Details of the Target

General Information of Target

Target ID LDTP13424
Target Name Vacuolar protein sorting-associated protein 28 homolog (VPS28)
Gene Name VPS28
Gene ID 51160
Synonyms
Vacuolar protein sorting-associated protein 28 homolog; H-Vps28; ESCRT-I complex subunit VPS28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSC
SRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHT
RPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLIL
EEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFF
LQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQ
GCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPP
YTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCD
FSFTEESDGLS
Target Bioclass
Other
Family
VPS28 family
Subcellular location
Cell membrane
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
Uniprot ID
Q9UK41
Ensemble ID
ENST00000292510.6
HGNC ID
HGNC:18178

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.Y36Ter DBIA    Probe Info 
NCIH1155 SNV: p.T138M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.69  LDD0402  [1]
STPyne
 Probe Info  		K35(1.64); K78(1.14)  LDD0277  [2]
BTD
 Probe Info  		C103(1.04)  LDD2100  [3]
EA-probe
 Probe Info  		C128(0.97)  LDD2210  [4]
DBIA
 Probe Info  		C103(7.65)  LDD0209  [5]
HHS-475
 Probe Info  		Y36(0.75)  LDD0264  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C103(0.00); C96(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C103(0.00); C96(0.00); C128(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C103(0.00); C96(0.00); C128(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		C103(0.00); C128(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C96(0.00); C70(0.00); C60(0.00)  LDD0027  [9]
Acrolein
 Probe Info  		C96(0.00); C103(0.00)  LDD0217  [11]
W1
 Probe Info  		C103(0.00); C96(0.00)  LDD0236  [12]
AOyne
 Probe Info  		14.50  LDD0443  [13]
NAIA_5
 Probe Info  		C96(0.00); C128(0.00); C103(0.00); C70(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C103(0.98); C96(0.99); C128(1.09); C60(0.98)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C103(0.93); C96(0.92); C128(1.04); C60(0.96)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C103(1.07); C96(1.08); C128(0.94); C60(0.99)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C103(1.08); C96(1.08); C128(1.06); C60(1.08)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C103(1.06); C96(1.13); C128(1.12); C60(0.92)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C103(0.99); C96(1.02); C128(1.07); C60(1.13)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C103(1.02); C96(0.98); C128(1.09); C60(1.06)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C103(1.04); C96(0.96); C128(1.01); C60(1.05)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C103(0.95); C96(0.89); C128(0.83); C60(1.24)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C103(1.02); C96(1.07); C128(1.19); C60(0.97)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C103(1.07); C96(1.15); C128(1.12); C60(1.19)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C103(1.08); C96(1.02); C128(1.04); C60(1.12)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C103(1.10); C96(1.11); C128(1.11); C60(1.00)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C103(1.09); C96(1.10); C128(1.03); C60(1.12)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C103(1.16); C96(1.09); C128(1.17); C60(0.96)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C103(1.00); C96(0.98); C128(1.05); C60(1.00)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C103(0.96); C96(1.01); C128(0.96); C60(0.84)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C103(1.10); C96(0.99); C128(0.91); C60(1.26)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C103(1.05); C96(0.94); C128(1.03); C60(1.05)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C103(0.97); C96(0.89); C128(0.95); C60(1.01)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C103(0.91); C96(1.03); C128(0.88); C60(0.87)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C103(1.03); C96(1.01); C128(1.04); C60(0.91)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C103(0.96); C96(0.94); C128(1.01); C60(1.14)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C103(1.11); C96(1.02); C128(1.07); C60(1.00)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C103(1.05); C96(1.03); C128(1.24); C60(1.12)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C103(1.02); C96(1.12); C128(1.07); C60(0.98)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C103(1.08); C96(1.05); C128(1.01); C60(0.94)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C103(1.09); C96(1.03); C128(1.15); C60(1.30)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C103(1.06); C96(1.16); C128(1.07); C60(1.26)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C103(1.12); C96(1.15); C128(1.13); C60(1.02)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C103(1.02); C96(0.97); C128(1.01); C60(1.27)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C103(1.00); C96(0.93); C128(1.02); C60(0.84)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C103(1.17); C96(1.17); C128(1.06); C60(1.12)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C103(1.06); C96(1.03); C128(1.15); C60(1.24)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C103(0.99); C96(1.01); C128(1.03); C60(0.95)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C103(1.07); C96(1.13); C128(0.97); C60(0.96)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C103(1.08); C96(1.16); C128(1.23); C60(1.29)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C103(1.00); C96(0.87); C128(1.05); C60(1.03)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C103(1.07); C96(1.17); C128(1.12); C60(0.93)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C103(1.08); C96(1.09); C128(1.02); C60(1.01)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C103(1.12); C96(1.23); C128(1.25); C60(1.12)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C103(1.05); C96(1.07); C128(1.15); C60(0.98)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C103(0.92); C96(0.99); C128(1.03); C60(0.90)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C103(0.95); C96(0.97); C128(0.98); C60(0.94)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C103(1.10); C96(1.18); C128(0.94); C60(0.94)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C103(1.04); C96(1.07); C128(1.15); C60(1.23)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C103(1.01); C96(1.21); C128(1.11); C60(1.16)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C103(1.12); C96(1.22); C128(1.20); C60(1.05)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C103(1.01); C96(1.03); C128(1.02); C60(1.08)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C103(1.13); C96(1.06); C128(1.14); C60(0.89)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C103(1.04); C96(0.97); C128(1.18); C60(0.98)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C103(1.08); C96(1.07); C128(1.01); C60(0.93)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C103(1.13); C96(1.07); C128(1.00); C60(0.89)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C103(0.96); C96(1.04); C128(1.05); C60(0.85)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C103(1.09); C96(1.07); C128(1.09); C60(1.21)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C103(0.99); C96(0.97); C128(1.06); C60(1.02)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C103(1.02); C96(1.09); C128(1.09); C60(1.03)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C103(1.12); C96(0.93); C128(1.01); C60(1.17)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C103(1.05); C96(1.07); C128(1.01); C60(0.91)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C103(0.95); C96(0.98); C128(1.00); C60(0.93)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C103(1.02); C96(0.97); C128(0.97); C60(0.80)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C103(1.04); C96(1.07); C128(1.05); C60(0.98)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C103(0.98); C96(1.04); C128(1.12); C60(1.05)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C103(1.00); C96(1.06); C128(1.12); C60(1.07)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C128(1.25)  LDD2214  [15]
 LDCM0108  Chloroacetamide HeLa C103(0.00); C96(0.00); C70(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C96(20.00); C103(0.89); C103(0.86)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C103(1.06); C96(1.00); C128(1.08); C60(1.16)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C103(1.09); C96(0.86); C128(1.09); C60(1.05)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C103(1.00); C96(0.87); C128(0.93); C60(1.14)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C103(0.97); C96(1.03); C128(1.10); C60(1.18)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C103(1.06); C96(0.85); C128(1.02); C60(1.18)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C103(1.06); C96(0.92); C128(1.10)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C103(0.95); C96(0.84); C128(0.97); C60(1.12)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C103(0.98); C96(1.11); C128(1.05); C60(1.14)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C103(1.02); C96(1.00); C128(0.99); C60(1.18)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C103(1.14); C96(0.93); C128(1.03)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C103(0.89); C96(0.88); C128(0.95); C60(1.10)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C103(1.03); C96(0.95); C128(0.96); C60(1.06)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C103(1.07); C96(1.02); C128(1.08); C60(1.61)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C103(0.96); C96(0.82); C128(0.96); C60(1.08)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C103(1.01); C96(0.87); C128(0.97)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C103(0.90); C96(0.88); C128(0.95); C60(0.95)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C103(1.12); C96(1.15); C128(1.13); C60(1.14)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C103(1.08); C96(0.94); C128(1.01); C60(1.03)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C103(1.05); C96(0.99); C128(0.98)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C103(1.01); C96(1.01); C128(0.99); C60(1.05)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C103(0.95); C96(1.08); C128(1.14); C60(1.05)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C103(0.97); C96(0.95); C128(1.01); C60(1.10)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C103(1.09); C96(1.00); C128(1.06)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C103(1.27); C96(1.10); C128(1.16); C60(1.38)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C103(0.97); C96(0.97); C128(1.08); C60(1.11)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C103(0.94); C96(0.98); C128(1.15); C60(1.22)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C103(0.97); C96(0.97); C128(1.09); C60(1.02)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C103(1.08); C96(0.86); C128(1.04)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C103(0.92); C96(0.93); C128(1.03); C60(1.03)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C103(0.98); C96(0.97); C128(1.15); C60(1.24)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C103(1.07); C96(1.10); C128(1.11); C60(1.03)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C103(1.09); C96(0.94); C128(1.03)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C103(1.01); C96(0.92); C128(1.04); C60(0.93)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C103(0.90); C96(0.91); C128(1.04); C60(1.05)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C103(1.03); C96(0.88); C128(1.08); C60(1.10)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C103(1.01); C96(0.90); C128(1.08)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