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C198(0.30); C202(0.30); C441(0.25)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C198(0.24); C202(0.24); C441(0.21)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C198(1.66); C202(1.66); C441(1.38)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C198(1.44); C202(1.44); C441(1.23)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C198(1.74); C202(1.74); C441(1.46)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C198(1.45); C202(1.45); C441(1.45)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C198(0.77); C202(0.77); C441(1.25)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C198(1.69); C202(1.69); C441(1.50)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C198(1.80); C202(1.80); C441(1.64)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C198(1.50); C202(1.50); C441(1.01)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C198(1.77); C202(1.77); C441(1.63)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C198(1.95); C202(1.95); C441(1.46)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C198(1.90); C202(1.90); C441(1.45)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C198(1.38); C202(1.38); C441(1.08)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C198(1.48); C202(1.48); C441(1.43)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C198(1.88); C202(1.88); C441(1.64)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C198(1.56); C202(1.56); C441(1.42)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C198(0.37); C202(0.37); C441(0.90)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C198(1.47); C202(1.47); C441(1.22)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C198(0.86); C202(0.86); C441(0.83)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C198(0.82); C202(0.82); C441(0.83)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C198(0.67); C202(0.67); C441(0.62)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C198(0.50); C202(0.50); C441(0.55)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C198(0.83); C202(0.83); C441(0.75)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C198(0.42); C202(0.42); C441(0.38)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C198(0.59); C202(0.59); C441(0.51)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C198(0.39); C202(0.39); C441(0.40)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C198(0.56); C202(0.56); C441(0.50)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C198(0.44); C202(0.44); C441(1.38)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C198(0.49); C202(0.49); C441(0.46)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C198(0.62); C202(0.62); C441(0.53)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C198(1.00); C202(1.00); C441(0.90)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C198(0.63); C202(0.63); C441(0.57)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C198(0.54); C202(0.54); C441(0.55)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C190(1.01); C198(0.54); C202(0.54); C441(0.96)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C190(0.93); C198(0.56); C202(0.56); C441(1.10)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C190(0.79); C198(0.84); C202(0.84); C441(0.96)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C190(1.11); C198(0.57); C202(0.57); C441(0.92)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C198(0.36); C202(0.36); C441(0.85)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C190(0.93); C198(0.51); C202(0.51); C441(0.92)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C190(1.17); C198(0.71); C202(0.71); C441(1.19)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C190(1.13); C198(0.33); C202(0.33); C441(1.07)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C190(1.46); C198(0.37); C202(0.37); C441(0.90)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C190(1.15); C198(0.26); C202(0.26); C441(0.65)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C190(1.14); C198(0.76); C202(0.76); C441(1.08)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C190(1.02); C198(0.87); C202(0.87); C441(1.22)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C190(1.26); C198(0.71); C202(0.71); C441(1.21)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C190(1.24); C198(0.46); C202(0.46); C441(1.11)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C190(1.13); C198(0.17); C202(0.17); C441(0.77)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C198(0.66); C202(0.66); C441(0.99)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C190(1.37); C198(1.34); C202(1.34); C441(1.34)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C198(0.75); C202(0.75); C441(0.91)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C198(0.81); C202(0.81); C441(0.95)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C198(0.69); C202(0.69); C441(1.43)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C198(0.64); C202(0.64); C441(1.36)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C198(0.68); C202(0.68); C441(1.24)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C198(0.77); C202(0.77); C441(1.03)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C198(0.79); C202(0.79); C441(1.01)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C198(0.64); C202(0.64); C441(1.00)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C198(0.61); C202(0.61); C441(1.17)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C274(0.92); C120(1.08); C198(0.93); C202(0.73)  LDD1698  [26]
 LDCM0175  Ethacrynic acid HeLa C120(0.93)  LDD2210  [6]
 LDCM0625  F8 Ramos C441(0.78); C120(0.82)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C441(0.77); C428(1.57)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C441(20.00); C120(0.27)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C441(1.04)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C441(1.37)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C441(1.00); C120(0.58); C428(0.62)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C441(1.26); C428(1.75)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C441(0.99)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C441(1.33)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C441(1.09)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C441(0.88); C120(0.34)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C441(1.33); C428(4.22)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C441(1.45)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C441(0.77)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C198(0.61); C202(0.61); C441(0.57)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C441(1.02)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C441(0.96); C120(0.85)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C198(0.26); C202(0.26); C441(0.20)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C441(1.80)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C441(1.36)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C441(0.85); C120(0.65)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C441(0.69)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y347(0.75)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y347(0.67)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y347(0.80)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y347(0.71)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y347(0.69)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C441(1.07); C120(1.01); C202(0.79)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C441(0.92); C120(1.03); C202(0.87)  LDD1497  [26]
 LDCM0024  KB05 HMCB C441(1.68); C274(1.64)  LDD3312  [28]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C185(0.78)  LDD2123  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fumaric Acid Small molecular drug DB01677
D-malic Acid . DB03499
Mesoxalic Acid . DB03589
Tartronate . DB03680

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840