Details of the Target

General Information of Target

Target ID LDTP14153
Target Name Trafficking protein particle complex subunit 1 (TRAPPC1)
Gene Name TRAPPC1
Gene ID 58485
Synonyms
BET5; MUM2; Trafficking protein particle complex subunit 1; BET5 homolog; Multiple myeloma protein 2; MUM-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPNDEAFSKPSTPSEAPHAPGVPPQGRAGGFGKASGALVGAASGSSAGGSSRGGGSGSGA
SDLGAGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVA
LRRQQAQEEELGISHPIPLPSAAELLVKRENNGSNPCLMTECSGTSQPPPASVPTTAASE
GRMVIQDIPAVTSRGHVENTPDLVSDSTYYSSFYQPSLFPYYNNLYNCPQYSMALAADSA
SGEVGNPLGGSPVKNSLRGLPGPYVPGQTGNQWQMKNMENRHAMSSQYRMHSYYPPPSYL
GQSVPQFFTFEDAPSYPEARASVFSPPSSQDSGLVSLSSSSPISNKSTKAVLECEPASEP
SSFTVTPVIEEDE
Target Bioclass
Other
Family
TRAPP small subunits family, BET5 subfamily
Subcellular location
Golgi apparatus, cis-Golgi network
Function May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Uniprot ID
Q9Y5R8
Ensemble ID
ENST00000303731.9
HGNC ID
HGNC:19894