C103(0.99); C96(0.98); C128(1.04); C60(1.35)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C103(1.14); C96(0.86); C128(1.15); C60(1.37)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C103(1.00); C96(1.02); C128(1.05); C60(1.02)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C103(1.04); C96(1.10); C128(0.96); C60(1.24)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C103(1.04); C96(0.95); C128(1.06); C60(1.05)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C103(1.24); C96(1.12); C128(1.18); C60(1.16)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C103(1.53); C96(1.07); C128(1.05); C60(1.46)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C103(1.17); C96(1.13); C128(1.11); C60(1.12)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C103(1.12); C96(1.15); C128(1.13); C60(1.54)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C103(1.17); C96(1.32); C128(1.32); C60(0.94)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C103(1.02); C96(1.06); C128(1.19); C60(1.22)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C103(1.01); C96(1.09); C128(1.07); C60(1.08)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C103(1.06); C96(0.95); C128(1.11)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C103(0.95); C96(0.97); C128(1.01); C60(0.93)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C103(1.01); C96(1.01); C128(1.14); C60(1.34)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C103(1.09); C96(1.06); C128(1.08)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C103(0.93); C96(1.14); C128(1.01); C60(0.94)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C103(1.06); C96(1.09); C128(0.99); C60(1.11)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C103(1.19); C96(1.03); C128(1.08); C60(1.30)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C103(1.14); C96(0.78); C128(1.12); C60(1.36)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C103(1.22); C96(1.16); C128(1.05); C60(1.11)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C103(1.08); C96(1.09); C128(1.05); C60(1.39)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C103(1.51); C96(1.04); C128(1.19); C60(1.20)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C103(1.07); C96(1.16); C128(1.20); C60(1.14)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C103(1.11); C96(1.02); C128(1.06)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C103(0.94); C96(0.89); C128(1.00); C60(1.13)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C103(0.99); C96(1.01); C128(1.08); C60(1.40)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C103(1.08); C96(0.97); C128(1.11); C60(1.18)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C103(1.04); C96(1.11); C128(1.05); C60(0.93)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C103(1.25); C96(1.13); C128(1.06); C60(1.20)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C103(1.14); C96(1.04); C128(1.12); C60(1.16)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C103(1.14); C96(1.03); C128(1.07); C60(1.18)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C103(1.29); C96(1.17); C128(1.00); C60(1.07)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C103(1.13); C96(1.09); C128(1.17); C60(1.71)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C103(1.27); C96(1.28); C128(1.27); C60(1.48)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C103(0.93); C96(1.07); C128(1.08); C60(1.13)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C103(1.02); C96(1.00); C128(1.26); C60(1.37)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C103(1.01); C96(0.94); C128(1.05); C60(1.06)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C103(0.92); C96(0.89); C128(1.01); C60(1.21)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C103(1.08); C96(0.88); C128(1.18); C60(1.23)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C103(1.04); C96(0.91); C128(1.10); C60(0.96)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C103(1.19); C96(1.06); C128(0.98); C60(1.18)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C103(1.21); C96(1.16); C128(1.14); C60(1.15)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C103(1.16); C96(0.98); C128(1.03); C60(1.19)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C103(1.30); C96(1.13); C128(1.05); C60(1.03)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C103(1.07); C96(0.99); C128(1.07); C60(1.58)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C103(1.03); C96(0.94); C128(1.07); C60(1.09)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C103(1.40); C96(1.18); C128(1.42); C60(1.08)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C103(0.96); C96(1.14); C128(1.28); C60(1.11)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C103(1.05); C96(0.97); C128(1.18); C60(1.02)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C103(1.07); C96(1.03); C128(1.08)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C103(1.10); C96(0.95); C128(0.99); C60(1.17)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C103(1.03); C96(1.13); C128(1.18); C60(1.05)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C103(1.05); C96(1.01); C128(1.01); C60(0.94)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C103(1.13); C96(1.07); C128(0.98); C60(1.00)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C103(1.32); C96(1.11); C128(1.15); C60(1.29)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C103(1.16); C96(0.92); C128(1.12); C60(1.29)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C103(1.06); C96(0.97); C128(0.94); C60(1.10)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C103(1.21); C96(1.13); C128(1.03); C60(1.14)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C103(1.05); C96(0.96); C128(1.07); C60(1.43)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C103(1.29); C96(1.36); C128(1.34); C60(1.39)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