Details of the Target

General Information of Target

Target ID LDTP01772
Target Name Cytochrome c oxidase subunit 1 (MT-CO1)
Gene Name MT-CO1
Gene ID 4512
Synonyms
COI; COXI; MTCO1; Cytochrome c oxidase subunit 1; EC 7.1.1.9; Cytochrome c oxidase polypeptide I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA
HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA
GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ
TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH
PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN
SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKR
KVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
Target Bioclass
Enzyme
Family
Heme-copper respiratory oxidase family
Subcellular location
Mitochondrion inner membrane
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Uniprot ID
P00395
Ensemble ID
ENST00000361624.2
HGNC ID
HGNC:7419
ChEMBL ID
CHEMBL6173

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C498(1.31)  LDD3332  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
Jackson_14
 Probe Info  		2.38  LDD0123  [4]
EA-probe
 Probe Info  		C498(0.96)  LDD2210  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
JN0003
 Probe Info  		20.00  LDD0469  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C498(2.33)  LDD0372  [10]
 LDCM0214  AC1 HEK-293T C498(1.00)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C498(1.02)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C498(0.96)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C498(1.01)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C498(0.96)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C498(0.96)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C498(1.02)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C498(1.02)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C498(1.01)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C498(0.96)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C498(1.00)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C498(1.00)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C498(0.98)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C498(0.95)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C498(1.01)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C498(1.02)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C498(0.98)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C498(1.00)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C498(1.01)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C498(0.95)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C498(0.99)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C498(0.99)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C498(1.01)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C498(1.00)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C498(0.99)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C498(0.99)  LDD1534  [11]
 LDCM0296  AC35 PaTu 8988t C498(1.03)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C498(1.02)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C498(1.14)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C498(1.15)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C498(1.10)  LDD1179  [12]
 LDCM0301  AC4 HEK-293T C498(0.99)  LDD1540  [11]
 LDCM0302  AC40 PaTu 8988t C498(1.05)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C498(1.06)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C498(1.16)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C498(1.11)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C498(0.99)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C498(1.05)  LDD1186  [12]
 LDCM0308  AC46 PaTu 8988t C498(0.97)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C498(0.81)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C498(0.81)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C498(0.94)  LDD1190  [12]
 LDCM0312  AC5 HEK-293T C498(0.98)  LDD1551  [11]
 LDCM0313  AC50 PaTu 8988t C498(0.95)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C498(1.00)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C498(1.06)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C498(0.78)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C498(0.91)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C498(0.89)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C498(0.81)  LDD1198  [12]
 LDCM0320  AC57 HEK-293T C498(1.02)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C498(1.06)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C498(1.07)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C498(1.00)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C498(1.04)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C498(1.06)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C498(0.98)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C498(0.97)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C498(1.02)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C498(0.98)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C498(1.02)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C498(0.98)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C498(0.98)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C498(1.03)  LDD1514  [11]
 LDCM0630  CCW28-3 231MFP C498(1.49)  LDD2214  [13]
 LDCM0367  CL1 HEK-293T C498(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C498(1.20)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C498(0.96)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C498(0.97)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C498(0.93)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C498(1.05)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C498(0.98)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C498(0.93)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C498(0.98)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C498(0.99)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C498(1.00)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C498(0.96)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C498(1.09)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C498(0.94)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C498(1.00)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C498(0.98)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C498(0.96)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C498(0.94)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C498(1.08)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C498(1.01)  LDD1590  [11]
 LDCM0387  CL117 PaTu 8988t C498(1.20)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C498(1.20)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C498(1.06)  LDD1268  [12]
 LDCM0390  CL12 HEK-293T C498(1.14)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C498(1.12)  LDD1270  [12]