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(2.64)  LDD3312  [1]
EA-probe
 Probe Info  		C115(1.45)  LDD2210  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C15(0.00); C115(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C15(0.00); C115(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C15(0.00); C115(0.00)  LDD0037  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
IPM
 Probe Info  		C115(0.00); C15(0.00)  LDD2156  [5]
VSF
 Probe Info  		N.A.  LDD0007  [4]
W1
 Probe Info  		N.A.  LDD0236  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C115(1.00)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C115(1.02)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C115(1.01)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C115(0.91)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C115(0.95)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C115(0.95)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C115(0.93)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C115(1.04)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C115(0.93)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C115(0.96)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C115(1.06)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C115(0.90)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C115(0.95)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C115(0.82)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C115(0.95)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C115(1.15)  LDD0883  [10]
 LDCM0286  AC26 HEK-293T C115(0.89)  LDD0884  [10]
 LDCM0287  AC27 HEK-293T C115(0.87)  LDD0885  [10]
 LDCM0288  AC28 HEK-293T C115(1.09)  LDD0886  [10]
 LDCM0289  AC29 HEK-293T C115(1.21)  LDD0887  [10]
 LDCM0290  AC3 HEK-293T C115(0.93)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C115(0.91)  LDD0889  [10]
 LDCM0292  AC31 HEK-293T C115(0.80)  LDD0890  [10]
 LDCM0293  AC32 HEK-293T C115(1.22)  LDD0891  [10]
 LDCM0294  AC33 HEK-293T C115(0.89)  LDD0892  [10]
 LDCM0295  AC34 HEK-293T C115(1.04)  LDD0893  [10]
 LDCM0296  AC35 HEK-293T C115(1.06)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C115(1.06)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C115(1.07)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C115(0.94)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C115(1.02)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C115(1.01)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C115(1.02)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C115(0.85)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C115(1.11)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C115(1.06)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C115(1.04)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C115(0.92)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C115(0.41)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C115(0.44)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C115(0.49)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C115(0.72)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C115(0.94)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C115(0.48)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C115(0.52)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C115(0.66)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C115(0.49)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C115(0.75)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C115(0.62)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C115(0.51)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C115(1.14)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C115(1.49)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C115(1.20)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C115(0.95)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C115(1.62)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C115(1.71)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C115(1.32)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C115(1.54)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C115(1.35)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C115(1.71)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C115(1.32)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C115(1.51)  LDD0929  [10]
 LDCM0334  AC7 HEK-293T C115(1.04)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C115(0.93)  LDD1569  [9]
 LDCM0349  AC83 HEK-293T C115(1.74)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C115(1.50)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C115(1.32)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C115(1.37)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C115(1.26)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C115(1.29)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C115(1.45)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C115(2.29)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C115(1.58)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C115(1.42)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C115(1.25)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C115(1.47)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C115(2.05)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C115(1.43)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C115(2.29)  LDD0962  [10]
 LDCM0248  AKOS034007472 HEK-293T C115(0.99)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C115(1.04)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C115(1.01)  LDD1514  [9]
 LDCM0630  CCW28-3 231MFP C115(0.04)  LDD2214  [11]
 LDCM0632  CL-Sc Hep-G2 C115(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C115(1.08)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C115(1.30)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C115(1.04)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C115(0.88)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C115(1.02)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C115(1.09)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C115(1.07)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C115(1.02)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C115(1.02)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C115(1.05)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C115(1.07)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C115(1.13)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C115(1.58)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C115(1.20)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C115(1.05)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C115(0.91)  LDD0980  [10]
 LDCM0383  CL113 HEK-293T C115(0.89)  LDD0981  [10]
 LDCM0384  CL114 HEK-293T C115(1.59)  LDD0982  [10]
 LDCM0385  CL115 HEK-293T C115(1.35)  LDD0983  [10]
 LDCM0386  CL116 HEK-293T C115(1.33)  LDD0984  [10]
 LDCM0387  CL117 HEK-293T C115(0.94)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C115(1.00)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C115(1.06)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C115(1.41)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C115(0.96)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C115(0.67)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C115(0.39)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C115(0.39)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C115(0.68)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C115(1.24)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C115(1.40)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C115(1.00)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C115(1.24)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C115(1.10)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C115(0.86)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C115(1.23)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C115(1.06)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C115(0.98)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C115(1.12)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C115(1.24)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C115(1.09)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C115(1.09)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C115(1.66)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C115(1.17)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C115(1.25)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C115(1.42)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C115(0.99)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C115(0.88)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C115(1.11)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C115(1.03)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C115(1.04)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C115(1.17)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C115(0.94)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C115(1.23)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C115(1.11)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C115(1.59)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C115(1.21)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C115(1.18)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C115(1.32)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C115(1.12)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C115(1.15)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C115(1.02)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C115(1.02)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C115(0.93)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C115(1.01)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C115(1.26)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C115(1.02)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C115(1.24)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C115(1.19)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C115(1.29)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C115(1.29)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C115(1.07)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C115(0.95)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C115(1.05)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C115(1.01)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C115(0.97)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C115(1.32)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C115(1.11)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C115(1.24)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C115(1.09)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C115(1.27)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C115(1.26)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C115(1.26)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C115(1.23)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C115(1.03)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C115(1.04)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C115(1.16)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C115(1.09)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C115(1.00)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C115(1.03)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C115(1.10)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C115(1.07)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C115(1.47)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C115(1.17)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C115(1.01)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C115(1.15)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C115(1.14)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C115(1.12)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C115(0.97)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C115(1.03)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C115(1.06)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C115(1.04)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C115(1.05)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C115(0.77)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C115(0.99)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C115(1.14)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C115(1.04)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C115(1.25)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C115(1.24)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C115(1.07)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C115(0.85)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C115(1.13)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C115(0.98)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C115(0.98)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C115(1.10)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C115(1.27)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C115(1.13)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C115(1.14)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C115(1.43)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C115(1.01)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C115(1.11)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C115(1.34)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C115(1.06)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C115(1.15)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C115(1.03)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C115(1.10)  LDD1698  [9]
 LDCM0175  Ethacrynic acid HeLa C115(1.45)  LDD2210  [2]
 LDCM0625  F8 Ramos C115(0.63)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C115(0.98)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C15(15.29)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C115(1.20)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C115(0.94)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C15(1.79); C115(1.60)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C115(0.88)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C115(1.03)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C115(0.67)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C115(0.79)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C15(1.28); C115(0.70)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C115(1.22)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C115(0.82)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C115(1.04)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C115(0.97)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C115(0.86)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C115(1.26)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C115(0.92)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C115(1.10)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C115(0.74)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C15(1.57); C115(0.80)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C115(0.90)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C115(0.91)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C115(0.89)  LDD1497  [9]
 LDCM0024  KB05 HMCB C115(2.64)  LDD3312  [1]
 LDCM0131  RA190 MM1.R C115(1.30)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trafficking protein particle complex subunit 3 (TRAPPC3) TRAPP small subunits family O43617

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-palmitoyl-l-cysteine . DB08342

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.