C103(1.03); C96(0.98); C128(1.02); C60(1.64)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C103(0.96); C96(0.90); C128(1.03); C60(1.00)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C103(0.89); C96(0.97); C128(0.95); C60(1.10)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C103(1.07); C96(0.88); C128(1.03); C60(1.06)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C103(0.96); C96(0.98); C128(1.01); C60(1.05)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C103(1.07); C96(1.02); C128(0.91); C60(0.97)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C103(1.27); C96(0.78); C128(1.41); C60(1.50)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C103(1.14); C96(1.10); C128(1.00); C60(1.24)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C103(1.17); C96(0.99); C128(1.10); C60(1.35)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C103(1.16); C96(1.05); C128(1.09); C60(0.99)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C103(1.13); C96(1.00); C128(1.03); C60(1.43)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C103(1.20); C96(0.90); C128(1.06); C60(1.08)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C103(0.97); C96(1.06); C128(1.24); C60(1.06)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C103(1.00); C96(1.09); C128(1.12); C60(1.19)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C103(1.04); C96(0.96); C128(1.07)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C103(0.91); C96(0.95); C128(1.10); C60(1.04)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C103(1.01); C96(1.05); C128(1.24); C60(1.34)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C103(1.17); C96(0.97); C128(0.97); C60(1.14)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C103(1.06); C96(0.94); C128(1.16); C60(1.23)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C103(1.08); C96(1.12); C128(1.04); C60(1.03)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C103(1.20); C96(1.04); C128(1.20); C60(1.17)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C103(1.24); C96(1.07); C128(1.13); C60(1.30)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C103(1.16); C96(1.14); C128(1.22); C60(1.32)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C103(1.09); C96(0.86); C128(1.03); C60(1.54)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C103(1.20); C96(1.00); C128(1.13); C60(1.20)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C103(1.04); C96(0.93); C128(1.08); C60(1.18)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C103(1.06); C96(0.89); C128(0.98); C60(0.99)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C103(0.96); C96(0.90); C128(1.02)  LDD1697  [14]
 LDCM0634  CY-0357 Hep-G2 C96(0.79)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C103(1.10); C96(0.93); C128(1.12)  LDD1698  [14]
 LDCM0175  Ethacrynic acid HeLa C128(0.97)  LDD2210  [4]
 LDCM0625  F8 Ramos C103(0.80)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C103(1.11)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C103(0.38)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C103(1.70)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C103(0.81)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C103(1.20)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C103(1.44)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C103(0.86)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C103(0.25)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C103(0.79)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C103(0.57)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C103(1.11)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C103(1.02)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C103(0.99)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C103(1.00); C96(0.89); C128(1.01)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C103(1.44)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C103(1.69)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C103(0.98); C96(1.06); C128(1.14); C60(1.08)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C103(1.01)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C103(0.77)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C103(0.88)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C103(0.96)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y36(0.75)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y36(0.92)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y36(1.02)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y36(1.14)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y36(1.00)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C103(0.89); C96(1.16); C128(1.01); C60(1.01)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C103(7.65)  LDD0209  [5]
 LDCM0024  KB05 HMCB C128(2.31)  LDD3312  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C103(0.81)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0226  [11]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C103(1.04)  LDD2100  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C60(0.89)  LDD2120  [3]
 LDCM0131  RA190 MM1.R C60(1.61); C70(1.61)  LDD0304  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
GTP-binding protein GEM (GEM) RGK family P55040
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Huntingtin (HTT) Huntingtin family P42858
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin-45 (BLZF1) . Q9H2G9
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX2 (BEX2) BEX family Q9BXY8
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Nuclear exosome regulator NRDE2 (NRDE2) NRDE2 family Q9H7Z3
Ski-like protein (SKIL) SKI family P12757
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Translin-associated protein X (TSNAX) Translin family Q99598
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
SHC-transforming protein 3 (SHC3) . Q92529

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.