 LDCM0392  CL121 PaTu 8988t C498(0.89)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C498(0.84)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C498(0.80)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C498(0.96)  LDD1274  [12]
 LDCM0396  CL125 HEK-293T C498(1.03)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C498(1.03)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C498(1.07)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C498(0.95)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C498(0.99)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C498(0.98)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C498(1.06)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C498(1.01)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C498(1.00)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C498(1.00)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C498(1.03)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C498(1.06)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C498(1.09)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C498(0.98)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C498(1.05)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C498(1.03)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C498(1.11)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C498(1.01)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C498(0.99)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C498(1.02)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C498(1.06)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C498(1.00)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C498(1.11)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C498(0.98)  LDD1623  [11]
 LDCM0420  CL31 PaTu 8988t C498(1.04)  LDD1299  [12]
 LDCM0421  CL32 PaTu 8988t C498(0.87)  LDD1300  [12]
 LDCM0422  CL33 PaTu 8988t C498(0.82)  LDD1301  [12]
 LDCM0423  CL34 PaTu 8988t C498(0.96)  LDD1302  [12]
 LDCM0424  CL35 PaTu 8988t C498(1.23)  LDD1303  [12]
 LDCM0425  CL36 PaTu 8988t C498(0.70)  LDD1304  [12]
 LDCM0426  CL37 PaTu 8988t C498(0.91)  LDD1305  [12]
 LDCM0428  CL39 PaTu 8988t C498(0.90)  LDD1307  [12]
 LDCM0429  CL4 HEK-293T C498(1.12)  LDD1633  [11]
 LDCM0430  CL40 PaTu 8988t C498(0.99)  LDD1309  [12]
 LDCM0431  CL41 PaTu 8988t C498(0.91)  LDD1310  [12]
 LDCM0432  CL42 PaTu 8988t C498(0.99)  LDD1311  [12]
 LDCM0433  CL43 PaTu 8988t C498(1.07)  LDD1312  [12]
 LDCM0434  CL44 PaTu 8988t C498(1.09)  LDD1313  [12]
 LDCM0435  CL45 PaTu 8988t C498(1.05)  LDD1314  [12]
 LDCM0436  CL46 PaTu 8988t C498(1.01)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C498(1.27)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C498(1.36)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C498(1.33)  LDD1318  [12]
 LDCM0440  CL5 HEK-293T C498(1.06)  LDD1644  [11]
 LDCM0441  CL50 PaTu 8988t C498(1.11)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C498(1.47)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C498(1.23)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C498(1.17)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C498(1.42)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C498(1.09)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C498(1.84)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C498(1.57)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C498(1.22)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C498(1.24)  LDD1329  [12]
 LDCM0451  CL6 HEK-293T C498(1.04)  LDD1654  [11]
 LDCM0452  CL60 PaTu 8988t C498(1.39)  LDD1331  [12]
 LDCM0453  CL61 HEK-293T C498(1.01)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C498(0.99)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C498(1.05)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C498(0.92)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C498(1.03)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C498(1.02)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C498(1.04)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C498(0.95)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C498(0.98)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C498(1.12)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C498(1.03)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C498(0.97)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C498(1.05)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C498(0.95)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C498(0.97)  LDD1670  [11]
 LDCM0469  CL76 PaTu 8988t C498(0.72)  LDD1348  [12]
 LDCM0470  CL77 PaTu 8988t C498(0.61)  LDD1349  [12]
 LDCM0471  CL78 PaTu 8988t C498(0.96)  LDD1350  [12]
 LDCM0472  CL79 PaTu 8988t C498(0.94)  LDD1351  [12]
 LDCM0473  CL8 HEK-293T C498(1.18)  LDD1676  [11]
 LDCM0474  CL80 PaTu 8988t C498(0.76)  LDD1353  [12]
 LDCM0475  CL81 PaTu 8988t C498(1.12)  LDD1354  [12]
 LDCM0476  CL82 PaTu 8988t C498(0.86)  LDD1355  [12]
 LDCM0477  CL83 PaTu 8988t C498(1.20)  LDD1356  [12]
 LDCM0478  CL84 PaTu 8988t C498(0.61)  LDD1357  [12]
 LDCM0479  CL85 PaTu 8988t C498(1.34)  LDD1358  [12]
 LDCM0480  CL86 PaTu 8988t C498(0.73)  LDD1359  [12]
 LDCM0481  CL87 PaTu 8988t C498(0.83)  LDD1360  [12]
 LDCM0482  CL88 PaTu 8988t C498(0.84)  LDD1361  [12]
 LDCM0483  CL89 PaTu 8988t C498(0.80)  LDD1362  [12]
 LDCM0484  CL9 HEK-293T C498(1.06)  LDD1687  [11]
 LDCM0485  CL90 PaTu 8988t C498(1.17)  LDD1364  [12]
 LDCM0486  CL91 HEK-293T C498(1.05)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C498(1.01)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C498(1.01)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C498(1.00)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C498(1.05)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C498(1.04)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C498(0.99)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C498(1.04)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C498(1.02)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C498(1.04)  LDD1698  [11]
 LDCM0175  Ethacrynic acid HeLa C498(0.96)  LDD2210  [5]
 LDCM0468  Fragment33 HEK-293T C498(0.98)  LDD1671  [11]
 LDCM0427  Fragment51 PaTu 8988t C498(0.86)  LDD1306  [12]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HEK-293T C498(0.99)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C498(1.00)  LDD1497  [11]
 LDCM0024  KB05 MKN45 C498(1.31)  LDD3332  [2]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.38  LDD0123  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) Cytochrome c oxidase IV family P13073
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) COA3 family Q9Y2R0
Mitochondrial import inner membrane translocase subunit Tim21 (TIMM21) TIM21 family Q9BVV7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholic Acid Small molecular drug DB02659
Copper . DB09130
Oxygen . DB09140
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.